{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:50:57Z","timestamp":1785196257618,"version":"3.55.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T00:00:00Z","timestamp":1334188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s10147-012-0405-9","type":"journal-article","created":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T04:38:05Z","timestamp":1334119085000},"page":"478-486","source":"Crossref","is-referenced-by-count":32,"title":["Circulating cell-free human telomerase reverse transcriptase mRNA in plasma and its potential diagnostic and prognostic value for gastric cancer"],"prefix":"10.1007","volume":"18","author":[{"given":"Yi","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peichun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,12]]},"reference":[{"key":"405_CR1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal A, Bray F, Center MM et al (2011) Global cancer statistics. CA Cancer J Clin 61:69\u201390","journal-title":"CA Cancer J Clin"},{"key":"405_CR2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4251\/wjgo.v3.i1.10","volume":"3","author":"M Menges","year":"2011","unstructured":"Menges M (2011) Gastric cancer: Where is the place for the surgeon, the oncologist and the endoscopist today? World J Gastrointest Oncol 3:10\u201313","journal-title":"World J Gastrointest Oncol"},{"key":"405_CR3","first-page":"674","volume":"57","author":"E Dilege","year":"2010","unstructured":"Dilege E, Mihmanli M, Demir U et al (2010) Prognostic value of preoperative CEA and CA19-9 levels in resectable gastric cancer. Hepatogastroenterology 57:674\u2013677","journal-title":"Hepatogastroenterology"},{"key":"405_CR4","first-page":"5089","volume":"23","author":"J Schneider","year":"2003","unstructured":"Schneider J, Schulze G (2003) Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer. Anticancer Res 23:5089\u20135093","journal-title":"Anticancer Res"},{"key":"405_CR5","first-page":"1961","volume":"5","author":"MS Kopreski","year":"1999","unstructured":"Kopreski MS, Benko FA, Kwak LW et al (1999) Detection of tumor messenger RNA in the serum of patients with malignant melanoma. Clin Cancer Res 5:1961\u20131965","journal-title":"Clin Cancer Res"},{"key":"405_CR6","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrc3066","volume":"11","author":"H Schwarzenbach","year":"2011","unstructured":"Schwarzenbach H, Hoon DS, Pantel K (2011) Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer 11:426\u2013437","journal-title":"Nat Rev Cancer"},{"key":"405_CR7","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1196\/annals.1368.028","volume":"1075","author":"F Dasi","year":"2006","unstructured":"Dasi F, Martinez-Rodes P, March JA et al (2006) Real-time quantification of human telomerase reverse transcriptase mRNA in the plasma of patients with prostate cancer. Ann N Y Acad Sci 1075:204\u2013210","journal-title":"Ann N Y Acad Sci"},{"key":"405_CR8","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1292\/jvms.70.993","volume":"70","author":"Y Kudo","year":"2008","unstructured":"Kudo Y, Ochi T, Shimada H et al (2008) Utility of plasma circulating mRNA as a marker to detect hepatic injury. J Vet Med Sci 70:993\u2013995","journal-title":"J Vet Med Sci"},{"key":"405_CR9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1479-5876-8-103","volume":"8","author":"S Takahashi","year":"2010","unstructured":"Takahashi S, Miura N, Harada T et al (2010) Prognostic impact of clinical course-specific mRNA expression profiles in the serum of perioperative patients with esophageal cancer in the ICU: a case control study. J Transl Med 8:103","journal-title":"J Transl Med"},{"key":"405_CR10","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.canlet.2008.01.008","volume":"263","author":"V Garcia","year":"2008","unstructured":"Garcia V, Garcia JM, Pena C et al (2008) Free circulating mRNA in plasma from breast cancer patients and clinical outcome. Cancer Lett 263:312\u2013320","journal-title":"Cancer Lett"},{"key":"405_CR11","doi-asserted-by":"crossref","first-page":"e8173","DOI":"10.1371\/journal.pone.0008173","volume":"4","author":"V Garcia","year":"2009","unstructured":"Garcia V, Garcia JM, Silva J et al (2009) Extracellular tumor-related mRNA in plasma of lymphoma patients and survival implications. PLoS ONE 4:e8173","journal-title":"PLoS