{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:54:40Z","timestamp":1790294080103,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s10147-025-02816-z","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T14:43:47Z","timestamp":1750862627000},"page":"1764-1774","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multimodal treatments for patients with locally advanced synchronous esophageal and head and neck cancer"],"prefix":"10.1007","volume":"30","author":[{"given":"Satoshi","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7327-7949","authenticated-orcid":false,"given":"Tomoya","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akifumi","family":"Notsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Hamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Fushiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotoe","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Ohba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Tsushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Onozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Mukaigawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Tsubosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Onoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"2816_CR1","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1002\/jso.2930380207","volume":"38","author":"E Abemayor","year":"1988","unstructured":"Abemayor E, Moore DM, Hanson DG (1988) Identification of synchronous esophageal tumors in patients with head and neck cancer. J Surg Oncol 38:94\u201396","journal-title":"J Surg Oncol"},{"key":"2816_CR2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1002\/jso.2930460208","volume":"46","author":"H Kuwano","year":"1991","unstructured":"Kuwano H, Morita M, Tsutsui S et al (1991) Comparison of characteristics of esophageal squamous cell carcinoma associated with head and neck cancer and those with gastric cancer. J Surg Oncol 46:107\u2013109","journal-title":"J Surg Oncol"},{"key":"2816_CR3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/ijc.2910580211","volume":"58","author":"M Morita","year":"1994","unstructured":"Morita M, Kuwano H, Ohno S et al (1994) Multiple occurrence of carcinoma in the upper aerodigestive tract associated with esophageal cancer: reference to smoking, drinking and family history. Int J Cancer 58:207\u2013210","journal-title":"Int J Cancer"},{"key":"2816_CR4","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1002\/ijc.23798","volume":"123","author":"SC Chuang","year":"2008","unstructured":"Chuang SC, Scelo G, Tonita JM et al (2008) Risk of second primary cancer among patients with head and neck cancers: a pooled analysis of 13 cancer registries. Int J Cancer 123:2390\u20132396","journal-title":"Int J Cancer"},{"key":"2816_CR5","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/S0929-6646(10)60072-1","volume":"109","author":"CS Chung","year":"2010","unstructured":"Chung CS, Lee YC, Wang CP et al (2010) Secondary prevention of esophageal squamous cell carcinoma in areas where smoking, alcohol, and betel quid chewing are prevalent. J Formos Med Assoc 109:408\u2013421","journal-title":"J Formos Med Assoc"},{"key":"2816_CR6","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.anl.2017.12.005","volume":"45","author":"T Okamoto","year":"2018","unstructured":"Okamoto T, Katada C, Komori S et al (2018) A retrospective study of treatment for curative synchronous double primary cancers of the head and neck and the esophagus. Auris Nasus Larynx 45:1053\u20131060","journal-title":"Auris Nasus Larynx"},{"key":"2816_CR7","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/j.1572-0241.2005.30189.x","volume":"100","author":"CL Hashimoto","year":"2005","unstructured":"Hashimoto CL, Iriya K, Baba ER et al (2005) Lugol\u2019s dye spray chromoendoscopy establishes early diagnosis of esophageal cancer in patients with primary head and neck cancer. Am J Gastroenterol 100:275\u2013282","journal-title":"Am J Gastroenterol"},{"key":"2816_CR8","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1055\/s-0030-1255514","volume":"42","author":"CT Lee","year":"2010","unstructured":"Lee CT, Chang CY, Lee YC et al (2010) Narrow-band imaging with magnifying endoscopy for the screening of esophageal cancer in patients with primary head and neck cancers. Endoscopy 42:613\u2013619","journal-title":"Endoscopy"},{"key":"2816_CR9","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1007\/s00455-022-10488-4","volume":"38","author":"M