{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:15:52Z","timestamp":1793222152441,"version":"4.5.0"},"reference-count":108,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T00:00:00Z","timestamp":1311638400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1007\/s10147-011-0291-6","type":"journal-article","created":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T02:08:05Z","timestamp":1311559685000},"page":"452-463","source":"Crossref","is-referenced-by-count":11,"title":["Liver resection for advanced or aggressive colorectal cancer metastases in the era of effective chemotherapy: a review"],"prefix":"10.1007","volume":"16","author":[{"given":"Kuniya","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itaru","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,7,26]]},"reference":[{"key":"291_CR1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/path.1711500308","volume":"150","author":"L Weiss","year":"1986","unstructured":"Weiss L, Grundmann E, Torhorst J et al (1986) Haematogenous metastatic patterns in colonic carcinoma: an analysis of 1541 necropsies. J Pathol 150:195\u2013203","journal-title":"J Pathol"},{"key":"291_CR2","unstructured":"National Comprehensive Cancer Network. (2008) Colon cancer practice guidelines in oncology. Version 2. http:\/\/www.nccn.org"},{"key":"291_CR3","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1023\/A:1008353227103","volume":"10","author":"MM Borner","year":"1999","unstructured":"Borner MM (1999) Neoadjuvant chemotherapy for unresectable liver metastases of colorectal cancer\u2013too good to be true? Ann Oncol 10:623\u2013626","journal-title":"Ann Oncol"},{"key":"291_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/gut.50.1.1","volume":"50","author":"JN Primrose","year":"2002","unstructured":"Primrose JN (2002) Treatment of colorectal metastases: surgery, cryotherapy, or radiofrequency ablation. Gut 50:1\u20135","journal-title":"Gut"},{"key":"291_CR5","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/00000658-198405000-00002","volume":"199","author":"JS Wagner","year":"1984","unstructured":"Wagner JS, Adson MA, Van Heerden JA et al (1984) The natural history of hepatic metastases from colorectal cancer. A comparison with resective treatment. Ann Surg 199:502\u2013508","journal-title":"Ann Surg"},{"key":"291_CR6","first-page":"285","volume":"2","author":"CB Wood","year":"1976","unstructured":"Wood CB, Gillis CR, Blumgart LH (1976) A retrospective study of the natural history of patients with liver metastases from colorectal cancer. Clin Oncol 2:285\u2013288","journal-title":"Clin Oncol"},{"issue":"Suppl 2","key":"291_CR7","doi-asserted-by":"crossref","first-page":"ii13","DOI":"10.1093\/annonc\/mdg731","volume":"14","author":"R Adam","year":"2003","unstructured":"Adam R (2003) Chemotherapy and surgery: new perspectives on the treatment of unresectable liver metastases. Ann Oncol 14(Suppl 2):ii13\u2013ii16","journal-title":"Ann Oncol"},{"key":"291_CR8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0960-7404(97)00003-0","volume":"6","author":"TJ Hugh","year":"1997","unstructured":"Hugh TJ, Kinsella AR, Poston GJ (1997) Management strategies for colorectal liver metastases\u2013Part II. Surg Oncol 6:31\u201348","journal-title":"Surg Oncol"},{"key":"291_CR9","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/bjs.1800730917","volume":"73","author":"H Ekberg","year":"1986","unstructured":"Ekberg H, Tranberg KG, Andersson R et al (1986) Determinants of survival in liver resection for colorectal secondaries. Br J Surg 73:727\u2013731","journal-title":"Br J Surg"},{"key":"291_CR10","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1200\/JCO.2008.19.9273","volume":"27","author":"R Adam","year":"2009","unstructured":"Adam R, Wicherts DA, de Haas RJ et al (2009) Patients with initially unresectable colorectal liver metastases: is there a possibility of cure? J Clin Oncol 27:1829\u20131835","journal-title":"J Clin Oncol"},{"key":"291_CR11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/00000658-199610000-00009","volume":"224","author":"H Bismuth","year":"1996","unstructured":"Bismuth H, Adam R, L\u00e9vi F et al (1996) Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy. Ann Surg 224:509\u2013522","journal-title":"Ann Surg"},{"key":"291_CR12","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/01.sla.0000145964.08365.01","volume":"240","author":"R Adam","year":"2004","unstructured":"Adam R, Delvart V, Pascal G et al (2004) Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival. Ann Surg 240:644\u2013657","journal-title":"Ann Surg"},{"key":"291_CR13","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/sj.bjc.6603033","volume":"94","author":"PC Simmonds","year":"2006","unstructured":"Simmonds PC, Primrose JN, Colquitt JL et al (2006) Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies. Br J Cancer 94:982\u2013999","journal-title":"Br J Cancer"},{"key":"291_CR14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/SLA.0b013e31815aa2c2","volume":"247","author":"M