{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:28:46Z","timestamp":1754159326936,"version":"3.41.2"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25ck0106950h0002"],"award-info":[{"award-number":["JP25ck0106950h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Cancer Center Research Development Fund","award":["2024-A-05"],"award-info":[{"award-number":["2024-A-05"]}]},{"name":"SCRUM-Japan Funds"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Physical activity (PA) has been consistently associated with improved cancer outcomes across multiple epidemiological studies. While the evidence for clinical benefits is strong, the underlying molecular mechanisms remain poorly understood. Recent technological advances now enable both continuous monitoring of PA through wearable devices and comprehensive molecular profiling through multi-omics approaches, including whole-genome sequencing (WGS)-based molecular residual disease (MRD) detection. This review examines current evidence regarding PA\u2019s effects on cancer biology and introduces the LIFELOG study, which aims to address critical knowledge gaps in this field.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We review the current literature on PA and cancer with emphasis on molecular mechanisms, and present the design of the LIFELOG study, an ancillary study to MONSTAR-SCREEN-3. The LIFELOG study will enroll 170 post-surgical cancer patients who will wear the mSafety\u2122 wrist device for continuous PA monitoring. We will investigate associations between PA metrics and multi-omics profiles including WGS-based MRD detection, transcriptome analyses, plasma proteomics, and gut microbiome analyses. The feasibility phase has already begun with encouraging preliminary results regarding device compliance and data quality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Discussion<\/jats:title>\n            <jats:p>Despite substantial evidence supporting PA\u2019s benefits in cancer prevention and survivorship, understanding which specific PA characteristics most effectively influence cancer outcomes remains unclear. The LIFELOG study represents the first comprehensive analysis integrating continuous PA monitoring with molecular profiling in cancer patients. By examining relationships between PA patterns and both MRD dynamics and multi-omics profiles, we aim to identify molecular mechanisms underlying exercise benefits and potentially guide development of evidence-based, precision PA interventions for cancer survivorship.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial Registration<\/jats:title>\n            <jats:p>This ancillary study (Institutional Review Board number: 2024-111, approved on November 18, 2024) is conducted under the MONSTAR-SCREEN-3 trial platform, which is registered in the UMIN Clinical Trials Registry (UMIN000053975, registered on March 27, 2024).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10147-025-02798-y","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T14:50:10Z","timestamp":1749567010000},"page":"1439-1447","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Physical activity and cancer biology: a narrative review of molecular mechanisms and introduction of the SCRUM-MONSTAR LIFELOG study"],"prefix":"10.1007","volume":"30","author":[{"given":"Shugo","family":"Yajima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadayoshi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riu","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Misumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutoshi","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Horasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuho","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Shibuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Tsukada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Bando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"2798_CR1","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1038\/s41591-022-02100-x","volume":"28","author":"E Stamatakis","year":"2022","unstructured":"Stamatakis E, Ahmadi MN, Gill JMR et al (2022) Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality. 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However, as this study utilizes data from the MONSTAR-SCREEN-3 trial, potential indirect competing interests may exist through that relationship. Here is that list: Hashimoto T. reports honoraria from CytoGen and Takata Pharmaceutical. Nakamura Y. reports personal fees from Guardant Health Pte, Ltd., Natera, Inc., Roche, Ltd., Premo Partners, Inc., Takeda Pharmaceutical, Exact Sciences Corporation, Gilead Sciences, Inc., MSD, Eisai Co., Ltd., Zeria Pharmaceutical Co., Ltd., Miyarisan Pharmaceutical Co., Ltd., Merck Biopharma Co., Ltd., CareNet, Inc., Hisamitsu Pharmaceutical Co., Inc., Taiho Pharmaceutical Co., Ltd., Becton, Dickinson and Company, and Guardant Health Japan Corp.; grants and personal fees from Seagen, Inc., Daiichi Sankyo Co., Ltd., and Chugai Pharmaceutical Co., Ltd.; as well as grants from Genomedia Inc., Guardant Health AMEA, Inc., Guardant Health, Inc., Tempus Labs, Inc., and Roche Diagnostics K.K. outside the submitted work. Fujisawa T. reports personal fees from Amelieff and AstraZeneca outside the submitted work. Imai M. reports personal fees from Caris Life Sciences, Guardant Health, Inc., and Sumitomo Corp outside the submitted work. Misumi T. reports honoraria from Chugai and AstraZeneca. Bando H. reports personal fees from Ono Pharmaceutical, Taiho Pharmaceutical, and Eli Lilly Japan K. K. outside the submitted work. Yoshino T. reports personal fees from Chugai Pharmaceutical Co. Ltd., Takeda Pharmaceutical, Merck Biopharma Co. Ltd., Bayer Yakuhin, Ono Pharmaceutical, MSD, and Sumitomo Corp, as well as grants from Amgen, Chugai Pharmaceutical, Daiichi Sankyo, Eisai Co. Ltd., FALCO Biosystems, Genomedia, Molecular Health, MSD, Nippon Boehringer Ingelheim Co., Ltd., Ono Pharmaceutical, Pfizer, Roche Diagnostics, Sanofi, Sysmex, and Taiho Pharmaceutical outside the submitted work. The other authors have no competing interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Institutional Review Board of the National Cancer Center Hospital East (approval number: 2024-111). All study procedures will be conducted in accordance with the Declaration of Helsinki and Japan's Ethical Guidelines for Medical and Health Research Involving Human Subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent will be obtained from all the participants before enrollment in the study. The informed consent process includes detailed explanation of the study procedures, data collection methods, and potential risks and benefits.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All participants have provided written informed consent for publication of the research results in academic journals and presentation at medical conferences. The data will be presented in a manner that ensures no individual participant can be identified.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}