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Several new diagnostic classification systems for salivary gland cytology have recently been proposed. However, none incorporate histology and grade of malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We developed a new cytology classification system that incorporates histology and grade of malignancy of salivary gland tumors (OMC classification), consisting of 11 categories. Our OMC classification was applied to 1175 patients who had preoperative cytology and confirmed final pathological diagnosis available from the past 20\u00a0years at our hospital (benign tumor: 981 patients, malignant tumor: 194 patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on the cytology, 729 patients (62.0%) had benign histology (Category 4\u20131), and 87 patients (7.4%) were diagnosed with grade of malignancy (Category 6\u20133\u2009+\u20096\u20134). Based on the final pathological diagnosis, the accuracy rate of Category 4\u20131 and Category 6\u20133\u2009+\u20096\u20134 of our classification system was 93.4% and 88.5%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on the correct diagnosis rate, the inclusion of histology and grade of malignancy in the salivary gland cytology classification was considered feasible. Thus, the OMC classification system is considered a useful tool when determining the treatment strategy for a salivary gland tumor.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s10147-020-01816-5","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T18:03:31Z","timestamp":1605895411000},"page":"326-334","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A novel clinically-oriented classification of fine-needle aspiration cytology for salivary gland tumors: a 20-year retrospective analysis of 1175 patients"],"prefix":"10.1007","volume":"26","author":[{"given":"Masataka","family":"Taniuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2427-8122","authenticated-orcid":false,"given":"Ryo","family":"Kawata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Omura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin- Ichi","family":"Haginomori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Terada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Higashino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Kurisu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"issue":"3","key":"1816_CR1","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1177\/0194599816643041","volume":"155","author":"AJ Feinstein","year":"2016","unstructured":"Feinstein AJ, Alonso J, Yang SE et al (2016) Diagnostic accuracy of fine-needle aspiration for parotid and submandibular gland lesions. 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