Rees","year":"2008","unstructured":"Rees M, Tekkis PP, Welsh FK et al (2008) Evaluation of long-term survival after hepatic resection for metastatic colorectal cancer: a multifactorial model of 929 patients. Ann Surg 247:125\u2013135","journal-title":"Ann Surg"},{"key":"291_CR15","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1097\/01.sla.0000145964.08365.01","volume":"240","author":"R Adam","year":"2004","unstructured":"Adam R, Pascal G, Castaing D et al (2004) Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases? Ann Surg 240:1052\u20131064","journal-title":"Ann Surg"},{"key":"291_CR16","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1471-2407-8-120","volume":"8","author":"B Gruenberger","year":"2008","unstructured":"Gruenberger B, Scheithauer W, Punzengruber R et al (2008) Importance of response to neoadjuvant chemotherapy in potentially curable colorectal cancer liver metastases. BMC Cancer 8:120","journal-title":"BMC Cancer"},{"key":"291_CR17","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1245\/s10434-006-9068-y","volume":"14","author":"P Kornprat","year":"2007","unstructured":"Kornprat P, Jarnagin WR, Gonen M et al (2007) Outcome after hepatectomy for multiple (four or more) colorectal metastases in the era of effective chemotherapy. Ann Surg Oncol 14:1151\u20131160","journal-title":"Ann Surg Oncol"},{"key":"291_CR18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1091-255X(02)00121-X","volume":"7","author":"PJ Allen","year":"2003","unstructured":"Allen PJ, Kemeny N, Jarnagin W et al (2003) Importance of response to neoadjuvant chemotherapy in patients undergoing resection of synchronous colorectal liver metastases. J Gastrointest Surg 7:109\u2013115","journal-title":"J Gastrointest Surg"},{"key":"291_CR19","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1200\/JCO.2007.13.7471","volume":"26","author":"R Adam","year":"2008","unstructured":"Adam R, Wicherts DA, de Haas RJ et al (2008) Complete pathologic response after preoperative chemotherapy for colorectal liver metastases: myth or reality? J Clin Oncol 26:1635\u20131641","journal-title":"J Clin Oncol"},{"key":"291_CR20","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1097\/SLA.0b013e3181b0c6e4","volume":"250","author":"K Tanaka","year":"2009","unstructured":"Tanaka K, Takakura H, Takeda K et al (2009) Importance of complete pathologic response to prehepatectomy chemotherapy in treating colorectal cancer metastases. Ann Surg 250:935\u2013942","journal-title":"Ann Surg"},{"key":"291_CR21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1200\/JCO.2004.09.046","volume":"22","author":"RM Goldberg","year":"2004","unstructured":"Goldberg RM, Sargent DJ, Morton RF et al (2004) A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 22:23\u201330","journal-title":"J Clin Oncol"},{"key":"291_CR22","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1200\/JCO.2004.11.037","volume":"22","author":"A Grothey","year":"2004","unstructured":"Grothey A, Sargent D, Goldberg RM et al (2004) Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 22:1209\u20131214","journal-title":"J Clin Oncol"},{"key":"291_CR23","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1200\/JCO.2004.05.113","volume":"22","author":"C Tournigand","year":"2004","unstructured":"Tournigand C, Andr\u00e9 T, Achille E et al (2004) FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 22:229\u2013237","journal-title":"J Clin Oncol"},{"key":"291_CR24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1056\/NEJMoa033025","volume":"351","author":"D Cunningham","year":"2004","unstructured":"Cunningham D, Humblet Y, Siena S et al (2004) Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351:337\u2013345","journal-title":"N Engl J Med"},{"key":"291_CR25","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1056\/NEJMoa032691","volume":"350","author":"H Hurwitz","year":"2004","unstructured":"Hurwitz H, Fehrenbacher L, Novotny W et al (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335\u20132342","journal-title":"N Engl J Med"},{"key":"291_CR26","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1200\/JCO.2004.10.182","volume":"22","author":"LB Saltz","year":"2004","unstructured":"Saltz LB, Meropol NJ, Loehrer PJ Sr et al (2004) Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 22:1201\u20131208","journal-title":"J Clin Oncol"},{"key":"291_CR27","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/BF01655821","volume":"11","author":"H Ekberg","year":"1987","unstructured":"Ekberg H, Tranberg KG, Andersson R et al (1987) Pattern of recurrence in liver resection for colorectal secondaries. World J Surg 11:541\u2013547","journal-title":"World J Surg"},{"key":"291_CR28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.surg.2007.08.015","volume":"143","author":"K Tanaka","year":"2008","unstructured":"Tanaka K, Shimada H, Kubota K et al (2008) Role of hepatectomy in treating multiple bilobar colorectal cancer metastases. Surgery 