{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T18:16:55Z","timestamp":1779387415463,"version":"3.53.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s10147-024-02665-2","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T06:40:37Z","timestamp":1732689637000},"page":"40-50","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is it feasible to prolong the flushing interval for totally implantable venous access devices (TIVADs)? A systematic review and meta-analysis"],"prefix":"10.1007","volume":"30","author":[{"given":"Lei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanlun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinsheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laiyou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"2665_CR1","doi-asserted-by":"publisher","first-page":"10767","DOI":"10.1038\/s41598-023-37902-7","volume":"13","author":"L Liu","year":"2023","unstructured":"Liu L, Liu Z, Wang J et al (2023) Exploring risk factors for totally implantable venous access devices (TIVADs)-related thrombotic occlusion in the off-treatment period. Sci Rep 13:10767\u201310777. https:\/\/doi.org\/10.1038\/s41598-023-37902-7","journal-title":"Sci Rep"},{"key":"2665_CR2","doi-asserted-by":"publisher","first-page":"e22","DOI":"10.1200\/JOP.2016.01084","volume":"13","author":"JA Diaz","year":"2017","unstructured":"Diaz JA, Rai SN, Wu X et al (2017) Phase II trial on extending the maintenance flushing interval of implanted ports. J Oncol Pract 13:e22\u2013e28. https:\/\/doi.org\/10.1200\/JOP.2016.01084","journal-title":"J Oncol Pract"},{"key":"2665_CR3","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1097\/JCMA.0000000000000601","volume":"85","author":"HC Hsieh","year":"2022","unstructured":"Hsieh HC, Hung SC, Huang SY et al (2022) A prospective, randomized study assessing different modalities for flushing totally implanted vascular access device in children with malignancy. J Chin Med Assoc 85:114\u2013119. https:\/\/doi.org\/10.1097\/JCMA.0000000000000601","journal-title":"J Chin Med Assoc"},{"issue":"1","key":"2665_CR4","first-page":"S1","volume":"39","author":"LA Gorski","year":"2021","unstructured":"Gorski LA et al (2021) Infusion therapy standards of practice. J Inf Nurs Norwood 39(1):S1","journal-title":"J Inf Nurs Norwood"},{"key":"2665_CR5","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.18295\/squmj.2021.21.01.014","volume":"21","author":"PC D'Souza","year":"2021","unstructured":"D\u2019Souza PC, Kumar S, Kakaria A et al (2021) Complications and management of totally implantable central venous access ports in cancer patients at a University Hospital in Oman. Sultan Qaboos Univ Med J 21:e103\u2013e109","journal-title":"Sultan Qaboos Univ Med J"},{"key":"2665_CR6","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.ejso.2008.01.020","volume":"35","author":"A Ignatov","year":"2009","unstructured":"Ignatov A, Hoffman O, Smith B et al (2009) An 11-year retrospective study of totally implanted central venous access ports: complications and patient satisfaction. Eur J Surg Oncol 35:241\u2013246. https:\/\/doi.org\/10.1016\/j.ejso.2008.01.020","journal-title":"Eur J Surg Oncol"},{"key":"2665_CR7","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1177\/11297298209509","volume":"22","author":"X Wu","year":"2021","unstructured":"Wu X, Zhang T, Chen L et al (2021) Prolonging the flush-lock interval of totally implantable venous access ports in patients with cancer: a systematic review and meta-analysis. J Vasc Access 22:814\u2013821. https:\/\/doi.org\/10.1177\/11297298209509","journal-title":"J Vasc Access"},{"key":"2665_CR8","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.ijnss.2021.05.005","volume":"8","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Zhao R, Jiang N et al (2021) A retrospective observational study on maintenance and complications of totally implantable venous access ports in 563 patients: prolonged versus short flushing intervals. Int J Nurs Sci 8:252\u2013256. https:\/\/doi.org\/10.1016\/j.ijnss.2021.05.005","journal-title":"Int J Nurs