{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:02:47Z","timestamp":1789401767065,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosurg Rev"],"DOI":"10.1007\/s10143-026-04493-6","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T02:35:32Z","timestamp":1789353332000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of stereotactic radiosurgery for spine multiple myeloma\u2014a systematic review"],"prefix":"10.1007","volume":"49","author":[{"given":"Muhammad","family":"Izhar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke S.","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahed H.","family":"Kattaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"issue":"1","key":"4493_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.70129","volume":"13","author":"B Mo","year":"2025","unstructured":"Mo B, Sacks S, Markar J (2025) Unmasking multiple myeloma: the importance of suspecting malignancy in atypical chronic pain mimicking degenerative conditions-a case report. Clin Case Rep 13(1):e70129. https:\/\/doi.org\/10.1002\/ccr3.70129","journal-title":"Clin Case Rep"},{"issue":"12","key":"4493_CR2","doi-asserted-by":"publisher","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","volume":"15","author":"SV Rajkumar","year":"2014","unstructured":"Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV et al (2014) International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol 15(12):e538-548. https:\/\/doi.org\/10.1016\/S1470-2045(14)70442-5","journal-title":"Lancet Oncol"},{"issue":"1","key":"4493_CR3","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s10067-020-05256-4","volume":"40","author":"E Yilmaz","year":"2021","unstructured":"Yilmaz E (2021) Presentation of multiple myeloma occurring in the humerus after strain: a case report. Clin Rheumatol 40(1):389\u201392. https:\/\/doi.org\/10.1007\/s10067-020-05256-4","journal-title":"Clin Rheumatol"},{"key":"4493_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1282569","volume":"13","author":"R Vijjhalwar","year":"2023","unstructured":"Vijjhalwar R, Song K, Shrestha R, Bowcock S, Sanchez-Santos MT, Ramasamy K et al (2023) Patient-reported symptoms and diagnostic journey in multiple myeloma. Front Oncol 13:1282569. https:\/\/doi.org\/10.3389\/fonc.2023.1282569","journal-title":"Front Oncol"},{"issue":"3","key":"4493_CR5","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1016\/S1470-2045(20)30559-3","volume":"22","author":"E Terpos","year":"2021","unstructured":"Terpos E, Zamagni E, Lentzsch S, Drake MT, Garc\u00eda-Sanz R, Abildgaard N et al (2021) Treatment of multiple myeloma-related bone disease: recommendations from the Bone Working Group of the International Myeloma Working Group. Lancet Oncol 22(3):e119-30. https:\/\/doi.org\/10.1016\/S1470-2045(20)30559-3","journal-title":"Lancet Oncol"},{"issue":"11","key":"4493_CR6","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1016\/j.spinee.2020.07.004","volume":"20","author":"H Zijlstra","year":"2020","unstructured":"Zijlstra H, Wolterbeek N, Drost RW, Koene HR, van der Woude HJ, Terpstra WE et al (2020) Identifying predictive factors for vertebral collapse fractures in multiple myeloma patients. Spine J Off J North Am Spine Soc 20(11):1832\u20131839 .004 PubMed PMID: 32673729","journal-title":"Spine J Off J North Am Spine Soc"},{"key":"4493_CR7","doi-asserted-by":"publisher","first-page":"103205","DOI":"10.1016\/j.critrevonc.2020.103205","volume":"160","author":"B Chen","year":"2021","unstructured":"Chen B, Cai L, Zhou F (2021) Management of acute spinal cord compression in multiple myeloma. Crit Rev Oncol Hematol 160:103205. https:\/\/doi.org\/10.1016\/j.critrevonc.2020.103205 PubMed PMID: 33387626","journal-title":"Crit Rev Oncol Hematol"},{"key":"4493_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s13013-016-0107-6","volume":"11","author":"ZA Audat","year":"2016","unstructured":"Audat ZA, Hajyousef MH, Fawareh MD, Alawneh KM, Odat MA, Barbarawi MM et al (2016) Comparison if the addition of multilevel vertebral augmentation to conventional therapy will improve the outcome of patients with multiple myeloma. Scoliosis Spinal Disord 11:47. https:\/\/doi.org\/10.1186\/s13013-016-0107-6","journal-title":"Scoliosis Spinal Disord"},{"issue":"5","key":"4493_CR9","doi-asserted-by":"publisher","first-page":"571","DOI":"10.14444\/5070","volume":"12","author":"MS