143:259\u2013270","journal-title":"Surgery"},{"key":"291_CR29","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1200\/JCO.20.6.1499","volume":"20","author":"MM Kemeny","year":"2002","unstructured":"Kemeny MM, Adak S, Gray B et al (2002) Combined-modality treatment for resectable metastatic colorectal carcinoma to the liver: surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy\u2014an intergroup study. J Clin Oncol 20:1499\u20131505","journal-title":"J Clin Oncol"},{"key":"291_CR30","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1046\/j.0007-1323.2001.01821.x","volume":"88","author":"J Figueras","year":"2001","unstructured":"Figueras J, Valls C, Rafecas A et al (2001) Resection rate and effect of postoperative chemotherapy on survival after surgery for colorectal liver metastases. Br J Surg 88:980\u2013985","journal-title":"Br J Surg"},{"key":"291_CR31","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0140-6736(08)60455-9","volume":"371","author":"B Nordlinger","year":"2008","unstructured":"Nordlinger B, Sorbye H, Glimelius B et al (2008) Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet 371:1007\u20131016","journal-title":"Lancet"},{"key":"291_CR32","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1023\/A:1008347829017","volume":"10","author":"S Giacchetti","year":"1999","unstructured":"Giacchetti S, Itzhaki M, Gruia G et al (1999) Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery. Ann Oncol 10:663\u2013669","journal-title":"Ann Oncol"},{"key":"291_CR33","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/annonc\/mdn735","volume":"20","author":"B Nordlinger","year":"2009","unstructured":"Nordlinger B, Van Cutsem E, Gruenberger T et al (2009) Combination of surgery and chemotherapy and the role of targeted agents in the treatment of patients with colorectal liver metastases: recommendations from an expert panel. Ann Oncol 20:985\u2013992","journal-title":"Ann Oncol"},{"issue":"Abstr#3526","key":"291_CR34","first-page":"252","volume":"23","author":"S Giacchetti","year":"2004","unstructured":"Giacchetti S, Bjarnason GA, Garufi C et al (2004) First line infusion of 5-fluorouracil, leucovorin and oxaliplatin for metastatic colorectal cancer: 4-day chronomodulated (FFL4-10) versus 2-day FOLFOX2. A multicenter randomized Phase III trial of the Chronotherapy Group of the European Organization for Research and Treatment of Cancer (EORTC 05963). Proc ASCO 23(Abstr#3526):252","journal-title":"Proc ASCO"},{"key":"291_CR35","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1200\/JCO.2006.09.0928","volume":"25","author":"A Falcone","year":"2007","unstructured":"Falcone A, Ricci S, Brunetti I et al (2007) Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J Clin Oncol 25:1670\u20131676","journal-title":"J Clin Oncol"},{"key":"291_CR36","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1056\/NEJMoa0805019","volume":"360","author":"E Cutsem Van","year":"2009","unstructured":"Van Cutsem E, K\u00f6hne CH, Hitre E et al (2009) Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 360:1408\u20131417","journal-title":"N Engl J Med"},{"key":"291_CR37","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1200\/JCO.2008.20.8397","volume":"27","author":"C Bokemeyer","year":"2009","unstructured":"Bokemeyer C, Bondarenko I, Makhson A et al (2009) Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 27:663\u2013671","journal-title":"J Clin Oncol"},{"key":"291_CR38","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1093\/annonc\/mdi246","volume":"16","author":"G Folprecht","year":"2005","unstructured":"Folprecht G, Grothey A, Alberts S et al (2005) Neoadjuvant treatment of unresectable colorectal liver metastases: correlation between tumour response and resection rates. Ann Oncol 16:1311\u20131319","journal-title":"Ann Oncol"},{"key":"291_CR39","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.surg.2004.07.007","volume":"137","author":"K Tanaka","year":"2005","unstructured":"Tanaka K, Shimada H, Kubota K et al (2005) Effectiveness of prehepatectomy intra-arterial chemotherapy for multiple bilobar colorectal cancer metastases to the liver: a clinicopathologic study of peritumoral vasculobiliary invasion. Surgery 137:156\u2013164","journal-title":"Surgery"},{"key":"291_CR40","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1200\/JCO.2006.05.8156","volume":"24","author":"T Aloia","year":"2006","unstructured":"Aloia T, Sebagh M, Plasse M et al (2006) Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases. J Clin Oncol 24:4983\u20134990","journal-title":"J Clin Oncol"},{"key":"291_CR41","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1200\/JCO.2005.05.3074","volume":"24","author":"JN Vauthey","year":"2006","unstructured":"Vauthey JN, Pawlik TM, Ribero D et al (2006) Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol 24:2065\u20132072","journal-title":"J Clin Oncol"},{"key":"291_CR42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.sla.0000193603.26265.c3","volume":"243","author":"M Karoui","year":"2006","unstructured":"Karoui M, Penna