ONE"},{"key":"405_CR12","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1126\/science.277.5328.955","volume":"277","author":"TM Nakamura","year":"1997","unstructured":"Nakamura TM, Morin GB, Chapman KB et al (1997) Telomerase catalytic subunit homologs from fission yeast and human. Science 277:955\u2013959","journal-title":"Science"},{"key":"405_CR13","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1038\/onc.2009.136","volume":"28","author":"J Yuan","year":"2009","unstructured":"Yuan J, Yang BM, Zhong ZH et al (2009) Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase. Oncogene 28:2678\u20132689","journal-title":"Oncogene"},{"key":"405_CR14","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/jez.b.21302","volume":"312","author":"Y Xu","year":"2009","unstructured":"Xu Y, Yu M, Wu F et al (2009) Effects of ectopic expression of human telomerase reverse transcriptase on immortalization of feather keratinocyte stem cells. J Exp Zool B Mol Dev Evol 312:872\u2013884","journal-title":"J Exp Zool B Mol Dev Evol"},{"key":"405_CR15","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/jmv.21875","volume":"82","author":"YL Yip","year":"2010","unstructured":"Yip YL, Tsang CM, Deng W et al (2010) Expression of Epstein\u2013Barr virus-encoded LMP1 and hTERT extends the life span and immortalizes primary cultures of nasopharyngeal epithelial cells. J Med Virol 82:1711\u20131723","journal-title":"J Med Virol"},{"key":"405_CR16","doi-asserted-by":"crossref","first-page":"6810","DOI":"10.1158\/1078-0432.CCR-09-0973","volume":"15","author":"W Mai","year":"2009","unstructured":"Mai W, Kawakami K, Shakoori A et al (2009) Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase. Clin Cancer Res 15:6810\u20136819","journal-title":"Clin Cancer Res"},{"key":"405_CR17","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1046\/j.1440-1746.2000.02236.x","volume":"15","author":"K Suzuki","year":"2000","unstructured":"Suzuki K, Kashimura H, Ohkawa J et al (2000) Expression of human telomerase catalytic subunit gene in cancerous and precancerous gastric conditions. J Gastroenterol Hepatol 15:744\u2013751","journal-title":"J Gastroenterol Hepatol"},{"key":"405_CR18","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1097\/01.MP.0000077517.44687.B6","volume":"16","author":"J Yoo","year":"2003","unstructured":"Yoo J, Park SY, Kang SJ et al (2003) Expression of telomerase activity, human telomerase RNA, and telomerase reverse transcriptase in gastric adenocarcinomas. Mod Pathol 16:700\u2013707","journal-title":"Mod Pathol"},{"key":"405_CR19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3748\/wjg.v10.i2.177","volume":"10","author":"W Wang","year":"2004","unstructured":"Wang W, Luo HS, Yu BP (2004) Expression of NF-kappaB and human telomerase reverse transcriptase in gastric cancer and precancerous lesions. World J Gastroenterol 10:177\u2013181","journal-title":"World J Gastroenterol"},{"key":"405_CR20","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3109\/13547500903225912","volume":"14","author":"CO Gigek","year":"2009","unstructured":"Gigek CO, Leal MF, Silva PN et al (2009) hTERT methylation and expression in gastric cancer. Biomarkers 14:630\u2013636","journal-title":"Biomarkers"},{"key":"405_CR21","first-page":"3823","volume":"6","author":"XQ Chen","year":"2000","unstructured":"Chen XQ, Bonnefoi H, Pelte MF et al (2000) Telomerase RNA as a detection marker in the serum of breast cancer patients. Clin Cancer Res 6:3823\u20133826","journal-title":"Clin Cancer Res"},{"key":"405_CR22","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1111\/j.1349-7006.2006.00342.x","volume":"97","author":"N Miura","year":"2006","unstructured":"Miura N, Nakamura H, Sato R et al (2006) Clinical usefulness of serum telomerase reverse transcriptase (hTERT) mRNA and epidermal growth factor receptor (EGFR) mRNA as a novel tumor marker for lung cancer. Cancer Sci 97:1366\u20131373","journal-title":"Cancer Sci"},{"key":"405_CR23","first-page":"1207","volume":"27","author":"N Tani","year":"2007","unstructured":"Tani N, Ichikawa D, Ikoma D et al (2007) Circulating cell-free mRNA in plasma as a tumor marker for patients with primary and recurrent gastric cancer. Anticancer Res 27:1207\u20131212","journal-title":"Anticancer Res"},{"key":"405_CR24","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1159\/000070303","volume":"64","author":"N Miura","year":"2003","unstructured":"Miura