{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:37:15Z","timestamp":1786365435391,"version":"build-2736575974"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T00:00:00Z","timestamp":1453939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s10147-015-0935-z","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T11:07:09Z","timestamp":1453979229000},"page":"684-695","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Colorectal cancer in young patients: is it a distinct clinical entity?"],"prefix":"10.1007","volume":"21","author":[{"given":"Hadar","family":"Goldvaser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Purim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Kundel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Shepshelovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzippy","family":"Shochat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lital","family":"Shemesh-Bar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Sulkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baruch","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,28]]},"reference":[{"key":"935_CR1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3322\/caac.21254","volume":"65","author":"RL Siegel","year":"2015","unstructured":"Siegel RL, Miller KD, Jemal A (2015) Cancer statistics. CA Cancer J Clin 65:5\u201329","journal-title":"CA Cancer J Clin"},{"key":"935_CR2","unstructured":"NCI. Surveillance epidemiology and end results (SEER). Fast stats. http:\/\/www.seer.cancer.gov . Accessed 7 Jul 2015"},{"key":"935_CR3","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1002\/cncr.27514","volume":"118","author":"C Eheman","year":"2012","unstructured":"Eheman C, Henley SJ, Ballard-Barbash R et al (2012) Annual report to the nation on the status of cancer, 1975\u20132008, featuring cancers associated with excess weight and lack of sufficient physical activity. Cancer 118:2338\u20132366","journal-title":"Cancer"},{"key":"935_CR4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1001\/archinternmed.2011.602","volume":"172","author":"YN You","year":"2012","unstructured":"You YN, Xing Y, Feig BW et al (2012) Young-onset colorectal cancer: is it time to pay attention? Arch Intern Med 172:287\u2013289","journal-title":"Arch Intern Med"},{"key":"935_CR5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1001\/jamasurg.2014.1756","volume":"150","author":"CE Bailey","year":"2015","unstructured":"Bailey CE, Hu CY, You YN et al (2015) Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975\u20132010. JAMA Surg 150:17\u201322","journal-title":"JAMA Surg."},{"key":"935_CR6","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1007\/s00268-010-0748-1","volume":"34","author":"L Shemesh-Bar","year":"2010","unstructured":"Shemesh-Bar L, Kundel Y, Idelevich E et al (2010) Colorectal cancer in young patients in Israel: a distinct clinicopathological entity? World J Surg 34:2701\u20132709","journal-title":"World J Surg"},{"key":"935_CR7","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.amjsurg.2003.12.020","volume":"187","author":"JB O\u2019Connell","year":"2004","unstructured":"O\u2019Connell JB, Maggard MA, Livingston EH et al (2004) Colorectal cancer in the young. Am J Surg 187:343\u2013348","journal-title":"Am J Surg"},{"key":"935_CR8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/bjs.4015","volume":"90","author":"JT Liang","year":"2003","unstructured":"Liang JT, Huang KC, Cheng AL et al (2003) Clinicopathological and molecular biological features of colorectal cancer in patients less than 40\u00a0years of age. Br J Surg 90:205\u2013214","journal-title":"Br J Surg"},{"key":"935_CR9","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1046\/j.1445-1433.2001.02272.x","volume":"71","author":"D Turkiewicz","year":"2001","unstructured":"Turkiewicz D, Miller B, Schache D et al (2001) Young patients with colorectal cancer: how do they fare? ANZ J Surg. 71:707\u2013710","journal-title":"ANZ J Surg."},{"key":"935_CR10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1463-1318.2004.00596.x","volume":"6","author":"MH Kam","year":"2004","unstructured":"Kam MH, Eu KE, Barben CP et al (2004) Colorectal cancer in the young: a 12\u00a0year review of patients 30\u00a0years or less. Colorectal Dis 6:191\u2013194","journal-title":"Colorectal Dis"},{"key":"935_CR11","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.canep.2012.06.011","volume":"36","author":"LG Shack","year":"2012","unstructured":"Shack LG, Shah A, Lambert PC et al (2012) Cure by age and stage at diagnosis for colorectal cancer patients in North West England, 1997\u20132004: a population-based study. Cancer Epidemiol. 