{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:25:05Z","timestamp":1785799505929,"version":"3.56.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosurg Rev"],"DOI":"10.1007\/s10143-025-04075-y","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:31:29Z","timestamp":1769214689000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The use of cellular therapies for trigeminal neuralgia: a systematic review of behavioral and molecular outcomes"],"prefix":"10.1007","volume":"49","author":[{"given":"Juan P.","family":"Navarro-Garcia de Llano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus E.","family":"Sanchez-Garavito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshvardhan","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Fuentes-Tapias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Safa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loizos","family":"Michaelides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Ramos-Fresnedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchun","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abba C.","family":"Zubair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Quinones-Hinojosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeet S.","family":"Grewal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"issue":"9","key":"4075_CR1","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/S1474-4422(20)30233-7","volume":"19","author":"L Bendtsen","year":"2020","unstructured":"Bendtsen L, Zakrzewska JM, Heinskou TB, Hodaie M, Leal PRL, Nurmikko T et al (2020) Advances in diagnosis, classification, pathophysiology, and management of trigeminal neuralgia. Lancet Neurol 19(9):784\u201396. https:\/\/doi.org\/10.1016\/S1474-4422(20)30233-7","journal-title":"Lancet Neurol"},{"issue":"Pt 12","key":"4075_CR2","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1093\/brain\/124.12.2347","volume":"124","author":"S Love","year":"2001","unstructured":"Love S, Coakham HB (2001) Trigeminal neuralgia: pathology and pathogenesis. Brain 124(Pt 12):2347\u20132360. https:\/\/doi.org\/10.1093\/brain\/124.12.2347","journal-title":"Brain"},{"issue":"2","key":"4075_CR3","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0304-3959(94)90086-8","volume":"56","author":"HZ Rappaport","year":"1994","unstructured":"Rappaport HZ, Devor M (1994) Trigeminal neuralgia: the role of self-sustaining discharge in the trigeminal ganglion. Pain 56(2):127\u2013. https:\/\/doi.org\/10.1016\/0304-3959(94)90086-8. 38","journal-title":"Pain"},{"issue":"1","key":"4075_CR4","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/00002508-200201000-00002","volume":"18","author":"M Devor","year":"2002","unstructured":"Devor M, Amir R, Rappaport ZH (2002) Pathophysiology of trigeminal neuralgia: the ignition hypothesis. Clin J Pain 18(1):4\u201313. https:\/\/doi.org\/10.1097\/00002508-200201000-00002","journal-title":"Clin J Pain"},{"issue":"6","key":"4075_CR5","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1111\/ene.13950","volume":"26","author":"L Bendtsen","year":"2019","unstructured":"Bendtsen L, Zakrzewska JM, Abbott J, Braschinsky M, Di Stefano G, Donnet A et al (2019) European academy of neurology guideline on trigeminal neuralgia. Eur J Neurol 26(6):831\u201349. https:\/\/doi.org\/10.1111\/ene.13950","journal-title":"Eur J Neurol"},{"issue":"4","key":"4075_CR6","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1097\/SCS.0000000000000984","volume":"25","author":"L Xia","year":"2014","unstructured":"Xia L, Zhong J, Zhu J, Wang YN, Dou NN, Liu MX et al (2014) Effectiveness and safety of microvascular decompression surgery for treatment of trigeminal neuralgia: a systematic review. J Craniofac Surg 25(4):1413\u20137. https:\/\/doi.org\/10.1097\/SCS.0000000000000984","journal-title":"J Craniofac Surg"},{"issue":"5","key":"4075_CR7","doi-asserted-by":"publisher","first-page":"201","DOI":"10.5125\/jkaoms.2013.39.5.201","volume":"39","author":"I Kim","year":"2013","unstructured":"Kim I (2013) A brief overview of cell therapy and its product. J Korean Assoc Oral Maxillofac Surg 39(5):201\u2013202. https:\/\/doi.org\/10.5125\/jkaoms.2013.39.5.201","journal-title":"J Korean Assoc Oral Maxillofac Surg"},{"key":"4075_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.756029","volume":"8","author":"AE El-Kadiry","year":"2021","unstructured":"El-Kadiry