{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T19:42:58Z","timestamp":1770493378034,"version":"3.49.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s10147-022-02127-7","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T07:03:44Z","timestamp":1644476624000},"page":"958-968","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of carcinoma in situ on the outcome of intravesical Bacillus Calmette-Gu\u00e9rin therapy for non-muscle-invasive bladder cancer: a comparative analysis of large real-world data"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2518-0197","authenticated-orcid":false,"given":"Ryotaro","family":"Tomida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9503-7356","authenticated-orcid":false,"given":"Makito","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoei","family":"Minato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunta","family":"Hori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikara","family":"Ohyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiya","family":"Hongo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikiya","family":"Taoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotaka","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyohide","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyoshi","family":"Hashine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Japanese Urological Oncology Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"2127_CR1","doi-asserted-by":"publisher","first-page":"2796","DOI":"10.1016\/S0140-6736(16)30512-8","volume":"388","author":"A Kamat","year":"2016","unstructured":"Kamat A, Hahn N, Efstathiou J et al (2016) Bladder cancer. Lancet 388:2796\u20132810","journal-title":"Lancet"},{"key":"2127_CR2","first-page":"31","volume":"10","author":"E Pasin","year":"2008","unstructured":"Pasin E, Josephson D, Mitra A et al (2008) Superficial bladder cancer: an update on etiology, molecular development, classification, and natural history. Rev Urol 10:31\u201343","journal-title":"Rev Urol"},{"key":"2127_CR3","first-page":"2020","volume":"6","author":"National Comprehensive Cancer Network","year":"2020","unstructured":"National Comprehensive Cancer Network (2020) NCCN Clinical Practice Guidelines in Oncology: bladder cancer. Version 6:2020","journal-title":"Version"},{"key":"2127_CR4","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.eururo.2019.08.016","volume":"76","author":"M Babjuk","year":"2019","unstructured":"Babjuk M, Burger M, Gontero P et al (2019) European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (TaT1 and Carcinoma In Situ)\u20142019 update. Eur Urol 76:639\u2013657","journal-title":"Eur Urol"},{"key":"2127_CR5","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.eururo.2009.12.024","volume":"57","author":"R Sylvester","year":"2010","unstructured":"Sylvester R, Brausi M, Kirkels W et al (2010) Long-term efficacy results of EORTC genito-urinary group randomized phase 3 study 30911 comparing intravesical instillations of epirubicin, bacillus Calmette-Gu\u00e9rin, and bacillus Calmette-Gu\u00e9rin plus isoniazid in patients with intermediate- and high-risk stage Ta T1 urothelial carcinoma of the bladder. Eur Urol 57:766\u2013773","journal-title":"Eur Urol"},{"key":"2127_CR6","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1016\/j.juro.2009.07.016","volume":"182","author":"J Fernandez-Gomez","year":"2009","unstructured":"Fernandez-Gomez J, Madero R, Solsona E et al (2009) Predicting nonmuscle invasive bladder cancer recurrence and progression in patients treated with bacillus Calmette-Guerin: the CUETO scoring model. J Urol 182:2195\u20132203","journal-title":"J Urol"},{"key":"2127_CR7","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s12885-021-07966-7","volume":"21","author":"M Miyake","year":"2021","unstructured":"Miyake M, Iida K, Nishimura N et al (2021) Non-maintenance intravesical Bacillus Calmette-Gu\u00e9rin induction therapy with eight doses in patients with high- or highest-risk non-muscle invasive bladder cancer: a retrospective non-randomized comparative study. BMC Cancer 21:266","journal-title":"BMC Cancer"},{"key":"2127_CR8","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.eururo.2014.06.040","volume":"67","author":"P Gontero","year":"2015","unstructured":"Gontero P, Sylvester R, Pisano F et al (2015) Prognostic factors and risk groups in T1G3 non\u2013muscle-invasive bladder cancer patients initially treated with bacillus Calmette-Gu\u00e9rin: results of a Retrospective Multicenter Study of 2451 Patients. Eur Urol 67:74\u201382","journal-title":"Eur Urol"},{"key":"2127_CR9","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.eururo.2005.12.031","volume":"49","author":"R Sylvester","year":"2006","unstructured":"Sylvester R, Meiden A, Oosterlinck W et al (2006) Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials. Eur Urol 49:466\u2013477","journal-title":"Eur Urol"},{"key":"2127_CR10","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.eururo.2011.10.029","volume":"62","author":"J Palou","year":"2012","unstructured":"Palou J, Sylvester R, Faba O et al (2012) Female gender and carcinoma In Situ in the prostatic urethra are prognostic factors for recurrence, progression, and disease-specific mortality in T1G3 bladder cancer patients treated with Bacillus Calmette-Gu\u00e9rin. Eur Urol 62:118\u2013125","journal-title":"Eur Urol"},{"key":"2127_CR11","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.ijsu.2018.02.045","volume":"52","author":"S Chen","year":"2018","unstructured":"Chen S, Zhang N, Shao J et al (2018) Maintenance versus non-maintenance intravesical Bacillus Calmette-Guerin instillation for non-muscle invasive bladder cancer: a systematic review and meta-analysis of randomized