Bin-Manie","year":"2023","unstructured":"Bin-Manie M, Choi Y, Roh JL et al (2023) Risk factors for feeding tube dependency in patients undergoing function preservation surgery for advanced-stage laryngohypopharyngeal cancer. Dysphagia 38:466\u2013473","journal-title":"Dysphagia"},{"key":"2816_CR10","first-page":"1","volume":"30","author":"A Matsumoto","year":"2017","unstructured":"Matsumoto A, Watanabe M, Mine S et al (2017) Comparison of synchronous versus staged surgeries for patients with synchronous double cancers of the esophagus and head-and-neck. Dis Esophagus 30:1\u20136","journal-title":"Dis Esophagus"},{"key":"2816_CR11","doi-asserted-by":"publisher","first-page":"41785","DOI":"10.1038\/srep41785","volume":"7","author":"YH Chen","year":"2017","unstructured":"Chen YH, Lu HI, Chien CY et al (2017) Treatment outcomes of patients with locally advanced synchronous esophageal and head\/neck squamous cell carcinoma receiving curative concurrent chemoradiotherapy. Sci Rep 7:41785","journal-title":"Sci Rep"},{"key":"2816_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3390\/jcm9010197","volume":"9","author":"YH Chen","year":"2020","unstructured":"Chen YH, Lu HI, Chien CY et al (2020) Efficacy of different chemotherapy regimens in patients with locally advanced synchronous esophageal and head\/neck squamous cell carcinoma receiving curative concurrent chemoradiotherapy. J Clin Med 9:197","journal-title":"J Clin Med"},{"key":"2816_CR13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/jso.2930450110","volume":"45","author":"Y Tachimori","year":"1990","unstructured":"Tachimori Y, Watanabe H, Kato H et al (1990) Treatment for synchronous and metachronous carcinomas of the head and neck and esophagus. J Surg Oncol 45:43\u201345","journal-title":"J Surg Oncol"},{"key":"2816_CR14","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1245\/s10434-013-3453-0","volume":"21","author":"M Morita","year":"2014","unstructured":"Morita M, Saeki H, Ito S et al (2014) Technical improvement of total pharyngo-laryngo-esophagectomy for esophageal cancer and head and neck cancer. Ann Surg Oncol 21:1671\u20131677","journal-title":"Ann Surg Oncol"},{"key":"2816_CR15","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1245\/s10434-013-2875-z","volume":"20","author":"M Morita","year":"2013","unstructured":"Morita M, Kawano H, Otsu H et al (2013) Surgical resection for esophageal cancer synchronously or metachronously associated with head and neck cancer. Ann Surg Oncol 20:2434\u20132439","journal-title":"Ann Surg Oncol"},{"key":"2816_CR16","first-page":"909","volume":"31","author":"M Morita","year":"2017","unstructured":"Morita M, Egashira A, Nakaji YU et al (2017) Treatment of squamous cell carcinoma of the esophagus synchronously associated with head and neck cancer. In Vivo 31:909\u2013916","journal-title":"In Vivo"},{"key":"2816_CR17","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.radonc.2015.07.042","volume":"117","author":"ME Christianen","year":"2015","unstructured":"Christianen ME, Verdonck-de Leeuw IM, Doornaert P et al (2015) Patterns of long-term swallowing dysfunction after definitive radiotherapy or chemoradiation. Radiother Oncol 117:139\u2013144","journal-title":"Radiother Oncol"},{"key":"2816_CR18","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1002\/hed.25434","volume":"41","author":"CML Driessen","year":"2019","unstructured":"Driessen CML, Leijendeckers J, Snik A et al (2019) Ototoxicity in locally advanced head and neck cancer patients treated with induction chemotherapy followed by intermediate or high-dose cisplatin-based chemoradiotherapy. Head Neck 41:488\u2013494","journal-title":"Head Neck"},{"key":"2816_CR19","doi-asserted-by":"publisher","first-page":"3582","DOI":"10.1200\/JCO.2007.14.8841","volume":"26","author":"M Machtay","year":"2008","unstructured":"Machtay M, Moughan J, Trotti A et al (2008) Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol 26:3582\u20133589","journal-title":"J Clin Oncol"},{"key":"2816_CR20","doi-asserted-by":"publisher","first-page":"906","DOI":"10.3390\/healthcare11060906","volume":"11","author":"KJ Taylor","year":"2023","unstructured":"Taylor KJ, Amdal CD, Bjordal K et al (2023) Serious long-term effects of head and neck cancer from the survivors\u2019 point of view. Healthcare (Basel) 11:906","journal-title":"Healthcare (Basel)"},{"key":"2816_CR21","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/COC.0b013e3181e84b4b","volume":"34","author":"M