{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:46:18Z","timestamp":1793943978132,"version":"4.8.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T00:00:00Z","timestamp":1676764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T00:00:00Z","timestamp":1676764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"JOA-Subsidized Science Project Research","award":["2019-4"],"award-info":[{"award-number":["2019-4"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thanks to recent advancement in cancer treatment, an increasing number of cancer patients are expected to live longer with cancer. The ambulatory ability is essential for cancer patients to spend their own independent lives, but locomotive syndrome (LS), a condition of reduced mobility due to impairment of locomotive organs, in cancer patients has been seldom examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single-institutional cross-sectional study. Cancer patients receiving cancer therapy between April 2020 and March 2021 were asked to participate. LS was classified as stage 0\u20133, and compared with their performance status (PS). Physical component summary (PCS) and mental component summary (MCS) were calculated from the results of Short Form-8. Logistic regression analysis was performed to identify risk factors for LS stage 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred and seventy-six cancer patients were included. The rate of LS was 96.0%. That of LS stage 3 was 40.9% and as high as 29.7% even if limited to those with PS 0. The mean PCS and MCS were both inferior to the national averages. PCS decreased as the LS stage advanced. Old age and underweight were revealed as independent risk factors for LS stage 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The ratio of LS in cancer patients was extremely high, and the LS stage correlated with physical QOL. Even those with PS 0 can have severe LS; thus, LS can be a sensitive detector of physical disability of cancer patients than PS. The improvement of LS can be a key to the preservation of their ADL and QOL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10147-023-02312-2","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T11:33:31Z","timestamp":1677152011000},"page":"603-609","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Cancer may accelerate locomotive syndrome and deteriorate quality of life: a single-centre cross-sectional study of locomotive syndrome in cancer patients"],"prefix":"10.1007","volume":"28","author":[{"given":"Masahiro","family":"Hirahata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7127-8817","authenticated-orcid":false,"given":"Jungo","family":"Imanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Fujinuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Inui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoshi","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Iimuro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Retsu","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Tokizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,19]]},"reference":[{"key":"2312_CR1","doi-asserted-by":"publisher","unstructured":"Global, regional, and national age-sex specific mortality for 264 causes of death, 1980\u20132016: a systematic analysis for the Global Burden of Disease Study 2016 (2017). Lancet 390 (10100):1151\u20131210. https:\/\/doi.org\/10.1016\/s0140-6736(17)32152-9","DOI":"10.1016\/s0140-6736(17)32152-9"},{"issue":"7","key":"2312_CR2","doi-asserted-by":"publisher","first-page":"426","DOI":"10.2188\/jea.JE20200416","volume":"31","author":"K Katanoda","year":"2021","unstructured":"Katanoda K, Hori M, Saito E et al (2021) Updated trends in cancer in japan: incidence in 1985\u20132015 and mortality in 1958\u20132018-a sign of decrease in cancer incidence. J Epidemiol 31(7):426\u2013450. https:\/\/doi.org\/10.2188\/jea.JE20200416","journal-title":"J Epidemiol"},{"key":"2312_CR3","unstructured":"Monitoring of Cancer Incidence in Japan\u2014Survival 2009\u20132011 report (2020) Center for Cancer Control and Information Services, National Cancer Center. https:\/\/ganjoho.jp\/reg_stat\/statistics\/data\/dl\/en.html. Accessed 