{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:56:35Z","timestamp":1784735795256,"version":"3.55.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s10147-017-1224-9","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T03:49:32Z","timestamp":1513568972000},"page":"547-552","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of everolimus treatment for renal angiomyolipoma associated with tuberous sclerosis complex: an evaluation based on tumor density"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8163-0087","authenticated-orcid":false,"given":"Takashi","family":"Hatano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahito","family":"Atsuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Inaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhisa","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Egawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"1224_CR1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1749-6632.1991.tb37754.x","volume":"615","author":"JP Osborne","year":"1991","unstructured":"Osborne JP, Fryer A, Webb DW (1991) Epidemiology of tuberous sclerosis. Ann NY Acad Sci 615:125\u2013127","journal-title":"Ann NY Acad Sci"},{"key":"1224_CR2","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.277.5327.805","volume":"277","author":"M Slegtenhorst van","year":"1997","unstructured":"van Slegtenhorst M, de Hoogt R, Hermans C et al (1997) Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 277:805\u2013808","journal-title":"Science"},{"key":"1224_CR3","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/0092-8674(93)90618-Z","volume":"75","author":"The European Chromosome 16 Tuberous Sclerosis Consortium","year":"1993","unstructured":"The European Chromosome 16 Tuberous Sclerosis Consortium (1993) Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 75:1305\u20131315","journal-title":"Cell"},{"key":"1224_CR4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1136\/jmg.26.1.28","volume":"26","author":"JR Sampson","year":"1989","unstructured":"Sampson JR, Scahill SJ, Stephenson JB et al (1989) Genetic aspects of tuberous sclerosis in the west of Scotland. J Med Genet 26:28\u201331","journal-title":"J Med Genet"},{"key":"1224_CR5","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1038\/ncomms2295","volume":"3","author":"A Sato","year":"2012","unstructured":"Sato A, Kasai S, Kobayashi T et al (2012) Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex. Nat Commun 3:1292\u20131300","journal-title":"Nat Commun"},{"key":"1224_CR6","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/j.juro.2007.07.058","volume":"178","author":"M Castagnetti","year":"2007","unstructured":"Castagnetti M, Vezzu B, Laverda A et al (2007) Urological counseling and followup in pediatric tuberous sclerosis complex. J Urol 178:2155\u20132159","journal-title":"J Urol"},{"key":"1224_CR7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1071-9091(98)80005-3","volume":"5","author":"HP Neumann","year":"1998","unstructured":"Neumann HP, Schwarzkopf G, Henske EP (1998) Renal angiomyolipomas, cysts, and cancer in tuberous sclerosis complex. Semin Pediatr Neurol 5:269\u2013275","journal-title":"Semin Pediatr Neurol"},{"key":"1224_CR8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.diii.2013.01.003","volume":"94","author":"O Rouviere","year":"2013","unstructured":"Rouviere O, Nivet H, Grenier N et al (2013) Kidney damage due to tuberous sclerosis complex: management recommendations. Diagn Interv Imaging 94:225\u2013237","journal-title":"Diagn Interv Imaging"},{"key":"1224_CR9","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/iju.13168","volume":"23","author":"T Hatano","year":"2016","unstructured":"Hatano T, Chikaraishi K, Inaba Y et al (2016) Outcomes of everolimus treatment for renal angiomyolipoma with tuberous sclerosis complex: a single institution experience in Japan. Int J Urol 23:833\u2013838","journal-title":"Int J Urol"},{"key":"1224_CR10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.pediatrneurol.2013.08.002","volume":"48","author":"DA Krueger","year":"2013","unstructured":"Krueger DA, Northrup H, International Tuberous Sclerosis Complex Consensus Group (2013) Tuberous sclerosis complex surveillance and management: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference. Pediatr Neurol 48:255\u2013265","journal-title":"Pediatr Neurol"},{"key":"1224_CR11","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/iju.13428","volume":"24","author":"T Hatano","year":"2017","unstructured":"Hatano T, Atsuta M, Inaba Y et al (2017) Intermittent everolimus admonistration for renal angiomyolipoma with tuberous sclerosis complex. Int J Urol 24:780\u2013785","journal-title":"Int J Urol"},{"key":"1224_CR12","doi-asserted-by":"crossref","first-page":"308","DOI":"10.4329\/wjr.v8.i3.308","volume":"8","author":"RA Sheth","year":"2016","unstructured":"Sheth RA, Feldman AS, Paul E et al (2016) Angiographic and volumetric effects of mammalian target of rapamycin inhibitors on angiomyolipoma in tuberous sclerosis. World J Radiol 8:308\u2013315","journal-title":"World J Radiol"},{"key":"1224_CR13","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0140-6736(12)61767-X","volume":"381","author":"JJ Bissler","year":"2013","unstructured":"Bissler JJ, Kingswood JC, Radzikowska E et al (2013) Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicenter, randomized, double-blind, placebo-controlled trial. Lancet 381:817\u2013824","journal-title":"Lancet"},{"key":"1224_CR14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/ndt\/gfv249","volume":"31","author":"JJ Bissler","year":"2016","unstructured":"Bissler JJ, Kingswood JC, Radzikowska E et al (2016) Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: extension of a randomized, controlled trial. Nephrol Dial Transplant 31:111\u2013119","journal-title":"Nephrol Dial Transplant"},{"key":"1224_CR15","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.molmed.2007.04.002","volume":"13","author":"SG Dann","year":"2007","unstructured":"Dann SG, Selvaraj A, Thomas G (2007) mTOR complex1-S6K1 signaling at the crossroads of obesity, diabetes and cancer. Trends Mol Med 13:252\u2013259","journal-title":"Trends Mol Med"},{"key":"1224_CR16","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1200\/JCO.2007.14.5482","volume":"26","author":"J Tabernero","year":"2008","unstructured":"Tabernero J, Rojo F, Calvo E et al (2008) Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamics study in patients with advanced solid tumors. J Clin Oncol 26:1603\u20131610","journal-title":"J Clin Oncol"},{"key":"1224_CR17","first-page":"68","volume-title":"Whole body computed tomography","author":"OH Wegener","year":"1992","unstructured":"Wegener OH (1992) Whole body computed tomography, 2nd edn. Blackwell Science Publications, Cambridge, pp 68\u201381","edition":"2"},{"key":"1224_CR18","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1148\/radiol.2251011477","volume":"225","author":"K Yamakado","year":"2002","unstructured":"Yamakado K, Tanaka N, Nakagawa T et al (2002) Renal angiomyolipoma: relationships between tumor size, aneurysm formation, and rupture. Radiology 225:78\u201382","journal-title":"Radiology"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10147-017-1224-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-017-1224-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-017-1224-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T12:58:36Z","timestamp":1526302716000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10147-017-1224-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,18]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["1224"],"URL":"https:\/\/doi.org\/10.1007\/s10147-017-1224-9","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,18]]}}}