Patel","year":"2018","unstructured":"Patel MS, Ghasem A, Greif DN, Huntley SR, Conway SA, Al Maaieh M (2018) Evaluating treatment strategies for spinal lesions in multiple myeloma: a review of the literature. Int J Spine Surg 12(5):571\u201381. https:\/\/doi.org\/10.14444\/5070","journal-title":"Int J Spine Surg"},{"issue":"7","key":"4493_CR10","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1002\/jso.22101","volume":"105","author":"C Kasperk","year":"2012","unstructured":"Kasperk C, Haas A, Hillengass J, Weiss C, Neben K, Goldschmidt H et al (2012) Kyphoplasty in patients with multiple myeloma a retrospective comparative pilot study. J Surg Oncol 105(7):679\u2013686. https:\/\/doi.org\/10.1002\/jso.22101","journal-title":"J Surg Oncol"},{"issue":"10","key":"4493_CR11","first-page":"1897","volume":"18","author":"ME Jensen","year":"1997","unstructured":"Jensen ME, Evans AJ, Mathis JM, Kallmes DF, Cloft HJ, Dion JE (1997) Percutaneous polymethylmethacrylate vertebroplasty in the treatment of osteoporotic vertebral body compression fractures: technical aspects. AJNR Am J Neuroradiol 18(10):1897\u20131904 PubMed PMID: 9403451; PubMed Central PMCID: PMC8337380","journal-title":"AJNR Am J Neuroradiol"},{"issue":"2","key":"4493_CR12","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3928\/01477447-20090201-15","volume":"32","author":"N McArthur","year":"2009","unstructured":"McArthur N, Kasperk C, Baier M, Tanner M, Gritzbach B, Schoierer O et al (2009) 1150 kyphoplasties over 7 years: indications, techniques, and intraoperative complications. Orthopedics 32(2):90 PubMed PMID: 19301801","journal-title":"Orthopedics"},{"issue":"3","key":"4493_CR13","doi-asserted-by":"publisher","first-page":"294","DOI":"10.4103\/0256-4947.81542","volume":"31","author":"NA Al-Nakshabandi","year":"2011","unstructured":"Al-Nakshabandi NA (2011) Percutaneous vertebroplasty complications. Ann Saudi Med 31(3):294\u20137. https:\/\/doi.org\/10.4103\/0256-4947.81542","journal-title":"Ann Saudi Med"},{"issue":"1","key":"4493_CR14","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.spinee.2023.09","volume":"24","author":"JP Te Velde","year":"2024","unstructured":"Te Velde JP, Zijlstra H, Lans A, Patel CG, Raje N, Delawi D et al (2024) Fracture rate after conventional external beam radiation therapy to the spine in multiple myeloma patients. Spine J Off J North Am Spine Soc 24(1):137\u2013145. https:\/\/doi.org\/10.1016\/j.spinee.2023.09.009 PubMed PMID: 37734495","journal-title":"Spine J Off J North Am Spine Soc"},{"key":"4493_CR15","unstructured":"Jin R, Rock J, Jin JY, Janakiraman N, Jae HK, Movsas B et al (2009) Single fraction spine radiosurgery for myeloma epidural spinal cord compression. J Exp Ther Oncol [Internet]. ;8(1):35\u201341. Located at: Embase. Available from: https:\/\/www.embase.com\/search\/results?subaction=viewrecord%26;id=L355262414%26;from=export"},{"issue":"4","key":"4493_CR16","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.ijrobp.2010.11.026","volume":"79","author":"S Lutz","year":"2011","unstructured":"Lutz S, Berk L, Chang E, Chow E, Hahn C, Hoskin P et al (2011) Palliative Radiotherapy for Bone Metastases: An ASTRO Evidence-Based Guideline. Int J Radiat Oncol 79(4):965\u2013976. https:\/\/doi.org\/10.1016\/j.ijrobp.2010.11.026","journal-title":"Int J Radiat Oncol"},{"issue":"3","key":"4493_CR17","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3171\/2016.8.SPINE16412","volume":"26","author":"JA Miller","year":"2017","unstructured":"Miller JA, Balagamwala EH, Chao ST, Emch T, Suh JH, Djemil T et al (2017) Spine stereotactic radiosurgery for the treatment of multiple myeloma. J Neurosurg Spine 26(3):282\u201390. https:\/\/doi.org\/10.3171\/2016.8.SPINE16412","journal-title":"J Neurosurg Spine"},{"issue":"1","key":"4493_CR18","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s10143-026-04257-2","volume":"49","author":"M Izhar","year":"2026","unstructured":"Izhar M, Hori YS, Ahmad Z, Kattaa AH, Park DJ, Chang SD (2026) Treatment outcomes of stereotactic radiosurgery for thyroid cancer spine metastases\u2014systematic review. Neurosurg Rev 49(1):321. https:\/\/doi.org\/10.1007\/s10143-026-04257-2","journal-title":"Neurosurg Rev"},{"key":"4493_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.105918","volume":"88","author":"C