{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T05:28:06Z","timestamp":1794547686911,"version":"4.9.1"},"reference-count":103,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10147-025-02906-y","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:36:32Z","timestamp":1761665792000},"page":"2489-2503","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The role of hypoxia-inducible factor-1\u03b1 on colon cancer progression and metastasis"],"prefix":"10.1007","volume":"30","author":[{"given":"Mohamed J.","family":"Saadh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mareb Hamed","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafid Jihad","family":"Albadr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Sanghvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Roopashree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Kashyap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sabarivani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasur","family":"Rizaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waam Mohammed","family":"Taher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariem","family":"Alwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmod Jasem","family":"Jawad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali M. Ali","family":"Al-Nuaimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"2906_CR1","doi-asserted-by":"crossref","unstructured":"Ouakrim DA, Pizot C, Boniol M (2015) Trends in colorectal cancer mortality in Europe: retrospective analysis of the WHO mortality database. Bmj 351.","DOI":"10.1136\/bmj.h4970"},{"issue":"2","key":"2906_CR2","first-page":"104","volume":"64","author":"R Siegel","year":"2014","unstructured":"Siegel R, DeSantis C, Jemal A (2014) Colorectal cancer statistics, 2014. CA Cancer J Clin 64(2):104\u2013117","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"2906_CR3","first-page":"7","volume":"68","author":"RL Siegel","year":"2018","unstructured":"Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. CA Cancer J Clin 68(1):7\u201330","journal-title":"CA Cancer J Clin"},{"issue":"7","key":"2906_CR4","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/nrc2645","volume":"9","author":"A Walther","year":"2009","unstructured":"Walther A, Johnstone E, Swanton C et al (2009) Genetic prognostic and predictive markers in colorectal cancer. Nat Rev Cancer 9(7):489\u2013499","journal-title":"Nat Rev Cancer"},{"issue":"11","key":"2906_CR5","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1038\/nm.3394","volume":"19","author":"DF Quail","year":"2013","unstructured":"Quail DF, Joyce JA (2013) Microenvironmental regulation of tumor progression and metastasis. Nat Med 19(11):1423\u20131437","journal-title":"Nat Med"},{"issue":"6","key":"2906_CR6","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/nrc3064","volume":"11","author":"WR Wilson","year":"2011","unstructured":"Wilson WR, Hay MP (2011) Targeting hypoxia in cancer therapy. Nat Rev Cancer 11(6):393\u2013410","journal-title":"Nat Rev Cancer"},{"issue":"11","key":"2906_CR7","doi-asserted-by":"publisher","first-page":"4528","DOI":"10.1091\/mbc.e06-05-0419","volume":"18","author":"C-J Hu","year":"2007","unstructured":"Hu C-J, Sataur A, Wang L et al (2007) The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1\u03b1 and HIF-2\u03b1. Mol Biol Cell 18(11):4528\u20134542","journal-title":"Mol Biol Cell"},{"issue":"24","key":"2906_CR8","doi-asserted-by":"publisher","first-page":"9361","DOI":"10.1128\/MCB.23.24.9361-9374.2003","volume":"23","author":"C-J Hu","year":"2003","unstructured":"Hu C-J, Wang L-Y, Chodosh LA et al (2003) Differential roles of hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1) and HIF-2\u03b1 in hypoxic gene regulation. Mol Cell Biol 23(24):9361\u20139374","journal-title":"Mol Cell Biol"},{"issue":"3","key":"2906_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090678","volume":"9","author":"L Chen","year":"2014","unstructured":"Chen L, Shi Y, Yuan J et al (2014) HIF-1 alpha overexpression correlates with poor overall survival and disease-free survival in gastric cancer patients post-gastrectomy. PLoS ONE 9(3):e90678","journal-title":"PLoS ONE"},{"issue":"7","key":"2906_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02797-z","volume":"11","author":"Y Mi","year":"2020","unstructured":"Mi Y, Mu L, Huang K et al (2020) Hypoxic colorectal cancer cells promote metastasis of normoxic cancer cells depending on IL-8\/p65 signaling pathway. Cell Death Dis 11(7):610","journal-title":"Cell Death Dis"},{"key":"2906_CR11","doi-asserted-by":"publisher","first-page":"686885","DOI":"10.3389\/fmed.2021.686885","volume":"8","author":"YF Chen","year":"2021","unstructured":"Chen YF, Yu ZL, Lv MY et al (2021) Genome-Wide analysis reveals hypoxic microenvironment is associated with immunosuppression in poor survival of stage II\/III colorectal cancer patients. Front Med 8:686885","journal-title":"Front