{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:58:23Z","timestamp":1780322303565,"version":"3.54.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10147-025-02947-3","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T05:09:07Z","timestamp":1766725747000},"page":"235-243","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cancer epidemiology in rare and hereditary colorectal diseases 2) anal canal cancer (cancer statistics)"],"prefix":"10.1007","volume":"31","author":[{"given":"Kazutaka","family":"Yamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumitsu","family":"Saiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuko","family":"Fukunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Yonemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoriyuki","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"2947_CR1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S1470-2045(04)01410-X","volume":"5","author":"MA Clark","year":"2004","unstructured":"Clark MA, Hartley A, Geh JI (2004) Cancer of the anal canal. Lancet Oncol 5:149\u2013157","journal-title":"Lancet Oncol"},{"key":"2947_CR2","unstructured":"International Agency for Research on Cancer. Global Cancer Observatory : Cancer Today. https:\/\/gco.iarc.fr\/today\/fact-sheets-populations. Accessed 3 Dec 2021."},{"key":"2947_CR3","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1002\/cam4.4631","volume":"11","author":"K Yamada","year":"2022","unstructured":"Yamada K, Saiki Y, Komori K et al (2022) Characteristics of anal canal cancer in Japan. Cancer Med 11:2735\u20132743","journal-title":"Cancer Med"},{"key":"2947_CR4","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y (2013) Investigation of the freely available easy-to-use software \u201cEZR\u201d (Easy R) for medical statistics. Bone Marrow Transplant 48:452\u2013458","journal-title":"Bone Marrow Transplant"},{"key":"2947_CR5","first-page":"55","volume-title":"TNM classification of Malignant Tumours, 8th edition(UICC)","author":"Digestive System Tumours","year":"2017","unstructured":"Digestive System Tumours (2017). In: Brierley JD, Gospodarowicz MK, Wittekind C (eds) TNM classification of Malignant Tumours, 8th edition(UICC). Wiley, Blackwell, pp 55\u2013103"},{"key":"2947_CR6","first-page":"185","volume-title":"AJCC Cancer Staging Manual","author":"Upper Gastrointestinal Tract","year":"2017","unstructured":"Upper Gastrointestinal Tract (2017) Lower Gastrointestinal Tract and Hepatobiliary System. In: Amin MB (ed) AJCC Cancer Staging Manual, 8th edn. Springer, pp 185\u2013347","edition":"8"},{"key":"2947_CR7","unstructured":"Japanese Society for Cancer of the Colon and Rectum. Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma, 9th Japanese edition. Kanehara & Co., Ltd, 2018"},{"key":"2947_CR8","unstructured":"National Cancer Institute. Surveillance, Epidemiology, and End Results (SEER) Program. Cancer Stat Facts: Anus, Anal Canal, and Anorectum. Bethesda, MD: National Cancer Institute; 2024. https:\/\/seer.cancer.gov\/statfacts\/html\/anus.html Accessed 21 Oct 2025."},{"key":"2947_CR9","unstructured":"Cancer research UK: Anal Cancer Statistics https:\/\/www.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/anal-cancer Accessed October 21, 2025."},{"key":"2947_CR10","unstructured":"Bruni L, Albero G, Serrano B, et al. Human Papillomavirus and Related Diseases Report: Japan. ICO\/IARC HPV Information Centre; 2023. https:\/\/hpvcentre.net\/statistics\/reports\/JPN_FS.pdf Accessed October 21, 2025."},{"key":"2947_CR11","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1002\/(SICI)1097-0142(19990415)85:8<1686::AID-CNCR7>3.0.CO;2-7","volume":"85","author":"JV Klas","year":"1999","unstructured":"Klas JV, Rothenberger DA, Wong WD et al (1999) Malignant tumors of the anal canal. The spectrum of disease, treatment, and outcomes. Cancer 85:1686\u20131693","journal-title":"Cancer"},{"key":"2947_CR12","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/cncr.20364","volume":"101","author":"LG Johnson","year":"2004","unstructured":"Johnson LG, Madeleine MM, Newcomer LM et al (2004) Anal cancer incidence and survival: the surveillance, epidemiology, and end results experience, 1973\u20132000. Cancer 101:281\u2013288","journal-title":"Cancer"},{"key":"2947_CR13","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1002\/cncr.23744","volume":"113","author":"DA Joseph","year":"2008","unstructured":"Joseph DA, Miller JW, Wu X et al (2008) Understanding the burden of human papillomavirus-associated anal cancers in the US. Cancer 113:2892\u20132900","journal-title":"Cancer"},{"key":"2947_CR14","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/sj.bjc.6603175","volume":"95","author":"DH