{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:24:01Z","timestamp":1787664241834,"version":"build-2736575974"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002332","name":"Semmelweis University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spinal metastases commonly cause pain, neurological deterioration, and instability. Surgery is palliative, aiming to relieve symptoms and maintain oncologic treatment eligibility. Optimal surgical timing, however, remains debated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 664 patients who underwent 760 operations for spinal metastases at Semmelweis University (2008\u20132022). Clinical data included demographics, comorbidities, primary tumor, neurological status, surgical approach, and timing of surgery relative to the symptom onset. Survival was assessed with both Kaplan\u2013Meier and log-rank testing, with subgroup analyses by surgical timing and operative hours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pain (83%) and motor deficits (46%) were the most frequent symptoms. Lung, renal, breast, and hematologic cancers predominated. Median survival was 294 days; 30% exceeded two years. No survival advantage was detected for conventional acute surgical thresholds (\u2264\u200948\u00a0h, \u2264\u200972\u00a0h, \u2264\u20091 week). Delays beyond one week correlated with reduced survival. Pain improved postoperatively in ~\u200990% of cases, independent of timing. Severe preoperative motor dysfunction predicted poor survival and recovery, emphasizing the need for urgent surgery in this subgroup. Procedures during working hours were associated with superior postoperative symptom control (OR 3.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), though survival outcomes were unchanged.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Surgical management of spinal metastases provides consistent pain relief. Urgent intervention is critical in patients with progressive motor deficits, whereas multidisciplinary preoperative optimization is preferable in others. Operations during working hours yield better symptomatic outcomes, but survival remains primarily determined by the oncologic disease burden. Prospective multicenter studies are warranted to refine timing guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10147-026-03099-8","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:18:53Z","timestamp":1781633933000},"page":"1901-1910","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of surgical timing in survival of patients with spinal metastases"],"prefix":"10.1007","volume":"31","author":[{"given":"Mikl\u00f3s","family":"Kopa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1d\u00e1m","family":"K\u0151v\u00e1ri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luk\u00e1cs","family":"N\u00e9meth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"B\u00e1skay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Pollner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Banczerowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Mezei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"issue":"3","key":"3099_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229\u2013263. https:\/\/doi.org\/10.3322\/caac.21834","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"3099_CR2","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3322\/caac.21838","volume":"74","author":"N Jokhadze","year":"2024","unstructured":"Jokhadze N, Das A, Dizon DS (2024) Global cancer statistics: a healthy population relies on population health. CA Cancer J Clin 74(3):224\u2013226. https:\/\/doi.org\/10.3322\/caac.21838","journal-title":"CA Cancer J Clin"},{"issue":"11","key":"3099_CR3","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.clon.2020.07.010","volume":"32","author":"A Challapalli","year":"2020","unstructured":"Challapalli A, Aziz S, Khoo V et al (2020) Spine and non-spine bone metastases - current controversies and future direction. Clin Oncol (R Coll Radiol) 32(11):728\u2013744. https:\/\/doi.org\/10.1016\/j.clon.2020.07.010","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"3099_CR4","doi-asserted-by":"publisher","first-page":"100446","DOI":"10.1016\/j.jbo.2022.100446","volume":"35","author":"R