Med"},{"issue":"12","key":"2906_CR12","doi-asserted-by":"publisher","first-page":"153247","DOI":"10.1016\/j.prp.2020.153247","volume":"216","author":"V Karpisheh","year":"2020","unstructured":"Karpisheh V, Joshi N, Zekiy AO et al (2020) EP4 receptor as a novel promising therapeutic target in colon cancer. Pathol Res Pract 216(12):153247","journal-title":"Pathol Res Pract"},{"key":"2906_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2019.106338","volume":"144","author":"V Karpisheh","year":"2019","unstructured":"Karpisheh V, Nikkhoo A, Hojjat-Farsangi M et al (2019) Prostaglandin E2 as a potent therapeutic target for treatment of colon cancer. Prostaglandins Other Lipid Mediat 144:106338","journal-title":"Prostaglandins Other Lipid Mediat"},{"issue":"1","key":"2906_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.canlet.2015.06.005","volume":"366","author":"GP Nagaraju","year":"2015","unstructured":"Nagaraju GP, Bramhachari PV, Raghu G et al (2015) Hypoxia inducible factor-1\u03b1: its role in colorectal carcinogenesis and metastasis. Cancer Lett 366(1):11\u201318","journal-title":"Cancer Lett"},{"issue":"1","key":"2906_CR15","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/s41420-024-02100-5","volume":"10","author":"J Contenti","year":"2024","unstructured":"Contenti J, Guo Y, Larcher M et al (2024) HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma. Cell Death Discov 10(1):338","journal-title":"Cell Death Discov"},{"key":"2906_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.949509","volume":"13","author":"Q Gao","year":"2022","unstructured":"Gao Q, Luo J, Pan J et al (2022) Integrative analyses identify HIF-1\u03b1 as a potential protective role with immune cell infiltration in adamantinomatous craniopharyngioma. Front Immunol 13:949509","journal-title":"Front Immunol"},{"issue":"1","key":"2906_CR17","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s12935-024-03393-3","volume":"24","author":"M Sadeghi","year":"2024","unstructured":"Sadeghi M, Moslehi A, Kheiry H et al (2024) The sensitivity of acute myeloid leukemia cells to cytarabine is increased by suppressing the expression of heme oxygenase-1 and hypoxia-inducible factor 1-alpha. Cancer Cell Int 24(1):217","journal-title":"Cancer Cell Int"},{"issue":"6","key":"2906_CR18","doi-asserted-by":"publisher","first-page":"391","DOI":"10.2174\/1568009033481732","volume":"3","author":"SJ Welsh","year":"2003","unstructured":"Welsh SJ, Powis G (2003) Hypoxia inducible factor as a cancer drug target. Curr Cancer Drug Targets 3(6):391\u2013405","journal-title":"Curr Cancer Drug Targets"},{"issue":"407","key":"2906_CR19","doi-asserted-by":"publisher","first-page":"cm8","DOI":"10.1126\/stke.4072007cm8","volume":"2007","author":"GL Semenza","year":"2007","unstructured":"Semenza GL (2007) Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE 2007(407):cm8\u2013cm8","journal-title":"Sci STKE"},{"issue":"11","key":"2906_CR20","doi-asserted-by":"publisher","first-page":"5667","DOI":"10.1073\/pnas.94.11.5667","volume":"94","author":"PJ Kallio","year":"1997","unstructured":"Kallio PJ, Pongratz I, Gradin K et al (1997) Activation of hypoxia-inducible factor 1\u03b1: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor. Proc Natl Acad Sci U S A 94(11):5667\u20135672","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2906_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/emm.2004.1","volume":"36","author":"J-W Lee","year":"2004","unstructured":"Lee J-W, Bae S-H, Jeong J-W et al (2004) Hypoxia-inducible factor (HIF-1) \u03b1: its protein stability and biological functions. Exp Mol Med 36(1):1\u201312","journal-title":"Exp Mol Med"},{"issue":"21","key":"2906_CR22","doi-asserted-by":"publisher","first-page":"9700","DOI":"10.1073\/pnas.91.21.9700","volume":"91","author":"JG Herman","year":"1994","unstructured":"Herman JG, Latif F, Weng Y et al (1994) Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci U S A 91(21):9700\u20139704","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"2906_CR23","doi-asserted-by":"publisher","first-page":"4015","DOI":"10.1158\/0008-5472.CAN-10-4142","volume":"71","author":"MY Koh","year":"2011","unstructured":"Koh MY, Lemos R Jr., Liu X et al (2011) The hypoxia-associated factor switches cells from HIF-1\u03b1- to HIF-2\u03b1-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion. Cancer Res 71(11):4015\u20134027","journal-title":"Cancer Res"},{"issue":"6","key":"2906_CR24","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.ccr.2009.03.018","volume":"15","author":"Z Li","year":"2009","unstructured":"Li Z, Bao S, Wu Q et al (2009) Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15(6):501\u2013513","journal-title":"Cancer Cell"},{"key":"2906_CR25","doi-asserted-by":"publisher","first-page":"1082057","DOI":"10.3389\/fcell.2023.1082057","volume":"11","author":"G Ozcan","year":"2023","unstructured":"Ozcan G (2023) The hypoxia-inducible factor-1\u03b1 in stemness and resistance to chemotherapy in gastric cancer: future directions for