{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:43:31Z","timestamp":1790837011692,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s10147-021-02080-x","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T09:04:56Z","timestamp":1637139896000},"page":"488-494","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A risk factor for newly diagnosed secondary cancer in patients with early-stage laryngeal, oropharyngeal, or hypopharyngeal cancer: sub-analysis of a prospective observation study"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9944-4474","authenticated-orcid":false,"given":"Goshi","family":"Nishimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Kitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Hiiragi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Oridate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"2080_CR1","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.2214\/ajr.184.4.01841326","volume":"184","author":"F Dammann","year":"2005","unstructured":"Dammann F, Horger M, Mueller-Berg M et al (2005) Rational diagnosis of squamous cell carcinoma of the head and neck region: comparative evaluation of CT, MRI, and 18FDG PET. AJR Am J Roentgenol 184:1326\u20131331","journal-title":"AJR Am J Roentgenol"},{"key":"2080_CR2","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.otohns.2007.12.034","volume":"138","author":"A Watanabe","year":"2008","unstructured":"Watanabe A, Taniguchi M, Tsujie H et al (2008) The value of narrow band imaging endoscope for early head and neck cancers. Otolaryngol Head Neck Surg 138:446\u2013451","journal-title":"Otolaryngol Head Neck Surg"},{"key":"2080_CR3","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1007\/s00595-013-0713-3","volume":"44","author":"M Morita","year":"2014","unstructured":"Morita M, Saeki H, Ito S et al (2014) Surgical strategies for esophageal cancer associated with head and neck cancer. Surg Today 44:1603\u20131610","journal-title":"Surg Today"},{"key":"2080_CR4","doi-asserted-by":"publisher","first-page":"e235","DOI":"10.2196\/resprot.8907","volume":"6","author":"G Nishimura","year":"2017","unstructured":"Nishimura G, Sano D, Yabuki K et al (2017) The second-look procedure for transoral videolaryngoscopic surgery for T1 and T2 laryngeal, oropharyngeal, and hypopharyngeal cancer patients: protocol for a nonrandomized clinical trial. JMIR Res Protoc 6:e235","journal-title":"JMIR Res Protoc"},{"key":"2080_CR5","doi-asserted-by":"publisher","first-page":"7197","DOI":"10.1002\/cam4.2588","volume":"8","author":"G Nishimura","year":"2019","unstructured":"Nishimura G, Sano D, Arai Y et al (2019) A prospective clinical trial of the second-look procedure for transoral surgery in patients with T1 and T2 laryngeal, oropharyngeal, and hypopharyngeal cancer. Cancer Med 8:7197\u20137206","journal-title":"Cancer Med"},{"key":"2080_CR6","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1007\/s10147-021-01992-y","volume":"26","author":"G Nishimura","year":"2021","unstructured":"Nishimura G, Sano D, Arai Y et al (2021) Validation of the risk factors for primary control of early T-stage laryngeal, oropharyngeal, and hypopharyngeal squamous cell carcinoma by transoral surgery: a prospective observational study. Int J Clin Oncol 26:1995","journal-title":"Int J Clin Oncol"},{"key":"2080_CR7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s10147-020-01779-7","volume":"26","author":"G Nishimura","year":"2021","unstructured":"Nishimura G, Sano D, Arai Y et al (2021) The incidence of newly diagnosed secondary cancer; Sub-analysis the prospective study of the second-look procedure for transoral surgery in patients with T1 and T2 head and neck cancer. Int J Clin Oncol 26:59\u201365","journal-title":"Int J Clin Oncol"},{"key":"2080_CR8","volume-title":"TNM classification of malignant tumours","author":"L Sobin","year":"2009","unstructured":"Sobin L, Wittekind C (2009) TNM classification of malignant tumours, 7th edn. Wiley-Liss, New York","edition":"7"},{"key":"2080_CR9","volume-title":"TNM classification of malignant tumours","author":"JD Brierley","year":"2017","unstructured":"Brierley JD, Gospodarowicz MK, Wittekind C (2017) TNM classification of malignant tumours, 8th edn. Wiley-Liss, New York","edition":"8"},{"key":"2080_CR10","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1001\/archotol.1984.00800350006003","volume":"110","author":"B Vikram","year":"1984","unstructured":"Vikram B (1984) Changing patterns of failure in advanced head and neck cancer. Arch Otolaryngol 110:564\u2013565","journal-title":"Arch Otolaryngol"},{"key":"2080_CR11","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1200\/JCO.1995.13.4.876","volume":"13","author":"EE Vokes","year":"1995","unstructured":"Vokes EE, Kies M, Haraf DJ et al (1995) Induction chemotherapy followed by concomitant chemoradiotherapy for advanced head and neck cancer: impact on the natural history of the disease. J Clin Oncol 13:876\u2013883","journal-title":"J Clin Oncol"},{"key":"2080_CR12","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1093\/jnci\/89.3.199","volume":"89","author":"FR Khuri","year":"1997","unstructured":"Khuri FR, Lippman SM, Spitz MR et al (1997) Molecular epidemiology and retinoid chemoprevention of head and neck cancer. J Natl Cancer Inst 89:199\u2013211","journal-title":"J Natl Cancer Inst"},{"key":"2080_CR13","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/0360-3016(89)90095-3","volume":"17","author":"S McDonald","year":"1989","unstructured":"McDonald S, Haie C, Rubin