Van den Brande","year":"2022","unstructured":"Van den Brande R, Cornips EM, Peeters M, Ost P, Billiet C, Van de Kelft E (2022) Epidemiology of spinal metastases, metastatic epidural spinal cord compression and pathologic vertebral compression fractures in patients with solid tumors: a systematic review. J Bone Oncol 35:100446. https:\/\/doi.org\/10.1016\/j.jbo.2022.100446","journal-title":"J Bone Oncol"},{"issue":"1","key":"3099_CR5","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1186\/s12891-024-07741-2","volume":"25","author":"L Liu","year":"2024","unstructured":"Liu L, Shi L, Su Y, Wang K, Wang H (2024) Epidemiological features of spinal intradural tumors, a single-center clinical study in Beijing, China. BMC Musculoskelet Disord 25(1):613. https:\/\/doi.org\/10.1186\/s12891-024-07741-2","journal-title":"BMC Musculoskelet Disord"},{"key":"3099_CR6","doi-asserted-by":"publisher","DOI":"10.1201\/b13439","volume-title":"Russell & Rubinstein\u2019s pathology of tumors of the nervous system","author":"MR Roger McLendon","year":"2006","unstructured":"Roger McLendon MR, Darell B (2006) Russell & Rubinstein\u2019s pathology of tumors of the nervous system, 7th edn. CRC","edition":"7"},{"key":"3099_CR7","doi-asserted-by":"publisher","first-page":"i2539","DOI":"10.1136\/bmj.i2539","volume":"353","author":"R Al-Qurainy","year":"2016","unstructured":"Al-Qurainy R, Collis E (2016) Metastatic spinal cord compression: diagnosis and management. BMJ 353:i2539. https:\/\/doi.org\/10.1136\/bmj.i2539","journal-title":"BMJ"},{"key":"3099_CR8","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.wneu.2017.08.130","volume":"108","author":"SZ Yang","year":"2017","unstructured":"Yang SZ, Tang Y, Zhang Y, Chen WG, Sun J, Chu TW (2017) Prognostic factors and comparison of conservative treatment, percutaneous vertebroplasty, and open surgery in the treatment of spinal metastases from lung cancer. World Neurosurg 108:163\u2013175. https:\/\/doi.org\/10.1016\/j.wneu.2017.08.130","journal-title":"World Neurosurg"},{"issue":"6","key":"3099_CR9","doi-asserted-by":"publisher","first-page":"S552","DOI":"10.1016\/j.recot.2023.09.006","volume":"67","author":"V Pipola","year":"2023","unstructured":"Pipola V, Pasini S, Ghermandi R et al (2023) Management of symptomatic spine metastases: a multidisciplinary approach based flow-chart. Rev Esp Cir Ortop Traumatol 67(6):S552\u2013S559. https:\/\/doi.org\/10.1016\/j.recot.2023.09.006","journal-title":"Rev Esp Cir Ortop Traumatol"},{"issue":"3","key":"3099_CR10","first-page":"140","volume":"67","author":"HM Barragan-Campos","year":"2015","unstructured":"Barragan-Campos HM, Jimenez-Zarazua O, Mondragon JD (2015) Diagnosis and treatment options of spinal metastases. Rev Invest Clin 67(3):140\u2013157","journal-title":"Rev Invest Clin"},{"issue":"3","key":"3099_CR11","doi-asserted-by":"publisher","first-page":"337","DOI":"10.4055\/cios20014","volume":"12","author":"YH Kim","year":"2020","unstructured":"Kim YH, Kim J, Chang SY, Kim H, Chang BS (2020) Treatment strategy for impending instability in spinal metastases. Clin Orthop Surg 12(3):337\u2013342. https:\/\/doi.org\/10.4055\/cios20014","journal-title":"Clin Orthop Surg"},{"issue":"4","key":"3099_CR12","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1097\/PPO.0000000000000205","volume":"22","author":"S Jabbari","year":"2016","unstructured":"Jabbari S, Gerszten PC, Ruschin M, Larson DA, Lo SS, Sahgal A (2016) Stereotactic body radiotherapy for spinal metastases: practice guidelines, outcomes, and risks. Cancer J 22(4):280\u2013289. https:\/\/doi.org\/10.1097\/PPO.0000000000000205","journal-title":"Cancer J"},{"issue":"6","key":"3099_CR13","first-page":"265","volume":"8","author":"A Gasbarrini","year":"2004","unstructured":"Gasbarrini A, Cappuccio M, Mirabile L et al (2004) Spinal metastases: treatment evaluation algorithm. Eur Rev Med Pharmacol Sci 8(6):265\u2013274","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"3099_CR14","unstructured":"(NICE) NIfHaCE (2023) Spinal metastases and metastatic spinal cord compression, NICE guideline