{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:47:50Z","timestamp":1782409670757,"version":"3.54.5"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303089"],"award-info":[{"award-number":["82303089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s10147-026-03045-8","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:02:40Z","timestamp":1777514560000},"page":"1307-1315","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age-related prognostic trends in surgically resected female lymph node-metastatic gastric cancer: insights from SEER"],"prefix":"10.1007","volume":"31","author":[{"given":"Bozhi","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjiang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2617-9841","authenticated-orcid":false,"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"issue":"10251","key":"3045_CR1","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","volume":"396","author":"EC Smyth","year":"2020","unstructured":"Smyth EC, Nilsson M, Grabsch HI et al (2020) Gastric cancer. Lancet 396(10251):635\u2013648","journal-title":"Lancet"},{"key":"3045_CR2","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000003259","author":"X Wang","year":"2024","unstructured":"Wang X, Gao X, Yu J et al (2024) Emerging trends in early-onset gastric cancer. Chin Med J. https:\/\/doi.org\/10.1097\/cm9.0000000000003259","journal-title":"Chin Med J"},{"issue":"3","key":"3045_CR3","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1158\/2159-8290.CD-22-1038","volume":"13","author":"I Ben-Aharon","year":"2023","unstructured":"Ben-Aharon I, van Laarhoven HWM, Fontana E et al (2023) Early-onset cancer in the gastrointestinal tract is on the rise-evidence and implications. Cancer Discov 13(3):538\u2013551","journal-title":"Cancer Discov"},{"issue":"6","key":"3045_CR4","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v16.i6.106228","volume":"16","author":"JL Cui","year":"2025","unstructured":"Cui JL, Zhao K, Li XL et al (2025) Swollen lymph node metastasis and survival in gastric cancer: multi-institutional post-resection analysis. World J Clin Oncol 16(6):106228","journal-title":"World J Clin Oncol"},{"key":"3045_CR5","doi-asserted-by":"publisher","first-page":"4795","DOI":"10.2147\/OTT.S144801","volume":"10","author":"S Song","year":"2017","unstructured":"Song S, Li C, Li S et al (2017) Clinicopathological features and prognoses in younger and older patients with gastric cancer. OncoTargets Ther 10:4795\u20134802","journal-title":"OncoTargets Ther"},{"issue":"1","key":"3045_CR6","doi-asserted-by":"publisher","first-page":"252","DOI":"10.4143\/crt.2025.149","volume":"58","author":"Y Choi","year":"2026","unstructured":"Choi Y, Kim N, Kim JH et al (2026) Survival Rates of Patients with Gastric Cancer According to Age and Sex: A Large-Scale Study Using Data from 14,739 Patients. Cancer Res Treat 58(1):252\u2013263","journal-title":"Cancer Res Treat"},{"issue":"4","key":"3045_CR7","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1089\/jayao.2019.0162","volume":"9","author":"B Zhao","year":"2020","unstructured":"Zhao B, Mei D, Lv W et al (2020) Clinicopathologic features, survival outcome, and prognostic factors in gastric cancer patients 18-40 years of age. J Adolesc Young Adult Oncol 9(4):514\u2013521","journal-title":"J Adolesc Young Adult Oncol"},{"issue":"6","key":"3045_CR8","first-page":"960","volume":"32","author":"W Jiang","year":"2025","unstructured":"Jiang W, Sun X, Xiong R et al (2025) Analysis of clinicopathological features and prognostic factors in young female patients with gastric adenocarcinoma. Chin J Clin Med 32(6):960\u2013966","journal-title":"Chin J Clin Med"},{"issue":"4","key":"3045_CR9","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1002\/jso.24533","volume":"115","author":"KA Rona","year":"2017","unstructured":"Rona KA, Schwameis K, Zehetner J et al (2017) Gastric cancer in the young: An advanced disease with poor prognostic features. J Surg Oncol 115(4):371\u2013375","journal-title":"J Surg Oncol"},{"issue":"3","key":"3045_CR10","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1159\/000219331","volume":"26","author":"H Moreira","year":"2009","unstructured":"Moreira H, Pinto-de-Sousa J, Carneiro F et al (2009) Early onset gastric cancer no longer presents as an advanced disease with ominous prognosis. Dig Surg 26(3):215\u2013221","journal-title":"Dig Surg"},{"key":"3045_CR11","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goaf099","volume":"13","author":"B Li","year":"2025","unstructured":"Li B, Sun Z, Liu J et al (2025) Clinical and molecular implications of sex differences in surgically treated early-onset gastric cancer. Gastroenterol Rep Oxf 13:goaf099","journal-title":"Gastroenterol Rep Oxf"},{"issue":"12","key":"3045_CR12","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1158\/1055-9965.2203.13.12","volume":"13","author":"M Lindblad","year":"2004","unstructured":"Lindblad