P et al (1989) Second malignant tumors in patients with laryngeal carcinoma: diagnosis, treatment, and prevention. Int J Radiat Oncol Biol Phys 17:457\u2013465","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2080_CR14","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/0360-3016(89)90094-1","volume":"17","author":"JS Cooper","year":"1989","unstructured":"Cooper JS, Pajak TF, Rubin P et al (1989) Second malignancies in patients who have head and neck cancer: incidence, effect on survival and implications based on the RTOG experience. Int J Radiat Oncol Biol Phys 17:449\u2013456","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2080_CR15","doi-asserted-by":"publisher","first-page":"4653","DOI":"10.1002\/cncr.30920","volume":"123","author":"AK Bhatia","year":"2017","unstructured":"Bhatia AK, Lee JW, Pinto HA et al (2017) Double-blind, randomized phase 3 trial of low-dose 13-cis retinoic acid in the prevention of second primaries in head and neck cancer: long-term follow-up of a trial of the eastern cooperative oncology group-ACRIN cancer research group (C0590). Cancer 123:4653\u20134662","journal-title":"Cancer"},{"key":"2080_CR16","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1016\/j.bjoms.2019.09.018","volume":"57","author":"SN Rogers","year":"2019","unstructured":"Rogers SN, Swain A, Carroll C et al (2019) Incidence, timing, presentation, treatment, and outcomes of second primary head and neck squamous cell carcinoma after oral cancer. Br J Oral Maxillofac Surg 57:1074\u20131080","journal-title":"Br J Oral Maxillofac Surg"},{"key":"2080_CR17","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.1016\/j.joms.2018.06.169","volume":"76","author":"RA Ord","year":"2018","unstructured":"Ord RA, Isaiah A, Dyalram D et al (2018) Is long-term follow-up mandatory for stage I oral tongue cancer? J Oral Maxillofac Surg 76:2676\u20132683","journal-title":"J Oral Maxillofac Surg"},{"key":"2080_CR18","doi-asserted-by":"publisher","first-page":"3560","DOI":"10.1002\/cncr.32938","volume":"126","author":"M Xiang","year":"2020","unstructured":"Xiang M, Chang DT, Pollom EL (2020) Second cancer risk after primary cancer treatment with three-dimensional conformal, intensity-modulated, or proton beam radiation therapy. Cancer 126:3560\u20133568","journal-title":"Cancer"},{"key":"2080_CR19","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1126\/science.aag0299","volume":"354","author":"LB Alexandrov","year":"2016","unstructured":"Alexandrov LB, Ju YS, Haase K et al (2016) Mutational signatures associated with tobacco smoking in human cancer. Science 354:618\u2013622","journal-title":"Science"},{"key":"2080_CR20","unstructured":"Cancer Registry and Statistics. National Cancer Center, Japan: Cancer Information Service. https:\/\/ganjoho.jp\/public\/pre_scr\/cause_prevention\/smoking\/index.html. Accessed 16 Nov 2021 (in Japanese)"},{"key":"2080_CR21","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1002\/cncr.32590","volume":"126","author":"M Zaitsu","year":"2020","unstructured":"Zaitsu M, Takeuchi T, Kobayashi Y et al (2020) Light to moderate amount of lifetime alcohol consumption and risk of cancer in Japan. Cancer 126:1031\u20131040","journal-title":"Cancer"},{"key":"2080_CR22","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/sj.bjc.6602277","volume":"92","author":"M Inoue","year":"2005","unstructured":"Inoue M, Tsugane S, JPHC Study Group (2005) Impact of alcohol drinking on total cancer risk: data from a large-scale population-based cohort study in Japan. Br J Cancer 92:182\u2013187","journal-title":"Br J Cancer"},{"key":"2080_CR23","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/s41586-018-0811-x","volume":"565","author":"A Yokoyama","year":"2019","unstructured":"Yokoyama A, Kakiuchi N, Yoshizato T et al (2019) Age-related remodelling of oesophageal epithelia by mutated cancer drivers. Nature 565:312\u2013317","journal-title":"Nature"},{"key":"2080_CR24","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1159\/000360991","volume":"87","author":"T Hama","year":"2014","unstructured":"Hama T, Tokumaru Y, Fujii M et al (2014) Prevalence of human papillomavirus in oropharyngeal cancer: a multicenter study in Japan. Oncology 87:173\u2013182","journal-title":"Oncology"},{"key":"2080_CR25","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1177\/0003489416681582","volume":"126","author":"J Toman","year":"2017","unstructured":"Toman J, Von Larson S, Umeno H et al (2017) HPV-positive oropharyngeal cancer via p16 immunohistochemistry in Japan. Ann Otol Rhinol Laryngol 126:152\u2013158","journal-title":"Ann Otol Rhinol Laryngol"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-021-02080-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-021-02080-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-021-02080-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T14:06:01Z","timestamp":1645970761000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-021-02080-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,17]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["2080"],"URL":"https:\/\/doi.org\/10.1007\/s10147-021-02080-x","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,17]]},"assertion":[{"value":"13 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval for the study was obtained from the Yokohama City University Institutional Review Board (#B210400057).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from the participants to publish their data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}