Sohrabi","year":"2020","unstructured":"Sohrabi C, Franchi T, Mathew G, Kerwan A, Nicola M, Griffin M et al (2020) PRISMA 2020 statement: what\u2019s new and the importance of reporting guidelines. Int J Surg 88:105918. https:\/\/doi.org\/10.1016\/j.ijsu.2021.105918","journal-title":"Int J Surg"},{"issue":"1","key":"4493_CR20","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3390\/publications14010004","volume":"14","author":"E Gualdi-Russo","year":"2026","unstructured":"Gualdi-Russo E, Zaccagni L (2026) The Newcastle\u2013Ottawa Scale for Assessing the Quality of Studies in Systematic Reviews. Publications 14(1):4. https:\/\/doi.org\/10.3390\/publications14010004","journal-title":"Publications"},{"issue":"3","key":"4493_CR21","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3171\/2016.8.SPINE16412","volume":"26","author":"JA Miller","year":"2017","unstructured":"Miller JA, Balagamwala EH, Chao ST, Emch T, Suh JH, Djemil T et al (2017) Spine stereotactic radiosurgery for the treatment of multiple myeloma. J Neurosurg Spine 26(3):282\u2013290. https:\/\/doi.org\/10.3171\/2016.8.SPINE16412","journal-title":"J Neurosurg Spine"},{"issue":"1","key":"4493_CR22","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s13566-017-0333-4","volume":"7","author":"E Elibe","year":"2018","unstructured":"Elibe E, Boyce-Fappiano D, Ryu S, Siddiqui MS, Wen N, Lee I et al (2018) Stereotactic radiosurgery for multiple myeloma of the spine. J Radiat Oncol 7(1):37\u201344. https:\/\/doi.org\/10.1007\/s13566-017-0333-4","journal-title":"J Radiat Oncol"},{"issue":"2","key":"4493_CR23","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","volume":"45","author":"EA Eisenhauer","year":"2009","unstructured":"Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R et al (2009) New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer 45(2):228\u2013247. https:\/\/doi.org\/10.1016\/j.ejca.2008.10.026","journal-title":"Eur J Cancer"},{"issue":"11","key":"4493_CR24","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1056\/NEJMra1011442","volume":"364","author":"A Palumbo","year":"2011","unstructured":"Palumbo A, Anderson K (2011) Multiple Myeloma. N Engl J Med 364(11):1046\u20131060. https:\/\/doi.org\/10.1056\/NEJMra1011442","journal-title":"N Engl J Med"},{"issue":"1","key":"4493_CR25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41572-024-00529-7","volume":"10","author":"F Malard","year":"2024","unstructured":"Malard F, Neri P, Bahlis NJ, Terpos E, Moukalled N, Hungria VTM et al (2024) Multiple myeloma. Nat Rev Dis Primer 10(1):45. https:\/\/doi.org\/10.1038\/s41572-024-00529-7","journal-title":"Nat Rev Dis Primer"},{"issue":"5","key":"4493_CR26","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1093\/jnci\/djae321","volume":"117","author":"A Mafra","year":"2025","unstructured":"Mafra A, Laversanne M, Marcos-Gragera R, Chaves HVS, Mcshane C, Bray F et al (2025) The global multiple myeloma incidence and mortality burden in 2022 and predictions for 2045. JNCI J Natl Cancer Inst 117(5):907\u2013914. https:\/\/doi.org\/10.1093\/jnci\/djae321","journal-title":"JNCI J Natl Cancer Inst"},{"issue":"1","key":"4493_CR27","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0167-8140(96)01858-0","volume":"42","author":"M Wallington","year":"1997","unstructured":"Wallington M, Mendis S, Premawardhana U, Sanders P, Shahsavar-Haghighi K (1997) Local control and survival in spinal cord compression from lymphoma and myeloma. Radiother Oncol 42(1):43\u20137. https:\/\/doi.org\/10.1016\/S0167-8140(96)01858-0","journal-title":"Radiother Oncol"},{"issue":"5","key":"4493_CR28","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1111\/j.1445-5994.1986.tb00010.x","volume":"16","author":"E Woo","year":"1986","unstructured":"Woo E, Yu YL, Ng M, Huang CY, Todd D (1986) Spinal cord compression in multiple myeloma: who gets it? Aust N Z J Med 16(5):671\u20135. https:\/\/doi.org\/10.1111\/j.1445-5994.1986.tb00010.x","journal-title":"Aust N Z J Med"},{"key":"4493_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/104546","volume":"2013","author":"P Tosi","year":"2013","unstructured":"Tosi P (2013) Diagnosis and treatment of bone disease in multiple myeloma: spotlight on spinal involvement. Scientifica (Cairo) 