therapeutic targeting. Front Cell Dev Biol 11:1082057","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"2906_CR26","doi-asserted-by":"publisher","first-page":"10592","DOI":"10.1038\/s41598-017-09244-8","volume":"7","author":"J Qin","year":"2017","unstructured":"Qin J, Liu Y, Lu Y et al (2017) Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression. Sci Rep 7(1):10592","journal-title":"Sci Rep"},{"issue":"1","key":"2906_CR27","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.gde.2009.10.009","volume":"20","author":"GL Semenza","year":"2010","unstructured":"Semenza GL (2010) HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 20(1):51\u201356","journal-title":"Curr Opin Genet Dev"},{"issue":"1","key":"2906_CR28","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3390\/ijms22010268","volume":"22","author":"A Albanese","year":"2020","unstructured":"Albanese A, Daly LA, Mennerich D et al (2020) The role of hypoxia-inducible factor post-translational modifications in regulating its localisation, stability, and activity. Int J Mol Sci 22(1):268","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2906_CR29","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.gendis.2023.02.039","volume":"11","author":"Y Zhao","year":"2024","unstructured":"Zhao Y, Xing C, Deng Y et al (2024) HIF-1\u03b1 signaling: essential roles in tumorigenesis and implications in targeted therapies. Genes Dis 11(1):234\u2013251","journal-title":"Genes Dis"},{"issue":"1","key":"2906_CR30","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12935-023-02996-6","volume":"23","author":"Z Hatami","year":"2023","unstructured":"Hatami Z, Hashemi ZS, Eftekhary M et al (2023) Natural killer cell-derived exosomes for cancer immunotherapy: innovative therapeutics art. Cancer Cell Int 23(1):157","journal-title":"Cancer Cell Int"},{"key":"2906_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119132","volume":"284","author":"V Karpisheh","year":"2021","unstructured":"Karpisheh V, Mousavi SM, Sheykholeslami PN et al (2021) The role of regulatory t cells in the pathogenesis and treatment of prostate cancer. Life Sci 284:119132","journal-title":"Life Sci"},{"issue":"2","key":"2906_CR32","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0955-0674(00)00194-0","volume":"13","author":"GL Semenza","year":"2001","unstructured":"Semenza GL (2001) HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol 13(2):167\u2013171","journal-title":"Curr Opin Cell Biol"},{"issue":"1","key":"2906_CR33","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrc3183","volume":"12","author":"B Keith","year":"2012","unstructured":"Keith B, Johnson RS, Simon MC (2012) HIF1\u03b1 and HIF2\u03b1: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 12(1):9\u201322","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"2906_CR34","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ijpharm.2014.10.065","volume":"478","author":"E \u015ealva","year":"2015","unstructured":"\u015ealva E, Turan S\u00d6, Eren F et al (2015) The enhancement of gene silencing efficiency with chitosan-coated liposome formulations of siRNAs targeting HIF-1\u03b1 and VEGF. Int J Pharm 478(1):147\u2013154","journal-title":"Int J Pharm"},{"issue":"36","key":"2906_CR35","doi-asserted-by":"publisher","first-page":"5552","DOI":"10.1038\/sj.onc.1208719","volume":"24","author":"Q Xu","year":"2005","unstructured":"Xu Q, Briggs J, Park S et al (2005) Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene 24(36):5552\u20135560","journal-title":"Oncogene"},{"issue":"3","key":"2906_CR36","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.cmet.2006.02.002","volume":"3","author":"J-w Kim","year":"2006","unstructured":"Kim J-w, Tchernyshyov I, Semenza GL et al (2006) HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3(3):177\u2013185","journal-title":"Cell Metab"},{"issue":"9","key":"2906_CR37","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/nrc2468","volume":"8","author":"NC Denko","year":"2008","unstructured":"Denko NC (2008) Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer 8(9):705\u2013713","journal-title":"Nat Rev Cancer"},{"issue":"9","key":"2906_CR38","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1101\/gad.1529107","volume":"21","author":"JJ Lum","year":"2007","unstructured":"Lum JJ, Bui T, Gruber M et al (2007) The transcription factor HIF-1\u03b1 plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev 21(9):1037\u20131049","journal-title":"Genes Dev"},{"issue":"8","key":"2906_CR39","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1182\/blood-2004-03-1109","volume":"104","author":"C Murdoch","year":"2004","unstructured":"Murdoch C, Giannoudis A, Lewis CE (2004) Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 104(8):2224\u20132234","journal-title":"Blood"},{"key":"2906_CR40","doi-asserted-by":"publisher","first-page":"7339","DOI":"10.1007\/s13277-015-4004-z","volume":"36","author":"Y Yazdani","year":"2015","unstructured":"Yazdani Y, Mohammadnia-Afrouzi