C, Amin-Hashem M et al (2006) Influence of preoperative chemotherapy on the risk of major hepatectomy for colorectal liver metastases. Ann Surg 243:1\u20137","journal-title":"Ann Surg"},{"key":"291_CR43","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/SLA.0b013e31815774de","volume":"247","author":"H Nakano","year":"2008","unstructured":"Nakano H, Oussoultzoglou E, Rosso E et al (2008) Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy. Ann Surg 247:118\u2013124","journal-title":"Ann Surg"},{"key":"291_CR44","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1038\/bjc.1998.333","volume":"77","author":"PD Peppercorn","year":"1998","unstructured":"Peppercorn PD, Reznek RH, Wilson P et al (1998) Demonstration of hepatic steatosis by computerized tomography in patients receiving 5-fluorouracil-based therapy for advanced colorectal cancer. Br J Cancer 77:2008\u20132011","journal-title":"Br J Cancer"},{"key":"291_CR45","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1002\/1097-0142(19950515)75:10<2592::AID-CNCR2820751029>3.0.CO;2-G","volume":"75","author":"P S\u00f8rensen","year":"1995","unstructured":"S\u00f8rensen P, Edal AL, Madsen EL et al (1995) Reversible hepatic steatosis in patients treated with interferon alfa-2a and 5-fluorouracil. Cancer 75:2592\u20132596","journal-title":"Cancer"},{"key":"291_CR46","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1200\/JCO.1993.11.12.2386","volume":"11","author":"CG Moertel","year":"1993","unstructured":"Moertel CG, Fleming TR, Macdonald JS et al (1993) Hepatic toxicity associated with fluorouracil plus levamisole adjuvant therapy. J Clin Oncol 11:2386\u20132390","journal-title":"J Clin Oncol"},{"key":"291_CR47","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.surg.2005.09.023","volume":"139","author":"K Tanaka","year":"2006","unstructured":"Tanaka K, Shimada H, Ueda M et al (2006) Perioperative complications after hepatectomy with or without intra-arterial chemotherapy for bilobar colorectal cancer liver metastases. Surgery 139:599\u2013607","journal-title":"Surgery"},{"key":"291_CR48","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ejso.2007.07.007","volume":"34","author":"G Morris-Stiff","year":"2008","unstructured":"Morris-Stiff G, Tan YM, Vauthey JN (2008) Hepatic complications following preoperative chemotherapy with oxaliplatin or irinotecan for hepatic colorectal metastases. Eur J Surg Oncol 34:609\u2013614","journal-title":"Eur J Surg Oncol"},{"key":"291_CR49","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1007\/s11605-007-0149-4","volume":"11","author":"TM Pawlik","year":"2007","unstructured":"Pawlik TM, Olino K, Gleisner AL et al (2007) Preoperative chemotherapy for colorectal liver metastases: impact on hepatic histology and postoperative outcome. J Gastrointest Surg 11:860\u2013868","journal-title":"J Gastrointest Surg"},{"key":"291_CR50","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jamcollsurg.2005.01.024","volume":"200","author":"FG Fernandez","year":"2005","unstructured":"Fernandez FG, Ritter J, Goodwin JW et al (2005) Effect of steatohepatitis associated with irinotecan or oxaliplatin pretreatment on resectability of hepatic colorectal metastases. J Am Coll Surg 200:845\u2013853","journal-title":"J Am Coll Surg"},{"key":"291_CR51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1055\/s-2002-23204","volume":"22","author":"LD DeLeve","year":"2002","unstructured":"DeLeve LD, Shulman HM, McDonald GB (2002) Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis 22:27\u201342","journal-title":"Semin Liver Dis"},{"key":"291_CR52","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.gassur.2003.09.012","volume":"7","author":"DA Kooby","year":"2003","unstructured":"Kooby DA, Fong Y, Suriawinata A et al (2003) Impact of steatosis on perioperative outcome following hepatic resection. J Gastrointest Surg 7:1034\u20131044","journal-title":"J Gastrointest Surg"},{"key":"291_CR53","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1091-255X(98)80025-5","volume":"2","author":"KE Behrns","year":"1998","unstructured":"Behrns KE, Tsiotos GG, DeSouza NF et al (1998) Hepatic steatosis as a potential risk factor for major hepatic resection. J Gastrointest Surg 2:292\u2013298","journal-title":"J Gastrointest Surg"},{"key":"291_CR54","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S1072-7515(00)00261-1","volume":"191","author":"J Belghiti","year":"2000","unstructured":"Belghiti J, Hiramatsu K, Benoist S et al (2000) Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection. J Am Coll Surg 191:38\u201346","journal-title":"J Am Coll Surg"},{"key":"291_CR55","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1097\/SLA.0b013e3181c79403","volume":"251","author":"O Soubrane","year":"2010","unstructured":"Soubrane O, Brouquet A, Zalinski S et al (2010) Predicting high grade lesions of sinusoidal obstruction syndrome related to oxaliplatin-based chemotherapy for colorectal liver metastases: correlation with post-hepatectomy outcome. Ann Surg 