10 Oct 2022"},{"key":"2312_CR4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1479-5868-7-39","volume":"7","author":"DE Warburton","year":"2010","unstructured":"Warburton DE, Charlesworth S, Ivey A et al (2010) A systematic review of the evidence for Canada\u2019s Physical Activity Guidelines for Adults. Int J Behav Nutr Phys Act 7:39. https:\/\/doi.org\/10.1186\/1479-5868-7-39","journal-title":"Int J Behav Nutr Phys Act"},{"issue":"1","key":"2312_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00776-007-1202-6","volume":"13","author":"K Nakamura","year":"2008","unstructured":"Nakamura K (2008) A \u201csuper-aged\u201d society and the \u201clocomotive syndrome.\u201d J Orthop Sci 13(1):1\u20132. https:\/\/doi.org\/10.1007\/s00776-007-1202-6","journal-title":"J Orthop Sci"},{"issue":"5","key":"2312_CR6","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1007\/s00776-015-0737-1","volume":"20","author":"T Ogata","year":"2015","unstructured":"Ogata T, Muranaga S, Ishibashi H et al (2015) Development of a screening program to assess motor function in the adult population: a cross-sectional observational study. J Orthop Sci 20(5):888\u2013895. https:\/\/doi.org\/10.1007\/s00776-015-0737-1","journal-title":"J Orthop Sci"},{"issue":"2","key":"2312_CR7","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00776-011-0193-5","volume":"17","author":"A Seichi","year":"2012","unstructured":"Seichi A, Hoshino Y, Doi T et al (2012) Development of a screening tool for risk of locomotive syndrome in the elderly: the 25-question Geriatric Locomotive Function Scale. J Orthop Sci 17(2):163\u2013172. https:\/\/doi.org\/10.1007\/s00776-011-0193-5","journal-title":"J Orthop Sci"},{"key":"2312_CR8","unstructured":"Council LC (2020) Assessment method of locomotive syndrome. Japanese Orthopaedic Association. https:\/\/locomo-joa.jp\/check\/judge\/. Accessed 10 Oct 2022"},{"issue":"6","key":"2312_CR9","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1097\/00000421-198212000-00014","volume":"5","author":"MM Oken","year":"1982","unstructured":"Oken MM, Creech RH, Tormey DC et al (1982) Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5(6):649\u2013655","journal-title":"Am J Clin Oncol"},{"key":"2312_CR10","volume-title":"How to score and interpret single-item health status measures, vol. 15. A manual for users of the SF-8 health survey","author":"JEKM Ware","year":"2001","unstructured":"Ware JEKM, Dewey JE, Gandek B (2001) How to score and interpret single-item health status measures, vol. 15. A manual for users of the SF-8 health survey. QualityMetric Inc, Lincoln"},{"issue":"11","key":"2312_CR11","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/s0895-4356(98)00095-x","volume":"51","author":"S Fukuhara","year":"1998","unstructured":"Fukuhara S, Bito S, Green J et al (1998) Translation, adaptation, and validation of the SF-36 Health Survey for use in Japan. J Clin Epidemiol 51(11):1037\u20131044. https:\/\/doi.org\/10.1016\/s0895-4356(98)00095-x","journal-title":"J Clin Epidemiol"},{"issue":"6","key":"2312_CR12","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/j.jos.2020.01.011","volume":"25","author":"K Yamada","year":"2020","unstructured":"Yamada K, Ito YM, Akagi M et al (2020) Reference values for the locomotive syndrome risk test quantifying mobility of 8681 adults aged 20\u201389 years: a cross-sectional nationwide study in Japan. J Orthop Sci 25(6):1084\u20131092. https:\/\/doi.org\/10.1016\/j.jos.2020.01.011","journal-title":"J Orthop Sci"},{"issue":"6","key":"2312_CR13","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1007\/s00774-019-01012-0","volume":"37","author":"N Yoshimura","year":"2019","unstructured":"Yoshimura N, Muraki S, Iidaka T et al (2019) Prevalence and co-existence of locomotive syndrome, sarcopenia, and frailty: the third survey of Research on Osteoarthritis\/Osteoporosis Against Disability (ROAD) study. J Bone Miner Metab 37(6):1058\u20131066. https:\/\/doi.org\/10.1007\/s00774-019-01012-0","journal-title":"J Bone Miner Metab"},{"key":"2312_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2020.08.007","author":"H