{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:48:18Z","timestamp":1773146898557,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s10147-024-02630-z","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T16:05:28Z","timestamp":1728921928000},"page":"1896-1907","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lateral node metastasis in low rectal cancer as a hallmark to predict recurrence patterns"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-1789","authenticated-orcid":false,"given":"Eiji","family":"Shinto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Ike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Ohue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihide","family":"Kanemitsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Suto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsushi","family":"Kinugasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-ichi","family":"Hida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Itabashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heita","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Nozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yojiro","family":"Hashiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Hase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Sugihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Ajioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"2630_CR1","volume-title":"TNM classification of malignant tumors","author":"J Brierley","year":"2017","unstructured":"Brierley J, Gospodarowicz M, Wittekind C (2017) TNM classification of malignant tumors, 8th edn. Wiley-Blackwell, West Sussex","edition":"8"},{"key":"2630_CR2","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.surg.2017.02.005","volume":"162","author":"Y Kanemitsu","year":"2017","unstructured":"Kanemitsu Y, Komori K, Shida D et al (2017) Potential impact of lateral lymph node dissection (LLND) for low rectal cancer on prognoses and local control: a comparison of 2 high-volume centers in Japan that employ different policies concerning LLND. Surgery 162:303\u2013314","journal-title":"Surgery"},{"key":"2630_CR3","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1097\/SLA.0b013e3182565d9d","volume":"255","author":"T Akiyoshi","year":"2012","unstructured":"Akiyoshi T, Watanabe T, Miyata S et al (2012) Results of a Japanese nationwide multi-institutional study on lateral pelvic lymph node metastasis in low rectal cancer: is it regional or distant disease? Ann Surg 255:1129\u20131134","journal-title":"Ann Surg"},{"key":"2630_CR4","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1007\/s10147-023-02391-1","volume":"28","author":"D Yamai","year":"2023","unstructured":"Yamai D, Shimada Y, Nakano M et al (2023) Clinical significance of metastatic tumor deposit foci in rectal cancer in the lateral pelvic lymph node area. Int J Clin Oncol 28:1388\u20131397","journal-title":"Int J Clin Oncol"},{"key":"2630_CR5","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s10147-019-01523-w","volume":"25","author":"Y Hiyoshi","year":"2020","unstructured":"Hiyoshi Y, Miyamoto Y, Kiyozumi Y et al (2020) Risk factors and prognostic significance of lateral pelvic lymph node metastasis in advanced rectal cancer. Int J Clin Oncol 25:110\u2013117","journal-title":"Int J Clin Oncol"},{"key":"2630_CR6","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s10147-015-0858-8","volume":"20","author":"E Oki","year":"2015","unstructured":"Oki E, Ando K, Kasagi Y et al (2015) Recent advances in multidisciplinary approach for rectal cancer. Int J Clin Oncol 20:641\u2013649","journal-title":"Int J Clin Oncol"},{"key":"2630_CR7","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.ygyno.2017.02.018","volume":"145","author":"B Geppert","year":"2017","unstructured":"Geppert B, L\u00f6nnerfors C, Bollino M et al (2017) A study on uterine lymphatic anatomy for standardization of pelvic sentinel lymph node detection in endometrial cancer. Gynecol Oncol 145:256\u2013261","journal-title":"Gynecol Oncol"},{"key":"2630_CR8","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.juro.2015.01.008","volume":"194","author":"K Yuen","year":"2015","unstructured":"Yuen K, Miura T, Sakai I et al (2015) Intraoperative fluorescence imaging for detection of sentinel lymph nodes and lymphatic vessels during open prostatectomy using indocyanine green. J Urol 194:371\u2013377","journal-title":"J Urol"},{"key":"2630_CR9","first-page":"610","volume-title":"Breakthroughs in statistics. Foundations and basic theory","author":"H Akaike","year":"1973","unstructured":"Akaike H (1973) Information theory and extension of the maximum likelihood principle. In: Kotz S, Johnson NL (eds) Breakthroughs in statistics. Foundations and basic theory, vol 1. Springer-Verlag, New York, pp 610\u2013624"},{"key":"2630_CR10","doi-asserted-by":"publisher","first-page":"006","DOI":"10.1093\/bjsopen\/zrac006","volume":"6","author":"E Shinto","year":"2022","unstructured":"Shinto E, Ike H, Ito M et al (2022) Optimizing nodal and staging classification in low rectal cancers with lateral node metastasis: multicentre retrospective cohort study. BJS Open 6:006","journal-title":"BJS Open"},{"key":"2630_CR11","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1200\/JCO.18.00032","volume":"37","author":"A Ogura","year":"2019","unstructured":"Ogura A, Konishi