251:454\u2013460","journal-title":"Ann Surg"},{"key":"291_CR56","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1200\/JCO.2009.27.5701","volume":"28","author":"MJ Overman","year":"2010","unstructured":"Overman MJ, Maru DM, Charnsangavej C et al (2010) Oxaliplatin-mediated increase in spleen size as a biomarker for the development of hepatic sinusoidal injury. J Clin Oncol 28:2549\u20132555","journal-title":"J Clin Oncol"},{"key":"291_CR57","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1245\/s10434-009-0447-z","volume":"16","author":"B Aussilhou","year":"2009","unstructured":"Aussilhou B, Dokmak S, Faivre S et al (2009) Preoperative liver hypertrophy induced by portal flow occlusion before major hepatic resection for colorectal metastases can be impaired by bevacizumab. Ann Surg Oncol 16:1553\u20131559","journal-title":"Ann Surg Oncol"},{"key":"291_CR58","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1002\/cncr.24912","volume":"116","author":"RC Auer","year":"2010","unstructured":"Auer RC, White RR, Kemeny NE et al (2010) Predictors of a true complete response among disappearing liver metastases from colorectal cancer after chemotherapy. Cancer 116:1502\u20131509","journal-title":"Cancer"},{"key":"291_CR59","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0140-6736(08)61063-6","volume":"372","author":"N Snoeren","year":"2008","unstructured":"Snoeren N, Voest E, van Hillegersberg R (2008) Surgery vs surgery and chemotherapy for colorectal liver metastases. Lancet 372:202\u2013203 author report 203","journal-title":"Lancet"},{"key":"291_CR60","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/sj.bjc.6603670","volume":"96","author":"FK Welsh","year":"2007","unstructured":"Welsh FK, Tilney HS, Tekkis PP et al (2007) Safe liver resection following chemotherapy for colorectal metastases is a matter of timing. Br J Cancer 96:1037\u20131042","journal-title":"Br J Cancer"},{"key":"291_CR61","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0140-6736(08)60429-8","volume":"371","author":"S Kopetz","year":"2008","unstructured":"Kopetz S, Vauthey JN (2008) Perioperative chemotherapy for resectable hepatic metastases. Lancet 371:963\u2013965","journal-title":"Lancet"},{"key":"291_CR62","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1245\/s10434-006-9074-0","volume":"14","author":"M D\u2019Angelica","year":"2007","unstructured":"D\u2019Angelica M, Kornprat P, Gonen M et al (2007) Lack of evidence for increased operative morbidity after hepatectomy with perioperative use of bevacizumab: a matched case\u2013control study. Ann Surg Oncol 14:759\u2013765","journal-title":"Ann Surg Oncol"},{"key":"291_CR63","doi-asserted-by":"crossref","first-page":"5254","DOI":"10.1200\/JCO.2008.17.7857","volume":"26","author":"SB Kesmodel","year":"2008","unstructured":"Kesmodel SB, Ellis LM, Lin E et al (2008) Preoperative bevacizumab does not significantly increase postoperative complication rates in patients undergoing hepatic surgery for colorectal cancer liver metastases. J Clin Oncol 26:5254\u20135260","journal-title":"J Clin Oncol"},{"key":"291_CR64","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1245\/s10434-008-0035-7","volume":"15","author":"D Zorzi","year":"2008","unstructured":"Zorzi D, Chun YS, Madoff DC et al (2008) Chemotherapy with bevacizumab does not affect liver regeneration after portal vein embolization in the treatment of colorectal liver metastases. Ann Surg Oncol 15:2765\u20132772","journal-title":"Ann Surg Oncol"},{"key":"291_CR65","first-page":"686","volume":"237","author":"AW Hemming","year":"2003","unstructured":"Hemming AW, Reed AI, Howard RJ et al (2003) Preoperative portal vein embolization for extended hepatectomy. Ann Surg 237:686\u2013691","journal-title":"Ann Surg"},{"key":"291_CR66","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/01.sla.0000193599.57858.9b","volume":"243","author":"Y Fong","year":"2006","unstructured":"Fong Y, Bentrem DJ (2006) CASH (chemotherapy-associated steatohepatitis) costs. Ann Surg 243:8\u20139","journal-title":"Ann Surg"},{"key":"291_CR67","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1091-255X(02)00370-0","volume":"7","author":"M Shoup","year":"2003","unstructured":"Shoup M, Gonen M, D\u2019Angelica M et al (2003) Volumetric analysis predicts hepatic dysfunction in patients undergoing major liver resection. J Gastrointest Surg 7:325\u2013330","journal-title":"J Gastrointest Surg"},{"key":"291_CR68","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/00000658-200012000-00006","volume":"232","author":"R Adam","year":"2000","unstructured":"Adam R, Laurent A, Azoulay D et al (2000) Two-stage hepatectomy: a planned strategy to treat irresectable liver tumors. Ann Surg 232:777\u2013785","journal-title":"Ann Surg"},{"key":"291_CR69","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S1072-7515(03)00334-X","volume":"197","author":"R Kianmanesh","year":"2003","unstructured":"Kianmanesh R, Farges O, Abdalla EK et al (2003) Right portal vein ligation: a new planned two-step