M, Ye W, Rubio C et al (2004) Estrogen and risk of gastric cancer: a protective effect in a nationwide cohort study of patients with prostate cancer in Sweden. Cancer Epidemiol Biomarkers Prev 13(12):2203\u20132207","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"7","key":"3045_CR13","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1002\/ijc.30588","volume":"140","author":"N Brusselaers","year":"2017","unstructured":"Brusselaers N, Maret-Ouda J, Konings P et al (2017) Menopausal hormone therapy and the risk of esophageal and gastric cancer. Int J Cancer 140(7):1693\u20131699","journal-title":"Int J Cancer"},{"issue":"1","key":"3045_CR14","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1158\/1055-9965.EPI-11-0834","volume":"21","author":"MC Camargo","year":"2012","unstructured":"Camargo MC, Goto Y, Zabaleta J et al (2012) Sex hormones, hormonal interventions, and gastric cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 21(1):20\u201338","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"6","key":"3045_CR15","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.3892\/ijo.2014.2660","volume":"45","author":"X Wang","year":"2014","unstructured":"Wang X, Huang X, Fu Z et al (2014) Biphasic ER-\u03b136-mediated estrogen signaling regulates growth of gastric cancer cells. Int J Oncol 45(6):2325\u20132330","journal-title":"Int J Oncol"},{"issue":"2","key":"3045_CR16","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3892\/ol.2013.1416","volume":"6","author":"X Wang","year":"2013","unstructured":"Wang X, Deng H, Zou F et al (2013) ER-\u03b136-mediated gastric cancer cell proliferation via the c-Src pathway. Oncol Lett 6(2):329\u2013335","journal-title":"Oncol Lett"},{"issue":"2","key":"3045_CR17","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1007\/s10120-016-0603-7","volume":"20","author":"SJ Merchant","year":"2017","unstructured":"Merchant SJ, Kim J, Choi AH et al (2017) A rising trend in the incidence of advanced gastric cancer in young Hispanic men. Gastric Cancer 20(2):226\u2013234","journal-title":"Gastric Cancer"},{"issue":"5","key":"3045_CR18","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1136\/gutjnl-2019-320234","volume":"69","author":"M Arnold","year":"2020","unstructured":"Arnold M, Park JY, Camargo MC et al (2020) Is gastric cancer becoming a rare disease? A global assessment of predicted incidence trends to 2035. Gut 69(5):823\u2013829","journal-title":"Gut"},{"issue":"12","key":"3045_CR19","doi-asserted-by":"publisher","first-page":"3602","DOI":"10.1007\/s10620-019-05690-8","volume":"64","author":"M Glover","year":"2019","unstructured":"Glover M, Mansoor E, Panhwar M et al (2019) Epidemiology of colorectal cancer in average risk adults 20-39 years of age: a population-based national study. Dig Dis Sci 64(12):3602\u20133609","journal-title":"Dig Dis Sci"},{"issue":"2","key":"3045_CR20","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1053\/j.gastro.2017.05.012","volume":"153","author":"SY Cho","year":"2017","unstructured":"Cho SY, Park JW, Liu Y et al (2017) Sporadic early-onset diffuse gastric cancers have high frequency of somatic CDH1 alterations, but low frequency of somatic RHOA mutations compared with late-onset cancers. Gastroenterology 153(2):536-549.e526","journal-title":"Gastroenterology"},{"issue":"5","key":"3045_CR21","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1056\/NEJMoa2005936","volume":"384","author":"C Hu","year":"2021","unstructured":"Hu C, Hart SN, Gnanaolivu R et al (2021) A Population-Based Study of Genes Previously Implicated in Breast Cancer. N Engl J Med 384(5):440\u2013451","journal-title":"N Engl J Med"},{"issue":"3","key":"3045_CR22","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1097\/01.pas.0000190787.85024.cb","volume":"30","author":"T Kiyokawa","year":"2006","unstructured":"Kiyokawa T, Young RH, Scully RE (2006) Krukenberg tumors of the ovary: a clinicopathologic analysis of 120 cases with emphasis on their variable pathologic manifestations. Am J Surg Pathol 30(3):277\u2013299","journal-title":"Am J Surg Pathol"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-026-03045-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-026-03045-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-026-03045-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:19:18Z","timestamp":1782407958000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-026-03045-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["3045"],"URL":"https:\/\/doi.org\/10.1007\/s10147-026-03045-8","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]},"assertion":[{"value":"18 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest associated with this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study is exempt from ethical review because the SEER database is public and has open access.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}