Tsuji","year":"2020","unstructured":"Tsuji H, Tetsunaga T, Tetsunaga T et al (2020) Cognitive factors associated with locomotive syndrome in chronic pain patients: a retrospective study. J Orthop Sci. https:\/\/doi.org\/10.1016\/j.jos.2020.08.007","journal-title":"J Orthop Sci"},{"key":"2312_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2021.07.018","author":"M Sato","year":"2021","unstructured":"Sato M, Furuya T, Shiga Y et al (2021) Assessment of locomotive syndrome in patients with visceral cancer, the comparison with non-cancer patients using propensity score matching. J Orthop Sci. https:\/\/doi.org\/10.1016\/j.jos.2021.07.018","journal-title":"J Orthop Sci"},{"issue":"4","key":"2312_CR16","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/s00774-022-01324-8","volume":"40","author":"N Yoshimura","year":"2022","unstructured":"Yoshimura N, Iidaka T, Horii C et al (2022) Epidemiology of locomotive syndrome using updated clinical decision limits: 6-year follow-ups of the ROAD study. J Bone Miner Metab 40(4):623\u2013635. https:\/\/doi.org\/10.1007\/s00774-022-01324-8","journal-title":"J Bone Miner Metab"},{"key":"2312_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2021.11.021","author":"T Kobayashi","year":"2022","unstructured":"Kobayashi T, Morimoto T, Shimanoe C et al (2022) The association of comorbidities with the 25-question geriatric locomotive function scale and the diagnosis of locomotive syndrome. J Orthop Sci. https:\/\/doi.org\/10.1016\/j.jos.2021.11.021","journal-title":"J Orthop Sci"},{"issue":"8","key":"2312_CR18","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s10147-022-02194-w","volume":"27","author":"H Kawano","year":"2022","unstructured":"Kawano H, Hirahata M, Imanishi J (2022) Locomotive syndrome in cancer patients: a new role of orthopaedic surgeons as a part of comprehensive cancer care. Int J Clin Oncol 27(8):1233\u20131237. https:\/\/doi.org\/10.1007\/s10147-022-02194-w","journal-title":"Int J Clin Oncol"},{"issue":"1","key":"2312_CR19","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1152\/jappl.2000.89.1.81","volume":"89","author":"I Janssen","year":"2000","unstructured":"Janssen I, Heymsfield SB, Wang ZM et al (2000) Skeletal muscle mass and distribution in 468 men and women aged 18\u201388 yr. J Appl Physiol 89(1):81\u201388. https:\/\/doi.org\/10.1152\/jappl.2000.89.1.81","journal-title":"J Appl Physiol"},{"issue":"6","key":"2312_CR20","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.clnu.2008.06.013","volume":"27","author":"WJ Evans","year":"2008","unstructured":"Evans WJ, Morley JE, Argil\u00e9s J et al (2008) Cachexia: a new definition. Clin Nutr 27(6):793\u2013799. https:\/\/doi.org\/10.1016\/j.clnu.2008.06.013","journal-title":"Clin Nutr"},{"issue":"9","key":"2312_CR21","doi-asserted-by":"publisher","first-page":"e047175","DOI":"10.1136\/bmjopen-2020-047175","volume":"11","author":"S Bunzli","year":"2021","unstructured":"Bunzli S, O\u2019Brien P, Aston W et al (2021) Life or limb: an international qualitative study on decision making in sarcoma surgery during the COVID-19 pandemic. BMJ Open 11(9):e047175. https:\/\/doi.org\/10.1136\/bmjopen-2020-047175","journal-title":"BMJ Open"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-023-02312-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-023-02312-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-023-02312-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T11:48:13Z","timestamp":1680522493000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-023-02312-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,19]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["2312"],"URL":"https:\/\/doi.org\/10.1007\/s10147-023-02312-2","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,19]]},"assertion":[{"value":"24 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was supported by the research grant (2019\u20134) from the Japanese Orthopaedic Association.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the Institutional Review Board of our institution (19-239, 19-272, 20-007) prior to the commencement of this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}