{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:02:48Z","timestamp":1789956168080,"version":"4.0.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e0 degli Studi di Roma La Sapienza","id":[{"id":"https:\/\/ror.org\/02be6w209","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosurg Rev"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Central neurocytoma is a rare intraventricular tumor with favorable prognosis following gross total resection (GTR). However, the role of Ki67-MIB1 values in the postoperative decision making-process of treatment, as well as the indication for adjuvant radiotherapy, remain debated. Medical record data of patients with confirmed diagnosis of central neurocytoma who underwent surgical resection at Department of Neurosurgery of \u201cOspedale del Mare\u201d in Naples \u2013 Italy, between January and December 2022, were retrospectively reviewed. Inclusion criteria were adult patients (&gt;\u200918 years old), minimum follow up 42 months, complete demographic, clinical, neuroradiological and histopathological data, type of management, complications and outcome, time to recurrence, follow-up duration. Five adult patients were enrolled according to the inclusion criteria. Most patients were women (80%), with mean age 24 years old. Main presenting symptoms were headache and visual deficit. Lesions always involved lateral ventricles, with extension to the third ventricle in all but one cases. Transcortical approach to the ipsilateral lateral ventricle with extension to the third ventricle was the main adopted surgical route. GTR was achieved in all cases without postoperative complications nor postoperative new onset neurological deficits. No patients required ventricular shunting procedures for hydrocephalus during the surveillance period. Follow-up ranged from 43 to 54 months. Ki67-MIB1 values ranged from 5% to 10%. No patients underwent adjuvant radiotherapy. Our findings suggest that GTR alone may be sufficient even in patients with moderately elevated Ki-67. A tailored, risk-adapted postoperative strategy is recommended rather than routine adjuvant treatment.<\/jats:p>","DOI":"10.1007\/s10143-026-04441-4","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:27:23Z","timestamp":1789954043000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Central neurocytomas: Decision-making process of postoperative treatment. Lesson learned"],"prefix":"10.1007","volume":"49","author":[{"given":"Sergio","family":"Corvino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Corazzelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Di Nuzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Seneca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Granata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"De Paulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Cella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Altieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Catapano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"issue":"2 Suppl","key":"4441_CR1","doi-asserted-by":"publisher","first-page":"S17e15","DOI":"10.1016\/j.wneu.2012.02.023","volume":"79","author":"HW Schroeder","year":"2013","unstructured":"Schroeder HW (2013) Intraventricular tumors. World Neurosurg 79(2 Suppl):S17e15\u2013S17e19. https:\/\/doi.org\/10.1016\/j.wneu.2012.02.023","journal-title":"World Neurosurg"},{"key":"4441_CR2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.wneu.2020.01.185","volume":"137","author":"J Kaye","year":"2020","unstructured":"Kaye J, Zeller S, Patel NV, Herschman Y, Jumah F, Nanda A, Presentation (2020) Surgical Management, and Postoperative Outcome of a Fourth Ventricular Cavernous Malformation: Case Report and Review of Literature. World Neurosurg 137:78\u201383. https:\/\/doi.org\/10.1016\/j.wneu.2020.01.185","journal-title":"World Neurosurg"},{"key":"4441_CR3","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jocn.2018.04.015","volume":"53","author":"SW Dutta","year":"2018","unstructured":"Dutta SW, Kaleem TA, Muller DA et al (2018) Central neurocytoma: Clinical characteristics, patterns of care, and survival. J Clin Neurosci 53:106\u2013111. https:\/\/doi.org\/10.1016\/j.jocn.2018.04.015","journal-title":"J Clin Neurosci"},{"issue":"6","key":"4441_CR4","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3109\/02688690903254350","volume":"23","author":"KA Choudhari","year":"2009","unstructured":"Choudhari KA, Kaliaperumal C, Jain A et al (2009) Central neurocytoma: a multi-disciplinary review. Br J Neurosurg 23(6):585\u2013595. https:\/\/doi.org\/10.3109\/02688690903254350","journal-title":"Br J Neurosurg"},{"issue":"8","key":"4441_CR5","doi-asserted-by":"publisher","first-page":"02","DOI":"10.1093\/neuonc\/noab106","volume":"08","author":"DN Louis","year":"2021","unstructured":"Louis DN, Perry A, Wesseling P et al (2021) The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol 08(8):02. https:\/\/doi.org\/10.1093\/neuonc\/noab106","journal-title":"Neuro Oncol"},{"issue":"3","key":"4441_CR6","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s11060-005-9047-3","volume":"77","author":"D Rades","year":"2006","unstructured":"Rades D, Schild SE (2006) Treatment recommendations for the various subgroups of neurocytomas. J Neurooncol 77(3):305\u2013309. https:\/\/doi.org\/10.1007\/s11060-005-9047-3","journal-title":"J Neurooncol"},{"key":"4441_CR7","doi-asserted-by":"publisher","first-page":"1014506","DOI":"10.3389\/fonc.2022.1014506","volume":"12","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Yu J, Zhang C et al (2022) Clinical prognostic factors for central neurocytoma and subgroup analysis of different treatment measures: A SEER database-based retrospective analysis from 2003 to 2019. Front Oncol 