{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T19:19:02Z","timestamp":1770578342353,"version":"3.49.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s10147-020-01705-x","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T13:04:05Z","timestamp":1590152645000},"page":"1596-1603","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Chemoradiotherapy for high-risk stage II laryngeal cancer"],"prefix":"10.1007","volume":"25","author":[{"given":"Satoshi","family":"Hamauchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7327-7949","authenticated-orcid":false,"given":"Tomoya","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Onozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Onoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Kamijo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Onitsuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,22]]},"reference":[{"issue":"6","key":"1705_CR1","first-page":"2903","volume":"36","author":"UC Megwalu","year":"2016","unstructured":"Megwalu UC, Panossian H (2016) Survival outcomes in early stage laryngeal cancer. Anticancer Res 36(6):2903\u20132907","journal-title":"Anticancer Res"},{"issue":"22","key":"1705_CR2","doi-asserted-by":"publisher","first-page":"3693","DOI":"10.1200\/JCO.2006.07.4559","volume":"24","author":"DG Pfister","year":"2006","unstructured":"American Society of Clinical O, Pfister DG, Laurie SA et al (2006) American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. J Clin Oncol 24(22):3693\u20133704. https:\/\/doi.org\/10.1200\/JCO.2006.07.4559","journal-title":"J Clin Oncol"},{"key":"1705_CR3","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.oraloncology.2016.10.013","volume":"62","author":"G Eskiizmir","year":"2016","unstructured":"Eskiizmir G, Baskin Y, Yalcin F et al (2016) Risk factors for radiation failure in early-stage glottic carcinoma: a systematic review and meta-analysis. Oral Oncol 62:90\u2013100. https:\/\/doi.org\/10.1016\/j.oraloncology.2016.10.013","journal-title":"Oral Oncol"},{"issue":"1","key":"1705_CR4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0360-3016(97)00284-8","volume":"39","author":"QT Le","year":"1997","unstructured":"Le QT, Fu KK, Kroll S et al (1997) Influence of fraction size, total dose, and overall time on local control of T1\u2013T2 glottic carcinoma. Int J Radiat Oncol Biol Phys 39(1):115\u2013126","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"1705_CR5","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/S0360-3016(98)00547-1","volume":"43","author":"G Marshak","year":"1999","unstructured":"Marshak G, Brenner B, Shvero J et al (1999) Prognostic factors for local control of early glottic cancer: the Rabin Medical Center retrospective study on 207 patients. Int J Radiat Oncol Biol Phys 43(5):1009\u20131013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"1705_CR6","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s00066-004-1164-y","volume":"180","author":"A Zouhair","year":"2004","unstructured":"Zouhair A, Azria D, Coucke P et al (2004) Decreased local control following radiation therapy alone in early-stage glottic carcinoma with anterior commissure extension. Strahlentherapie und Onkologie Organ der Deutschen Rontgengesellschaft [et al] 180(2):84\u201390. https:\/\/doi.org\/10.1007\/s00066-004-1164-y","journal-title":"Strahlentherapie und Onkologie Organ der Deutschen Rontgengesellschaft [et al]"},{"issue":"5","key":"1705_CR7","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1001\/archoto.2009.47","volume":"135","author":"ED McCoul","year":"2009","unstructured":"McCoul ED, Har-El G (2009) Meta-analysis of impaired vocal cord mobility as a prognostic factor in T2 glottic carcinoma. Arch Otolaryngol Head Neck Surg 135(5):479\u2013486. https:\/\/doi.org\/10.1001\/archoto.2009.47","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"4","key":"1705_CR8","doi-asserted-by":"publisher","first-page":"862","DOI":"10.4143\/crt.2014.203","volume":"47","author":"YJ Lim","year":"2015","unstructured":"Lim YJ, Wu HG, Kwon TK et al (2015) Long-term outcome of definitive radiotherapy for early glottic cancer: prognostic factors and patterns of local failure. Cancer Res Treat 47(4):862\u2013870. https:\/\/doi.org\/10.4143\/crt.2014.203","journal-title":"Cancer Res Treat"},{"issue":"8","key":"1705_CR9","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1080\/00016489.2017.1293295","volume":"137","author":"E Okazaki","year":"2017","unstructured":"Okazaki