AE, Rafei M, Shammaa R (2021) Cell therapy: types, regulation, and clinical benefits. Front Med (Lausanne) 8:756029. https:\/\/doi.org\/10.3389\/fmed.2021.756029","journal-title":"Front Med (Lausanne)"},{"issue":"4","key":"4075_CR9","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3344\/kjp.2022.35.4.383","volume":"35","author":"Z Yang","year":"2022","unstructured":"Yang Z, Wang C, Zhang X, Li J, Zhang Z, Tan Z et al (2022) Stem cells from human exfoliated deciduous teeth attenuate trigeminal neuralgia in rats by inhibiting endoplasmic reticulum stress. Korean J Pain 35(4):383\u201390. https:\/\/doi.org\/10.3344\/kjp.2022.35.4.383","journal-title":"Korean J Pain"},{"issue":"12","key":"4075_CR10","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.4103\/1673-5374.221171","volume":"12","author":"C Wang","year":"2017","unstructured":"Wang C, Lu CF, Peng J, Hu CD, Wang Y (2017) Roles of neural stem cells in the repair of peripheral nerve injury. Neural Regen Res 12(12):2106\u20132112. https:\/\/doi.org\/10.4103\/1673-5374.221171","journal-title":"Neural Regen Res"},{"issue":"1\u20132","key":"4075_CR11","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/s0006-8993(03)02539-3","volume":"974","author":"T Murakami","year":"2003","unstructured":"Murakami T, Fujimoto Y, Yasunaga Y, Ishida O, Tanaka N, Ikuta Y et al (2003) Transplanted neuronal progenitor cells in a peripheral nerve gap promote nerve repair. Brain Res 974(1\u20132):17\u201324. https:\/\/doi.org\/10.1016\/s0006-8993(03)02539-3","journal-title":"Brain Res"},{"issue":"1","key":"4075_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2990.2005.00637.x","volume":"31","author":"WF Blakemore","year":"2005","unstructured":"Blakemore WF (2005) The case for a central nervous system (CNS) origin for the Schwann cells that remyelinate CNS axons following concurrent loss of oligodendrocytes and astrocytes. Neuropathol Appl Neurobiol 31(1):1\u201310. https:\/\/doi.org\/10.1111\/j.1365-2990.2005.00637.x","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"3","key":"4075_CR13","doi-asserted-by":"publisher","first-page":"A12","DOI":"10.7326\/ACPJC-1995-123-3-A12","volume":"123","author":"WS Richardson","year":"1995","unstructured":"Richardson WS, Wilson MC, Nishikawa J, Hayward RS (1995) The well-built clinical question: a key to evidence-based decisions. ACP J Club 123(3):A12\u2013A13","journal-title":"ACP J Club"},{"issue":"7","key":"4075_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(7):e1000097. https:\/\/doi.org\/10.1371\/journal.pmed.1000097","journal-title":"PLoS Med"},{"key":"4075_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-43","volume":"14","author":"CR Hooijmans","year":"2014","unstructured":"Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW (2014) SYRCLE\u2019s risk of bias tool for animal studies. BMC Med Res Methodol 14:43. https:\/\/doi.org\/10.1186\/1471-2288-14-43","journal-title":"BMC Med Res Methodol"},{"key":"4075_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2023.148732","volume":"1825","author":"J Lu","year":"2024","unstructured":"Lu J, Yang B, Zhang W, Cheng H, Zeng J, Wang Y et al (2024) Transplantation of olfactory ensheathing cells can alleviate neuroinflammatory responses in rats with trigeminal neuralgia. Brain Res 1825:148732. https:\/\/doi.org\/10.1016\/j.brainres.2023.148732","journal-title":"Brain Res"},{"issue":"1","key":"4075_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02221-6","volume":"21","author":"R Guo","year":"2023","unstructured":"Guo R, Fang Y, Zhang Y, Liu L, Li N, Wu J et al (2023) SHED-derived exosomes attenuate trigeminal neuralgia after CCI of the infraorbital nerve in mice via the miR-24-3p\/IL-1R1\/p-p38 MAPK pathway. J Nanobiotechnology 21(1):458. https:\/\/doi.org\/10.1186\/s12951-023-02221-6","journal-title":"J Nanobiotechnology"},{"issue":"2","key":"4075_CR18","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/joor.13243","volume":"49","author":"X Bai","year":"2022","unstructured":"Bai X, Xiao K, Yang Z, Zhang Z, Li J, Yan Z et al (2022) Stem cells from human exfoliated deciduous teeth relieve pain via downregulation of c-Jun in a rat model of trigeminal neuralgia. J Oral Rehabil 49(2):219\u201327. https:\/\/doi.org\/10.1111\/joor.13243","journal-title":"J Oral Rehabil"},{"key":"4075_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12060706","author":"J