M, Yousefi M et al (2015) Myeloid-derived suppressor cells in B cell malignancies. Tumor Biol 36:7339\u20137353","journal-title":"Tumor Biol"},{"issue":"3","key":"2906_CR41","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.ccr.2008.01.034","volume":"13","author":"R Du","year":"2008","unstructured":"Du R, Lu KV, Petritsch C et al (2008) HIF1\u03b1 induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13(3):206\u2013220","journal-title":"Cancer Cell"},{"issue":"4","key":"2906_CR42","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.immuni.2014.09.008","volume":"41","author":"A Palazon","year":"2014","unstructured":"Palazon A, Goldrath AW, Nizet V et al (2014) HIF transcription factors, inflammation, and immunity. Immunity 41(4):518\u2013528","journal-title":"Immunity"},{"issue":"6282","key":"2906_CR43","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1126\/science.aaf4405","volume":"352","author":"EB Rankin","year":"2016","unstructured":"Rankin EB, Giaccia AJ (2016) Hypoxic control of metastasis. Science 352(6282):175\u2013180","journal-title":"Science"},{"key":"2906_CR44","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s10555-007-9054-2","volume":"26","author":"D Lukashev","year":"2007","unstructured":"Lukashev D, Ohta A, Sitkovsky M (2007) Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues. Cancer Metastasis Rev 26:273\u2013279","journal-title":"Cancer Metastasis Rev"},{"key":"2906_CR45","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.ijbiomac.2019.03.223","volume":"133","author":"A Masjedi","year":"2019","unstructured":"Masjedi A, Hassannia H, Atyabi F et al (2019) Downregulation of A2AR by siRNA loaded PEG-chitosan-lactate nanoparticles restores the T cell mediated anti-tumor responses through blockage of PKA\/CREB signaling pathway. Int J Biol Macromol 133:436\u2013445","journal-title":"Int J Biol Macromol"},{"issue":"11","key":"2906_CR46","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/ni.2714","volume":"14","author":"AL Doedens","year":"2013","unstructured":"Doedens AL, Phan AT, Stradner MH et al (2013) Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen. Nat Immunol 14(11):1173\u20131182","journal-title":"Nat Immunol"},{"issue":"5","key":"2906_CR47","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1039\/C6TX00079G","volume":"5","author":"LY Hemeryck","year":"2016","unstructured":"Hemeryck LY, Rombouts C, Hecke TV et al (2016) In vitro DNA adduct profiling to mechanistically link red meat consumption to colon cancer promotion. Toxicol Res 5(5):1346\u20131358","journal-title":"Toxicol Res"},{"issue":"2","key":"2906_CR48","first-page":"106","volume":"56","author":"A Jemal","year":"2006","unstructured":"Jemal A, Siegel R, Ward E et al (2006) Cancer statistics, 2006. CA Cancer J Clin 56(2):106","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"2906_CR49","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1067\/mge.2000.105082","volume":"51","author":"DA Lieberman","year":"2000","unstructured":"Lieberman DA, De Garmo PL, Fleischer DE et al (2000) Colonic neoplasia in patients with nonspecific GI symptoms. Gastrointest Endosc 51(6):647\u2013651","journal-title":"Gastrointest Endosc"},{"issue":"7","key":"2906_CR50","doi-asserted-by":"publisher","first-page":"848","DOI":"10.3748\/wjg.v17.i7.848","volume":"17","author":"S Popek","year":"2011","unstructured":"Popek S, Tsikitis VL (2011) Neoadjuvant vs adjuvant pelvic radiotherapy for locally advanced rectal cancer: which is superior? World J Gastroenterol 17(7):848","journal-title":"World J Gastroenterol"},{"issue":"17","key":"2906_CR51","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1056\/NEJMoa040694","volume":"351","author":"R Sauer","year":"2004","unstructured":"Sauer R, Becker H, Hohenberger W et al (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. New England J Med 351(17):1731\u20131740","journal-title":"New England J Med"},{"issue":"3","key":"2906_CR52","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/nrc2344","volume":"8","author":"RG Bristow","year":"2008","unstructured":"Bristow RG, Hill RP (2008) Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 8(3):180\u2013192","journal-title":"Nat Rev Cancer"},{"issue":"24","key":"2906_CR53","doi-asserted-by":"publisher","first-page":"10113","DOI":"10.1158\/0008-5472.CAN-08-1839","volume":"68","author":"N Rohwer","year":"2008","unstructured":"Rohwer N, Welzel M, Daskalow K et al (2008) Hypoxia-inducible factor 1\u03b1 mediates anoikis resistance via suppression of \u03b15 integrin. Cancer Res 68(24):10113\u201310120","journal-title":"Cancer Res"},{"key":"2906_CR54","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14246054","author":"BP Bui","year":"2022","unstructured":"Bui BP, Nguyen PL, Lee K et al (2022) Hypoxia-inducible factor-1: a novel therapeutic target for the management of cancer, drug resistance, and cancer-related