Sci"},{"key":"2665_CR9","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.12968\/bjon.2018.27.8.S4","volume":"27","author":"L Rasero","year":"2018","unstructured":"Rasero L, Golin L, Ditta S et al (2018) Effects of prolonged flushing interval in totally implantable venous access devices (TIVADs). Br J Nurs 27:S4\u2013S10","journal-title":"Br J Nurs"},{"key":"2665_CR10","doi-asserted-by":"publisher","first-page":"e12978","DOI":"10.1111\/ecc.12978","volume":"28","author":"C Fornaro","year":"2019","unstructured":"Fornaro C, Piubeni M, Tovazzi V et al (2019) Eight-week interval in flushing and locking port-a-cath in cancer patients: a single-institution experience and systematic review. Eur J Cancer Care (Engl) 28:e12978\u2013e12986. https:\/\/doi.org\/10.1111\/ecc.12978","journal-title":"Eur J Cancer Care (Engl)"},{"key":"2665_CR11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000294919","volume":"70","author":"A Ignatov","year":"2010","unstructured":"Ignatov A, Ignatov T, Taran A et al (2010) Interval between port catheter flushing can be extended to four months. Gynecol Obstet Invest 70:91\u201394. https:\/\/doi.org\/10.1159\/000294919","journal-title":"Gynecol Obstet Invest"},{"key":"2665_CR12","doi-asserted-by":"publisher","first-page":"e24720","DOI":"10.1097\/MD.0000000000024720","volume":"100","author":"W Yan","year":"2010","unstructured":"Yan W, Zhang C, Luo C et al (2010) Management of outpatient with totally implantable venous access Ports during the COVID-19 epidemic. Medicine (Baltimore) 100:e24720\u2013e24725. https:\/\/doi.org\/10.1097\/MD.0000000000024720","journal-title":"Medicine (Baltimore)"},{"key":"2665_CR13","doi-asserted-by":"publisher","first-page":"1021488","DOI":"10.3389\/fonc.2022.1021488","volume":"12","author":"Y Wang","year":"2022","unstructured":"Wang Y, Tian H, Chen X et al (2022) Safety and feasibility assessment of extending the flushing interval in totally implantable venous access port flushing during the non-treatment stage for patients with breast cancer. Front Oncol 12:1021488\u20131021510. https:\/\/doi.org\/10.3389\/fonc.2022.1021488","journal-title":"Front Oncol"},{"key":"2665_CR14","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1365-2354.2008.00973.x","volume":"18","author":"U Kefeli","year":"2009","unstructured":"Kefeli U, Dane F, Yumuk PF et al (2009) Prolonged interval in prophylactic heparin flushing for maintenance of subcutaneous implanted port care in patients with cancer. Eur J Cancer Care (Engl) 18:191\u2013194. https:\/\/doi.org\/10.1111\/j.1365-2354.2008.00973.x","journal-title":"Eur J Cancer Care (Engl)"},{"key":"2665_CR15","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ejon.2013.09.002","volume":"18","author":"A Palese","year":"2013","unstructured":"Palese A, Baldassar D, Rupil A et al (2013) Maintaining patency in totally implantable venous access devices (TIVAD): a time-to-event analysis of different lock irrigation intervals. Eur J Oncol Nurs 18:66\u201371. https:\/\/doi.org\/10.1016\/j.ejon.2013.09.002","journal-title":"Eur J Oncol Nurs"},{"key":"2665_CR16","doi-asserted-by":"publisher","first-page":"e1438","DOI":"10.1200\/OP.22.00060","volume":"18","author":"T Lang","year":"2022","unstructured":"Lang T, Jaboury S, West A et al (2022) Is There a relationship between frequency of port-care maintenance and related complications in patients with cancer? JCO Oncol Pract 18:e1438\u2013e1446. https:\/\/doi.org\/10.1200\/OP.22.00060","journal-title":"JCO Oncol Pract"},{"key":"2665_CR17","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1080\/07357900500276923","volume":"23","author":"YS Kuo","year":"2005","unstructured":"Kuo YS, Schwartz B, Santiago J et al (2005) How often should a port-A-cath be flushed? Cancer Invest 23:582\u2013585. https:\/\/doi.org\/10.1080\/07357900500276923","journal-title":"Cancer Invest"},{"key":"2665_CR18","first-page":"687","volume":"20","author":"Z Wenling","year":"2022","unstructured":"Wenling Z, Ruchun S, Chunli L et al (2022) Discussion on the flushing intervals of implanted infusion ports for caner patients. Chinese General Practice Nursing 20:687\u2013691","journal-title":"Chinese General Practice Nursing"},{"issue":"72","key":"2665_CR19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160","volume":"2021","author":"MJ Page","year":"2020","unstructured":"Page MJ, Moher D, Bossuyt PMPRISMA et al (2020) explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ 2021(72):n160. https:\/\/doi.org\/10.1136\/bmj.n160","journal-title":"BMJ"},{"key":"2665_CR20","unstructured":"Wells GA. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Available via DIALOG. https:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp. Accessed 2 Aug 2023"},{"key":"2665_CR21","unstructured":"Higgins JPT et al Cochrane Handbook for Systematic Reviews of Interventions, version 5.1.0 (updated March 2011). Available via DIALOG. https:\/\/training.cochrane.org\/resource\/introducing-rob-2. Accessed 2 Aug 2023."},{"key":"2665_CR22","doi-asserted-by":"publisher","first-page":"e2322743","DOI":"10.1001\/jamanetworkopen.2023.22743","volume":"6","author":"H Joo","year":"2023","unstructured":"Joo H, Fern\u00e1ndez A, Wick EC et al (2023) Association of language barriers with perioperative and surgical outcomes: a systematic review. JAMA Netw Open 6:e2322743\u2013e2322814. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.22743","journal-title":"JAMA Netw Open"},{"key":"2665_CR23","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.1001\/jama.2017.19344","volume":"318","author":"JG Zhao","year":"2017","unstructured":"Zhao JG, Zeng XT, Wang J et al (2017) Association between calcium or vitamin d supplementation and fracture incidence in community-dwelling older adults: a systematic review and meta-analysis. JAMA 318:2466\u20132482. https:\/\/doi.org\/10.1001\/jama.2017.19344","journal-title":"JAMA"},{"key":"2665_CR24","doi-asserted-by":"publisher","first-page":"453","DOI":"10.5301\/jva.5000576","volume":"17","author":"M Pittiruti","year":"2016","unstructured":"Pittiruti M, Bertoglio S, Scoppettuolo G et al (2016) Evidence-based criteria for the choice and the clinical use of the most appropriate lock solutions for central venous catheters (Excluding dialysis catheters): a GAVeCeLT consensus. J Vascular Access 17:453\u2013465. https:\/\/doi.org\/10.5301\/jva.5000576","journal-title":"J Vascular Access"},{"key":"2665_CR25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/NCC.0000000000000819","volume":"44","author":"M Clari","year":"2021","unstructured":"Clari M, Spoto M, Franceschi G et al (2021) Short versus long timing of flushing of totally implantable venous access devices when not used routinely: a systematic review and meta-analysis. Cancer Nurs 44:205\u2013213. https:\/\/doi.org\/10.1097\/NCC.0000000000000819","journal-title":"Cancer Nurs"},{"key":"2665_CR26","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1177\/11297298211003003","volume":"22","author":"ZY Xiong","year":"2021","unstructured":"Xiong ZY, Zhou HM, Li SY (2021) Prolonged flushing and locking interval for totally implantable vascular access device: a systematic review and meta-analysis. J Vasc Access 22:969\u2013978. https:\/\/doi.org\/10.1177\/11297298211003003","journal-title":"J Vasc Access"},{"key":"2665_CR27","first-page":"536","volume":"57","author":"W Xifeng","year":"2022","unstructured":"Xifeng W, Yang J, Yiqun Y (2022) Effect of prolonging the maintenance interval for totally implantable venous access ports on complications in patients during the period of non-treatment. Chin J Nurs 57:536\u2013543","journal-title":"Chin J Nurs"},{"key":"2665_CR28","doi-asserted-by":"publisher","first-page":"114","DOI":"10.4103\/0019-509X.98934","volume":"49","author":"KK Bassi","year":"2012","unstructured":"Bassi KK, Giri AK, Pattanayak M et al (2012) Totally implantable venous access ports: retrospective review of long-term complications in 81 patients. Indian J Cancer 49:114\u2013118. https:\/\/doi.org\/10.4103\/0019-509X.98934","journal-title":"Indian J Cancer"},{"key":"2665_CR29","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.ejon.2010.11.007","volume":"15","author":"A Dal