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The Cancer-VTE Registry was a large-scale, multicenter, prospective, observational study in Japanese patients with cancer. This study aimed to clarify the relationship between D-dimer level at cancer diagnosis (baseline) and the incidence of events during cancer treatment (1-year follow-up period).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a post hoc sub-analysis of patients from the Cancer-VTE Registry whose D-dimer levels were measured at baseline. The incidence of events during the 1-year follow-up period was evaluated stratified by baseline\u00a0D-dimer level. Adjusted hazard ratios for D-dimer level and events during the follow-up period were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the total enrolled patients, baseline D-dimer level was measured in 9020 patients. The mean\u2009\u00b1\u2009standard deviation baseline\u00a0D-dimer level was 1.57\u2009\u00b1\u20093.94\u00a0\u00b5g\/mL. During the follow-up period, the incidence of VTE, cerebral infarction\/transient ischemic attack (TIA)\/systemic embolic events (SEE), bleeding, and all-cause death increased with increasing baseline D-dimer level. The incidence of all-cause death increased with increasing D-dimer level regardless of cancer stage. The adjusted hazard ratio of all-cause death was 1.03 (95% confidence interval: 1.02\u20131.03) per 1.0-\u00b5g\/mL increase in baseline D-dimer level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increases in D-dimer levels were associated with a higher risk of thrombotic events, such as VTE and cerebral infarction\/TIA\/SEE, during cancer treatment. Furthermore, higher D-dimer levels at cancer diagnosis were associated with a higher mortality rate, regardless of cancer stage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10147-024-02475-6","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T01:01:21Z","timestamp":1709341281000},"page":"407-416","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association of D-dimer level with thrombotic events, bleeding, and mortality in Japanese patients with solid tumors: a Cancer-VTE Registry subanalysis"],"prefix":"10.1007","volume":"29","author":[{"given":"Mashio","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Sakon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Sasako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Okusaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Mukai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Kunitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari S.","family":"Oba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hosokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Takita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,2]]},"reference":[{"key":"2475_CR1","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.1182\/blood-2008-06-165845","volume":"113","author":"SS Adam","year":"2009","unstructured":"Adam SS, Key NS, Greenberg CS (2009) D-dimer antigen: current concepts and future prospects. 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Jun Hosokawa and Atsushi Takita are employees of Daiichi Sankyo Co., Ltd. Masataka Ikeda received honoraria and research funding from Daiichi Sankyo Co., Ltd. Masato Sakon, Mitsuru Sasako, Takuji Okusaka, Keiichi Fujiwara, Mari S. Oba, and Hideo Wada has no COI to be declared.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study adhered to the Declaration of Helsinki and the Ethical Guidelines for Medical and Health Research Involving Human Subjects by the Japanese Ministry of Health, Labour and Welfare. The Non-Profit Organization Clinical Research Promotion Network Japan approved the protocol (approval number: not applicable). Written informed consent were obtained from all patients. The Cancer-VTE Registry was registered at UMIN Clinical Trials Registry under the identifier number UMIN000024942.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research ethics"}}]}}