2013:1\u201312. https:\/\/doi.org\/10.1155\/2013\/104546","journal-title":"Scientifica (Cairo)"},{"issue":"16","key":"4493_CR30","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.2106\/JBJS.22.01335","volume":"105","author":"H Zijlstra","year":"2023","unstructured":"Zijlstra H, Striano BM, Crawford AM, Groot OQ, Raje N, Tobert DG et al (2023) Neurologic outcomes after radiation therapy for severe spinal cord compression in multiple myeloma: a study of 162 patients. J Bone Joint Surg Am 105(16):1261\u20139. https:\/\/doi.org\/10.2106\/JBJS.22.01335","journal-title":"J Bone Joint Surg Am"},{"issue":"3","key":"4493_CR31","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1515\/raon-2016-0029","volume":"50","author":"D Rades","year":"2016","unstructured":"Rades D, Conde-Moreno AJ, Cacicedo J, Segedin B, Rudat V, Schild SE (2016) Excellent outcomes after radiotherapy alone for malignant spinal cord compression from myeloma. Radiol Oncol 50(3):337\u201340. https:\/\/doi.org\/10.1515\/raon-2016-0029","journal-title":"Radiol Oncol"},{"key":"4493_CR32","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3389\/fonc.2019.00601","volume":"9","author":"D Mark","year":"2019","unstructured":"Mark D, Gilbo P, Meshrekey R, Ghaly M (2019) Local Radiation Therapy for Palliation in Patients With Multiple Myeloma of the Spine. Front Oncol 9:601. https:\/\/doi.org\/10.3389\/fonc.2019.00601","journal-title":"Front Oncol"},{"issue":"5","key":"4493_CR33","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1016\/j.ijrobp.2005.10.018","volume":"64","author":"D Rades","year":"2006","unstructured":"Rades D, Hoskin PJ, Stalpers LJA, Schulte R, Poortmans P, Veninga T et al (2006) Short-course radiotherapy is not optimal for spinal cord compression due to myeloma. Int J Radiat Oncol Biol Phys 64(5):1452\u20137. https:\/\/doi.org\/10.1016\/j.ijrobp.2005.10.018","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"4493_CR34","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.spinee.2023.09.009","volume":"24","author":"JP te Velde","year":"2024","unstructured":"te Velde JP, Zijlstra H, Lans A, Patel CG, Raje N, Delawi D et al (2024) Fracture rate after conventional external beam radiation therapy to the spine in multiple myeloma patients. Spine J 24(1):137\u201345. https:\/\/doi.org\/10.1016\/j.spinee.2023.09.009","journal-title":"Spine J"},{"issue":"7","key":"4493_CR35","doi-asserted-by":"publisher","first-page":"e355","DOI":"10.3324\/haematol.2019.235804","volume":"105","author":"B Adnan Elhammali","year":"2020","unstructured":"Adnan Elhammali B, Amini EB, Ludmir JR, Gunther SA, Milgrom CC, Pinnix et al (2020) New paradigm for radiation in multiple myeloma: lower yet effective dose to avoid radiation toxicity. Haematologica 105(7):e355\u2013e357. https:\/\/doi.org\/10.3324\/haematol.2019.235804","journal-title":"Haematologica"},{"issue":"4","key":"4493_CR36","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1046\/j.1365-2141.1997.d01-2108.x","volume":"96","author":"F Lecouvet","year":"1997","unstructured":"Lecouvet F, Richard F, Berg BV, Malghem J, Maldague B, Jamart J et al (1997) Long-term effects of localized spinal radiation therapy on vertebral fractures and focal lesions appearance in patients with multiple myeloma. Br J Haematol 96(4):743\u2013745. https:\/\/doi.org\/10.1046\/j.1365-2141.1997.d01-2108.x","journal-title":"Br J Haematol"}],"container-title":["Neurosurgical Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-026-04493-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10143-026-04493-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-026-04493-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:04:35Z","timestamp":1789398275000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10143-026-04493-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4493"],"URL":"https:\/\/doi.org\/10.1007\/s10143-026-04493-6","relation":{},"ISSN":["1437-2320"],"issn-type":[{"value":"1437-2320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]},"assertion":[{"value":"28 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was conducted with prior approval from the Stanford University Institutional Review Board (#3910) panel on Medical Human Subjects.","order":1,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not Applicable.","order":3,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"565"}}