Lu","year":"2022","unstructured":"Lu J, Yang B, Liao J, Chen B, Lu M, Zhang W et al (2022) Olfactory ensheathing cells alleviate facial pain in rats with trigeminal neuralgia by inhibiting the expression of P2X7 receptor. Brain Sci. https:\/\/doi.org\/10.3390\/brainsci12060706","journal-title":"Brain Sci"},{"key":"4075_CR20","doi-asserted-by":"publisher","first-page":"613","DOI":"10.2147\/JPR.S347907","volume":"15","author":"X Yan","year":"2022","unstructured":"Yan X, Liu Y, Yu S, Huang D, Hu R (2022) Repair effects of bone marrow mesenchymal stem cells on demyelination of trigeminal ganglion in rats with trigeminal neuralgia. J Pain Res 15:613\u2013622. https:\/\/doi.org\/10.2147\/JPR.S347907","journal-title":"J Pain Res"},{"key":"4075_CR21","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8819884","volume":"2021","author":"X Bai","year":"2021","unstructured":"Bai X, Zhang X, Wang C, Liu Y, Liu X, Fan Y (2021) Stem cells from human exfoliated deciduous teeth attenuate trigeminal neuralgia in rats. Stem Cells Int 2021:8819884. https:\/\/doi.org\/10.1155\/2021\/8819884","journal-title":"Stem Cells Int"},{"issue":"6","key":"4075_CR22","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.mehy.2013.10.010","volume":"81","author":"C Collet","year":"2013","unstructured":"Collet C, Haen P, Laversanne S, Brignol L, Thiery G (2013) Trigeminal neuralgia: a new therapy? Med Hypotheses 81(6):1088\u20131089. https:\/\/doi.org\/10.1016\/j.mehy.2013.10.010","journal-title":"Med Hypotheses"},{"issue":"1","key":"4075_CR23","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/cne.10182","volume":"446","author":"WW Au","year":"2002","unstructured":"Au WW, Treloar HB, Greer CA (2002) Sublaminar organization of the mouse olfactory bulb nerve layer. J Comp Neurol 446(1):68\u201380. https:\/\/doi.org\/10.1002\/cne.10182","journal-title":"J Comp Neurol"},{"issue":"4","key":"4075_CR24","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1007\/s11064-020-03211-y","volume":"46","author":"L Zhao","year":"2021","unstructured":"Zhao L, Shen J, Jia K, Shi F, Hao Q, Gao F (2021) MicroRNA-24-3p inhibits microglia inflammation by regulating MK2 following spinal cord injury. Neurochem Res 46(4):843\u2013852. https:\/\/doi.org\/10.1007\/s11064-020-03211-y","journal-title":"Neurochem Res"},{"issue":"37","key":"4075_CR25","doi-asserted-by":"publisher","first-page":"34287","DOI":"10.1074\/jbc.M204973200","volume":"277","author":"N Morishima","year":"2002","unstructured":"Morishima N, Nakanishi K, Takenouchi H, Shibata T, Yasuhiko Y (2002) An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem 277(37):34287\u201334294. https:\/\/doi.org\/10.1074\/jbc.M204973200","journal-title":"J Biol Chem"},{"issue":"5","key":"4075_CR26","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1016\/j.ajpath.2011.07.031","volume":"179","author":"A Mozos","year":"2011","unstructured":"Mozos A, Roue G, Lopez-Guillermo A, Jares P, Campo E, Colomer D et al (2011) The expression of the endoplasmic reticulum stress sensor BiP\/GRP78 predicts response to chemotherapy and determines the efficacy of proteasome inhibitors in diffuse large b-cell lymphoma. Am J Pathol 179(5):2601\u201310. https:\/\/doi.org\/10.1016\/j.ajpath.2011.07.031","journal-title":"Am J Pathol"},{"issue":"5","key":"4075_CR27","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/s0166-2236(96)01000-4","volume":"20","author":"T Herdegen","year":"1997","unstructured":"Herdegen T, Skene P, Bahr M (1997) The c-Jun transcription factor\u2013bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci 20(5):227\u2013231. https:\/\/doi.org\/10.1016\/s0166-2236(96)01000-4","journal-title":"Trends Neurosci"},{"issue":"1","key":"4075_CR28","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00221-009-1760-2","volume":"196","author":"WD Willis Jr.","year":"2009","unstructured":"Willis WD Jr. (2009) The role of TRPV1 receptors in pain evoked by noxious thermal and chemical stimuli. Exp Brain Res 196(1):5\u201311. https:\/\/doi.org\/10.1007\/s00221-009-1760-2","journal-title":"Exp Brain Res"},{"issue":"2","key":"4075_CR29","first-page":"187","volume":"15","author":"DS Luo","year":"2012","unstructured":"Luo DS, Zhang T, Zuo CX, Zuo ZF, Li H, Wu SX et al (2012) An animal model for trigeminal neuralgia by compression of the trigeminal nerve root. Pain Physician 