{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:49:12Z","timestamp":1771307352615,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s10147-025-02752-y","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T01:52:23Z","timestamp":1743472343000},"page":"1193-1200","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Simple definition of biologically borderline resectable colorectal liver metastases based on early surgical failure"],"prefix":"10.1007","volume":"30","author":[{"given":"Kenei","family":"Furukawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Tsunematsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Haruki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Onda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyohei","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michinori","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Taniai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Yanagaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Ikegami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,30]]},"reference":[{"key":"2752_CR1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3322\/caac.21601","volume":"70","author":"RL Siegel","year":"2020","unstructured":"Siegel RL, Miller KD, Goding Sauer A et al (2020) Colorectal cancer statistics, 2020. CA Cancer J Clin 70:145\u2013164","journal-title":"CA Cancer J Clin"},{"key":"2752_CR2","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1002\/ags3.12227","volume":"3","author":"R Adam","year":"2019","unstructured":"Adam R, Kitano Y (2019) Multidisciplinary approach of liver metastases from colorectal cancer. Ann Gastroenterol Surg 3:50\u201356","journal-title":"Ann Gastroenterol Surg"},{"key":"2752_CR3","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1245\/s10434-008-9935-9","volume":"15","author":"L Vigan\u00f2","year":"2008","unstructured":"Vigan\u00f2 L, Ferrero A, Lo Tesoriere R et al (2008) Liver surgery for colorectal metastases: results after 10 years of follow-up. Long-term survivors, late recurrences, and prognostic role of morbidity. Ann Surg Oncol 15:2458\u20132464","journal-title":"Ann Surg Oncol"},{"key":"2752_CR4","doi-asserted-by":"publisher","first-page":"3677","DOI":"10.1200\/JCO.2008.20.5278","volume":"27","author":"S Kopetz","year":"2009","unstructured":"Kopetz S, Chang GJ, Overman MJ et al (2009) Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy. J Clin Oncol 27:3677\u20133683","journal-title":"J Clin Oncol"},{"key":"2752_CR5","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1097\/SLA.0000000000003043","volume":"271","author":"JM Cloyd","year":"2020","unstructured":"Cloyd JM, Mizuno T, Kawaguchi Y et al (2020) Comprehensive complication index validates improved outcomes over time despite increased complexity in 3707 consecutive Hepatectomies. Ann Surg 271:724\u2013731","journal-title":"Ann Surg"},{"key":"2752_CR6","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/S1470-2045(13)70447-9","volume":"14","author":"B Nordlinger","year":"2013","unstructured":"Nordlinger B, Sorbye H, Glimelius B et al (2013) Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial. Lancet Oncol 14:1208\u20131215","journal-title":"Lancet Oncol"},{"key":"2752_CR7","doi-asserted-by":"publisher","first-page":"439","DOI":"10.6004\/jnccn.2021.0017","volume":"19","author":"MA Tempero","year":"2021","unstructured":"Tempero MA, Malafa MP, Al-Hawary M et al (2021) Pancreatic adenocarcinoma, Version 2.2021, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 19:439\u2013457","journal-title":"J Natl Compr Canc Netw"},{"key":"2752_CR8","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s00534-011-0460-z","volume":"19","author":"T Beppu","year":"2012","unstructured":"Beppu T, Sakamoto Y, Hasegawa K et al (2012) A nomogram predicting disease-free survival in patients with colorectal liver metastases treated with hepatic resection: multicenter data collection as a project study for hepatic surgery of the Japanese society of hepato-biliary-pancreatic surgery. J Hepatobiliary Pancreat Sci 19:72\u201384","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"2752_CR9","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1097\/SLA.0b013e31815aa2c2","volume":"247","author":"M Rees","year":"2008","unstructured":"Rees M, Tekkis PP, Welsh FK et al (2008) Evaluation of long-term survival after hepatic resection for metastatic colorectal cancer: a multifactorial model of 929 patients. Ann Surg 247:125\u2013135","journal-title":"Ann Surg"},{"key":"2752_CR10","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/jhbp.1389","volume":"31","author":"T Takematsu","year":"2024","unstructured":"Takematsu T, Mima K, Hayashi H et al (2024) RAS mutation status in combination with the JSHBPS nomogram may be useful for preoperative identification of colorectal liver metastases with high risk of recurrence and mortality after hepatectomy. J Hepatobiliary Pancreat Sci 31:69\u201379","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"2752_CR11","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1245\/s10434-014-3504-1","volume":"21","author":"M Oba","year":"2014","unstructured":"Oba M, Hasegawa K, Matsuyama Y et al (2014) Discrepancy between recurrence-free survival and overall survival in patients with resectable colorectal liver metastases: a potential surrogate endpoint for time to surgical failure. Ann Surg Oncol 21:1817\u20131824","journal-title":"Ann Surg Oncol"},{"key":"2752_CR12","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/sj.bjc.6601242","volume":"89","author":"LM Forrest","year":"2003","unstructured":"Forrest LM, McMillan DC, McArdle CS et al (2003) Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer. Br J Cancer 89:1028\u20131030","journal-title":"Br J Cancer"},{"key":"2752_CR13","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1093\/annonc\/mdw235","volume":"27","author":"E Van Cutsem","year":"2016","unstructured":"Van Cutsem E, Cervantes A, Adam R et al (2016) ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Ann Oncol 27:1386\u20131422","journal-title":"Ann Oncol"},{"key":"2752_CR14","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1200\/JCO.21.01032","volume":"39","author":"Y Kanemitsu","year":"2021","unstructured":"Kanemitsu Y, Shimizu Y, Mizusawa J et al (2021) Hepatectomy Followed by mFOLFOX6 Versus hepatectomy alone for