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We evaluated the feasibility, short-term safety, and postoperative imaging characteristics of onlay TachoSil\u00ae ventricular sealing after supratentorial high-grade glioma resection, supported by a focused synthesis of the available neurosurgical literature. We retrospectively reviewed 32 consecutive adult patients undergoing WHO grade 3\u20134 glioma resection between January 2024 and January 2026 in whom an intraoperative ventricular opening was sealed with a TachoSil\u00ae patch placed over the ependymal defect. CSF-related subcutaneous collection or wound leakage occurred in 5\/32 patients (15.6%) within 30 days; four were managed conservatively and one required temporary lumbar drainage. No patient developed meningitis or ventriculitis, shunt-dependent hydrocephalus, early patch-related obstruction requiring reoperation, or need for permanent CSF diversion. Serial MRI through 3 months demonstrated a thin laminar interface centered at the ventricular repair site, with predominantly preserved CSF-like intraventricular signal and no patch displacement, free intraventricular material, CSF-pathway obstruction, progressive ventriculomegaly, or definite radiological migration. These findings support the technical feasibility and short-term safety of onlay TachoSil\u00ae ventricular sealing and suggest that the patch may provide a stable neomembrane-like interface between the resection cavity and ventricular system. However, the absence of a control group, the 15.6% rate of CSF-related collections, and limited follow-up preclude conclusions regarding comparative efficacy or rare delayed complications. Prospective multicenter studies with standardized closure endpoints and longer follow-up are warranted.<\/jats:p>","DOI":"10.1007\/s10143-026-04484-7","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:41:40Z","timestamp":1790232100000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TachoSil\u00ae as a ventricular sealant after glioma resection: A single-center retrospective cohort study"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6354-3278","authenticated-orcid":false,"given":"Matteo Maria","family":"Ottaviani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Bevacqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Grespi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Conti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"issue":"3","key":"4484_CR1","doi-asserted-by":"publisher","first-page":"406","DOI":"10.3171\/jns.2000.92.3.0406","volume":"92","author":"M Al-Yamany","year":"2000","unstructured":"Al-Yamany M, Del RF (2000) Prevention of Subdural Fluid Collections Following Transcortical Intraventricular and\/or Paraventricular Procedures by Using Fibrin Adhesive. 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Premier J Sci 10:100080. https:\/\/premierscience.com\/pjs-25-938","journal-title":"Premier J Sci"}],"container-title":["Neurosurgical Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-026-04484-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10143-026-04484-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-026-04484-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:04:40Z","timestamp":1790276680000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10143-026-04484-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4484"],"URL":"https:\/\/doi.org\/10.1007\/s10143-026-04484-7","relation":{},"ISSN":["1437-2320"],"issn-type":[{"value":"1437-2320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"17 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval was waived due to the retrospective nature of the study, which involved the analysis of previously collected data without any intervention or direct interaction with participants.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The requirement for individual written informed consent was waived because of the retrospective design and use of de-identified routinely collected clinical and radiological data.","order":2,"name":"Ethics","label":"Consent\/Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Generative artificial intelligence was used solely as a language-editing aid during manuscript revision to improve grammar, clarity, concision, and readability. It was not used to formulate the research question, design the study, select patients, extract or analyze data, interpret imaging, generate figures or tables, draft clinical conclusions, or make clinical decisions. The tool used was OpenAI ChatGPT (GPT-5.5) through a cloud-based web interface. No patient-identifiable text, images, raw clinical records, or protected health information were provided to the tool; only de-identified manuscript text was used. No plug-ins, fine-tuning, local deployment, automated statistical analysis, image annotation, or external system integration was used, and no custom model parameters were selected. Prompts were limited to requests for language editing and checklist-based reporting improvements; no code snippets were generated. Matteo Maria Ottaviani supervised the AI-assisted revisions; all authors reviewed the outputs, verified clinical accuracy and references, edited or rejected suggested wording as appropriate, and take full responsibility for the integrity and accuracy of the final manuscript. Because AI was used only for language editing of de-identified text, algorithmic bias was considered unlikely to affect patient-level findings; nevertheless, all AI-assisted text was checked against the source data, clinical context, and ethical\/privacy requirements. The authors have no financial or other conflicts of interest related to OpenAI or any AI vendor. AI-generated artefacts are not deposited in a repository because no standalone data, code, figures, or analyses were generated.","order":5,"name":"Ethics","label":"Artificial intelligence use","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Patient- or carer-reported narratives, interviews, or quotations were not collected because this was a retrospective analysis of de-identified routinely collected data and the reported ventricular-sealing strategy was performed as part of standard operative management.","order":6,"name":"Ethics","label":"Patient and\/or carer perspective","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":7,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"584"}}