all-surgical approach for complete resection of primary gastrointestinal tumors with multiple bilateral liver metastases. J Am Coll Surg 197:164\u2013170","journal-title":"J Am Coll Surg"},{"key":"291_CR70","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1097\/01.sla.0000145965.86383.89","volume":"240","author":"D Jaeck","year":"2004","unstructured":"Jaeck D, Oussoultzoglou E, Rosso E et al (2004) A two-stage hepatectomy procedure combined with portal vein embolization to achieve curative resection for initially unresectable multiple and bilobar colorectal liver metastases. Ann Surg 240:1037\u20131051","journal-title":"Ann Surg"},{"key":"291_CR71","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1097\/SLA.0b013e3181907fd9","volume":"248","author":"DA Wicherts","year":"2008","unstructured":"Wicherts DA, Miller R, de Haas RJ et al (2008) Long-term results of two-stage hepatectomy for irresectable colorectal cancer liver metastases. Ann Surg 248:994\u20131005","journal-title":"Ann Surg"},{"key":"291_CR72","first-page":"208","volume":"237","author":"O Farges","year":"2003","unstructured":"Farges O, Belghiti J, Kianmanesh R et al (2003) Portal vein embolization before right hepatectomy: prospective clinical trial. Ann Surg 237:208\u2013217","journal-title":"Ann Surg"},{"key":"291_CR73","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0002-9610(02)01373-9","volume":"185","author":"D Jaeck","year":"2003","unstructured":"Jaeck D, Bachellier P, Nakano H et al (2003) One or two-stage hepatectomy combined with portal vein embolization for initially nonresectable colorectal liver metastases. Am J Surg 185:221\u2013229","journal-title":"Am J Surg"},{"key":"291_CR74","first-page":"472","volume":"49","author":"T Kaneko","year":"2002","unstructured":"Kaneko T, Nakao A, Takagi H (2002) Clinical studies of new material for portal vein embolization: comparison of embolic effect with different agents. Hepatogastroenterology 49:472\u2013477","journal-title":"Hepatogastroenterology"},{"key":"291_CR75","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1148\/radiol.2272011702","volume":"227","author":"GY Ko","year":"2003","unstructured":"Ko GY, Sung KB, Yoon HK et al (2003) Preoperative portal vein embolization with a new liquid embolic agent. Radiology 227:407\u2013413","journal-title":"Radiology"},{"key":"291_CR76","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ejso.2006.10.038","volume":"33","author":"K Tanaka","year":"2007","unstructured":"Tanaka K, Shimada H, Matsuo K et al (2007) Remnant liver regeneration after two-stage hepatectomy for multiple bilobar colorectal metastases. Eur J Surg Oncol 33:329\u2013335","journal-title":"Eur J Surg Oncol"},{"key":"291_CR77","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1159\/000176063","volume":"25","author":"V Pamecha","year":"2008","unstructured":"Pamecha V, Nedjat-Shokouhi B, Gurusamy K et al (2008) Prospective evaluation of two-stage hepatectomy combined with selective portal vein embolisation and systemic chemotherapy for patients with unresectable bilobar colorectal liver metastases. Dig Surg 25:387\u2013393","journal-title":"Dig Surg"},{"key":"291_CR78","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0748-7983(95)90468-9","volume":"21","author":"Y Ikeda","year":"1995","unstructured":"Ikeda Y, Matsumata T, Takenaka K et al (1995) Preliminary report of tumor metastasis during liver regeneration after hepatic resection in rats. Eur J Surg Oncol 21:188\u2013190","journal-title":"Eur J Surg Oncol"},{"key":"291_CR79","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/bjc.1992.170","volume":"65","author":"J Mizutani","year":"1992","unstructured":"Mizutani J, Hiraoka T, Yamashita R et al (1992) Promotion of hepatic metastases by liver resection in the rat. Br J Cancer 65:794\u2013797","journal-title":"Br J Cancer"},{"key":"291_CR80","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jss.2006.06.024","volume":"138","author":"N Harun","year":"2007","unstructured":"Harun N, Nikfarjam M, Muralidharan V et al (2007) Liver regeneration stimulates tumor metastases. J Surg Res 138:284\u2013290","journal-title":"J Surg Res"},{"key":"291_CR81","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1040-8428(98)00019-5","volume":"29","author":"W Jiang","year":"1999","unstructured":"Jiang W, Hiscox S, Matsumoto K et al (1999) Hepatocyte growth factor\/scatter factor, its molecular, cellular and clinical implications in cancer. Crit Rev Oncol Hematol 29:209\u2013248","journal-title":"Crit Rev Oncol Hematol"},{"issue":"Suppl 1","key":"291_CR82","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1186\/1476-5926-2-S1-S52","volume":"3","author":"B Lukomska","year":"2004","unstructured":"Lukomska B, Dluzniewska J, Polanski J et al (2004) Expression of growth factors in colorectal carcinoma liver metastatic patients after partial hepatectomy: implications for a functional role in cell proliferation during liver regeneration. Comp Hepatol 3(Suppl 1):S52","journal-title":"Comp