{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:10:37Z","timestamp":1787911837139,"version":"build-2784847793"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>To adopt HPV self-sampling in Japan, we assessed the concordance between self- and physician-collected human papillomavirus (HPV) samples from Japanese patients and examined the performance of HPV self-sampling for cervical intraepithelial neoplasia grade 2 or worse (CIN2+).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Patients who had previously tested negative for intraepithelial lesions or malignancy\/HPV-positive, and patients with atypical squamous cells of undetermined significance or worse (ASCUS+) cytology were eligible for this cross-sectional study. Participants performed HPV self-sampling using an Evalyn brush, which was submitted at the Fukui Prefectural Health Care Association. The Evalyn brush heads were stored in ThinPrep vials. The physician, however, performed HPV and cell sampling using an endocervical brush and immediately stored the brush heads in ThinPrep vials. All participants underwent colposcopy and biopsy. Histopathological diagnoses were made by pathologists at Fukui University Hospital. HPV infection was confirmed using a PCR-based Cobas 4800 HPV DNA test. Cytological analysis was performed at Fukui Prefectural Health Care Association.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>HPV-positive rates for physician-collected samples and self-collected samples were 51 and 50%, respectively. The perfect match rate of HPV type between the groups was 88% (<jats:italic>\u03ba<\/jats:italic>\u2009=\u20090.76). HPV16\/18 showed higher agreement rates than other HPVs (99%, kappa 0.96 and 89% kappa 0.77, respectively). Both groups showed 100% sensitivity to CIN2+, but specificity was 57.0 and 58.1%, respectively.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>For HPV typing, a good concordance rate was seen between self- and physician-collected samples. Self-sampling showed high sensitivity for CIN2+. Self-sampling using the Evalyn brush and Cobas 4800 may be feasible for screening Japanese individuals.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s10147-020-01727-5","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T14:22:00Z","timestamp":1596118920000},"page":"1854-1860","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Evaluation of the concordance in HPV type between self- and physician-collected samples using a brush-based device and a PCR-based HPV DNA test in Japanese referred patients with abnormal cytology or HPV infection"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6983-7584","authenticated-orcid":false,"given":"Toshimichi","family":"Onuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Shinagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Chino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"1727_CR1","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1177\/0969141315625702","volume":"23","author":"SJ Hanley","year":"2016","unstructured":"Hanley SJ, Fujita H, Yokoyama S et al (2016) HPV self-sampling in Japanese women: a feasibility study in a population with limited experience of tampon use. J Med Screen 23:164\u2013170. https:\/\/doi.org\/10.1177\/0969141315625702","journal-title":"J Med Screen"},{"key":"1727_CR2","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.canep.2015.08.001","volume":"39","author":"Y Motoki","year":"2015","unstructured":"Motoki Y, Mizushima S, Taguri M et al (2015) Increasing trends in cervical cancer mortality among young Japanese women below the age of 50\u00a0years: an analysis using the Kanagawa population-based Cancer Registry, 1975\u20132012. Cancer Epidemiol 39:700\u2013706. https:\/\/doi.org\/10.1016\/j.canep.2015.08.001","journal-title":"Cancer Epidemiol"},{"key":"1727_CR3","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ypmed.2007.06.007","volume":"45","author":"AR Spence","year":"2007","unstructured":"Spence AR, Goggin P, Franco EL (2007) Process of care failures in invasive cervical cancer: systematic review and meta-analysis. Prev Med 45:93\u2013106","journal-title":"Prev Med"},{"key":"1727_CR4","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1136\/jcp.55.4.244","volume":"55","author":"FX