{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:54:23Z","timestamp":1780379663542,"version":"3.54.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["23AA2003"],"award-info":[{"award-number":["23AA2003"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["22AA2003"],"award-info":[{"award-number":["22AA2003"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004721","name":"The University of Tokyo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004721","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The benefits of palliative care in patients with advanced cancer are well established. However, the effect of the skills of the palliative care team (PCT) on patient outcomes remains unclear. Our aim was to evaluate the association between hospital PCT intervention volume and patient outcomes in patients with cancer.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A retrospective cohort study was conducted using a nationwide inpatient database in Japan. Patients with cancer receiving chemotherapy and PCT intervention from 2015 to 2020 were included. The outcomes were incidence of hyperactive delirium within 30\u00a0days of admission, mortality within 30\u00a0days of admission, and decline in activities of daily living (ADL) at discharge. The exposure of interest was hospital PCT intervention volume (annual number of new PCT interventions in a hospital), which was categorized into low-, intermediate-, and high-volume groups according to tertiles. Multivariate logistic regression and restricted cubic-spline regression were conducted.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of 29,076 patients, 1495 (5.1%), 562 (1.9%), and 3026 (10.4%) developed delirium, mortality, and decline in ADL, respectively. Compared with the low hospital PCT intervention volume group (1\u2013103 cases\/year, n\u2009=\u20099712), the intermediate (104\u2013195, n\u2009=\u20099664) and high (196\u2013679, n\u2009=\u20099700) volume groups showed significant association with lower odds ratios of 30-day delirium (odds ratio, 0.79 [95% confidence interval, 0.69\u20130.91] and 0.80 [0.69\u20130.93], respectively), 30-day mortality (0.73 [0.60\u20130.90] and 0.59 [0.46\u20130.75], respectively), and decline in ADL (0.77 [0.70\u20130.84] and 0.52 [0.47\u20130.58], respectively).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Hospital PCT intervention volume is inversely associated with the odds ratios of delirium, mortality, and decline in ADL among hospitalized patients with cancer.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10147-024-02574-4","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T09:02:29Z","timestamp":1719219749000},"page":"1602-1609","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between hospital palliative care team intervention volume and patient outcomes"],"prefix":"10.1007","volume":"29","author":[{"given":"Hiroaki","family":"Abe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3662-8217","authenticated-orcid":false,"given":"Masahiko","family":"Sumitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reo","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohide","family":"Fushimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanji","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"2574_CR1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/S1053-4296(03)00024-9","volume":"13","author":"NM Aziz","year":"2003","unstructured":"Aziz NM, Rowland JH (2003) Trends and advances in cancer survivorship research: challenge and opportunity. Semin Radiat Oncol 13:248\u2013266","journal-title":"Semin Radiat Oncol"},{"key":"2574_CR2","unstructured":"World Health Organization (2024) Global cancer burden growing, amidst mounting need for services. https:\/\/www.who.int\/news\/item\/01-02-2024-global-cancer-burden-growing--amidst-mounting-need-for-services. Accessed May 2024"},{"key":"2574_CR3","unstructured":"World Health Organization (2020) Key facts of Palliative Care. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/palliative-care\/. Accessed May 2024"},{"key":"2574_CR4","unstructured":"National Cancer Institute (2021) Palliative care in cancer. https:\/\/www.cancer.gov\/about-cancer\/advanced-cancer\/care-choices\/palliative-care-fact-sheet. Accessed May 2024"},{"key":"2574_CR5","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1056\/NEJMoa1000678","volume":"363","author":"JS Temel","year":"2010","unstructured":"Temel JS, Greer JA, Muzikansky A et al (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363:733\u2013742","journal-title":"N Engl J Med"},{"key":"2574_CR6","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1001\/jamaoncol.2020.6343","volume":"7","author":"A El-Jawahri","year":"2021","unstructured":"El-Jawahri A, LeBlanc TW, Kavanaugh A et al (2021) Effectiveness of integrated palliative and oncology care for patients with acute myeloid leukemia: a randomized clinical trial. JAMA Oncol 7:238\u2013245","journal-title":"JAMA Oncol"},{"key":"2574_CR7","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1111\/j.1532-5415.2007.01234.x","volume":"55","author":"R Brumley","year":"2007","unstructured":"Brumley R, Enguidanos S, Jamison P et al (2007) Increased satisfaction with care and lower costs: results of a randomized trial of in-home palliative care. J Am Geriatr Soc 55:993\u20131000","journal-title":"J Am Geriatr Soc"},{"key":"2574_CR8","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.ejca.2019.11.009","volume":"124","author":"G Vanbutsele","year":"2020","unstructured":"Vanbutsele G, Van Belle S, Surmont V et al (2020) The effect of early and systematic integration of palliative care in oncology on quality of life and health care use near the end of life: A randomised controlled trial. Eur J Cancer 124:186\u2013193","journal-title":"Eur J Cancer"},{"key":"2574_CR9","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1007\/s00204-021-03068-2","volume":"95","author":"BA Baldo","year":"2021","unstructured":"Baldo BA (2021) Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity. Arch Toxicol 95:2627\u20132642","journal-title":"Arch Toxicol"},{"key":"2574_CR10","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1177\/0269881118795333","volume":"32","author":"O Dzahini","year":"2018","unstructured":"Dzahini O, Singh N, Taylor D et al (2018) Antipsychotic drug use and pneumonia: systematic review and meta-analysis. J Psychopharmacol 32:1167\u20131181","journal-title":"J Psychopharmacol"},{"key":"2574_CR11","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1111\/jgs.15066","volume":"65","author":"SJ Herzig","year":"2017","unstructured":"Herzig SJ, LaSalvia MT, Naidus E et al (2017) Antipsychotics and the risk of aspiration pneumonia in individuals hospitalized for nonpsychiatric conditions: a cohort study. J Am Geriatr Soc 65:2580\u20132586","journal-title":"J Am Geriatr Soc"},{"key":"2574_CR12","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1177\/147323001003800503","volume":"38","author":"A Heymann","year":"2010","unstructured":"Heymann A, Radtke F, Schiemann A et al (2010) Delayed treatment of delirium increases mortality rate in intensive care unit patients. J Int Med Res 38:1584\u20131595","journal-title":"J Int Med Res"},{"key":"2574_CR13","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/bjs.9958","volume":"103","author":"G Alsfasser","year":"2016","unstructured":"Alsfasser G, Leicht H, G\u00fcnster C et al (2016) Volume-outcome relationship in pancreatic surgery. Br J Surg 103:136\u2013143","journal-title":"Br J Surg"},{"key":"2574_CR14","unstructured":"Ministry of Health, Labour and Welfare of Japan (2022) Research on the use of the diagnosis procedure combination data for the evaluation of inpatient care in 2020\u20132021. https:\/\/mhlw-grants.niph.go.jp\/system\/files\/download_pdf\/2021\/202101008B.pdf. Accessed May 2024"},{"key":"2574_CR15","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.je.2016.09.009","volume":"27","author":"H Yamana","year":"2017","unstructured":"Yamana H, Moriwaki M, Horiguchi H et al (2017) Validity of diagnoses, procedures, and laboratory data in Japanese administrative data. J Epidemiol 27:476\u2013482","journal-title":"J Epidemiol"},{"key":"2574_CR16","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1002\/pds.4226","volume":"26","author":"DH Kim","year":"2017","unstructured":"Kim DH, Lee J, Kim CA et al (2017) Evaluation of algorithms to identify delirium in administrative claims and drug utilization database. Pharmacoepidemiol Drug Saf 26:945\u2013953","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"2574_CR17","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1191\/0269216304pm879oa","volume":"18","author":"C