Hepatol"},{"key":"291_CR83","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1245\/ASO.2006.03.060","volume":"13","author":"SS Yoon","year":"2006","unstructured":"Yoon SS, Kim SH, Gonen M et al (2006) Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastases. Ann Surg Oncol 13:353\u2013362","journal-title":"Ann Surg Oncol"},{"key":"291_CR84","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1007\/s00268-008-9610-0","volume":"32","author":"K Tanaka","year":"2008","unstructured":"Tanaka K, Shimada H, Matsumoto C et al (2008) Impact of the degree of liver resection on survival for patients with multiple liver metastases from colorectal cancer. World J Surg 32:2057\u20132069","journal-title":"World J Surg"},{"key":"291_CR85","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0002-9610(99)00044-6","volume":"177","author":"M Miyazaki","year":"1999","unstructured":"Miyazaki M, Ito H, Nakagawa K et al (1999) Aggressive surgical resection for hepatic metastases involving the inferior vena cava. Am J Surg 177:294\u2013298","journal-title":"Am J Surg"},{"key":"291_CR86","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jamcollsurg.2003.11.004","volume":"198","author":"T Aoki","year":"2004","unstructured":"Aoki T, Sugawara Y, Imamura H et al (2004) Hepatic resection with reconstruction of the inferior vena cava or hepatic venous confluence for metastatic liver tumor from colorectal cancer. J Am Coll Surg 198:366\u2013372","journal-title":"J Am Coll Surg"},{"key":"291_CR87","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4254\/wjh.v1.i1.79","volume":"1","author":"K Tanaka","year":"2009","unstructured":"Tanaka K, Matsuyama R, Takeda K et al (2009) Aggressive liver resection including major-vessel resection for colorectal liver metastases. World J Hepatol 1:79\u201389","journal-title":"World J Hepatol"},{"key":"291_CR88","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.surg.2006.06.033","volume":"141","author":"Y Yang","year":"2007","unstructured":"Yang Y, Nagano H, Ota H et al (2007) Patterns and clinicopathologic features of extrahepatic recurrence of hepatocellular carcinoma after curative resection. Surgery 141:196\u2013202","journal-title":"Surgery"},{"key":"291_CR89","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/bjs.1800771115","volume":"77","author":"J Scheele","year":"1990","unstructured":"Scheele J, Stangl R, Altendorf-Hofmann A (1990) Hepatic metastases from colorectal carcinoma: impact of surgical resection on the natural history. Br J Surg 77:1241\u20131246","journal-title":"Br J Surg"},{"key":"291_CR90","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1200\/JCO.2006.05.8727","volume":"24","author":"S Benoist","year":"2006","unstructured":"Benoist S, Brouquet A, Penna C et al (2006) Complete response of colorectal liver metastases after chemotherapy: does it mean cure? J Clin Oncol 24:3939\u20133945","journal-title":"J Clin Oncol"},{"key":"291_CR91","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/jso.20039","volume":"86","author":"D Elias","year":"2004","unstructured":"Elias D, Youssef O, Sideris L et al (2004) Evolution of missing colorectal liver metastases following inductive chemotherapy and hepatectomy. J Surg Oncol 86:4\u20139","journal-title":"J Surg Oncol"},{"key":"291_CR92","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1200\/JCO.2007.10.7128","volume":"25","author":"GK Dy","year":"2007","unstructured":"Dy GK, Krook JE, Green EM et al (2007) Impact of complete response to chemotherapy on overall survival in advanced colorectal cancer: results from Intergroup N9741. J Clin Oncol 25:3469\u20133474","journal-title":"J Clin Oncol"},{"key":"291_CR93","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/00000658-199804000-00019","volume":"227","author":"B Cady","year":"1998","unstructured":"Cady B, Jenkins RL, Steele GD Jr et al (1998) Surgical margin in hepatic resection for colorectal metastasis: a critical and improvable determinant of outcome. Ann Surg 227:566\u2013571","journal-title":"Ann Surg"},{"key":"291_CR94","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/01.sla.0000160703.75808.7d","volume":"241","author":"TM Pawlik","year":"2005","unstructured":"Pawlik TM, Scoggins CR, Zorzi D et al (2005) Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases. Ann Surg 241:715\u2013722","journal-title":"Ann Surg"},{"key":"291_CR95","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1001\/archsurg.137.7.833","volume":"137","author":"N Kokudo","year":"2002","unstructured":"Kokudo N, Miki Y, Sugai S et al (2002) Genetic and histological assessment of surgical margins in resected liver metastases from colorectal carcinoma: minimum surgical margins for successful resection. Arch Surg 137:833\u2013840","journal-title":"Arch Surg"},{"key":"291_CR96","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S1091-255X(02)00122-1","volume":"6","author":"DC Broering","year":"2002","unstructured":"Broering DC, Hillert C, Krupski G et al (2002) Portal vein embolization vs. portal vein ligation for induction