Bosch","year":"2002","unstructured":"Bosch FX, Lorincz A, Mu\u00f1oz N et al (2002) The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 55:244\u2013265","journal-title":"J Clin Pathol"},{"key":"1727_CR5","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1097\/01.AOG.0000109426.82624.f8","volume":"103","author":"TC Wright Jr","year":"2004","unstructured":"Wright TC Jr, Schiffman M, Solomon D et al (2004) Interim guidance for the use of human papillomavirus DNA testing as an adjunct to cervical cytology for screening. Obstet Gynecol 103:304\u2013309","journal-title":"Obstet Gynecol"},{"key":"1727_CR6","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1001\/jama.2018.7464","volume":"320","author":"GS Ogilvie","year":"2018","unstructured":"Ogilvie GS, van Niekerk D, Krajden M et al (2018) Effect of screening with primary cervical HPV testing vs cytology testing on high-grade cervical intraepithelial neoplasia at 48\u00a0months: the HPV FOCAL randomized clinical trial. JAMA 320:43\u201352. https:\/\/doi.org\/10.1001\/jama.2018.7464","journal-title":"JAMA"},{"key":"1727_CR7","doi-asserted-by":"publisher","first-page":"e96","DOI":"10.1016\/S2468-2667(17)30007-5","volume":"2","author":"JB Lew","year":"2017","unstructured":"Lew JB, Simms KT, Smith MA et al (2017) Primary HPV testing versus cytology-based cervical screening in women in Australia vaccinated for HPV and unvaccinated: effectiveness and economic assessment for the National Cervical Screening Program. Lancet Public Health 2:e96\u2013e107. https:\/\/doi.org\/10.1016\/S2468-2667(17)30007-5","journal-title":"Lancet Public Health"},{"key":"1727_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.09.006","author":"PJ Maver","year":"2019","unstructured":"Maver PJ, Poljak M (2019) Primary HPV-based cervical cancer screening in Europe: implementation status, challenges, and future plans. Clin Microbiol Infect. https:\/\/doi.org\/10.1016\/j.cmi.2019.09.006","journal-title":"Clin Microbiol Infect"},{"key":"1727_CR9","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.ygyno.2007.01.023","volume":"105","author":"P Petignat","year":"2007","unstructured":"Petignat P, Faltin DL, Bruchim I et al (2007) Are self-collected samples comparable to physician-collected cervical specimens for human papillomavirus DNA testing? A systematic review and meta-analysis. Gynecol Oncol 105:530\u2013535","journal-title":"Gynecol Oncol"},{"key":"1727_CR10","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1002\/ijc.27790","volume":"132","author":"PJ Snijders","year":"2013","unstructured":"Snijders PJ, Verhoef VM, Arbyn M et al (2013) High-risk HPV testing on self-sampled versus clinician-collected specimens: a review on the clinical accuracy and impact on population attendance in cervical cancer screening. Int J Cancer 132:2223\u20132236. https:\/\/doi.org\/10.1002\/ijc.27790","journal-title":"Int J Cancer"},{"key":"1727_CR11","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1136\/sextrans-2016-052609","volume":"93","author":"EJ Nelson","year":"2017","unstructured":"Nelson EJ, Maynard BR, Loux T et al (2017) The acceptability of self-sampled screening for HPV DNA: a systematic review and meta-analysis. Sex Transm Infect 93:56\u201361. https:\/\/doi.org\/10.1136\/sextrans-2016-052609","journal-title":"Sex Transm Infect"},{"key":"1727_CR12","doi-asserted-by":"publisher","first-page":"e159","DOI":"10.1007\/BF03405681","volume":"104","author":"CS Racey","year":"2013","unstructured":"Racey CS, Withrow DR, Gesink D (2013) Self-collected HPV testing improves participation in cervical cancer screening: a systematic review and meta-analysis. Can J Public Health 104:e159\u2013e166","journal-title":"Can J Public Health"},{"key":"1727_CR13","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1016\/j.ejca.2015.07.006","volume":"51","author":"F Verdoodt","year":"2015","unstructured":"Verdoodt F, Jentschke M, Hillemanns P et al (2015) Reaching women who do not participate in the regular cervical cancer screening programme by offering self-sampling kits: a systematic review and meta-analysis of randomised trials. Eur J Cancer 51:2375\u20132385. https:\/\/doi.org\/10.1016\/j.ejca.2015.07.006","journal-title":"Eur