Centeno","year":"2004","unstructured":"Centeno C, Sanz A, Bruera E (2004) Delirium in advanced cancer patients. Palliat Med 18:184\u2013194","journal-title":"Palliat Med"},{"key":"2574_CR18","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/S0140-6736(13)60688-1","volume":"383","author":"SK Inouye","year":"2014","unstructured":"Inouye SK, Westendorp RGJ, Saczynski JS (2014) Delirium in elderly people. Lancet 383:911\u2013922","journal-title":"Lancet"},{"key":"2574_CR19","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1177\/1049909115624703","volume":"34","author":"G \u015eenel","year":"2017","unstructured":"\u015eenel G, Uysal N, Oguz G et al (2017) Delirium frequency and risk factors among patients with cancer in palliative care unit. Am J Hosp Palliat Care 34:282\u2013286","journal-title":"Am J Hosp Palliat Care"},{"key":"2574_CR20","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1053\/j.gastro.2018.07.016","volume":"156","author":"SD Crockett","year":"2019","unstructured":"Crockett SD, Greer KB, Heidelbaugh JJ et al (2019) American Gastroenterological Association institute guideline on the medical management of opioid-induced constipation. Gastroenterology 156:218\u2013226","journal-title":"Gastroenterology"},{"key":"2574_CR21","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1001\/jama.1996.03530350034031","volume":"275","author":"SK Inouye","year":"1996","unstructured":"Inouye SK, Charpentier PA (1996) Precipitating factors for delirium in hospitalized elderly persons: predictive model and interrelationship with baseline vulnerability. JAMA 275:852\u2013857","journal-title":"JAMA"},{"key":"2574_CR22","first-page":"225","volume":"4","author":"N Campbell","year":"2009","unstructured":"Campbell N, Boustani M, Limbil T et al (2009) The cognitive impact of anticholinergics: a clinical review. Clin Interv Aging 4:225\u2013233","journal-title":"Clin Interv Aging"},{"key":"2574_CR23","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s00520-015-2831-5","volume":"24","author":"E Erichs\u00e9n","year":"2016","unstructured":"Erichs\u00e9n E, Milberg A, Jaarsma T et al (2016) Constipation in specialized palliative care: Factors related to constipation when applying different definitions. Support Care Cancer 24:691\u2013698","journal-title":"Support Care Cancer"},{"key":"2574_CR24","doi-asserted-by":"publisher","first-page":"iv111","DOI":"10.1093\/annonc\/mdy148","volume":"29","author":"PJ Larkin","year":"2018","unstructured":"Larkin PJ, Cherny NI, La Carpia D et al (2018) Diagnosis, assessment and management of constipation in advanced cancer: ESMO clinical practice guidelines. Ann Oncol 29:iv111\u2013iv125","journal-title":"Ann Oncol"},{"key":"2574_CR25","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1111\/j.1541-0420.2011.01619.x","volume":"67","author":"TJ VanderWeele","year":"2011","unstructured":"VanderWeele TJ, Shpitser I (2011) A new criterion for confounder selection. Biometrics 67:1406\u20131413","journal-title":"Biometrics"},{"key":"2574_CR26","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1097\/WCO.0b013e3282f1a06e","volume":"20","author":"G Kannarkat","year":"2007","unstructured":"Kannarkat G, Lasher EE, Schiff D (2007) Neurologic complications of chemotherapy agents. Curr Opin Neurol 20:719\u2013725","journal-title":"Curr Opin Neurol"},{"key":"2574_CR27","first-page":"61","volume":"14","author":"FI Mahoney","year":"1965","unstructured":"Mahoney FI, Barthel DW (1965) Functional evaluation: the Barthel index. Md State Med J 14:61\u201365","journal-title":"Md State Med J"},{"key":"2574_CR28","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL et al (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373\u2013383","journal-title":"J Chronic Dis"},{"key":"2574_CR29","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1097\/01.mlr.0000182534.19832.83","volume":"43","author":"H Quan","year":"2005","unstructured":"Quan H, Sundararajan V, Halfon P et al (2005) Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care 43:1130\u20131139","journal-title":"Med Care"},{"key":"2574_CR30","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1152\/ajpcell.1985.249.1.C1","volume":"249","author":"BK Slinker","year":"1985","unstructured":"Slinker BK, Glantz SA (1985) Multiple regression for physiological data analysis: the problem of