Shinoto","year":"2011","unstructured":"Shinoto M, Shioyama Y, Sasaki T et al (2011) Clinical results of definitive chemoradiotherapy for patients with synchronous head and neck squamous cell carcinoma and esophageal cancer. Am J Clin Oncol 34:362\u2013366","journal-title":"Am J Clin Oncol"},{"key":"2816_CR22","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s10388-012-0334-8","volume":"9","author":"H Saeki","year":"2012","unstructured":"Saeki H, Toh Y, Morita M et al (2012) The treatment outcomes of synchronous and metachronous esophageal squamous cell carcinoma and head and neck squamous cell carcinoma. Esophagus 9:158\u2013164","journal-title":"Esophagus"},{"key":"2816_CR23","volume":"12","author":"C Friedes","year":"2020","unstructured":"Friedes C, Klingensmith J, Nimo N et al (2020) Late feeding tube dependency in head and neck cancer patients treated with definitive radiation therapy and concurrent systemic therapy. Cureus 12:e7683","journal-title":"Cureus"},{"key":"2816_CR24","doi-asserted-by":"publisher","first-page":"1257853","DOI":"10.3389\/fonc.2023.1257853","volume":"13","author":"T Yokota","year":"2023","unstructured":"Yokota T, Mukaigawa T, Yasunaga Y et al (2023) Multidisciplinary tumor board for head and neck cancer from the perspective of medical oncologists-optimizing its effectiveness. Front Oncol 13:1257853","journal-title":"Front Oncol"},{"key":"2816_CR25","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1288\/00005537-199203000-00013","volume":"102","author":"T Guillot","year":"1992","unstructured":"Guillot T, Spielmann M, Kac J et al (1992) Neoadjuvant chemotherapy in multiple synchronous head and neck and esophagus squamous cell carcinomas. Laryngoscope 102:311\u2013319","journal-title":"Laryngoscope"}],"updated-by":[{"DOI":"10.1007\/s10147-026-03094-z","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000}}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-025-02816-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-025-02816-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-025-02816-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:28:06Z","timestamp":1783574886000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-025-02816-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["2816"],"URL":"https:\/\/doi.org\/10.1007\/s10147-025-02816-z","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6258482\/v1","asserted-by":"object"}]},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,25]]},"assertion":[{"value":"19 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In this article, Figs. 1 and 3 appeared incorrectly and have now been corrected in the original publication.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2026","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10147-026-03094-z","URL":"https:\/\/doi.org\/10.1007\/s10147-026-03094-z","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Tomoya Yokota serves as an advisor to Merck Biopharma, MSD, Rakuten Medical, and Astellas Pharma and has received lecture fees from Merck Biopharma; Ono Pharmaceutical Co., Ltd.; Bristol-Myers Squibb; AstraZeneca; Chugai Pharmaceutical Co., Ltd., MSD, Eli Lilly Japan, and Eisai. Satoshi Hamauchi has received lecture fees from Ono Pharmaceutical Co., Ltd. Yusuke Onozawa has received lecture fees from Novartis Pharma. Kunihiro Fushiki has received Ono pharmaceutical Co., Ltd., Bristol-Meyers Squibb Co., and MSD Co., Ltd. Takahiro Tsushima has received lecture fees from Taiho Pharmaceutical Co., Ltd., Ono pharmaceutical Co., Ltd., Bristol Meyers Squibb Co., and MSD. Kentaro Yamazaki has received research funding from Esai., Pfizer., and Ono Pharmaceutical Co., Ltd., and has received lecture fees from Chugai Pharmaceutical Co., Ltd., Takeda, Eli Lilly, Taiho Pharmaceutical Co., Ltd., Merck biopharma, Yakult, Ono pharmaceutical Co., Ltd., Bristol-Myers Squibb. Akihiro Ohba serves as an advisor to Jazz and received lecture fees from Yakult, Ono, Eisai, Taiho, AstraZeneca, Guardant and MSD, and received research funding from Chugai, Novartis, DaiichiSankyo and MSD. Satoshi Suzuki, Akifumi Notsu, Kotoe Oshima, Takeshi Kawakami, Hirofumi Yasui, Takashi Mukaigawa,\u00a0Yasuhiro Tsubosa, Hirofumi Ogawa, Tsuyoshi Onoe, have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Institutional Review Board of Shizuoka Cancer Center (approval num-ber: J2024-113-2024-1-3).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}