Brewster","year":"2006","unstructured":"Brewster DH, Bhatti LA (2006) Increasing incidence of squamous cell carcinoma of the anus in Scotland, 1975\u20132002. Br J Cancer 95:87\u201390","journal-title":"Br J Cancer"},{"key":"2947_CR15","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1002\/ijc.26115","volume":"130","author":"A Nielsen","year":"2012","unstructured":"Nielsen A, Munk C, Kjaer SK (2012) Trends in incidence of anal cancer and high-grade anal intraepithelial neoplasia in Denmark, 1978-2008. Int J Cancer 130:1168\u20131173","journal-title":"Int J Cancer"},{"key":"2947_CR16","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1016\/j.vaccine.2011.01.015","volume":"29","author":"F Jin","year":"2011","unstructured":"Jin F, Stein AN, Conway EL et al (2011) Trends in anal cancer in Australia, 1982\u20132005. Vaccine 29:2322\u20132327","journal-title":"Vaccine"},{"key":"2947_CR17","first-page":"92","volume":"35","author":"Y Sumikoshi","year":"1982","unstructured":"Sumikoshi Y (1982) Multi-institutional registration of anal cancer in Japan. J Jpn Soc Coloproctol 35:92\u201397","journal-title":"J Jpn Soc Coloproctol"},{"key":"2947_CR18","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3862\/jcoloproctology.58.415","volume":"58","author":"S Sameshima","year":"2005","unstructured":"Sameshima S, Sawada T, Nagasako K (2005) Squamous cell carcinoma of anus and carcinoma in association with anal fistula in Japan. J Jpn Soc Coloproctol 58:415\u2013421","journal-title":"J Jpn Soc Coloproctol"},{"issue":"1","key":"2947_CR19","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/1097-0142(19840701)54:1<114::AID-CNCR2820540124>3.0.CO;2-P","volume":"54","author":"BM Boman","year":"1984","unstructured":"Boman BM, Moertel CG, O\u2019Connell MJ et al (1984) Carcinoma of the anal canal A clinical and pathologic study of 188 cases. Cancer 54(1):114\u2013125","journal-title":"Cancer"},{"key":"2947_CR20","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1007\/BF02553933","volume":"27","author":"ND Nigro","year":"1984","unstructured":"Nigro ND (1984) An evaluation of combined therapy for squamous cell cancer of the anal canal. Dis Colon Rectum 27:763\u2013766","journal-title":"Dis Colon Rectum"},{"key":"2947_CR21","unstructured":"National Comprehensive Cancer Network. Anal carcinoma. Version 4. 2025. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/anal.pdf.Accessed 21 Oct 2025."},{"key":"2947_CR22","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1007\/s10147-023-02339-5","volume":"28","author":"K Yamada","year":"2023","unstructured":"Yamada K, Shiraishi K, Takashima A et al (2023) Characteristics of anal canal squamous cell carcinoma as an HPV-associated cancer in Japan. Int J Clin Oncol 28:990\u2013998","journal-title":"Int J Clin Oncol"},{"key":"2947_CR23","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/cncr.20365","volume":"101","author":"JR Daling","year":"2004","unstructured":"Daling JR, Madeleine MM, Johnson LG et al (2004) Human papillomavirus, smoking, and sexual practices in the etiology of anal cancer. Cancer 101:270\u2013280","journal-title":"Cancer"},{"key":"2947_CR24","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1056\/NEJM199711063371904","volume":"337","author":"M Frisch","year":"1997","unstructured":"Frisch M, Glimelius B, van den Brule AJ et al (1997) transmitted infection as a cause of anal cancer. N Engl J Med 337:1350\u20131358","journal-title":"N Engl J Med"},{"key":"2947_CR25","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.ygyno.2009.05.006","volume":"114","author":"W Jimenez","year":"2009","unstructured":"Jimenez W, Paszat L, Kupets R et al (2009) Presumed previous human papillomavirus related gynecological cancer in women diagnosed with anal cancer in the province of Ontario. Gynecol Oncol 114:395\u2013398","journal-title":"Gynecol Oncol"},{"key":"2947_CR26","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1056\/NEJM200003163421107","volume":"342","author":"DP Ryan","year":"2000","unstructured":"Ryan DP, Compton CC, Mayer RJ (2000) Carcinoma of the anal canal. N Engl J Med 342:792\u2013800","journal-title":"N Engl J Med"},{"key":"2947_CR27","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1002\/ijc.25080","volume":"127","author":"KG Sunesen","year":"2010","unstructured":"Sunesen KG, Norgaard M, Thorlacius-Ussing O et al (2010) Immunosuppressive disorders and risk of anal squamous cell carcinoma: a nationwide cohort study in Denmark 1978-2005. Int J Cancer 127:675\u2013684","journal-title":"Int J Cancer"},{"key":"2947_CR28","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1093\/jnci\/92.18.1500","volume":"92","author":"M