{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:55:31Z","timestamp":1790996131675,"version":"4.1.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosurg Rev"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To classify the severity of bone flap resorption (BFR) following autologous cranioplasty under bone tissue bank storage conditions and to identify potential risk factors by analyzing clinical cases exhibiting postoperative bone resorption. A retrospective analysis was conducted on clinical data from 61 patients who developed bone flap resorption after autologous cranioplasty performed with bone flaps stored under bone tissue bank conditions. Based on the Oulu Resorption Scale, patients were categorized into four groups: no bone flap resorption (NBFR), mild BFR (MBFR), intermediate BFR (IBFR), and severe BFR (SBFR). Clinical characteristics were compared across these groups. Variables showing statistical significance (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) in univariate analyses were subsequently entered into a multivariate ordinal logistic regression model to evaluate their association with the development and severity of BFR. All 61 patients completed follow-up, with a median follow-up duration of 378.0 days (interquartile range: 178.5\u2013605.5 days). By the end of follow-up, 16 patients (26.2%) had developed BFR, including 9 cases (14.8%) of MBFR, 4 cases (6.6%) of IBFR, and 3 cases (4.9%) of SBFR. Univariate analysis revealed that smoking Pre- decompressive craniectomy (Pre-DC), traumatic brain injury (TBI), number of bone flaps\u2009\u2265\u20092, cranial defect area\u2009&gt;\u200992.11\u00a0cm\u00b2, and bone flaps located in the frontotemporoparietal region were significantly associated with an increased risk of BFR (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Multivariate ordinal logistic regression analysis identified smoking Pre-DC, TBI, and cranial defect area\u2009&gt;\u200992.11\u00a0cm\u00b2 as independent risk factors for BFR, whereas having fewer than two bone flaps served as a protective factor against resorption (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Autologous cranioplasty using bone flaps preserved under bone tissue bank conditions is associated with a low complication rate. With careful patient selection, it remains an admissible reconstructive option following decompressive craniectomy.\u00a0\n                  <\/jats:p>","DOI":"10.1007\/s10143-026-04515-3","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:15:15Z","timestamp":1790993715000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bone flap resorption and its risk factors following autologous cranioplasty with bone tissue bank\u2013stored grafts"],"prefix":"10.1007","volume":"49","author":[{"given":"Xiaoliang","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lexiao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,3]]},"reference":[{"key":"4515_CR1","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1097\/SCS.0000000000011061","volume":"36","author":"R Carbonaro","year":"2025","unstructured":"Carbonaro R, Ghiringhelli G, Nataloni A et al (2025) Long-term series of custom-bone hydroxyapatite cranioplasty: outcomes and survival at 15 years. 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Given the retrospective nature of this analysis and the use of anonymized clinical data, the Ethics Committee of Xianyang Central Hospital waived the requirement for written informed consent. However, all patients had provided general consent for the use of their medical records for research purposes upon admission, and no participant objected to inclusion in this study.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"not applicable.","order":3,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable as a separate statement, as both Human Ethics approval and Consent to Participate have been explicitly addressed above in accordance with journal requirements.","order":4,"name":"Ethics","label":"Human ethics and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"597"}}