pain. Cancers. https:\/\/doi.org\/10.3390\/cancers14246054","journal-title":"Cancers"},{"issue":"11","key":"2906_CR55","doi-asserted-by":"publisher","first-page":"8445","DOI":"10.1007\/s00210-024-03189-2","volume":"397","author":"D Bhattacharjya","year":"2024","unstructured":"Bhattacharjya D, Sivalingam N (2024) Mechanism of 5-fluorouracil induced resistance and role of piperine and curcumin as chemo-sensitizers in colon cancer. Naunyn-Schmiedebergs Arch Pharmacol 397(11):8445\u20138475","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"issue":"35","key":"2906_CR56","doi-asserted-by":"publisher","first-page":"4176","DOI":"10.1200\/JCO.2015.63.4238","volume":"33","author":"T Andr\u00e9","year":"2015","unstructured":"Andr\u00e9 T, de Gramont A, Vernerey D et al (2015) Adjuvant fluorouracil, leucovorin, and oxaliplatin in stage II to III colon cancer: updated 10-year survival and outcomes according to BRAF mutation and mismatch repair status of the MOSAIC study. J Clin Oncol 33(35):4176\u20134187","journal-title":"J Clin Oncol"},{"issue":"9","key":"2906_CR57","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1590\/S0100-879X2001000900001","volume":"34","author":"I Grivicich","year":"2001","unstructured":"Grivicich I, Mans DR, Peters GJ et al (2001) Irinotecan and oxaliplatin: an overview of the novel chemotherapeutic options for the treatment of advanced colorectal cancer. Brazil J Medi Biol Res Revista Brasileira De Pesquisas Medicas E Biologicas 34(9):1087\u20131103","journal-title":"Brazil J Medi Biol Res Revista Brasileira De Pesquisas Medicas E Biologicas"},{"issue":"10","key":"2906_CR58","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/j.ejca.2009.04.018","volume":"45","author":"G Des Guetz","year":"2009","unstructured":"Des Guetz G, Schischmanoff O, Nicolas P et al (2009) Does microsatellite instability predict the efficacy of adjuvant chemotherapy in colorectal cancer? A systematic review with meta-analysis. Eur J Cancer 45(10):1890\u20131896","journal-title":"Eur J Cancer"},{"issue":"9863","key":"2906_CR59","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0140-6736(12)61900-X","volume":"381","author":"A Grothey","year":"2013","unstructured":"Grothey A, Cutsem EV, Sobrero A et al (2013) Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 381(9863):303\u2013312","journal-title":"Lancet"},{"issue":"23","key":"2906_CR60","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1056\/NEJMoa032691","volume":"350","author":"H Hurwitz","year":"2004","unstructured":"Hurwitz H, Fehrenbacher L, Novotny W et al (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350(23):2335\u20132342","journal-title":"N Engl J Med"},{"key":"2906_CR61","first-page":"3387","volume":"62","author":"C Km","year":"2002","unstructured":"Km C (2002) Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res 62:3387\u20133394","journal-title":"Cancer Res"},{"issue":"8","key":"2906_CR62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012038","volume":"5","author":"N Rohwer","year":"2010","unstructured":"Rohwer N, Dame C, Haugstetter A et al (2010) Hypoxia-inducible factor 1\u03b1 determines gastric cancer chemosensitivity via modulation of p53 and NF-\u03baB. PLoS ONE 5(8):e12038","journal-title":"PLoS ONE"},{"issue":"3","key":"2906_CR63","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.drup.2009.03.002","volume":"12","author":"A Rapisarda","year":"2009","unstructured":"Rapisarda A, Melillo G (2009) Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies. Drug Resist Updat 12(3):74\u201380","journal-title":"Drug Resist Updat"},{"issue":"7","key":"2906_CR64","doi-asserted-by":"publisher","first-page":"3735","DOI":"10.3390\/ijms25073735","volume":"25","author":"J Sun","year":"2024","unstructured":"Sun J, Zhao Z, Lu J et al (2024) The tumor microenvironment mediates the HIF-1\u03b1\/PD-L1 pathway to promote immune escape in colorectal cancer. Int J Mol Sci 25(7):3735","journal-title":"Int J Mol Sci"},{"issue":"9","key":"2906_CR65","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1631\/jzus.B1600266","volume":"17","author":"JZ Shan","year":"2016","unstructured":"Shan JZ, Xuan YY, Zhang Q et al (2016) Ursolic acid sensitized colon cancer cells to chemotherapy under hypoxia by inhibiting MDR1 through HIF-1\u03b1. J Zhejiang Univ Sci B 17(9):672\u2013682","journal-title":"J Zhejiang Univ Sci B"},{"issue":"3","key":"2906_CR66","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1158\/1535-7163.233.3.3","volume":"3","author":"S Welsh","year":"2004","unstructured":"Welsh S, Williams R, Kirkpatrick L et al (2004) Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol Cancer Ther 3(3):233\u2013244","journal-title":"Mol Cancer Ther"},{"key":"2906_CR67","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S511406","author":"P Pandey","year":"2025","unstructured":"Pandey P, Lakhanpal S, Mahmood D et al (2025) Recent update of natural compounds as HIF-1\u03b1 inhibitors in colorectal carcinoma. Drug Des Devel Ther. https:\/\/doi.org\/10.2147\/DDDT.S511406","journal-title":"Drug Des Devel