of hypertrophy of the future liver remnant. J Gastrointest Surg 6:905\u2013913","journal-title":"J Gastrointest Surg"},{"key":"291_CR97","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1055-3207(02)00091-1","volume":"12","author":"A Altendorf-Hofmann","year":"2003","unstructured":"Altendorf-Hofmann A, Scheele J (2003) A critical review of the major indicators of prognosis after resection of hepatic metastases from colorectal carcinoma. Surg Oncol Clin N Am 12:165\u2013192 xi","journal-title":"Surg Oncol Clin N Am"},{"key":"291_CR98","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1097\/SLA.0b013e31818a07f1","volume":"248","author":"RJ Haas de","year":"2008","unstructured":"de Haas RJ, Wicherts DA, Flores E et al (2008) R1 resection by necessity for colorectal liver metastases: is it still a contraindication to surgery? Ann Surg 248:626\u2013637","journal-title":"Ann Surg"},{"key":"291_CR99","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ejso.2011.01.007","volume":"37","author":"K Tanaka","year":"2011","unstructured":"Tanaka K, Nojiri K, Kumamoto T et al (2011) R1 resection for aggressive or advanced colorectal liver metastases is justified in combination with effective prehepatectomy chemotherapy. Eur J Surg Oncol 37:336\u2013343","journal-title":"Eur J Surg Oncol"},{"key":"291_CR100","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/cncr.23184","volume":"112","author":"JK Ng","year":"2008","unstructured":"Ng JK, Urbanski SJ, Mangat N et al (2008) Colorectal liver metastases contract centripetally with a response to chemotherapy: a histomorphologic study. Cancer 112:362\u2013371","journal-title":"Cancer"},{"key":"291_CR101","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/annonc\/mdl386","volume":"18","author":"L Rubbia-Brandt","year":"2007","unstructured":"Rubbia-Brandt L, Giostra E, Brezault C et al (2007) Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery. Ann Oncol 18:299\u2013304","journal-title":"Ann Oncol"},{"key":"291_CR102","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jamcollsurg.2008.02.017","volume":"207","author":"T Hashimoto","year":"2008","unstructured":"Hashimoto T, Minagawa M, Aoki T et al (2008) Caval invasion by liver tumor is limited. J Am Coll Surg 207:383\u2013392","journal-title":"J Am Coll Surg"},{"key":"291_CR103","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s005340070052","volume":"7","author":"T Maeba","year":"2000","unstructured":"Maeba T, Okano K, Mori S et al (2000) Extent of pathologic invasion of the inferior vena cava in resected liver cancer compared with possible caval invasion diagnosed by preoperative images. J Hepatobiliary Pancreat Surg 7:299\u2013305","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"291_CR104","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/jnci\/92.3.205","volume":"92","author":"P Therasse","year":"2000","unstructured":"Therasse P, Arbuck SG, Eisenhauer EA et al (2000) New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 92:205\u2013216","journal-title":"J Natl Cancer Inst"},{"key":"291_CR105","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1001\/jama.2009.1755","volume":"302","author":"YS Chun","year":"2009","unstructured":"Chun YS, Vauthey JN, Boonsirikamchai P et al (2009) Association of computed tomography morphologic criteria with pathologic response and survival in patients treated with bevacizumab for colorectal liver metastases. JAMA 302:2338\u20132344","journal-title":"JAMA"},{"key":"291_CR106","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1200\/JCO.2005.01.3441","volume":"24","author":"GK Abou-Alfa","year":"2006","unstructured":"Abou-Alfa GK, Schwartz L, Ricci S et al (2006) Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol 24:4293\u20134300","journal-title":"J Clin Oncol"},{"key":"291_CR107","first-page":"CD006014","volume":"1","author":"S Tangjitgamol","year":"2009","unstructured":"Tangjitgamol S, Manusirivithaya S, Laopaiboon M et al (2009) Interval debulking surgery for advanced epithelial ovarian cancer. Cochrane Database Syst Rev 1:CD006014 Review","journal-title":"Cochrane Database Syst Rev"},{"key":"291_CR108","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/cncr.11040","volume":"97","author":"MC Mormont","year":"2003","unstructured":"Mormont MC, Levi F (2003) Cancer chronotherapy: principles, applications, and perspectives. Cancer 97:155\u2013169","journal-title":"Cancer"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-011-0291-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10147-011-0291-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-011-0291-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T17:31:25Z","timestamp":1638120685000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10147-011-0291-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,26]]},"references-count":108,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["291"],"URL":"https:\/\/doi.org\/10.1007\/s10147-011-0291-6","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,26]]}}}