{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:54:37Z","timestamp":1781646877525,"version":"3.54.5"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007397","name":"Charles University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosurg Rev"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background\/Objectives neurofilament light chain (NfL) is a blood-accessible marker of neuroaxonal injury. We assessed the clinical utility of serum NfL in adults with idiopathic normal-pressure hydrocephalus (iNPH). Methods in a single-center prospective cohort (registered at ClinicalTrials.gov; partial overlap with a prior registry detailed in Supplementary Table S1), we enrolled 41 adults aged\u2009\u2265\u200950 years. The hydrocephalus arm included only anticipated ventriculoperitoneal (VP) shunt responders (Group A); non-hydrocephalus surgical patients served as controls (Group B). The primary analysis compared log-transformed serum NfL between groups using Welch\u2019s t-test. A prespecified paired subset was sampled before premedication (baseline) and 24 h after surgery start. As a sensitivity analysis, we fitted age-aware linear models for log(NfL) with group as the exposure and age and sex as covariates. Results serum NfL was right-skewed; analyses used log-transformed values. The primary between-group contrast showed no difference (geometric mean ratio [GMR] 1.03; 95% CI 0.51\u20132.10; p\u2009=\u20090.93). In age-adjusted models (log[NfL] ~ group\u2009+\u2009age\u2009+\u2009sex), the between-group difference remained non-significant with an effect magnitude comparable to the unadjusted GMR. In paired analyses, serum NfL did not change from baseline to 24 h overall (24 h vs. baseline GMR 1.13; 95% CI 0.89\u20131.45; p\u2009=\u20090.305) and remained non-significant within both Group A (n\u2009=\u200910) and Group B (n\u2009=\u200911). Conclusions in adults\u2009\u2265\u200950 years, serum NfL neither distinguished anticipated VP-shunt responders with iNPH from surgical controls nor exhibited an acute change at 24 h after surgery start under general anesthesia. These findings suggest limited standalone diagnostic\/prognostic utility of serum NfL in this setting. Interpretation should be age-aware and integrated with complementary clinical data and biomarkers; future studies should use standardized sampling and multimodal panels to refine risk stratification.<\/jats:p>","DOI":"10.1007\/s10143-026-04254-5","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:26:40Z","timestamp":1774938400000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum neurofilament light chain in hydrocephalus and surgical controls: baseline comparison and 24-hour perioperative dynamics under general anesthesia"],"prefix":"10.1007","volume":"49","author":[{"given":"Miroslav","family":"Cihlo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Tr\u00e1vn\u00ed\u010dek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Tich\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radom\u00edr","family":"Hy\u0161pler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Kalousov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"\u010ces\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Zadrob\u00edlek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Kukr\u00e1lov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Dost\u00e1l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Zima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Slukov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlasta","family":"Dost\u00e1lov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"4254_CR1","doi-asserted-by":"publisher","first-page":"912005","DOI":"10.3389\/fimmu.2022.912005","volume":"13","author":"RA K\u00f6lliker Frers","year":"2022","unstructured":"K\u00f6lliker Frers RA et al (2022) Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis. 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This trial has been registered at ClinicalTrials.gov (NCT05399602).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human ethics and consent to participate declaration"}},{"value":"This study was conducted in accordance with the principles of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical declarations"}},{"value":"See the Methods.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}},{"value":"All patients provided written informed consent for participation.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent statement"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"330"}}