Ther"},{"issue":"50","key":"2906_CR68","doi-asserted-by":"publisher","first-page":"7455","DOI":"10.1038\/sj.onc.1209085","volume":"24","author":"DA Altomare","year":"2005","unstructured":"Altomare DA, Testa JR (2005) Perturbations of the AKT signaling pathway in human cancer. Oncogene 24(50):7455\u20137464","journal-title":"Oncogene"},{"key":"2906_CR69","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0889","author":"P Oudet","year":"2009","unstructured":"Oudet P, Larsen AK, Gaub M-P et al (2009) Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammaliantarget of rapamycin\/hypoxia-inducible factor-1A axis. Clin Cancer Res. https:\/\/doi.org\/10.1158\/1078-0432.CCR-08-0889","journal-title":"Clin Cancer Res"},{"issue":"6","key":"2906_CR70","doi-asserted-by":"publisher","first-page":"e2843","DOI":"10.1038\/cddis.2017.235","volume":"8","author":"HS Ban","year":"2017","unstructured":"Ban HS, Kim B-K, Lee H et al (2017) The novel hypoxia-inducible factor-1\u03b1 inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth. Cell Death Dis 8(6):e2843\u2013e2843","journal-title":"Cell Death Dis"},{"issue":"1","key":"2906_CR71","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s13046-023-02724-y","volume":"42","author":"T-W Kao","year":"2023","unstructured":"Kao T-W, Bai G-H, Wang T-L et al (2023) Novel cancer treatment paradigm targeting hypoxia-induced factor in conjunction with current therapies to overcome resistance. J Exp Clin Cancer Res 42(1):171","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"2906_CR72","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.bbrc.2017.11.018","volume":"495","author":"D Jeon","year":"2018","unstructured":"Jeon D, Park HJ, Kim HS (2018) Protein S-glutathionylation induced by hypoxia increases hypoxia-inducible factor-1\u03b1 in human colon cancer cells. Biochem Biophys Res Commun 495(1):212\u2013216","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"2906_CR73","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3892\/or_00000844","volume":"24","author":"J Zheng","year":"2010","unstructured":"Zheng J, Sun X, Wang W et al (2010) Hypoxia-inducible factor-1\u03b1 modulates the down-regulation of the homeodomain protein CDX2 in colorectal cancer. Oncol Rep 24(1):97\u2013104","journal-title":"Oncol Rep"},{"issue":"2","key":"2906_CR74","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.3892\/ol.2016.4081","volume":"11","author":"H Zhang","year":"2016","unstructured":"Zhang H, Guo M, Chen H et al (2016) Effects of CIK on hypoxia inducible factor-1\u03b1 and T-cell subsets on colon 26 cancer xenograft mice. Oncol Lett 11(2):1371\u20131374","journal-title":"Oncol Lett"},{"issue":"3","key":"2906_CR75","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1158\/0008-5472.CAN-05-2887","volume":"66","author":"DT Dang","year":"2006","unstructured":"Dang DT, Chen F, Gardner LB et al (2006) Hypoxia-inducible factor-1\u03b1 promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts. Cancer Res 66(3):1684\u20131693","journal-title":"Cancer Res"},{"key":"2906_CR76","doi-asserted-by":"crossref","unstructured":"Zheng H, Zhou C, Lu X et al (2018) DJ-1 promotes survival of human colon cancer cells under hypoxia by modulating HIF-1\u03b1 expression through the PI3K-AKT pathway. Cancer Manag Res. 4615\u20134629.","DOI":"10.2147\/CMAR.S172008"},{"issue":"4","key":"2906_CR77","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s11596-022-2606-4","volume":"42","author":"W-b Long","year":"2022","unstructured":"Long W-b, Pu X, Tang Y et al (2022) Arginine ADP-ribosyltransferase 1 regulates glycolysis in colorectal cancer via the PI3K\/AKT\/HIF1\u03b1 pathway. Curr Med Sci 42(4):733\u2013741","journal-title":"Curr Med Sci"},{"issue":"6","key":"2906_CR78","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.21037\/tcr-22-1277","volume":"11","author":"X Chai","year":"2022","unstructured":"Chai X, Wu X, Ren J et al (2022) Expression of HIF-1\u03b1, ANXA3, CD133 and their associations with clinicopathological parameters in human colon carcinoma. Transl Cancer Res 11(6):1644","journal-title":"Transl Cancer Res"},{"issue":"20","key":"2906_CR79","doi-asserted-by":"publisher","first-page":"3568","DOI":"10.3760\/cma.j.issn.0366-6999.20141114","volume":"127","author":"L Mu","year":"2014","unstructured":"Mu L, Wang J, Chen Y et al (2014) Hypoxia-inducible factor-1\u03b1 and semaphorin4D genes involved with tumor-associated macrophage-induced metastatic behavior and clinical significance in colon cancer. Chin Med J 127(20):3568\u20133575","journal-title":"Chin Med J"},{"issue":"1","key":"2906_CR80","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.canlet.2016.02.022","volume":"376","author":"A Tanabe","year":"2016","unstructured":"Tanabe A, Tanikawa K, Tsunetomi M et al (2016) RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1\u03b1 mRNA is translated. Cancer Lett 376(1):34\u201342","journal-title":"Cancer Lett"},{"issue":"7","key":"2906_CR81","doi-asserted-by":"publisher","first-page":"8415","DOI":"10.1002\/cam4.5562","volume":"12","author":"M