clinical trials. Int J Surg 52:248\u2013257","journal-title":"Int J Surg"},{"key":"2127_CR12","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/j.juro.2016.12.090","volume":"197","author":"R Chou","year":"2017","unstructured":"Chou R, Selph S, Buckley D et al (2017) Intravesical therapy for the treatment of nonmuscle invasive bladder cancer: a systematic review and meta-analysis. J Urol 197:1189\u20131199","journal-title":"J Urol"},{"key":"2127_CR13","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.urology.2020.07.023","volume":"145","author":"K Richards","year":"2020","unstructured":"Richards K, Lin S, Chuo C et al (2020) Increased bacillus Calmette-Gu\u00e9rin treatment intensity associated with improved outcomes in elderly patients with non-muscle-invasive bladder cancer in united states clinical practice. Urology 145:172\u2013180","journal-title":"Urology"},{"key":"2127_CR14","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1016\/S0022-5347(05)65756-4","volume":"166","author":"H Herr","year":"2001","unstructured":"Herr H, Sogani P (2001) Does early cystectomy improve the survival of patients with high risk superficial bladder tumors? J Urol 166:1296\u20131299","journal-title":"J Urol"},{"key":"2127_CR15","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.clgc.2020.03.013","volume":"18","author":"K Tully","year":"2020","unstructured":"Tully K, Roghmann F, Noldus J et al (2020) Quantifying the overall survival benefit with early radical cystectomy for patients with histologically confirmed T1 non-muscle-invasive bladder cancer. Clin Genitourin Cancer 18:651\u2013659","journal-title":"Clin Genitourin Cancer"},{"key":"2127_CR16","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3233\/BLC-200404","volume":"7","author":"A Kokorovic","year":"2021","unstructured":"Kokorovic A, Westerman M, Krause K et al (2021) Revisiting an old conundrum: a systematic review and meta-analysis of Intravesical therapy for treatment of urothelial carcinoma of the prostate. Bladder Cancer 7:243\u2013252","journal-title":"Bladder Cancer"},{"key":"2127_CR17","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1111\/iju.14281","volume":"27","author":"H Matsumoto","year":"2020","unstructured":"Matsumoto H, Shiraishi K, Azuma H et al (2020) Clinical practice guidelines for bladder cancer 2019 update by the Japanese Urological Association: summary of the revision. Int J Urol 27:702\u2013709","journal-title":"Int J Urol"},{"key":"2127_CR18","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.urology.2006.05.059","volume":"69","author":"J Palou","year":"2007","unstructured":"Palou J, Baniel J, Klotz L et al (2007) Urotherial carcinoma of the prostate. Urology 69:50\u201361","journal-title":"Urology"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-022-02127-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-022-02127-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-022-02127-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T18:10:36Z","timestamp":1650564636000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-022-02127-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,10]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["2127"],"URL":"https:\/\/doi.org\/10.1007\/s10147-022-02127-7","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,10]]},"assertion":[{"value":"6 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted according to the guidelines of the Declaration of Helsinki, and Approved on 23 May 2019 by the Institutional Review Board of each participating institute (Reference Protocol ID: NMU-2217) of the Japan Urological Oncology Group framework. Official names of institutional review board of each collaborating institute are listed here: the Medical ethics committee at Osaka University; the ethics committee of Kagawa University Faculty of Medicine; the Ethics Committee on Clinical Research, Kagoshima University; the Medical Ethics Committee for Kitasato University; the Kyushu University Hospital Ethics Committee; the Ethics Committee Graduate School and Faculty of Medicine Kyoto University; the Ethics committee of The Jikei University School of Medicine for Biomedical Research; the Ethics Committee of Shimane University; the Ethics Committee of Chiba University; the Ethics in Human Subject Research at the University of Tsukuba; the Ethics Committee of University of Toyama; the Ethical committee of Harasanshin Hospital; the Committee of Medical Ethics of Hirosaki University Graduate School of Medicine; the Independent Ethics Committee of Hokkaido University Graduate School of Medicine; the Ethical Review Committee of Yamagata University Faculty of Medicine; the Research Ethics Committee of University of Miyazaki; the Medical Ethics Review board of the Kyoto Prefectural University of Medicine; the Ethical committee of National Cancer Center Research Institute; the Ethical committee National Cancer Center Research Institute East; the Shikoku Cancer Center Ethics Committee; the Akita University School of Medicine Ethics Committee; Tottori University Faculty of Medicine Ethics Committee; the Tohoku University Graduate School of Medicine Ethics Committee; the Ethics Committee of Hamamatsu University School of Medicine; the Ethics Committee of Nara Prefecture General Medical Center; the Ethics Committee of Kokuho Chuo Hospital; the Ethics Committee of Nara City Hospital; the Ethics Committee of Yamato Koriyama Hospital; the Ethics Committee of Hirao Hospital; the Ethics Committee of Saiseikai Chuwa Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"An opt-out approach was used to obtain informed consent from the patients and personal information was protected during data collection.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}