12:1014506. https:\/\/doi.org\/10.3389\/fonc.2022.1014506","journal-title":"Front Oncol"},{"issue":"1","key":"4441_CR8","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00401-025-02894-3","volume":"149","author":"M Krech","year":"2025","unstructured":"Krech M, Muench A, Teichmann D et al (2025) Outcome-associated factors in a molecularly defined cohort of central neurocytoma. Acta Neuropathol 149(1):61. https:\/\/doi.org\/10.1007\/s00401-025-02894-3","journal-title":"Acta Neuropathol"},{"issue":"4","key":"4441_CR9","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.ijrobp.2006.10.018","volume":"67","author":"JL Leenstra","year":"2007","unstructured":"Leenstra JL, Rodriguez FJ, Frechette CM et al (2007) Central neurocytoma: management recommendations based on a 35-year experience. Int J Radiat Oncol Biol Phys 67(4):1145\u20131154. https:\/\/doi.org\/10.1016\/j.ijrobp.2006.10.018","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"4441_CR10","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s11060-015-1959-y","volume":"126","author":"BS Imber","year":"2016","unstructured":"Imber BS, Braunstein SE, Wu FY et al (2016) Clinical outcome and prognostic factors for central neurocytoma: twenty year institutional experience. J Neurooncol Jan 126(1):193\u2013200. https:\/\/doi.org\/10.1007\/s11060-015-1959-y","journal-title":"J Neurooncol Jan"},{"key":"4441_CR11","doi-asserted-by":"publisher","unstructured":"Wee CW, Park JW, Suh CO et al (2026) Improved tumor control with adjuvant radiotherapy in patients with central neurocytoma: a multicenter study. J Neurooncol Mar 23(2). https:\/\/doi.org\/10.1007\/s11060-026-05496-5","DOI":"10.1007\/s11060-026-05496-5"},{"key":"4441_CR12","doi-asserted-by":"publisher","unstructured":"Michel A, Rodemerk J, Rauschenbach L et al (2025) Treatment of central neurocytoma. Cancers (Basel) 17(12). https:\/\/doi.org\/10.3390\/cancers17122005","DOI":"10.3390\/cancers17122005"},{"issue":"1","key":"4441_CR13","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s11060-024-04713-3","volume":"169","author":"Y Yang","year":"2024","unstructured":"Yang Y, Wadhwani N, Shimomura A et al (2024) Long-term outcomes of central neurocytoma - an institutional experience. J Neurooncol 169(1):195\u2013201. https:\/\/doi.org\/10.1007\/s11060-024-04713-3","journal-title":"J Neurooncol"},{"key":"4441_CR14","doi-asserted-by":"publisher","first-page":"e176","DOI":"10.1016\/j.wneu.2020.01.114","volume":"137","author":"AK Mahavadi","year":"2020","unstructured":"Mahavadi AK, Patel PM, Kuchakulla M et al (2020) Central Neurocytoma Treatment Modalities: A Systematic Review Assessing the Outcomes of Combined Maximal Safe Resection and Radiotherapy with Gross Total Resection. World Neurosurg 137:e176\u2013e182. https:\/\/doi.org\/10.1016\/j.wneu.2020.01.114","journal-title":"World Neurosurg"},{"issue":"3","key":"4441_CR15","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s11060-018-2997-z","volume":"140","author":"J Byun","year":"2018","unstructured":"Byun J, Hong SH, Yoon MJ et al (2018) Prognosis and treatment outcomes of central neurocytomas: clinical interrogation based on a single center experience. J Neurooncol 140(3):669\u2013677. https:\/\/doi.org\/10.1007\/s11060-018-2997-z","journal-title":"J Neurooncol"},{"issue":"5","key":"4441_CR16","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1097\/00005072-199705000-00011","volume":"56","author":"F S\u00f6ylemezoglu","year":"1997","unstructured":"S\u00f6ylemezoglu F, Scheithauer BW, Esteve J, Kleihues P (1997) Atypical central neurocytoma. J Neuropathol Exp Neurol 56(5):551\u2013556. https:\/\/doi.org\/10.1097\/00005072-199705000-00011","journal-title":"J Neuropathol Exp Neurol"},{"key":"4441_CR17","doi-asserted-by":"publisher","unstructured":"Samhouri L, Meheissen MAM, Ibrahimi AKH et al (2021) Impact of adjuvant radiotherapy in patients with central neurocytoma: a multicentric international analysis. Cancers (Basel) 13(17). https:\/\/doi.org\/10.3390\/cancers13174308","DOI":"10.3390\/cancers13174308"},{"key":"4441_CR18","doi-asserted-by":"publisher","first-page":"881460","DOI":"10.3389\/fonc.2022.881460","volume":"12","author":"Q Xie","year":"2022","unstructured":"Xie Q, Xie B, Ou L et al (2022) Clinical Outcomes and Prognostic Analysis of 101 Patients of Central Neurocytoma: A 10-Year Treatment Experience at a Single Institution. Front Oncol 12:881460. https:\/\/doi.org\/10.3389\/fonc.2022.881460","journal-title":"Front Oncol"},{"key":"4441_CR19","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000003824","author":"CH Mallereau","year":"2025","unstructured":"Mallereau CH, Virbel G, Pallud J et al (2025) Long-Term Quality of Life and Functional Outcome Analysis of Surgically Managed Central Neurocytoma Patients: Results of a Multicenter Study. Neurosurgery. https:\/\/doi.org\/10.1227\/neu.0000000000003824","journal-title":"Neurosurgery"}],"container-title":["Neurosurgical Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-026-04441-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10143-026-04441-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-026-04441-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:27:24Z","timestamp":1789954044000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10143-026-04441-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4441"],"URL":"https:\/\/doi.org\/10.1007\/s10143-026-04441-4","relation":{},"ISSN":["1437-2320"],"issn-type":[{"value":"1437-2320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]},"assertion":[{"value":"24 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"<b>Ethics approval and consent to participate<\/b>","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"<b>Clinical trial number<\/b>","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"578"}}