Qin","year":"2023","unstructured":"Qin M, Liu Q, Yang W et al (2023) Igfl2-as1-induced suppression of HIF-1\u03b1 degradation promotes cell proliferation and invasion in colorectal cancer by upregulating CA9. Cancer Med 12(7):8415\u20138432","journal-title":"Cancer Med"},{"issue":"2","key":"2906_CR82","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1124\/mol.106.032920","volume":"72","author":"S Merighi","year":"2007","unstructured":"Merighi S, Benini A, Mirandola P et al (2007) Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1\u03b1, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells. Mol Pharmacol 72(2):395\u2013406","journal-title":"Mol Pharmacol"},{"issue":"21","key":"2906_CR83","doi-asserted-by":"publisher","first-page":"8499","DOI":"10.1158\/0008-5472.CAN-09-2213","volume":"69","author":"H Kikuchi","year":"2009","unstructured":"Kikuchi H, Pino MS, Zeng M et al (2009) Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1\u03b1 and-2\u03b1 in colon cancer. Cancer Res 69(21):8499\u20138506","journal-title":"Cancer Res"},{"issue":"27","key":"2906_CR84","doi-asserted-by":"publisher","first-page":"24089","DOI":"10.1074\/jbc.M111.219733","volume":"286","author":"R Tammali","year":"2011","unstructured":"Tammali R, Saxena A, Srivastava SK et al (2011) Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) and vascular endothelial growth factor (VEGF) by regulating 26 S proteasome-mediated protein degradation in human colon cancer cells. J Biol Chem 286(27):24089\u201324100","journal-title":"J Biol Chem"},{"issue":"5","key":"2906_CR85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096755","volume":"9","author":"B Iovine","year":"2014","unstructured":"Iovine B, Oliviero G, Garofalo M et al (2014) The anti-proliferative effect of L-carnosine correlates with a decreased expression of hypoxia inducible factor 1 alpha in human colon cancer cells. PLoS ONE 9(5):e96755","journal-title":"PLoS ONE"},{"issue":"6","key":"2906_CR86","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.3892\/ijo.2015.3200","volume":"47","author":"DH Kim","year":"2015","unstructured":"Kim DH, Sung B, Kang YJ et al (2015) Sulforaphane inhibits hypoxia-induced HIF-1\u03b1 and VEGF expression and migration of human colon cancer cells. Int J Oncol 47(6):2226\u20132232","journal-title":"Int J Oncol"},{"issue":"3","key":"2906_CR87","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1631\/jzus.B2200221","volume":"24","author":"G Pan","year":"2023","unstructured":"Pan G, Zhang P, Chen A et al (2023) Aerobic glycolysis in colon cancer is repressed by naringin via the HIF1A pathway. J Zhejiang Univ-Sci B 24(3):221\u2013231","journal-title":"J Zhejiang Univ-Sci B"},{"issue":"15","key":"2906_CR88","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.2174\/1871520618666180611112125","volume":"18","author":"D Seyfi","year":"2018","unstructured":"Seyfi D, Behzad SB, Nabiuni M et al (2018) Verbascoside attenuates Rac-1 and HIF-1\u03b1 signaling cascade in colorectal cancer cells. Anti-Cancer Agents Med Chem (Form Curr Med Chem-Anti-Cancer Agents) 18(15):2149\u20132155","journal-title":"Anti-Cancer Agents Med Chem (Form Curr Med Chem-Anti-Cancer Agents)"},{"issue":"5","key":"2906_CR89","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.3892\/or.2012.2012","volume":"28","author":"JH Kim","year":"2012","unstructured":"Kim JH, Park MY, Kim CN et al (2012) Expression of endothelial cell-specific molecule-1 regulated by hypoxia inducible factor-1\u03b1 in human colon carcinoma: impact of ESM-1 on prognosis and its correlation with clinicopathological features. Oncol Rep 28(5):1701\u20131708","journal-title":"Oncol Rep"},{"issue":"6","key":"2906_CR90","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.bcp.2013.07.020","volume":"86","author":"S Han","year":"2013","unstructured":"Han S, Kim K, Thakkar N et al (2013) Role of hypoxia inducible factor-1\u03b1 in the regulation of the cancer-specific variant of organic anion transporting polypeptide 1B3 (OATP1B3), in colon and pancreatic cancer. Biochem Pharmacol 86(6):816\u2013823","journal-title":"Biochem Pharmacol"},{"key":"2906_CR91","doi-asserted-by":"crossref","unstructured":"Lv Y, Zhao S, Han J et al (2015) Hypoxia-inducible factor-1\u03b1 induces multidrug resistance protein in colon cancer. Onco Targets Therapy. 