{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T08:10:42Z","timestamp":1758874242367,"version":"3.44.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009337","name":"Saitama Medical University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009337","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Neoadjuvant chemotherapy (NAC) using docetaxel\/cisplatin\/5-fluorouracil (DCF) for locally advanced esophageal cancer (EC) showed better clinical outcomes than conventional regimens; however, had high incidence of serious adverse events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Patients who underwent radical esophagectomy after neoadjuvant-DCF were classified into two-course and three-course groups (<jats:italic>n<\/jats:italic>\u2009=\u200960 and 41). Multiple clinical indicators related to nutrition and skeletal muscle that were reported to be associated with survival outcomes were compared between the two groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Changes in prognostic nutritional index (PNI), geriatric nutritional risk index (GNRI), and psoas muscle area (PMA) were significantly low in the three-course group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001,\u2009&lt;\u20090.001, and\u2009=\u20090.003). Multivariate analyses for PNI change rate showed initial PNI\u2009&lt;\u200945 and three-course DCF as independent associated factors (<jats:italic>B<\/jats:italic>\u2009=\u20090.129; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>B<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.057; <jats:italic>p<\/jats:italic>\u2009=\u20090.022); GNRI change rate showed body mass index\u2009\u2265\u200921, initial PNI\u2009&lt;\u200945, and three-course DCF as independent associated factors (B\u2009=\u2009\u2009\u2212\u20090.033; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>B<\/jats:italic>\u2009=\u20090.062; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, and <jats:italic>B<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.059; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001); PMA change rate showed three-course DCF and cStage IV as independent associated factors (<jats:italic>B<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.024; <jats:italic>p<\/jats:italic>\u2009=\u20090.011 and <jats:italic>B<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.025; <jats:italic>p<\/jats:italic>\u2009=\u20090.038). There were not significant differences in the long-term survivals between the two groups in pStages I\u2013IV.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Two courses were superior to three courses for improving nutritional status and mitigating skeletal muscle decreasing during NAC\u2013DCF for EC.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10147-025-02839-6","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T18:47:03Z","timestamp":1752778023000},"page":"1992-2002","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical advantages of two vs. three courses of neoadjuvant chemotherapy using docetaxel\u2009+\u2009cisplatin\u2009+\u20095-fluorouracil to improve preoperative nutritional status and mitigate decreasing skeletal muscle in resectable esophageal cancer"],"prefix":"10.1007","volume":"30","author":[{"given":"Kazuaki","family":"Matsui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Miyawaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Yoshizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Toriumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Ebara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Sakuramoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"issue":"3","key":"2839_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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