T, Cunningham C et al (2019) Neoadjuvant (Chemo)radiotherapy with total mesorectal excision only is not sufficient to prevent lateral local recurrence in enlarged nodes: results of the multicenter lateral node study of patients with low cT3\/4 rectal cancer. J Clin Oncol 37:33\u201343","journal-title":"J Clin Oncol"},{"key":"2630_CR12","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1002\/bjs5.50194","volume":"3","author":"T Akiyoshi","year":"2019","unstructured":"Akiyoshi T, Toda S, Tominaga T et al (2019) Prognostic impact of residual lateral lymph node metastasis after neoadjuvant (chemo)radiotherapy in patients with advanced low rectal cancer. BJS Open 3:822\u2013829","journal-title":"BJS Open"},{"key":"2630_CR13","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1056\/NEJMoa040694","volume":"351","author":"R Sauer","year":"2004","unstructured":"Sauer R, Becker H, Hohenberger W et al (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731\u20131740","journal-title":"N Engl J Med"},{"key":"2630_CR14","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1097\/01.sla.0000257358.56863.ce","volume":"246","author":"KCMJ Peeters","year":"2007","unstructured":"Peeters KCMJ, Marijnen CAM, Nagtegaal ID et al (2007) The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg 246:693\u2013701","journal-title":"Ann Surg"},{"key":"2630_CR15","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1200\/JCO.2013.51.7904","volume":"32","author":"D Schrag","year":"2014","unstructured":"Schrag D, Weiser MR, Goodman KA et al (2014) Neoadjuvant chemotherapy without routine use of radiation therapy for patients with locally advanced rectal cancer: a pilot trial. J Clin Oncol 32:513\u2013518","journal-title":"J Clin Oncol"},{"key":"2630_CR16","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1634\/theoncologist.2014-0233","volume":"19","author":"C Fernandez-Martos","year":"2014","unstructured":"Fernandez-Martos C, Brown G, Estevan R et al (2014) Preoperative chemotherapy in patients with intermediate-risk rectal adenocarcinoma selected by high-resolution magnetic resonance imaging: the GEMCAD 0801 Phase II multicenter trial. Oncologist 19:1042\u20131043","journal-title":"Oncologist"},{"key":"2630_CR17","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1093\/annonc\/mdw616","volume":"28","author":"UB Patel","year":"2017","unstructured":"Patel UB, Brown G, Machado I et al (2017) MRI assessment and outcomes in patients receiving neoadjuvant chemotherapy only for primary rectal cancer: long-term results from the GEMCAD 0801 trial. Ann Oncol 28:344\u2013353","journal-title":"Ann Oncol"},{"key":"2630_CR18","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s00280-010-1358-1","volume":"67","author":"T Hamaguchi","year":"2011","unstructured":"Hamaguchi T, Shirao K, Moriya Y et al (2011) Final results of randomized trials by the national surgical adjuvant study of colorectal cancer (NSAS-CC). Cancer Chemother Pharmacol 67:587\u2013596","journal-title":"Cancer Chemother Pharmacol"},{"key":"2630_CR19","doi-asserted-by":"publisher","first-page":"4558","DOI":"10.1200\/JCO.2012.42.8771","volume":"30","author":"JP G\u00e9rard","year":"2012","unstructured":"G\u00e9rard JP, Azria D, Gourgou-Bourgade S et al (2012) Clinical outcome of the accord 12\/0405 PRODIGE 2 randomized trial in rectal cancer. J Clin Oncol 30:4558\u20134565","journal-title":"J Clin Oncol"},{"key":"2630_CR20","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1093\/annonc\/mdv223","volume":"26","author":"C Fernandez-Martos","year":"2015","unstructured":"Fernandez-Martos C, Garcia-Albeniz X, Pericay C et al (2015) Chemoradiation, surgery and adjuvant chemotherapy versus induction chemotherapy followed by chemoradiation and surgery: long-term results of the Spanish GCR-3 phase II randomized trial\u2020. Ann Oncol 26:1722\u20131728","journal-title":"Ann Oncol"},{"key":"2630_CR21","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1093\/annonc\/mdz186","volume":"30","author":"B Cise\u0142","year":"2019","unstructured":"Cise\u0142 B, Pietrzak L, Michalski W et al (2019) Long-course preoperative chemoradiation versus 5 \u00d7 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study. Ann Oncol 30:1298\u20131303","journal-title":"Ann Oncol"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-024-02630-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-024-02630-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-024-02630-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T07:58:42Z","timestamp":1732607922000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-024-02630-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,14]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["2630"],"URL":"https:\/\/doi.org\/10.1007\/s10147-024-02630-z","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,14]]},"assertion":[{"value":"30 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We have nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the ethical review board of the Japanese Society for Cancer of the Colon and Rectum (Protocol number: 90\u20133) and by the institutional review board of each participating institution. The study was performed in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all patients in accordance with their respective institutional regulations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}