E, Matsushita N, Tashiro M et al (2017) Efficacy and toxicity profiles of two chemoradiotherapies for stage II laryngeal cancer: a comparison between late course accelerated hyperfractionation (LCAHF) and conventional fractionation (CF). Acta Otolaryngol 137(8):883\u2013887. https:\/\/doi.org\/10.1080\/00016489.2017.1293295","journal-title":"Acta Otolaryngol"},{"key":"1705_CR10","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/1748-717X-7-122","volume":"7","author":"N Hirasawa","year":"2012","unstructured":"Hirasawa N, Itoh Y, Naganawa S et al (2012) Multi-institutional analysis of early glottic cancer from 2000 to 2005. Radiat Oncol 7:122. https:\/\/doi.org\/10.1186\/1748-717X-7-122","journal-title":"Radiat Oncol"},{"key":"1705_CR11","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.oraloncology.2017.05.017","volume":"71","author":"Y Kitani","year":"2017","unstructured":"Kitani Y, Kubota A, Furukawa M et al (2017) Impact of combined modality treatment with radiotherapy and S-1 on T2N0 laryngeal cancer: possible improvement in survival through the prevention of second primary cancer and distant metastasis. Oral Oncol 71:54\u201359. https:\/\/doi.org\/10.1016\/j.oraloncology.2017.05.017","journal-title":"Oral Oncol"},{"issue":"12","key":"1705_CR12","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1093\/jjco\/hyu154","volume":"44","author":"T Taguchi","year":"2014","unstructured":"Taguchi T, Takahashi M, Nishimura G et al (2014) Phase II study of concurrent chemoradiotherapy with S-1 in patients with stage II (T2N0M0) squamous cell carcinoma of the pharynx or larynx. Jpn J Clin Oncol 44(12):1158\u20131163. https:\/\/doi.org\/10.1093\/jjco\/hyu154","journal-title":"Jpn J Clin Oncol"},{"issue":"4","key":"1705_CR13","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s00405-015-3579-8","volume":"273","author":"Y Kitani","year":"2016","unstructured":"Kitani Y, Kubota A, Furukawa M et al (2016) Prognostic factors for local control in patients receiving radiation therapy for early glottic cancer: anterior commissure involvement and effect of chemoradiotherapy. Eur Arch Otorhinolaryngol 273(4):1011\u20131017. https:\/\/doi.org\/10.1007\/s00405-015-3579-8","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"5","key":"1705_CR14","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1097\/00005537-199805000-00022","volume":"108","author":"JD Dahm","year":"1998","unstructured":"Dahm JD, Sessions DG, Paniello RC et al (1998) Primary subglottic cancer. Laryngoscope 108(5):741\u2013746. https:\/\/doi.org\/10.1097\/00005537-199805000-00022","journal-title":"Laryngoscope"},{"issue":"3 Pt 1","key":"1705_CR15","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1288\/00005537-199403000-00009","volume":"104","author":"MS Benninger","year":"1994","unstructured":"Benninger MS, Gillen J, Thieme P et al (1994) Factors associated with recurrence and voice quality following radiation therapy for T1 and T2 glottic carcinomas. Laryngoscope 104(3 Pt 1):294\u2013298. https:\/\/doi.org\/10.1288\/00005537-199403000-00009","journal-title":"Laryngoscope"},{"issue":"20","key":"1705_CR16","doi-asserted-by":"publisher","first-page":"4029","DOI":"10.1200\/JCO.2001.19.20.4029","volume":"19","author":"WM Mendenhall","year":"2001","unstructured":"Mendenhall WM, Amdur RJ, Morris CG et al (2001) T1\u2013T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy. J Clin Oncol 19(20):4029\u20134036. https:\/\/doi.org\/10.1200\/JCO.2001.19.20.4029","journal-title":"J Clin Oncol"},{"issue":"1","key":"1705_CR17","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1258\/rsmacta.41.1.38","volume":"41","author":"R Murakami","year":"2000","unstructured":"Murakami R, Baba Y, Furusawa M et al (2000) Early glottic squamous cell carcinoma. Predictive value of MR imaging for the rate of 5-year local control with radiation therapy. Acta Radiol 41(1):38\u201344","journal-title":"Acta Radiol"},{"issue":"2","key":"1705_CR18","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/S0360-3016(02)02920-6","volume":"54","author":"J Jin","year":"2002","unstructured":"Jin J, Liao Z, Gao L et al (2002) Analysis of prognostic factors for T(1)N(0)M(0) glottic cancer treated with definitive radiotherapy alone: experience of the cancer hospital of Peking Union Medical College and the Chinese Academy Of Medical Sciences. Int J Radiat Oncol Biol Phys 