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Using standardized assays, creatinine values were measured, and mGFR was determined using Technetium-99\u00a0m diethylenetriaminepentaacetic acid (Tc-99\u00a0m-DTPA) or Cr-51-ethylenediaminetetraacetic acid (Cr-51-EDTA) plasma clearance. Patients (<jats:italic>n<\/jats:italic>\u2009=\u2009146) with both mGFR and corresponding creatinine values available were included (<jats:italic>n<\/jats:italic>\u2009=\u2009345 measurements).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The CKD-EPI method consistently demonstrated superior accuracy, with the lowest Total Deviation Index of 21.8% at baseline and 22.9% for all measurements compared to Wright (23.4% \/24.1%), MDRD (26.2%\/25.5%), and Cockcroft\u2013Gault (25.x%\/25.1%). Bland Altman Limits of agreement (LOA) ranged from \u2212\u00a032\u00a0ml\/min (Cockcroft\u2013Gault) to\u2009+\u200933\u00a0ml\/min (MDRD), with CKD-EPI showing the narrowest LOA (\u2212\u00a027\u00a0ml\/min to\u2009+\u200924\u00a0ml\/min and lowest bias (0.3\u00a0ml\/min). Establishing an eGFR threshold at 85\u00a0ml\/min\u2014considering both the lower limit of agreement (LOA) and the minimum cisplatin limit at 60\u00a0ml\/min\u2014allows for the safe omission of mGFR in 30% of patients in this cohort.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>CKD-EPI equation emerged as the most suitable for estimating kidney function in this patient group although not meeting benchmark criteria. We recommend its use for initial assessment and ongoing monitoring, and suggest mGFR for patients with a CKD-EPI estimated GFR below 85\u00a0ml\/min. This approach could reduce costs and decrease laboratory time for 30% of our UC patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10147-023-02454-3","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T09:02:01Z","timestamp":1704445321000},"page":"309-317","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Glomerular filtration rate measurement during platinum treatment for urothelial carcinoma: optimal methods for clinical practice"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-9218","authenticated-orcid":false,"given":"Dag Rune","family":"Stormoen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla Nordstr\u00f6m","family":"Joensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gedske","family":"Daugaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Oturai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil","family":"Hyllested","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Lauritsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helle","family":"Pappot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"2454_CR1","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1093\/annonc\/mdx692","volume":"29","author":"A Bamias","year":"2018","unstructured":"Bamias A, Tzannis K, Harshman LC et al (2018) Impact of contemporary patterns of chemotherapy utilization on survival in patients with advanced cancer of the urinary tract: a retrospective international study of invasive\/advanced cancer of the urothelium (RISC). 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UNJ: no COI related to this study. GD: no COI related to this study. PSO: no COI related to this study. EH: no COI related to this study. JL: no COI related to this study. HP: no COI related to this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The regional data protection agency approved this study (Approval code: R-21077476), and according to Danish law, patient consent can be waived in this type of study. We adhere to the declaration of Helsinki [].","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}