{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:39:10Z","timestamp":1789749550763,"version":"4.0.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosurg Rev"],"DOI":"10.1007\/s10143-026-04360-4","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T02:19:54Z","timestamp":1780885194000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rho-associated kinase inhibitors in cerebral cavernous malformations: a preclinical systematic review"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0744-2695","authenticated-orcid":false,"given":"Irem","family":"Uslu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9971-1154","authenticated-orcid":false,"given":"Ecem","family":"Senturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9719-9494","authenticated-orcid":false,"given":"Zeynep E.","family":"Celikkiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9263-6621","authenticated-orcid":false,"given":"Bilge","family":"Kara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8643-9459","authenticated-orcid":false,"given":"Merve G.","family":"Turkmenel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3804-9800","authenticated-orcid":false,"given":"Berkay","family":"Kilic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Alomari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8306-1524","authenticated-orcid":false,"given":"Doga D.","family":"Demir Yangi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0500-218X","authenticated-orcid":false,"given":"Kivanc","family":"Yangi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"issue":"1","key":"4360_CR1","doi-asserted-by":"publisher","first-page":"e6","DOI":"10.3171\/foc.2006.21.1.7","volume":"21","author":"LF Gonzalez","year":"2006","unstructured":"Gonzalez LF, Lekovic GP, Eschbacher J, Coons S, Porter RW, Spetzler RF (2006) Are cavernous sinus hemangiomas and cavernous malformations different entities? Neurosurg Focus 21(1):e6","journal-title":"Neurosurg Focus"},{"issue":"9","key":"4360_CR2","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1016\/j.mayocp.2019.11.005","volume":"95","author":"KD Flemming","year":"2020","unstructured":"Flemming KD, Lanzino G (2020) Cerebral Cavernous Malformation: What a Practicing Clinician Should Know. Mayo Clin Proc 95(9):2005\u20132020","journal-title":"Mayo Clin Proc"},{"key":"4360_CR3","doi-asserted-by":"crossref","first-page":"01","DOI":"10.1055\/a-2509-0223","volume":"87","author":"TE Baser","year":"2026","unstructured":"Baser TE, Gulsahin E, Elmuslimani S, Durna M, Gulec OB, Yerci S et al (2026) Efficacy of Medical Treatment Options for Reducing the Risk Of Bleeding in Patients with Cerebral Cavernous Malformations: A Systematic Review And Network Meta-Analysis. J Neurol Surg B Skull Base 87:01","journal-title":"J Neurol Surg B Skull Base"},{"issue":"12","key":"4360_CR4","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/s11886-017-0931-1","volume":"19","author":"KD Flemming","year":"2017","unstructured":"Flemming KD (2017) Clinical Management of Cavernous Malformations. Curr Cardiol Rep 19(12):122","journal-title":"Curr Cardiol Rep"},{"issue":"12","key":"4360_CR5","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1161\/STROKEAHA.108.520783","volume":"39","author":"C Stapf","year":"2008","unstructured":"Stapf C, Herv\u00e9 D (2008) From cavern-dwellers to cavernoma science: towards a new philosophy of cerebral cavernous malformations. Stroke 39(12):3129\u20133130","journal-title":"Stroke"},{"issue":"2","key":"4360_CR6","doi-asserted-by":"publisher","first-page":"570","DOI":"10.3171\/2016.2.JNS152322","volume":"126","author":"P Dammann","year":"2017","unstructured":"Dammann P, Wrede K, Zhu Y, Matsushige T, Maderwald S, Umutlu Lea et al (2017) Correlation of the venous angioarchitecture of multiple cerebral cavernous malformations with familial or sporadic disease: a susceptibility-weighted imaging study with 7-Tesla MRI. J Neurosurg 126(2):570\u2013577","journal-title":"J Neurosurg"},{"issue":"2","key":"4360_CR7","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1136\/jnnp-2012-302599","volume":"84","author":"P Dammann","year":"2013","unstructured":"Dammann P, Wrede KH, Maderwald S, El Hindy N, Mueller O, Chen Bea et al (2013) The venous angioarchitecture of sporadic cerebral cavernous malformations: a susceptibility weighted imaging study at 7 T MRI. J Neurol Neurosurg Psychiatry 84(2):194\u2013200","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"4360_CR8","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.freeradbiomed.2016.01.008","volume":"92","author":"H Choquet","year":"2016","unstructured":"Choquet H, Trapani E, Goitre L, Trabalzini L, Akers A, Fontanella Mea et al (2016) Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1. Free Radic Biol Med 