J Cancer"},{"key":"1727_CR14","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ypmed.2018.12.021","volume":"119","author":"NJ Polman","year":"2019","unstructured":"Polman NJ, Snijders PJF, Kenter GG et al (2019) HPV-based cervical screening: rationale, expectations and future perspectives of the new Dutch screening programme. Prev Med 119:108\u2013117. https:\/\/doi.org\/10.1016\/j.ypmed.2018.12.021","journal-title":"Prev Med"},{"key":"1727_CR15","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/S1470-2045(13)70570-9","volume":"15","author":"M Arbyn","year":"2014","unstructured":"Arbyn M, Verdoodt F, Snijders PJ et al (2014) Accuracy of human papillomavirus testing on self-collected versus clinician-collected samples: a meta-analysis. Lancet Oncol 15:172\u2013183","journal-title":"Lancet Oncol"},{"key":"1727_CR16","doi-asserted-by":"publisher","first-page":"3937","DOI":"10.1128\/JCM.01506-12","volume":"50","author":"R van Baars","year":"2012","unstructured":"van Baars R, Bosgraaf RP, ter Harmsel BW et al (2012) Dry storage and transport of a cervicovaginal self-sample by use of the Evalyn Brush, providing reliable human papillomavirus detection combined with comfort for women. J Clin Microbiol 50:3937\u20133943. https:\/\/doi.org\/10.1128\/JCM.01506-12","journal-title":"J Clin Microbiol"},{"key":"1727_CR17","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S1470-2045(18)30763-0","volume":"20","author":"NJ Polman","year":"2019","unstructured":"Polman NJ, Ebisch RMF, Heideman DAM et al (2019) Performance of human papillomavirus testing on self-collected versus clinician-collected samples for the detection of cervical intraepithelial neoplasia of grade 2 or worse: a randomised, paired screen-positive, non-inferiority trial. Lancet Oncol 20:229\u2013238. https:\/\/doi.org\/10.1016\/S1470-2045(18)30763-0","journal-title":"Lancet Oncol"},{"key":"1727_CR18","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.ygyno.2014.11.076","volume":"136","author":"TC Wright","year":"2015","unstructured":"Wright TC, Stoler MH, Behrens CM et al (2015) Primary cervical cancer screening with human papillomavirus: end of study results from the ATHENA study using HPV as the first-line screening test. Gynecol Oncol 136:189\u2013197. https:\/\/doi.org\/10.1016\/j.ygyno.2014.11.076","journal-title":"Gynecol Oncol"},{"key":"1727_CR19","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jcv.2017.12.008","volume":"99\u2013100","author":"MK Leinonen","year":"2018","unstructured":"Leinonen MK, Schee K, Jonassen CM et al (2018) Safety and acceptability of human papillomavirus testing of self-collected specimens: a methodologic study of the impact of collection devices and HPV assays on sensitivity for cervical cancer and high-grade lesions. J Clin Virol 99\u2013100:22\u201330. https:\/\/doi.org\/10.1016\/j.jcv.2017.12.008","journal-title":"J Clin Virol"},{"key":"1727_CR20","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1186\/s12879-018-3254-y","volume":"18","author":"M Tranberg","year":"2018","unstructured":"Tranberg M, Jensen JS, Bech BH et al (2018) Good concordance of HPV detection between cervico-vaginal self-samples and general practitioner-collected samples using the Cobas 4800 HPV DNA test. BMC Infect Dis 18:348. https:\/\/doi.org\/10.1186\/s12879-018-3254-y","journal-title":"BMC Infect Dis"},{"key":"1727_CR21","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/cyt.12576","volume":"29","author":"T Kurokawa","year":"2018","unstructured":"Kurokawa T, Onuma T, Shinagawa A et al (2018) The ideal strategy for cervical cancer screening in Japan: result from the Fukui Cervical Cancer Screening Study. Cytopathology 29:361\u2013367. https:\/\/doi.org\/10.1111\/cyt.12576","journal-title":"Cytopathology"},{"key":"1727_CR22","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1159\/000320924","volume":"55","author":"T Yoshida","year":"2011","unstructured":"Yoshida T, Sano T, Takada N et al (2011) Comparison of self-collected and clinician-collected materials for cervical cytology and human papillomavirus genotyping: analysis by linear array assay. Acta Cytol 55:106\u2013112. https:\/\/doi.org\/10.1159\/000320924","journal-title":"Acta