36:548\u2013553","journal-title":"Cancer Epidemiol."},{"key":"935_CR12","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.humpath.2012.07.003","volume":"44","author":"B Kenney","year":"2013","unstructured":"Kenney B, Deng Y, Mitchell K (2013) Expression of p27, COX-2, MLH1, and MSH2 in young patients with colon carcinoma and correlation with morphologic findings. Hum Pathol 44:591\u2013597","journal-title":"Hum Pathol"},{"key":"935_CR13","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/PAS.0b013e31818afd6b","volume":"33","author":"RK Yantiss","year":"2009","unstructured":"Yantiss RK, Goodarzi M, Zhou XK et al (2009) Clinical, pathologic, and molecular features of early onset colorectal carcinoma. Am J Surg Pathol 33:572\u2013582","journal-title":"Am J Surg Pathol"},{"key":"935_CR14","doi-asserted-by":"crossref","first-page":"e182","DOI":"10.1111\/j.1463-1318.2010.02223.x","volume":"12","author":"S Gupta","year":"2010","unstructured":"Gupta S, Bhattacharya D, Acharya AN et al (2010) Colorectal carcinoma in young adults: a retrospective study on Indian patients: 2000\u20132008. Colorectal Dis 12:e182\u2013e189","journal-title":"Colorectal Dis"},{"key":"935_CR15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3322\/caac.21220","volume":"64","author":"R Siegel","year":"2014","unstructured":"Siegel R, DeSantis C, Jemal A (2014) Colorectal cancer statistics. CA Cancer J Clin 64:104\u2013117","journal-title":"CA Cancer J Clin"},{"key":"935_CR16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10151-009-0501-7","volume":"13","author":"D Neufeld","year":"2009","unstructured":"Neufeld D, Shpitz B, Bugaev N et al (2009) Young-age onset of colorectal cancer in Israel. Tech Coloproctol 13:201\u2013204","journal-title":"Tech Coloproctol"},{"key":"935_CR17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ijc.22141","volume":"120","author":"P Rozen","year":"2007","unstructured":"Rozen P, Rosner G, Liphshitz I et al (2007) The changing incidence and sites of colorectal cancer in the Israeli Arab population and their clinical implications. Int J Cancer 120:147\u2013151","journal-title":"Int J Cancer"},{"key":"935_CR18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10689-007-9157-5","volume":"7","author":"J Zidan","year":"2008","unstructured":"Zidan J, Niessen RC, Laitman Y et al (2008) A novel MSH2 germline mutation in a Druze HNPCC family. Fam Cancer 7:135\u2013139","journal-title":"Fam Cancer"},{"key":"935_CR19","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1053\/j.gastro.2005.12.035","volume":"130","author":"MD Rutter","year":"2006","unstructured":"Rutter MD, Saunders BP, Wilkinson KH et al (2006) Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis. Gastroenterology 130:1030\u20131038","journal-title":"Gastroenterology"},{"key":"935_CR20","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1053\/j.gastro.2009.01.064","volume":"136","author":"S S\u00f6derlund","year":"2009","unstructured":"S\u00f6derlund S, Brandt L, Lapidus A et al (2009) Decreasing time-trends of colorectal cancer in a large cohort of patients with inflammatory bowel disease. Gastroenterology 136:1561\u20131567","journal-title":"Gastroenterology"},{"key":"935_CR21","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jpedsurg.2013.09.033","volume":"49","author":"RD Kennedy","year":"2014","unstructured":"Kennedy RD, Potter DD, Moir CR et al (2014) The natural history of familial adenomatous polyposis syndrome: a 24\u00a0year review of a single center experience in screening, diagnosis, and outcomes. J Pediatr Surg 49:82\u201386","journal-title":"J Pediatr Surg"},{"key":"935_CR22","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/codi.12648","volume":"16","author":"CS Sia","year":"2014","unstructured":"Sia CS, Paul E, Wale RJ et al (2014) No increase in colorectal cancer in patients under 50\u00a0years of age: a Victorian experience from the last decade. Colorectal Dis 16:690\u2013695","journal-title":"Colorectal Dis"},{"key":"935_CR23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10552-013-0321-y","volume":"25","author":"H Austin","year":"2014","unstructured":"Austin H, Henley SJ, King J et al (2014) Changes in colorectal cancer incidence rates in young and older adults in the United States: what does it tell us about screening. Cancer Causes Control 25:191\u2013201","journal-title":"Cancer Causes Control"},{"key":"935_CR24","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1245\/s10434-007-9465-x","volume":"14","author":"HM