{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:56:56Z","timestamp":1781650616602,"version":"3.54.5"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004721","name":"The University of Tokyo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004721","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosurg Rev"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Postoperative regression of periventricular anastomosis (PA) may have important implications for preventing hemorrhagic events in patients with moyamoya disease (MMD). We aimed to identify the genetic factors associated with postoperative PA regression. This retrospective cohort study enrolled 81 patients (102 hemispheres) who underwent combined revascularization surgery. PA types (lenticulostriate, choroidal, and thalamic) were scored from 0 to 2 preoperatively and postoperatively using magnetic resonance angiography, and postoperative regression was evaluated. We extracted all exonic variants in\n                    <jats:italic>RNF213<\/jats:italic>\n                    and analyzed differences in their effects on PA regression between the p.Arg4810Lys variant and other\n                    <jats:italic>RNF213<\/jats:italic>\n                    variants. Among the 81 participants, 51 (63.0%) carried p.Arg4810Lys (all heterozygotes: GA group), whereas 20 (24.5%) harbored other rare or damaging\n                    <jats:italic>RNF213<\/jats:italic>\n                    variants (GG with other variants group). All types of PA regressed significantly in the GA group (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001 for all), whereas only choroidal PA showed significant regression in the GG with other variants group (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.024). The postoperative decrease in choroidal PA score was greater in the GG with other variants group than in the GA group (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.058). Multivariate analysis using linear mixed-effect models suggested a potential association between choroidal PA score reduction and two factors: the GG genotype with other variants and age\u2009&lt;\u200916\u00a0years. Our findings indicate that harboring\n                    <jats:italic>RNF213<\/jats:italic>\n                    variants other than p.Arg4810Lys may be associated with greater regression of choroidal PA compared with harboring p.Arg4810Lys in this exploratory cohort. Comprehensive genetic analysis of\n                    <jats:italic>RNF213<\/jats:italic>\n                    may enable more accurate prediction of the surgical preventive effect on hemorrhagic events in MMD.\n                  <\/jats:p>","DOI":"10.1007\/s10143-026-04289-8","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T01:12:36Z","timestamp":1776647556000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of genetic profiles on periventricular anastomosis following bypass surgery in moyamoya disease"],"prefix":"10.1007","volume":"49","author":[{"given":"Seiei","family":"Torazawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6369-3391","authenticated-orcid":false,"given":"Satoru","family":"Miyawaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Hongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kiyofuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Komura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Katoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumpei","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhito","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"4289_CR1","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/s1474-4422(08)70240-0","volume":"7","author":"S Kuroda","year":"2008","unstructured":"Kuroda S, Houkin K (2008) Moyamoya disease: current concepts and future perspectives. Lancet Neurol 7:1056\u20131066. https:\/\/doi.org\/10.1016\/s1474-4422(08)70240-0","journal-title":"Lancet Neurol"},{"key":"4289_CR2","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1056\/nejmra0804622","volume":"360","author":"RM Scott","year":"2009","unstructured":"Scott RM, Smith ER (2009) Moyamoya disease and moyamoya syndrome. N Engl J Med 360:1226\u20131237. https:\/\/doi.org\/10.1056\/nejmra0804622","journal-title":"N Engl J Med"},{"key":"4289_CR3","doi-asserted-by":"publisher","first-page":"204","DOI":"10.2176\/nmc.oa.2014-0360","volume":"55","author":"T Funaki","year":"2015","unstructured":"Funaki T, Fushimi Y, Takahashi JC, Takagi Y, Araki Y, Yoshida K, Kikuchi T, Miyamoto S (2015) Visualization of periventricular collaterals in moyamoya disease with flow-sensitive black-blood magnetic resonance angiography: preliminary experience. Neurol Med Chir (Tokyo) 55:204\u2013209. https:\/\/doi.org\/10.2176\/nmc.oa.2014-0360","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"4289_CR4","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.3171\/2015.6.jns15845","volume":"124","author":"T Funaki","year":"2016","unstructured":"Funaki T, Takahashi JC, Yoshida K, Takagi Y, Fushimi Y, Kikuchi T, Mineharu Y, Okada T, Morimoto T, Miyamoto S (2016) Periventricular anastomosis in moyamoya disease: detecting fragile collateral vessels with MR angiography. J Neurosurg 124:1766\u20131772. https:\/\/doi.org\/10.3171\/2015.6.jns15845","journal-title":"J Neurosurg"},{"key":"4289_CR5","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3171\/2017.9.jns17576","volume":"130","author":"T Funaki","year":"2019","unstructured":"Funaki T, Takahashi JC, Houkin K, Kuroda S, Takeuchi S, Fujimura M, Tomata Y, Miyamoto S (2019) High rebleeding risk associated with choroidal collateral vessels in hemorrhagic moyamoya disease: analysis of a nonsurgical cohort in the Japan Adult Moyamoya Trial. J Neurosurg 130:525\u2013530. https:\/\/doi.org\/10.3171\/2017.9.jns17576","journal-title":"J Neurosurg"},{"key":"4289_CR6","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1161\/strokeaha.122.041932","volume":"54","author":"S Kuroda","year":"2023","unstructured":"Kuroda S, Yamamoto S, Funaki T, Fujimura M, Kataoka H, Hishikawa T, Takahashi J, Endo H, Nariai T, Osato T, Saito N, Sato N, Hori E, Ito YM, Miyamoto S, AMORE Study Group (2023) Five-year stroke risk and its predictors in asymptomatic moyamoya disease: Asymptomatic Moyamoya Registry (AMORE). 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Transl Stroke Res 15:1142\u20131153. https:\/\/doi.org\/10.1007\/s12975-023-01194-w","journal-title":"Transl Stroke Res"},{"key":"4289_CR17","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s12975-023-01159-z","volume":"16","author":"S Torazawa","year":"2023","unstructured":"Torazawa S, Miyawaki S, Imai H, Hongo H, Ishigami D, Shimizu M, Ono H, Shinya Y, Sato D, Sakai Y, Umekawa M, Kiyofuji S, Shimada D, Koizumi S, Komura D, Katoh H, Ishikawa S, Nakatomi H, Teraoka A, Saito N (2023) RNF213 p.Arg4810Lys wild type is associated with de novo hemorrhage in asymptomatic hemispheres with moyamoya disease. 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Dev Cell 36:79\u201393. https:\/\/doi.org\/10.1016\/j.devcel.2015.12.015","journal-title":"Dev Cell"}],"container-title":["Neurosurgical Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-026-04289-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10143-026-04289-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-026-04289-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:23:25Z","timestamp":1781648605000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10143-026-04289-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4289"],"URL":"https:\/\/doi.org\/10.1007\/s10143-026-04289-8","relation":{},"ISSN":["1437-2320"],"issn-type":[{"value":"1437-2320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]},"assertion":[{"value":"19 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the institutional research board (approval number: G10026; approval date: September 12, 2011). This study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent for genetic analysis and surgical procedure was obtained from all participants or from the legal guardians of patients aged\u2009<\u200918\u00a0years.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"\u2022 Disclosure of potential conflicts of interest: The authors have no relevant financial or non-financial interests to disclose.\u2022 Research involving Human Participants and\/or Animals: This study was approved by the institutional research board (approval number: G10026; approval date: September 12, 2011). This study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.\u2022 Informed consent: Written informed consent for genetic analysis and surgical procedure was obtained from all participants or from the legal guardians of patients aged\u2009<\u200918\u00a0years.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}],"article-number":"363"}}