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Pre-operative radiotherapy was administered with 50.4\u00a0Gy in 1.8\u00a0Gy fractions, with definitive surgery performed 4\u20138 weeks after completing pre-operative radiotherapy to allow inflammation to subside. Optimal methods for wound closure were performed by plastic surgeons, with the selective use of flap reconstructions (pedicled or free), skin grafts or direct closure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Diagnoses included well-differentiated liposarcoma\/atypical lipomatous tumors (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200966), myxoid liposarcoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931), leiomyosarcoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922), and others. After en-bloc (wide) resections, 78.8% (104\/132) underwent plastic reconstruction, including free flaps (51.5%), pedicled flaps (25.8%), and skin grafts (1.5%). The resection margins were R0 in 93.2% (123\/132), R1 or R2 in 6.8% (9\/132). The 5-year local recurrence-free rate was 99.1%, and distant metastasis-free survival was 90.6%, with nine metastases observed, mainly in myxoid liposarcoma. The disease-specific survival at 5 years was 99.2%. Wound complication-related reoperations occurred in 21.2% (28\/132), with similar rates between direct closure (21.4%, 6\/28) and plastic reconstruction (21.2%, 22\/104,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.705).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although surgical and oncological outcomes were favourable, the efficacy and invasiveness of pre-operative radiotherapy should be carefully balanced based on the patients\u2019 individual background, due to the potential post-operative complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10147-026-03059-2","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:03:14Z","timestamp":1779897794000},"page":"1389-1398","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["What are the surgical and oncologic outcomes, as well as the complications, associated with pre-operative radiotherapy in patients with low-grade soft-tissue sarcoma?"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3438-9814","authenticated-orcid":false,"given":"Hisaki","family":"Aiba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Mizuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Choong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Slavin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Di Bella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"3059_CR1","doi-asserted-by":"publisher","first-page":"186581","DOI":"10.1155\/2015\/186581","volume":"2015","author":"AL Lazarides","year":"2015","unstructured":"Lazarides AL, Eward WC, Speicher PJ et al (2015) The use of radiation therapy in well-differentiated soft tissue sarcoma of the extremities: an NCDB review. 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