{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:44:05Z","timestamp":1793724245944,"version":"4.6.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s10147-018-01387-6","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T07:02:35Z","timestamp":1555916555000},"page":"660-665","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacokinetics of S-1 monotherapy in plasma and in tears for gastric cancer patients"],"prefix":"10.1007","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7176-8354","authenticated-orcid":false,"given":"Hirofumi","family":"Yasui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroya","family":"Kashiwagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Omae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Yoshisue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kawahira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Tsushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomu","family":"Machida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Fukutomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,22]]},"reference":[{"key":"1387_CR1","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ajo.2005.01.052","volume":"140","author":"B Esmaeli","year":"2005","unstructured":"Esmaeli B, Golio D, Lubecki L et al (2005) Canalicular and nasolacrimal duct blockage: an ocular side effect associated with the antineoplastic drug S-1. Am J Ophtalmol 140:325\u2013327","journal-title":"Am J Ophtalmol"},{"key":"1387_CR2","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S1470-2045(08)70035-4","volume":"9","author":"W Koizumi","year":"2007","unstructured":"Koizumi W, Narahara H, Hara T et al (2007) S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial. Lancet Oncol 9:215\u2013221","journal-title":"Lancet Oncol"},{"key":"1387_CR3","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1093\/annonc\/mdu472","volume":"26","author":"Y Yamada","year":"2015","unstructured":"Yamada Y, Higuchi K, Nishikawa K et al (2015) Phase III study comparing oxaliplatin plus S-1 with cisplatin plus S-1 in chemotherapy-na\u00efve patients with advanced gastric cancer. Ann Oncol 26:141\u2013148","journal-title":"Ann Oncol"},{"key":"1387_CR4","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/S1470-2045(09)70259-1","volume":"10","author":"N Boku","year":"2009","unstructured":"Boku N, Yamamoto S, Fukuda H et al (2009) Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomized phase 3 study. Lancet Oncol 10:1063\u20131069","journal-title":"Lancet Oncol"},{"key":"1387_CR5","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1056\/NEJMoa072252","volume":"357","author":"S Sakuramoto","year":"2007","unstructured":"Sakuramoto S, Sasako M, Yamaguchi T et al (2007) Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med 357:1810\u20131820","journal-title":"N Engl J Med"},{"key":"1387_CR6","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1007\/s10120-015-0540-x","volume":"19","author":"H Tabuse","year":"2016","unstructured":"Tabuse H, Kashiwagi H, Hamauchi S et al (2016) Excessive watering eyes in gastric cancer patients receiving S-1 chemotherapy. Gastric Cancer 19:894\u2013901","journal-title":"Gastric Cancer"},{"key":"1387_CR7","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1097\/01.IOP.0000066648.33513.3D","volume":"19","author":"AS Eiseman","year":"2003","unstructured":"Eiseman AS, Flanagan JC, Brooks AB et al (2003) Ocular surface, ocular adnexal, and lacrimal complications associated with the use of systemic 5-fluorouracil. Ophthal Plast Reconstr Surg 19:216\u2013224","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"1387_CR8","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1093\/annonc\/mds106","volume":"23","author":"N Kim","year":"2012","unstructured":"Kim N, Park C, Park DJ et al (2012) Lacrimal drainage obstruction in gastric cancer patients receiving S-1 chemotherapy. Ann Oncol 23:2065\u20132071","journal-title":"Ann Oncol"},{"key":"1387_CR9","doi-asserted-by":"publisher","first-page":"890","DOI":"10.3341\/jkos.2010.51.6.890","volume":"51","author":"J-S Park","year":"2010","unstructured":"Park J-S, Ha SW, Lew H (2010) Two cases of lacrimal drainage obstruction associated with S-1 anticancer treatment. J Korean Ophthalmol Soc 51:890\u2013894","journal-title":"J Korean Ophthalmol Soc"},{"key":"1387_CR10","first-page":"259","volume":"38","author":"H Kitamura","year":"2011","unstructured":"Kitamura H, Miyanaga T, Shin H et al (2011) Investigation of epiphora following S-1 therapy. Jpn J Cancer Chemother 38:259\u2013262","journal-title":"Jpn J Cancer Chemother"},{"key":"1387_CR11","first-page":"1499","volume":"63","author":"K Shioda","year":"2009","unstructured":"Shioda K, Tanabe K, Kimura S et al (2009) Treatment of severe canalicular blockage secondary to peroral TS-1. J Clin Ophthalmol 63:1499\u20131502","journal-title":"J Clin Ophthalmol"},{"key":"1387_CR12","first-page":"1639","volume":"37","author":"H Kashiwagi","year":"2010","unstructured":"Kashiwagi H (2010) Ocular disorders of anticancer drugs\u2014ocular side effects. Jpn J Cancer Chemother 37:1639\u20131644","journal-title":"Jpn J Cancer Chemother"},{"key":"1387_CR13","first-page":"271","volume":"66","author":"J Sakai","year":"2012","unstructured":"Sakai J, Inoue Y, Kashiwagi H et al (2012) Multi-institutional survey on the lacrimal side effects of TS-1. J Clin Ophthalmol 66:271\u2013274","journal-title":"J Clin Ophthalmol"},{"key":"1387_CR14","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1007\/s10384-012-0127-6","volume":"56","author":"T Sasaki","year":"2012","unstructured":"Sasaki T, Miyashita H, Miyanaga T et al (2012) Dacryoendoscopic observation and incidence of canalicular obstruction\/stenosis associated with S-1, an oral anticancerdrug. Jpn J Ophthalmol 56:214\u2013218","journal-title":"Jpn J Ophthalmol"},{"key":"1387_CR15","doi-asserted-by":"crossref","unstructured":"Kim N, Kim JW, Baek JH et al (2017) S-1\u2013induced lacrimal drainage obstruction and its association with ingredients\/metabolites of S-1 in tears and plasma: a prospective multi-institutional study. Cancer Res Treat","DOI":"10.4143\/crt.2016.569"},{"key":"1387_CR16","doi-asserted-by":"publisher","first-page":"291","DOI":"10.2131\/jts.42.291","volume":"42","author":"S Kanie","year":"2017","unstructured":"Kanie S, Fujieda M, Hitotsumachi T et al (2017) Alleviating effects of artificial tear instillation on S-1-induced ocular toxicity in dogs. J Toxicol Sci 42:291\u2013300","journal-title":"J Toxicol Sci"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-018-01387-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10147-018-01387-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-018-01387-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T23:24:05Z","timestamp":1587425045000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10147-018-01387-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,22]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["1387"],"URL":"https:\/\/doi.org\/10.1007\/s10147-018-01387-6","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,22]]},"assertion":[{"value":"10 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Pharmacokinetic analysis was conducted by Taiho Pharmaceutical Co., Ltd. The manuscript was reviewed for medical accuracy by Taiho Pharmaceutical Co., Ltd. JK and KY are employees of Taiho Pharmaceutical Co. Ltd. All remaining authors have declared no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. All patients provided written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human rights statement and informed consent"}}]}}