1941\u20131948.","DOI":"10.2147\/OTT.S82835"},{"issue":"2","key":"2906_CR92","doi-asserted-by":"publisher","first-page":"750","DOI":"10.3892\/ijo.2014.2745","volume":"46","author":"Y Sun","year":"2015","unstructured":"Sun Y, Xing X, Liu Q et al (2015) Hypoxia-induced autophagy reduces radiosensitivity by the HIF-1\u03b1\/miR-210\/Bcl-2 pathway in colon cancer cells. Int J Oncol 46(2):750\u2013756","journal-title":"Int J Oncol"},{"issue":"1","key":"2906_CR93","doi-asserted-by":"publisher","first-page":"237","DOI":"10.21037\/jgo-23-844","volume":"15","author":"K Du","year":"2024","unstructured":"Du K, Wang P, Liu J et al (2024) Activation of RhoA\/ROCK2 signaling by hypoxia-inducible factor 1\u03b1 in promoting tumor growth and metastasis in human colon cancer. J Gastrointest Oncol 15(1):237","journal-title":"J Gastrointest Oncol"},{"key":"2906_CR94","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s11523-011-0184-7","volume":"6","author":"S Langhammer","year":"2011","unstructured":"Langhammer S, Najjar M, Hess-Stumpp H et al (2011) LDH-A influences hypoxia-inducible factor 1\u03b1 (HIF1 \u03b1) and is critical for growth of HT29 colon carcinoma cells in vivo. Target Oncol 6:155\u2013162","journal-title":"Target Oncol"},{"issue":"4","key":"2906_CR95","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1158\/1078-0432.CCR-08-0889","volume":"15","author":"E Pencreach","year":"2009","unstructured":"Pencreach E, Gu\u00e9rin E, Nicolet Cl et al (2009) Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin\/hypoxia-inducible factor-1\u03b1 axis. Clin Cancer Res 15(4):1297\u20131307","journal-title":"Clin Cancer Res"},{"issue":"5","key":"2906_CR96","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1177\/1533034616665720","volume":"16","author":"M Zhang","year":"2017","unstructured":"Zhang M, Chen C, Su F et al (2017) Knockdown of hypoxia-inducible factor 1\u03b1 improved the efficacy of low-dose metronomic chemotherapy of paclitaxel in human colon cancer xenografts. Technol Cancer Res Treat 16(5):609\u2013619","journal-title":"Technol Cancer Res Treat"},{"issue":"6","key":"2906_CR97","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.3892\/ijo.2017.4166","volume":"51","author":"SL Kim","year":"2017","unstructured":"Kim SL, Park YR, Lee ST et al (2017) Parthenolide suppresses hypoxia-inducible factor-1\u03b1 signaling and hypoxia induced epithelial-mesenchymal transition in colorectal cancer. Int J Oncol 51(6):1809\u20131820","journal-title":"Int J Oncol"},{"key":"2906_CR98","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2021.109729","volume":"351","author":"C Mi","year":"2022","unstructured":"Mi C, Cao X, Ma K et al (2022) Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1\u03b1 and STAT3 in KRAS mutant human colon cancer cells. Chem Biol Interact 351:109729","journal-title":"Chem Biol Interact"},{"issue":"S1","key":"2906_CR99","doi-asserted-by":"publisher","first-page":"E107","DOI":"10.1002\/mc.22052","volume":"53","author":"H Wang","year":"2014","unstructured":"Wang H, Zhao L, Zhu LT et al (2014) Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1\u03b1 and glycolysis, by inhibiting PI3K\/Akt signaling pathway. Mol Carcinog 53(S1):E107\u2013E118","journal-title":"Mol Carcinog"},{"issue":"10","key":"2906_CR100","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1016\/j.ymthe.2019.05.017","volume":"27","author":"K Xu","year":"2019","unstructured":"Xu K, Zhan Y, Yuan Z et al (2019) Hypoxia induces drug resistance in colorectal cancer through the HIF-1\u03b1\/miR-338-5p\/IL-6 feedback loop. Mol Ther 27(10):1810\u20131824","journal-title":"Mol Ther"},{"key":"2906_CR101","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121933","volume":"329","author":"DK Dey","year":"2023","unstructured":"Dey DK, Gahlot H, Chang SN et al (2023) CopA3 treatment suppressed multidrug resistivity in HCT-116 cell line by p53-induced degradation of hypoxia-inducible factor 1\u03b1. Life Sci 329:121933","journal-title":"Life Sci"},{"key":"2906_CR102","doi-asserted-by":"publisher","first-page":"153303382110363","DOI":"10.1177\/15330338211036304","volume":"20","author":"Y Li","year":"2021","unstructured":"Li Y, Zhao L, Li X-F (2021) Hypoxia and the tumor microenvironment. Technol Cancer Res Treat 20:15330338211036304","journal-title":"Technol Cancer Res Treat"},{"key":"2906_CR103","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.critrevonc.2017.02.025","volume":"113","author":"R Vadde","year":"2017","unstructured":"Vadde R, Vemula S, Jinka R et al (2017) Role of hypoxia-inducible factors (HIF) in the maintenance of stemness and malignancy of colorectal cancer. Crit Rev Oncol Hematol 113:22\u201327","journal-title":"Crit Rev Oncol Hematol"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-025-02906-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-025-02906-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-025-02906-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T22:02:48Z","timestamp":1764021768000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-025-02906-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,28]]},"references-count":103,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2906"],"URL":"https:\/\/doi.org\/10.1007\/s10147-025-02906-y","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,28]]},"assertion":[{"value":"5 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No author has any conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent for publication"}},{"value":"All of the authors consent for this article publication.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}