Frisch","year":"2000","unstructured":"Frisch M, Biggae RJ, Goedert JJ (2000) Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. J Natl Cancer Inst 92:1500\u20131510","journal-title":"J Natl Cancer Inst"},{"key":"2947_CR29","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1634\/theoncologist.12-5-524","volume":"12","author":"HE Uronis","year":"2007","unstructured":"Uronis HE, Bendell JC (2007) Anal cancer: an overview. Oncologist 12:524\u2013534","journal-title":"Oncologist"},{"issue":"1","key":"2947_CR30","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/ijc.28963","volume":"136","author":"L Alemany","year":"2015","unstructured":"Alemany L, Saunier M, Alvarado-Cabrero I et al (2015) HPV DNA prevalence and type distribution in anal carcinomas worldwide. Int J Cancer 136(1):98\u2013107","journal-title":"Int J Cancer"},{"key":"2947_CR31","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1038\/s41416-018-0049-2","volume":"118","author":"M Herfs","year":"2018","unstructured":"Herfs M, Roncarati P, Koopmansch B et al (2018) A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine. Br J Cancer 118:1302\u20131312","journal-title":"Br J Cancer"},{"issue":"2","key":"2947_CR32","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/jgh.15229","volume":"36","author":"M Uchino","year":"2021","unstructured":"Uchino M, Ikeuchi H, Hata K et al (2021) Intestinal cancer in patients with Crohn\u2019s disease: a systematic review and meta-analysis. J Gastroenterol Hepatol 36(2):329\u2013336","journal-title":"J Gastroenterol Hepatol"},{"issue":"9","key":"2947_CR33","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.14309\/ajg.0000000000002269","volume":"118","author":"T Ogino","year":"2023","unstructured":"Ogino T, Mizushima T, Fujii M et al (2023) Crohn\u2019s disease-associated anorectal cancer has a poor prognosis with high local recurrence: A subanalysis of the nationwide Japanese study. Am J Gastroenterol 118(9):1626\u20131637","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"2947_CR34","doi-asserted-by":"publisher","first-page":"e319","DOI":"10.1097\/SLA.0000000000005339","volume":"276","author":"C Lu","year":"2022","unstructured":"Lu C, Schardey J, Zhang T et al (2022) Survival outcomes and clinicopathological features in inflammatory bowel disease-associated colorectal cancer: a systematic review and meta-analysis. Ann Surg 276(5):e319\u2013e330","journal-title":"Ann Surg"},{"issue":"3","key":"2947_CR35","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1136\/gut.35.3.347","volume":"35","author":"RW Connell","year":"1994","unstructured":"Connell RW, Sheffield PJ, Kamm AM et al (1994) Lower gastrointestinal malignancy in Crohn\u2019s disease. Gut 35(3):347\u2013352","journal-title":"Gut"},{"key":"2947_CR36","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1007\/s10147-009-0892-5","volume":"14","author":"A Takashima","year":"2009","unstructured":"Takashima A, Shimada Y, Hamaguchi T et al (2009) Current therapeutic strategies for anal squamous cell carcinoma in Japan. Int J Clin Oncol 14:416\u2013420","journal-title":"Int J Clin Oncol"},{"issue":"1","key":"2947_CR37","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1093\/jrr\/rrac069","volume":"64","author":"K Murofushi","year":"2022","unstructured":"Murofushi K, Itasaka S, Shimokawa M et al (2022) A phase II study of concurrent chemoradiotherapy with 5-fluorouracil and mitomycin-C for squamous cell carcinoma of the anal canal (the JROSG 10-2 trial). J Radiat Res 64(1):154\u2013161","journal-title":"J Radiat Res"},{"key":"2947_CR38","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1007\/s10147-023-02361-7","volume":"28","author":"Y Ito","year":"2023","unstructured":"Ito Y, Hamaguchi T, Takashima A et al (2023) Definitive S-1\/mitomycin-C chemoradiotherapy for stage II\/III anal canal squamous cell carcinoma: a phase I\/II dose-finding and single-arm confirmatory study (JCOG0903). Int J Clin Oncol 28:1063\u20131072","journal-title":"Int J Clin Oncol"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-025-02947-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-025-02947-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-025-02947-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T04:07:52Z","timestamp":1769486872000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-025-02947-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["2947"],"URL":"https:\/\/doi.org\/10.1007\/s10147-025-02947-3","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,26]]},"assertion":[{"value":"31 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable (analysis of published aggregate data).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}