N, Shiota G, Nakagawa T et al (2003) Sensitive detection of human telomerase reverse transcriptase mRNA in the serum of patients with hepatocellular carcinoma. Oncology 64:430\u2013434","journal-title":"Oncology"},{"key":"405_CR25","doi-asserted-by":"crossref","first-page":"196","DOI":"10.4103\/0973-1482.29830","volume":"2","author":"FA Khan","year":"2006","unstructured":"Khan FA, Shukla AN (2006) Pathogenesis and treatment of gastric carcinoma: \u201can up-date with brief review\u201d. J Cancer Res Ther 2:196\u2013199","journal-title":"J Cancer Res Ther"},{"key":"405_CR26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/CEJ.0b013e3282b71f0d","volume":"17","author":"SM Yang","year":"2008","unstructured":"Yang SM, Fang DC, Yang JL et al (2008) Antisense human telomerase reverse transcriptase could partially reverse malignant phenotypes of gastric carcinoma cell line in vitro. Eur J Cancer Prev 17:209\u2013217","journal-title":"Eur J Cancer Prev"},{"key":"405_CR27","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1097\/00042737-200608000-00007","volume":"18","author":"MP Ebert","year":"2006","unstructured":"Ebert MP, Rocken C (2006) Molecular screening of gastric cancer by proteome analysis. Eur J Gastroenterol Hepatol 18:847\u2013853","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"405_CR28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/labinvest.3700710","volume":"88","author":"BK Oh","year":"2008","unstructured":"Oh BK, Kim H, Park YN et al (2008) High telomerase activity and long telomeres in advanced hepatocellular carcinomas with poor prognosis. Lab Invest 88:144\u2013152","journal-title":"Lab Invest"},{"key":"405_CR29","doi-asserted-by":"crossref","first-page":"7170","DOI":"10.1038\/sj.onc.1210530","volume":"26","author":"H Taubert","year":"2007","unstructured":"Taubert H, Wurl P, Greither T et al (2007) Stem cell-associated genes are extremely poor prognostic factors for soft-tissue sarcoma patients. Oncogene 26:7170\u20137174","journal-title":"Oncogene"},{"key":"405_CR30","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.oraloncology.2006.01.011","volume":"43","author":"HH Chen","year":"2007","unstructured":"Chen HH, Yu CH, Wang JT et al (2007) Expression of human telomerase reverse transcriptase (hTERT) protein is significantly associated with the progression, recurrence and prognosis of oral squamous cell carcinoma in Taiwan. Oral Oncol 43:122\u2013129","journal-title":"Oral Oncol"},{"key":"405_CR31","first-page":"1555","volume":"28","author":"L Boldrini","year":"2006","unstructured":"Boldrini L, Pistolesi S, Gisfredi S et al (2006) Telomerase activity and hTERT mRNA expression in glial tumors. Int J Oncol 28:1555\u20131560","journal-title":"Int J Oncol"},{"key":"405_CR32","first-page":"1157","volume":"29","author":"R Metzger","year":"2009","unstructured":"Metzger R, Vallbohmer D, Muller-Tidow C et al (2009) Increased human telomerase reverse transcriptase (hTERT) mRNA expression but not telomerase activity is related to survival in curatively resected non-small cell lung cancer. Anticancer Res 29:1157\u20131162","journal-title":"Anticancer Res"},{"key":"405_CR33","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1593\/neo.08578","volume":"10","author":"LF Grochola","year":"2008","unstructured":"Grochola LF, Greither T, Taubert HW et al (2008) Prognostic relevance of hTERT mRNA expression in ductal adenocarcinoma of the pancreas. Neoplasia 10:973\u2013976","journal-title":"Neoplasia"},{"key":"405_CR34","first-page":"959","volume":"52","author":"J Kawai","year":"2005","unstructured":"Kawai J, Kodera Y, Fujiwara M et al (2005) Telomerase activity as prognostic factor in gastrointestinal stromal tumors of the stomach. Hepatogastroenterology 52:959\u2013964","journal-title":"Hepatogastroenterology"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-012-0405-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10147-012-0405-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-012-0405-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:22:57Z","timestamp":1561594977000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10147-012-0405-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,12]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["405"],"URL":"https:\/\/doi.org\/10.1007\/s10147-012-0405-9","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,12]]}}}