Molin","year":"2011","unstructured":"Dal Molin A, Rasero L, Guerretta L et al (2011) The late complications of totally implantable central venous access ports: the results from an Italian multicenter prospective observation study. Eur J Oncol Nurs 15:377\u2013381. https:\/\/doi.org\/10.1016\/j.ejon.2010.11.007","journal-title":"Eur J Oncol Nurs"},{"key":"2665_CR30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4236\/mc.2013.22003","volume":"2","author":"E Girda","year":"2013","unstructured":"Girda E, Phaeton R, Goldberg GL et al (2013) Extending the interval for port-a-cath maintenance. Modern Chemother 2:15\u201318","journal-title":"Modern Chemother"},{"issue":"2","key":"2665_CR31","doi-asserted-by":"publisher","first-page":"216","DOI":"10.7475\/kjan.2018.30.2.216","volume":"30","author":"H Kim","year":"2018","unstructured":"Kim H, Ku H, Choi S-EA (2018) prospective study of extending the implanted port heparin flushing cycle in outpatients with solid tumors. Korean J Adult Nurs 30(2):216\u2013225","journal-title":"Korean J Adult Nurs"},{"key":"2665_CR32","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1111\/j.1365-2354.2009.01115.x","volume":"19","author":"C Heibl","year":"2010","unstructured":"Heibl C, Trommet V, Burgstaller S (2010) Complications associated with the use of Port-a-Caths in patients with malignant or haematological disease: a single-centre prospective analysis. Eur J Cancer Care (Engl) 19:676\u2013681. https:\/\/doi.org\/10.1111\/j.1365-2354.2009.01115.x","journal-title":"Eur J Cancer Care (Engl)"},{"key":"2665_CR33","doi-asserted-by":"publisher","first-page":"325","DOI":"10.5301\/jva.5000740","volume":"18","author":"G Solinas","year":"2017","unstructured":"Solinas G, Platini F, Trivellato M et al (2017) Port in oncology practice: 3-monthly locking with normal saline for catheter maintenance, a preliminary report. J Vasc Access 18:325\u2013327. https:\/\/doi.org\/10.5301\/jva.5000740","journal-title":"J Vasc Access"},{"key":"2665_CR34","doi-asserted-by":"publisher","first-page":"453","DOI":"10.5301\/jva.5000576","volume":"17","author":"M Pittiruti","year":"2016","unstructured":"Pittiruti M, Bertoglio S, Scoppettuolo G et al (2016) Evidence-based criteria for the choice and the clinical use of the most appropriate lock solutions for central venous catheters(excluding dialysis catheters):a GAVeCeLT consensus. J Vase Access 17:453\u2013464. https:\/\/doi.org\/10.5301\/jva.5000576","journal-title":"J Vase Access"},{"key":"2665_CR35","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.thromres.2009.06.008","volume":"125","author":"MM Beckers","year":"2010","unstructured":"Beckers MM, Ruven HJ, Seldenrijk CA et al (2010) Risk of thrombosis and infections of central venous catheters and totally implanted access ports in patients treated for cancer. Thromb Res 125:318\u2013321. https:\/\/doi.org\/10.1016\/j.thromres.2009.06.008","journal-title":"Thromb Res"},{"key":"2665_CR36","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/10.3892\/mco.2016.726","volume":"4","author":"L Ma","year":"2016","unstructured":"Ma L, Liu Y, Wang J et al (2016) Totally implantable venous access port systems and associated complications: a single-institution retrospective analysis of 2,996 breast cancer patients. Mol Clin Oncol 4:456\u2013460. https:\/\/doi.org\/10.1016\/10.3892\/mco.2016.726","journal-title":"Mol Clin Oncol"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-024-02665-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-024-02665-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-024-02665-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T04:02:49Z","timestamp":1769486569000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-024-02665-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["2665"],"URL":"https:\/\/doi.org\/10.1007\/s10147-024-02665-2","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]},"assertion":[{"value":"24 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors in this article declare that they have no financial or non-financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}