Quah","year":"2007","unstructured":"Quah HM, Joseph R, Schrag D et al (2007) Young age influences treatment but not outcome of colon cancer. Ann Surg Oncol 14:2759\u20132765","journal-title":"Ann Surg Oncol"},{"key":"935_CR25","doi-asserted-by":"crossref","unstructured":"Gunel N, Yamac D, Akcali Z et al (2001) The clinicopathologic characteristics of colorectal cancer in patients under 50\u00a0years of age: experience of an oncology center. Tumori 87:74\u201377","DOI":"10.1177\/030089160108700202"},{"key":"935_CR26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1620\/tjem.199.85","volume":"199","author":"S Alici","year":"2003","unstructured":"Alici S, Aykan NF, Sakar B et al (2003) Colorectal cancer in young patients: characteristics and outcome. Tohoku J Exp Med 199:85\u201393","journal-title":"Tohoku J Exp Med"},{"key":"935_CR27","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s00268-004-7306-7","volume":"28","author":"JB O\u2019Connell","year":"2004","unstructured":"O\u2019Connell JB, Maggard MA, Liu JH et al (2004) Do young colorectal cancer patients have worse outcomes? World J Surg 28:558\u2013562","journal-title":"World J Surg"},{"key":"935_CR28","doi-asserted-by":"crossref","unstructured":"Beckmann KR, Bennett A, Young GP et al (2014) Treatment patterns among colorectal cancer patients in South Australia: a demonstration of the utility of population-based data linkage. J Eval Clin Pract 20:467\u2013477","DOI":"10.1111\/jep.12183"},{"key":"935_CR29","doi-asserted-by":"crossref","unstructured":"Jorgensen ML, Young JM, Dobbins TA et al (2014) Does patient age still affect receipt of adjuvant therapy for colorectal cancer in New South Wales, Australia? J Geriatr Oncol 5:323\u2013330","DOI":"10.1016\/j.jgo.2014.02.007"},{"key":"935_CR30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/DCR.0b013e3182a586e7","volume":"57","author":"SR Steele","year":"2014","unstructured":"Steele SR, Park GE, Johnson EK et al (2014) The impact of age on colorectal cancer incidence, treatment, and outcomes in an equal-access health care system. Dis Colon Rectum 57:303\u2013310","journal-title":"Dis Colon Rectum"},{"key":"935_CR31","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1007\/s10350-004-0738-1","volume":"47","author":"JB O\u2019Connell","year":"2004","unstructured":"O\u2019Connell JB, Maggard MA, Liu JH et al (2004) Are survival rates different for young and older patients with rectal cancer? Dis Colon Rectum 47:2064\u20132069","journal-title":"Dis Colon Rectum"},{"key":"935_CR32","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1007\/s10151-004-0139-4","volume":"8","author":"T Frizis","year":"2004","unstructured":"Frizis T, Papadopoulos A, Akritidis G et al (2004) Are there any differences in colorectal cancer between young and elderly patients? Tech Coloproctol 8:S147\u2013S148","journal-title":"Tech Coloproctol"},{"key":"935_CR33","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4251\/wjgo.v6.i6.177","volume":"6","author":"R Akhtar","year":"2014","unstructured":"Akhtar R, Chandel S, Sarotra P et al (2014) Current status of pharmacological treatment of colorectal cancer. World J Gastrointest Oncol. 6:177\u2013183","journal-title":"World J Gastrointest Oncol."},{"key":"935_CR34","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/jso.21393","volume":"100","author":"F Giuliante","year":"2009","unstructured":"Giuliante F, Ardito F, Vellone M et al (2009) Role of the surgeon as a variable in long-term survival after liver resection for colorectal metastases. J Surg Oncol 100:538\u2013545","journal-title":"J Surg Oncol"},{"key":"935_CR35","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1186\/1471-2407-10-688","volume":"10","author":"K Hemminki","year":"2010","unstructured":"Hemminki K, Santi I, Weires M et al (2010) Tumor location and patient characteristics of colon and rectal adenocarcinomas in relation to survival and TNM classes. BMC Cancer 10:688","journal-title":"BMC Cancer"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-015-0935-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10147-015-0935-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-015-0935-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T02:38:32Z","timestamp":1567564712000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10147-015-0935-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,28]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["935"],"URL":"https:\/\/doi.org\/10.1007\/s10147-015-0935-z","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,28]]}}}