multicollinearity. Am J Physiol 249:R1\u2013R12","journal-title":"Am J Physiol"},{"key":"2574_CR31","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1097\/00001648-199507000-00005","volume":"6","author":"S Greenland","year":"1995","unstructured":"Greenland S (1995) Dose-response and trend analysis in epidemiology: alternatives to categorical analysis. Epidemiology 6:356\u2013365","journal-title":"Epidemiology"},{"key":"2574_CR32","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1097\/00001648-199507000-00025","volume":"6","author":"S Greenland","year":"1995","unstructured":"Greenland S (1995) Avoiding power loss associated with categorization and ordinal scores in dose-response and trend analysis. Epidemiology 6:450\u2013454","journal-title":"Epidemiology"},{"key":"2574_CR33","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/j.1365-2125.2011.04166.x","volume":"74","author":"DH Cousins","year":"2012","unstructured":"Cousins DH, Gerrett D, Warner B (2012) A review of medication incidents reported to the National Reporting and Learning System in England and Wales over 6 years (2005\u20132010). Br J Clin Pharmacol 74:597\u2013604","journal-title":"Br J Clin Pharmacol"},{"key":"2574_CR34","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1093\/bja\/59.1.61","volume":"59","author":"DJ Duthie","year":"1987","unstructured":"Duthie DJ, Nimmo WS (1987) Adverse effects of opioid analgesic drugs. Br J Anaesth 59:61\u201377","journal-title":"Br J Anaesth"},{"key":"2574_CR35","first-page":"1347","volume":"74","author":"JM Swegle","year":"2006","unstructured":"Swegle JM, Logemann C (2006) Management of common opioid-induced adverse effects. Am Fam Physician 74:1347\u20131354","journal-title":"Am Fam Physician"},{"key":"2574_CR36","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1001\/jamainternmed.2016.7491","volume":"177","author":"MR Agar","year":"2017","unstructured":"Agar MR, Lawlor PG, Quinn S et al (2017) Efficacy of oral risperidone, haloperidol, or placebo for symptoms of delirium among patients in palliative care: a randomized clinical trial. JAMA Intern Med 177:34\u201342","journal-title":"JAMA Intern Med"},{"key":"2574_CR37","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/SPC.0000000000000395","volume":"12","author":"D Hui","year":"2018","unstructured":"Hui D (2018) Benzodiazepines for agitation in patients with delirium: selecting the right patient, right time, and right indication. Curr Opin Support Palliat Care 12:489\u2013494","journal-title":"Curr Opin Support Palliat Care"},{"key":"2574_CR38","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1097\/BRS.0b013e318202ac56","volume":"36","author":"P Farjoodi","year":"2011","unstructured":"Farjoodi P, Skolasky RL, Riley LH (2011) The effects of hospital and surgeon volume on postoperative complications after LumbarSpine surgery. Spine 36:2069\u20132075","journal-title":"Spine"},{"key":"2574_CR39","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/MOU.0000000000000490","volume":"28","author":"P Grande","year":"2018","unstructured":"Grande P, Campi R, Roupr\u00eat M (2018) Relationship of surgeon\/hospital volume with outcomes in uro-oncology surgery. Curr Opin Urol 28:251\u2013259","journal-title":"Curr Opin Urol"},{"key":"2574_CR40","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1001\/jamacardio.2020.2221","volume":"5","author":"V Badhwar","year":"2020","unstructured":"Badhwar V, Vemulapalli S, Mack MA et al (2020) Volume-outcome association of mitral valve surgery in the United States. JAMA Cardiol 5:1092\u20131101","journal-title":"JAMA Cardiol"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-024-02574-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-024-02574-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-024-02574-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T17:06:07Z","timestamp":1727111167000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-024-02574-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,24]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["2574"],"URL":"https:\/\/doi.org\/10.1007\/s10147-024-02574-4","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,24]]},"assertion":[{"value":"14 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No competing financial interests exist.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}