92:100\u2013109","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"4360_CR9","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.1172\/JCI39679","volume":"120","author":"X Zheng","year":"2010","unstructured":"Zheng X, Xu C, Di Lorenzo A, Kleaveland B, Zou Z, Seiler Cea et al (2010) CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. J Clin Invest 120(8):2795\u20132804","journal-title":"J Clin Invest"},{"issue":"2","key":"4360_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nm.1911","volume":"15","author":"KJ Whitehead","year":"2009","unstructured":"Whitehead KJ, Chan AC, Navankasattusas S, Koh W, London NR, Ling Jea et al (2009) The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med 15(2):177\u2013184","journal-title":"Nat Med"},{"issue":"4","key":"4360_CR11","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1084\/jem.20091258","volume":"207","author":"RA Stockton","year":"2010","unstructured":"Stockton RA, Shenkar R, Awad IA, Ginsberg MH (2010) Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med 207(4):881\u2013896","journal-title":"J Exp Med"},{"issue":"2","key":"4360_CR12","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.devcel.2013.09.021","volume":"27","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Tang W, Zhang H, Niu X, Xu Y, Zhang Jea et al (2013) A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils. Dev Cell 27(2):215\u2013226","journal-title":"Dev Cell"},{"issue":"3","key":"4360_CR13","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/gim.2014.97","volume":"17","author":"R Shenkar","year":"2015","unstructured":"Shenkar R, Shi C, Rebeiz T, Stockton RA, McDonald DA, Mikati Aea et al (2015) Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. Genet Med 17(3):188\u2013196","journal-title":"Genet Med"},{"issue":"Pt 8","key":"4360_CR14","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1242\/jcs.061341","volume":"123","author":"M Fidalgo","year":"2010","unstructured":"Fidalgo M, Fraile M, Pires A, Force T, Pombo C, Zalvide J (2010) CCM3\/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. J Cell Sci 123(Pt 8):1274\u20131284","journal-title":"J Cell Sci"},{"issue":"24","key":"4360_CR15","doi-asserted-by":"publisher","first-page":"4466","DOI":"10.1242\/jcs.198614","volume":"129","author":"FK Mardakheh","year":"2016","unstructured":"Mardakheh FK, Self A, Marshall CJ (2016) RHO binding to FAM65A regulates Golgi reorientation during cell migration. J Cell Sci 129(24):4466\u20134479","journal-title":"J Cell Sci"},{"issue":"7455","key":"4360_CR16","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/nature12207","volume":"498","author":"L Maddaluno","year":"2013","unstructured":"Maddaluno L, Rudini N, Cuttano R, Bravi L, Giampietro C, Corada Mea et al (2013) EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature 498(7455):492\u2013496","journal-title":"Nature"},{"issue":"11","key":"4360_CR17","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.15252\/emmm.201505316","volume":"7","author":"S Marchi","year":"2015","unstructured":"Marchi S, Corricelli M, Trapani E, Bravi L, Pittaro A, Delle Monache Sea et al (2015) Defective autophagy is a key feature of cerebral cavernous malformations. EMBO Mol Med 7(11):1403\u20131417","journal-title":"EMBO Mol Med"},{"issue":"9","key":"4360_CR18","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/nm.4169","volume":"22","author":"H Jenny Zhou","year":"2016","unstructured":"Jenny Zhou H, Qin L, Zhang H, Tang W, Ji W, He Yea et al (2016) Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation. Nat Med 22(9):1033\u20131042","journal-title":"Nat Med"},{"key":"4360_CR19","doi-asserted-by":"publisher","DOI":"10.4161\/sgtp.29846","volume":"5","author":"L Julian","year":"2014","unstructured":"Julian L, Olson MF (2014) Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions. Small GTPases 5:e29846","journal-title":"Small GTPases"},{"issue":"2","key":"4360_CR20","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1083\/jcb.200705175","volume":"179","author":"A Glading","year":"2007","unstructured":"Glading A, Han J, Stockton RA, Ginsberg MH (2007) KRIT-1\/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. J Cell Biol 179(2):247\u2013254","journal-title":"J Cell Biol"},{"issue":"20","key":"4360_CR21","doi-asserted-by":"publisher","first-page":"13301","DOI":"10.1074\/jbc.C900009200","volume":"284","author":"LES Crose","year":"2009","unstructured":"Crose LES, Hilder TL, Sciaky N, Johnson GL (2009) Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells. J Biol Chem 284(20):13301\u201313305","journal-title":"J Biol Chem"},{"key":"4360_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020675","author":"S Wei","year":"2020","unstructured":"Wei S, Li Y, Polster SP, Weber CR, Awad IA, Shen L (2020) Cerebral cavernous malformation proteins in barrier maintenance and regulation. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21020675","journal-title":"Int J Mol Sci"},{"issue":"11","key":"4360_CR23","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1161\/ATVBAHA.112.300115","volume":"32","author":"M Corr","year":"2012","unstructured":"Corr M, Lerman I, Keubel JM, Ronacher L, Misra R, Lund Fea et al (2012) Decreased Krev interaction-trapped 1 expression leads to increased vascular permeability and modifies inflammatory responses in vivo. Arterioscler Thromb Vasc Biol 32(11):2702\u20132710","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"4360_CR24","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1161\/STROKEAHA.118.024058","volume":"50","author":"R Shenkar","year":"2019","unstructured":"Shenkar R, Peiper A, Pardo H, Moore T, Lightle R, Girard Rea et al (2019) Rho kinase inhibition blunts lesion development and hemorrhage in murine models of aggressive Pdcd10\/Ccm3 disease. Stroke 50(3):738\u2013744","journal-title":"Stroke"},{"issue":"1","key":"4360_CR25","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1161\/STROKEAHA.116.015013","volume":"48","author":"R Shenkar","year":"2017","unstructured":"Shenkar R, Shi C, Austin C, Moore T, Lightle R, Cao Yea et al (2017) RhoA kinase inhibition with fasudil versus simvastatin in murine models of cerebral cavernous malformations. Stroke 48(1):187\u2013194","journal-title":"Stroke"},{"issue":"2","key":"4360_CR26","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1161\/STROKEAHA.111.625467","volume":"43","author":"DA McDonald","year":"2012","unstructured":"McDonald DA, Shi C, Shenkar R, Stockton RA, Liu F, Ginsberg Mea et al (2012) Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. Stroke 43(2):571\u2013574","journal-title":"Stroke"},{"key":"4360_CR27","doi-asserted-by":"publisher","first-page":"182","DOI":"10.25259\/SNI_73_2026","volume":"17","author":"BC Erel","year":"2026","unstructured":"Erel BC, Uslu I, Kara B, Turkmenel MG, Celikkiran ZE, Gultekin Eea et al (2026) The effect of statins on the risk of bleeding in cerebral cavernous malformations: a systematic review and meta-analysis. Surg Neurol Int 17:182","journal-title":"Surg Neurol Int"},{"key":"4360_CR28","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow Cea et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71","journal-title":"BMJ"},{"issue":"1","key":"4360_CR29","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","volume":"5","author":"M Ouzzani","year":"2016","unstructured":"Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A (2016) Rayyan-a web and mobile app for systematic reviews. Syst Rev 5(1):210","journal-title":"Syst Rev"},{"key":"4360_CR30","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6890","volume":"368","author":"M Campbell","year":"2020","unstructured":"Campbell M, McKenzie JE, Sowden A, Katikireddi SV, Brennan SE, Ellis Sea et al (2020) Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline. BMJ 368:l6890","journal-title":"BMJ"},{"key":"4360_CR31","doi-asserted-by":"crossref","unstructured":"Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW (2014) SYRCLE\u2019s risk of bias tool for animal studies. BMC Med Res Methodol 14:43, 43","DOI":"10.1186\/1471-2288-14-43"},{"issue":"3","key":"4360_CR32","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s12975-019-00725-8","volume":"11","author":"L McKerracher","year":"2020","unstructured":"McKerracher L, Shenkar R, Abbinanti M, Cao Y, Peiper A, Liao Jea et al (2020) A brain-targeted orally available ROCK2 inhibitor benefits mild and aggressive cavernous angioma disease. Transl Stroke Res 11(3):365\u2013376","journal-title":"Transl Stroke Res"},{"issue":"1","key":"4360_CR33","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3171\/2011.8.JNS101241","volume":"116","author":"DD Cavalcanti","year":"2012","unstructured":"Cavalcanti DD, Kalani MY, Martirosyan NL, Eales J, Spetzler RF, Preul MC (2012) Cerebral cavernous malformations: from genes to proteins to disease. J Neurosurg 116(1):122\u2013132","journal-title":"J Neurosurg"},{"issue":"1","key":"4360_CR34","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000200121","volume":"10","author":"C Ayata","year":"2024","unstructured":"Ayata C, Kim H, Morrison L, Liao JK, Gutierrez J, Lopez-Toledano Mea et al (2024) Role of Rho-associated kinase in the pathophysiology of cerebral cavernous malformations. Neurol Genet 10(1):e200121","journal-title":"Neurol Genet"},{"issue":"7862","key":"4360_CR35","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/s41586-021-03562-8","volume":"594","author":"AA Ren","year":"2021","unstructured":"Ren AA, Snellings DA, Su YS, Hong CC, Castro M, Tang Aea et al (2021) PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism. Nature 594(7862):271\u2013276","journal-title":"Nature"},{"issue":"1","key":"4360_CR36","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1161\/CIRCRESAHA.121.318174","volume":"129","author":"DA