54(2):471\u2013478","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"1705_CR19","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/j.ijrobp.2007.05.077","volume":"69","author":"SP Reddy","year":"2007","unstructured":"Reddy SP, Hong RL, Nagda S et al (2007) Effect of tumor bulk on local control and survival of patients with T1 glottic cancer: a 30-year experience. Int J Radiat Oncol Biol Phys 69(5):1389\u20131394. https:\/\/doi.org\/10.1016\/j.ijrobp.2007.05.077","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"1705_CR20","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.ijrobp.2014.04.041","volume":"89","author":"A Trotti 3rd","year":"2014","unstructured":"Trotti A 3rd, Zhang Q, Bentzen SM et al (2014) Randomized trial of hyperfractionation versus conventional fractionation in T2 squamous cell carcinoma of the vocal cord (RTOG 9512). Int J Radiat Oncol Biol Phys 89(5):958\u2013963. https:\/\/doi.org\/10.1016\/j.ijrobp.2014.04.041","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1705_CR21","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1200\/JCO.2003.01.008","volume":"21","author":"DJ Adelstein","year":"2003","unstructured":"Adelstein DJ, Li Y, Adams GL et al (2003) An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol 21(1):92\u201398. https:\/\/doi.org\/10.1200\/JCO.2003.01.008","journal-title":"J Clin Oncol"},{"issue":"22","key":"1705_CR22","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1056\/NEJMoa031317","volume":"349","author":"AA Forastiere","year":"2003","unstructured":"Forastiere AA, Goepfert H, Maor M et al (2003) Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 349(22):2091\u20132098. https:\/\/doi.org\/10.1056\/NEJMoa031317","journal-title":"N Engl J Med"},{"issue":"6","key":"1705_CR23","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1056\/NEJMoa053422","volume":"354","author":"JA Bonner","year":"2006","unstructured":"Bonner JA, Harari PM, Giralt J et al (2006) Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354(6):567\u2013578. https:\/\/doi.org\/10.1056\/NEJMoa053422","journal-title":"N Engl J Med"},{"issue":"27","key":"1705_CR24","doi-asserted-by":"publisher","first-page":"2940","DOI":"10.1200\/JCO.2013.53.5633","volume":"32","author":"KK Ang","year":"2014","unstructured":"Ang KK, Zhang Q, Rosenthal DI et al (2014) Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522. J Clin Oncol 32(27):2940\u20132950. https:\/\/doi.org\/10.1200\/JCO.2013.53.5633","journal-title":"J Clin Oncol"},{"issue":"7","key":"1705_CR25","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1007\/s00520-016-3122-5","volume":"24","author":"T Yokota","year":"2016","unstructured":"Yokota T, Tachibana H, Konishi T et al (2016) Multicenter phase II study of an oral care program for patients with head and neck cancer receiving chemoradiotherapy. Support Care Cancer 24(7):3029\u20133036. https:\/\/doi.org\/10.1007\/s00520-016-3122-5","journal-title":"Support Care Cancer"},{"issue":"10166","key":"1705_CR26","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/S0140-6736(18)32779-X","volume":"393","author":"ML Gillison","year":"2019","unstructured":"Gillison ML, Trotti AM, Harris J et al (2019) Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial. Lancet 393(10166):40\u201350. https:\/\/doi.org\/10.1016\/S0140-6736(18)32779-X","journal-title":"Lancet"},{"issue":"2","key":"1705_CR27","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1385\/MO:21:2:095","volume":"21","author":"G Fountzilas","year":"2004","unstructured":"Fountzilas G, Ciuleanu E, Dafni U et al (2004) Concomitant radiochemotherapy vs radiotherapy alone in patients with head and neck cancer: a Hellenic Cooperative Oncology Group phase III study. Med Oncol 21(2):95\u2013107. https:\/\/doi.org\/10.1385\/MO:21:2:095","journal-title":"Med Oncol"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-020-01705-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-020-01705-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-020-01705-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T23:40:23Z","timestamp":1621640423000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-020-01705-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,22]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["1705"],"URL":"https:\/\/doi.org\/10.1007\/s10147-020-01705-x","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,22]]},"assertion":[{"value":"8 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflicts of interest associated with this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}