15(2):187\u2013196","journal-title":"Pain Physician"},{"issue":"1","key":"4075_CR30","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12974-025-03360-3","volume":"22","author":"C Acioglu","year":"2025","unstructured":"Acioglu C, Elkabes S (2025) Innate immune sensors and regulators at the blood brain barrier: focus on toll-like receptors and inflammasomes as mediators of neuro-immune crosstalk and inflammation. J Neuroinflammation 22(1):39. https:\/\/doi.org\/10.1186\/s12974-025-03360-3","journal-title":"J Neuroinflammation"},{"issue":"9","key":"4075_CR31","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1093\/stcltm\/szac051","volume":"11","author":"DB Erasmus","year":"2022","unstructured":"Erasmus DB, Durand N, Alvarez FA, Narula T, Hodge DO, Zubair AC (2022) Feasibility and safety of low-dose mesenchymal stem cell infusion in lung transplant recipients. Stem Cells Transl Med 11(9):891\u2013899. https:\/\/doi.org\/10.1093\/stcltm\/szac051","journal-title":"Stem Cells Transl Med"},{"issue":"11","key":"4075_CR32","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.jcyt.2020.04.040","volume":"22","author":"EF Wiest","year":"2020","unstructured":"Wiest EF, Zubair AC (2020) Challenges of manufacturing mesenchymal stromal cell-derived extracellular vesicles in regenerative medicine. Cytotherapy 22(11):606\u2013. https:\/\/doi.org\/10.1016\/j.jcyt.2020.04.040. 12","journal-title":"Cytotherapy"},{"issue":"12","key":"4075_CR33","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1089\/scd.2012.0594","volume":"22","author":"C Menard","year":"2013","unstructured":"Menard C, Pacelli L, Bassi G, Dulong J, Bifari F, Bezier I et al (2013) Clinical-grade mesenchymal stromal cells produced under various good manufacturing practice processes differ in their immunomodulatory properties: standardization of immune quality controls. Stem Cells Dev 22(12):1789\u2013801. https:\/\/doi.org\/10.1089\/scd.2012.0594","journal-title":"Stem Cells Dev"},{"key":"4075_CR34","doi-asserted-by":"crossref","unstructured":"Ramos-Fresnedo A, Al-Kharboosh R, Twohy EL, Basil AN, Szymkiewicz EC, Zubair AC et al (2023) Phase 1, dose escalation, nonrandomized, open-label, clinical trial evaluating the safety and preliminary efficacy of allogenic adipose-derived mesenchymal stem cells for recurrent glioblastoma: a clinical trial protocol. Neurosurg Pract 4(4)","DOI":"10.1227\/neuprac.0000000000000062"},{"issue":"11","key":"4075_CR35","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1056\/NEJM195709122571102","volume":"257","author":"ED Thomas","year":"1957","unstructured":"Thomas ED, Lochte HL Jr., Lu WC, Ferrebee JW (1957) Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. N Engl J Med 257(11):491\u20136. https:\/\/doi.org\/10.1056\/NEJM195709122571102","journal-title":"N Engl J Med"},{"key":"4075_CR36","unstructured":"FDA US (2024) Approved cellular and gene therapy products. https:\/\/www.fda.gov\/vaccines-blood-biologics\/cellular-gene-therapy-products\/approved-cellular-and-gene-therapy-products Accessed"},{"issue":"2","key":"4075_CR37","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.mayocp.2019.10.008","volume":"95","author":"M Bydon","year":"2020","unstructured":"Bydon M, Dietz AB, Goncalves S, Moinuddin FM, Alvi MA, Goyal A et al (2020) CELLTOP clinical trial: first report from a phase 1 trial of autologous adipose tissue-derived mesenchymal stem cells in the treatment of paralysis due to traumatic spinal cord injury. Mayo Clin Proc 95(2):406\u201314. https:\/\/doi.org\/10.1016\/j.mayocp.2019.10.008","journal-title":"Mayo Clin Proc"}],"container-title":["Neurosurgical Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-025-04075-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10143-025-04075-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-025-04075-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:31:31Z","timestamp":1769214691000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10143-025-04075-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,24]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4075"],"URL":"https:\/\/doi.org\/10.1007\/s10143-025-04075-y","relation":{},"ISSN":["1437-2320"],"issn-type":[{"value":"1437-2320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,24]]},"assertion":[{"value":"16 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"154"}}