Snellings","year":"2021","unstructured":"Snellings DA, Hong CC, Ren AA, Lopez-Ramirez MA, Girard R, Srinath Aea et al (2021) Cerebral cavernous malformation: from mechanism to therapy. Circ Res 129(1):195\u2013215","journal-title":"Circ Res"},{"key":"4360_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/biom15111607","author":"S Randar","year":"2025","unstructured":"Randar S, Silva-Velasco DL, Priviero F, Webb RC (2025) RhoA\/Rho-kinase signaling in vascular smooth muscle and endothelium: mechanistic insights and translational implications in hypertension. Biomolecules. https:\/\/doi.org\/10.3390\/biom15111607","journal-title":"Biomolecules"},{"key":"4360_CR38","doi-asserted-by":"crossref","unstructured":"Berridge BR, Baran SW, Kumar V, Bratcher-Petersen N, Ellis M, Liu Cea et al (2024) Digitalization of toxicology: improving preclinical to clinical translation. Front Toxicol 6:1377542, 1377542","DOI":"10.3389\/ftox.2024.1377542"},{"issue":"1","key":"4360_CR39","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.drudis.2021.08.010","volume":"27","author":"LH Chi","year":"2022","unstructured":"Chi LH, Burrows AD, Anderson RL (2022) Can preclinical drug development help to predict adverse events in clinical trials? Drug Discov Today 27(1):257\u2013268","journal-title":"Drug Discov Today"},{"issue":"2","key":"4360_CR40","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1517\/14740338.2.2.147","volume":"2","author":"CJ Gross","year":"2003","unstructured":"Gross CJ, Kramer JA (2003) The role of investigative molecular toxicology in early stage drug development. Expert Opin Drug Saf 2(2):147\u2013159","journal-title":"Expert Opin Drug Saf"},{"key":"4360_CR41","doi-asserted-by":"crossref","unstructured":"Yangi K, On TJ, Xu Y, Gholami AS, Hong J, Reed Aea et al (2025) Artificial intelligence integration in surgery through hand and instrument tracking: a systematic literature review. Front Surg 12:1528362, 1528362","DOI":"10.3389\/fsurg.2025.1528362"},{"key":"4360_CR42","unstructured":"Yangi K, Unsal U, Bozkurt I (2025) The Utilization of AI Technology in Adult Degenerative Scoliosis. pp. 305\u2009\u2013\u200916"},{"key":"4360_CR43","doi-asserted-by":"crossref","unstructured":"Cekic E, Cetin G, Ozer AG, Baylarov B, Gok E, Tatar Iea et al (2026) Digital 3D models in neurosurgical training, surgical planning, and intraoperative guidance: narrative review of the literature. World Neurosurg X 30:100580","DOI":"10.1016\/j.wnsx.2026.100580"},{"key":"4360_CR44","doi-asserted-by":"crossref","unstructured":"Hanalioglu S, Bahadir S, Ozak AC, Yangi K, Mignucci-Jim\u00e9nez G, Gurses ME et al (2024) Ultrahigh-resolution 7-Tesla anatomic magnetic resonance imaging and diffusion tensor imaging of ex vivo formalin-fixed human brainstem-cerebellum complex. Front Hum Neurosci. ;18","DOI":"10.3389\/fnhum.2024.1484431"},{"issue":"1","key":"4360_CR45","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1007\/s10143-025-03688-7","volume":"48","author":"S Hanalioglu","year":"2025","unstructured":"Hanalioglu S, Yangi K, Gurses ME, Aktas HA, Gok E, Tunc Oea et al (2025) Supracerebellar-supratrochlear and supracerebellar-infratrochlear triangles as gateways to the posterolateral midbrain and ambient cistern: descriptive and quantitative analysis of microsurgical anatomy. Neurosurg Rev 48(1):568","journal-title":"Neurosurg Rev"},{"key":"4360_CR46","doi-asserted-by":"crossref","unstructured":"Yangi K, Hong J, Gholami AS, On TJ, Reed AG, Puppalla Pea et al (2025) Deep learning in neurosurgery: a systematic literature review with a structured analysis of applications across subspecialties. Front Neurol 16:1532398, 1532398","DOI":"10.3389\/fneur.2025.1532398"}],"container-title":["Neurosurgical Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-026-04360-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10143-026-04360-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-026-04360-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T02:20:00Z","timestamp":1780885200000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10143-026-04360-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4360"],"URL":"https:\/\/doi.org\/10.1007\/s10143-026-04360-4","relation":{},"ISSN":["1437-2320"],"issn-type":[{"value":"1437-2320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"22 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. This systematic review synthesized data from previously published studies; no new animals were recruited. Institutional review board approval was therefore not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable. This article contains no individual person\u2019s data in any form.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical Trial Number"}}],"article-number":"437"}}