liver-only metastatic colorectal cancer (JCOG0603): a phase II or III randomized controlled trial. J Clin Oncol 39:3789\u20133799","journal-title":"J Clin Oncol"},{"key":"2752_CR15","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1002\/bjs5.50174","volume":"3","author":"MA Allard","year":"2019","unstructured":"Allard MA, Nishioka Y, Beghdadi N et al (2019) Multicentre study of perioperative versus adjuvant chemotherapy for resectable colorectal liver metastases. BJS Open 3:678\u2013686","journal-title":"BJS Open"},{"key":"2752_CR16","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.1007\/s00268-023-07133-y","volume":"47","author":"T Takamoto","year":"2023","unstructured":"Takamoto T, Nara S, Ban D et al (2023) Objective definition and optimized strategy for \u201cbiologically borderline resectable\u201d colorectal liver metastases. World J Surg 47:2834\u20132845","journal-title":"World J Surg"},{"key":"2752_CR17","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1002\/ags3.12631","volume":"7","author":"T Noda","year":"2022","unstructured":"Noda T, Takahashi H, Tei M et al (2022) Clinical outcomes of neoadjuvant chemotherapy for resectable colorectal liver metastasis with intermediate risk of postoperative recurrence: a multi-institutional retrospective study. Ann Gastroenterol Surg 7:479\u2013490","journal-title":"Ann Gastroenterol Surg"},{"key":"2752_CR18","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1245\/s10434-009-0781-1","volume":"17","author":"TC Chua","year":"2010","unstructured":"Chua TC, Saxena A, Liauw W et al (2010) Systematic review of randomized and nonrandomized trials of the clinical response and outcomes of neoadjuvant systemic chemotherapy for resectable colorectal liver metastases. Ann Surg Oncol 17:492\u2013501","journal-title":"Ann Surg Oncol"},{"key":"2752_CR19","doi-asserted-by":"publisher","first-page":"e170278","DOI":"10.1001\/jamaoncol.2017.0278","volume":"3","author":"G Tomasello","year":"2017","unstructured":"Tomasello G, Petrelli F, Ghidini M et al (2017) FOLFOXIRI plus bevacizumab as conversion therapy for patients with initially unresectable metastatic colorectal cancer: a systematic review and pooled analysis. JAMA Oncol 3:e170278","journal-title":"JAMA Oncol"},{"key":"2752_CR20","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1002\/ags3.12276","volume":"3","author":"K Imai","year":"2019","unstructured":"Imai K, Adam R, Baba H (2019) How to increase the resectability of initially unresectable colorectal liver metastases: a surgical perspective. Ann Gastroenterol Surg 3:476\u2013486","journal-title":"Ann Gastroenterol Surg"},{"key":"2752_CR21","doi-asserted-by":"publisher","first-page":"e86543","DOI":"10.1371\/journal.pone.0086543","volume":"9","author":"D Zhu","year":"2014","unstructured":"Zhu D, Zhong Y, Wei Y et al (2014) Effect of neoadjuvant chemotherapy in patients with resectable colorectal liver metastases. PLoS ONE 9:e86543","journal-title":"PLoS ONE"},{"key":"2752_CR22","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12957-019-1641-5","volume":"17","author":"H Ichida","year":"2019","unstructured":"Ichida H, Mise Y, Ito H et al (2019) Optimal indication criteria for neoadjuvant chemotherapy in patients with resectable colorectal liver metastases. World J Surg Oncol 17:100","journal-title":"World J Surg Oncol"},{"key":"2752_CR23","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1007\/s10147-021-02024-5","volume":"26","author":"M Ninomiya","year":"2021","unstructured":"Ninomiya M, Emi Y, Motomura T et al (2021) Efficacy of neoadjuvant chemotherapy in patients with high-risk resectable colorectal liver metastases. Int J Clin Oncol 26:2255\u20132264","journal-title":"Int J Clin Oncol"},{"key":"2752_CR24","doi-asserted-by":"publisher","first-page":"3888","DOI":"10.1245\/s10434-015-4470-y","volume":"22","author":"E Shinto","year":"2015","unstructured":"Shinto E, Takahashi K, Yamaguchi T et al (2015) Validation and modification of the Japanese classification system for liver metastases from colorectal cancer: a multi-institutional study. Ann Surg Oncol 22:3888\u20133895","journal-title":"Ann Surg Oncol"},{"key":"2752_CR25","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/jhbp.58","volume":"21","author":"T Beppu","year":"2014","unstructured":"Beppu T, Sakamoto Y, Hasegawa K et al (2014) Optimal cut-off value for the number of colorectal liver metastases: a project study for hepatic surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci 21:169\u2013175","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"2752_CR26","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1002\/jhbp.1256","volume":"30","author":"T Beppu","year":"2023","unstructured":"Beppu T, Yamamura K, Sakamoto K et al (2023) Validation study of the JSHBPS nomogram for patients with colorectal liver metastases who underwent hepatic resection in the recent era - a nationwide survey in Japan. J Hepatobiliary Pancreat Sci 30:591\u2013601","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"2752_CR27","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1002\/jso.27590","volume":"129","author":"T Beppu","year":"2024","unstructured":"Beppu T, Yamamura K, Imai K et al (2024) Recurrence-risk stratification using the Beppu score and selection of perioperative chemotherapy for colorectal liver metastases. J Surg Oncol 129:893\u2013900","journal-title":"J Surg Oncol"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-025-02752-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-025-02752-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-025-02752-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T05:10:58Z","timestamp":1748495458000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-025-02752-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,30]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["2752"],"URL":"https:\/\/doi.org\/10.1007\/s10147-025-02752-y","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,30]]},"assertion":[{"value":"8 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The institutional ethics committee approval was obtained (27\u2013177).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The requirement for informed consent was waived because of the study\u2019s retrospective design and use of anonymized data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}