Cytol"},{"key":"1727_CR23","doi-asserted-by":"publisher","first-page":"F88","DOI":"10.1016\/j.vaccine.2012.06.095","volume":"30","author":"M Arbyn","year":"2012","unstructured":"Arbyn M, Ronco G, Anttila A et al (2012) Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer. Vaccine 30:F88\u2013F99. https:\/\/doi.org\/10.1016\/j.vaccine.2012.06.095","journal-title":"Vaccine"},{"key":"1727_CR24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jviromet.2015.05.016","volume":"222","author":"ME \u00c1lvarez-Arg\u00fcelles","year":"2015","unstructured":"\u00c1lvarez-Arg\u00fcelles ME, de O\u00f1a-Navarro M, Rojo-Alba S et al (2015) Quantification of human papilloma virus (HPV) DNA using the Cobas 4800 system in women with and without pathological alterations attributable to the virus. J Virol Methods 222:95\u2013102. https:\/\/doi.org\/10.1016\/j.jviromet.2015.05.016","journal-title":"J Virol Methods"},{"key":"1727_CR25","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.jcv.2012.02.022","volume":"54","author":"MG Dijkstra","year":"2012","unstructured":"Dijkstra MG, Heideman DA, van Kemenade FJ et al (2012) Brush-based self-sampling in combination with GP5+\/6+-PCR-based hrHPV testing: high concordance with physician-taken cervical scrapes for HPV genotyping and detection of high-grade CIN. J Clin Virol 54:147\u2013151. https:\/\/doi.org\/10.1016\/j.jcv.2012.02.022","journal-title":"J Clin Virol"},{"key":"1727_CR26","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.jcv.2011.05.006","volume":"51","author":"I Gustavsson","year":"2011","unstructured":"Gustavsson I, Sanner K, Lindell M et al (2011) Type-specific detection of high-risk human papillomavirus (HPV) in self-sampled cervicovaginal cells applied to FTA elute cartridge. J Clin Virol 51:255\u2013258. https:\/\/doi.org\/10.1016\/j.jcv.2011.05.006","journal-title":"J Clin Virol"},{"key":"1727_CR27","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1111\/jog.13258","volume":"43","author":"KY Aiko","year":"2017","unstructured":"Aiko KY, Yoko M, Saito OM et al (2017) Accuracy of self-collected human papillomavirus samples from Japanese women with abnormal cervical cytology. J Obstet Gynaecol Res 43:710\u2013717. https:\/\/doi.org\/10.1111\/jog.13258","journal-title":"J Obstet Gynaecol Res"},{"key":"1727_CR28","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.pvr.2018.04.005","volume":"5","author":"DM Ejegod","year":"2018","unstructured":"Ejegod DM, Pedersen H, Alzua GP et al (2018) Time and temperature dependent analytical stability of dry-collected Evalyn HPV self-sampling brush for cervical cancer screening. Papillomavirus Res 5:192\u2013200. https:\/\/doi.org\/10.1016\/j.pvr.2018.04.005","journal-title":"Papillomavirus Res"},{"key":"1727_CR29","doi-asserted-by":"publisher","first-page":"187","DOI":"10.2147\/IJWH.S154212","volume":"10","author":"M Viviano","year":"2018","unstructured":"Viviano M, Tran PL, Kenfack BJ et al (2018) Self- versus physician-collected samples for the follow-up of human papillomavirus-positive women in sub-Saharan Africa. Int J Womens Health 10:187\u2013194. https:\/\/doi.org\/10.2147\/IJWH.S154212","journal-title":"Int J Womens Health"},{"key":"1727_CR30","doi-asserted-by":"publisher","first-page":"e267","DOI":"10.3390\/v9100267","volume":"9","author":"PE Gravitt","year":"2017","unstructured":"Gravitt PE, Winer RL (2017) Natural history of HPV infection across the lifespan: role of viral latency. Viruses 9:e267. https:\/\/doi.org\/10.3390\/v9100267","journal-title":"Viruses"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-020-01727-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-020-01727-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-020-01727-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T01:25:08Z","timestamp":1624497908000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-020-01727-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,24]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["1727"],"URL":"https:\/\/doi.org\/10.1007\/s10147-020-01727-5","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,24]]},"assertion":[{"value":"17 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors report no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}