NG234. London"},{"issue":"19","key":"3099_CR15","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.1097\/01.brs.0000180401.06919.a5","volume":"30","author":"Y Tokuhashi","year":"2005","unstructured":"Tokuhashi Y, Matsuzaki H, Oda H, Oshima M, Ryu J (2005) A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976) 30(19):2186\u20132191. https:\/\/doi.org\/10.1097\/01.brs.0000180401.06919.a5","journal-title":"Spine (Phila Pa 1976)"},{"issue":"3","key":"3099_CR16","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1097\/00007632-200102010-00016","volume":"26","author":"K Tomita","year":"2001","unstructured":"Tomita K, Kawahara N, Kobayashi T, Yoshida A, Murakami H, Akamaru T (2001) Surgical strategy for spinal metastases. Spine (Phila Pa 1976) 26(3):298\u2013306. https:\/\/doi.org\/10.1097\/00007632-200102010-00016","journal-title":"Spine (Phila Pa 1976)"},{"issue":"2","key":"3099_CR17","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3109\/17453679508995508","volume":"66","author":"HC Bauer","year":"1995","unstructured":"Bauer HC, Wedin R (1995) Survival after surgery for spinal and extremity metastases. Prognostication in 241 patients. Acta Orthop Scand 66(2):143\u2013146. https:\/\/doi.org\/10.3109\/17453679508995508","journal-title":"Acta Orthop Scand"},{"issue":"2","key":"3099_CR18","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1002\/cncr.20756","volume":"103","author":"YM van der Linden","year":"2005","unstructured":"van der Linden YM, Dijkstra SP, Vonk EJ, Marijnen CA, Leer JW, Dutch Bone Metastasis Study G (2005) Prediction of survival in patients with metastases in the spinal column: results based on a randomized trial of radiotherapy. Cancer 103(2):320\u2013328. https:\/\/doi.org\/10.1002\/cncr.20756","journal-title":"Cancer"},{"issue":"1","key":"3099_CR19","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.21871","volume":"75","author":"RL Siegel","year":"2025","unstructured":"Siegel RL, Kratzer TB, Giaquinto AN, Sung H, Jemal A (2025) Cancer statistics, 2025. CA Cancer J Clin 75(1):10\u201345. https:\/\/doi.org\/10.3322\/caac.21871","journal-title":"CA Cancer J Clin"},{"issue":"10125","key":"3099_CR20","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/S0140-6736(17)33326-3","volume":"391","author":"C Allemani","year":"2018","unstructured":"Allemani C, Matsuda T, Di Carlo V et al (2018) Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet 391(10125):1023\u20131075. https:\/\/doi.org\/10.1016\/S0140-6736(17)33326-3","journal-title":"Lancet"},{"issue":"1","key":"3099_CR21","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.1016\/j.clon.2022.09.054","volume":"35","author":"T Mezei","year":"2023","unstructured":"Mezei T, Horvath A, Nagy Z et al (2023) A novel prognostication system for spinal metastasis patients based on network science and correlation analysis. Clin Oncol (R Coll Radiol) 35(1):e20\u2013e29. https:\/\/doi.org\/10.1016\/j.clon.2022.09.054","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"3099_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60040631","author":"N Bresolin","year":"2024","unstructured":"Bresolin N, Sartori L, Drago G et al (2024) Systematic review and meta-analysis on optimal timing of surgery for acute symptomatic metastatic spinal cord compression. Med (Kaunas). https:\/\/doi.org\/10.3390\/medicina60040631","journal-title":"Med (Kaunas)"},{"key":"3099_CR23","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-025-08804-1","author":"J Wanman","year":"2025","unstructured":"Wanman J, Vedemyr E, Crnalic S (2025) Predictors of ambulation recovery after surgery in patients with metastatic spinal cord compression who lost walking ability for more than 48\u00a0h. Eur Spine J. https:\/\/doi.org\/10.1007\/s00586-025-08804-1","journal-title":"Eur Spine J"},{"issue":"3","key":"3099_CR24","doi-asserted-by":"publisher","first-page":"308","DOI":"10.23736\/S0390-5616.17.04003-6","volume":"63","author":"JK Yue","year":"2019","unstructured":"Yue JK, Tsolinas RE, Burke JF et al (2019) Vasopressor support in managing acute spinal cord injury: current knowledge. J Neurosurg Sci 63(3):308\u2013317. https:\/\/doi.org\/10.23736\/S0390-5616.17.04003-6","journal-title":"J Neurosurg Sci"},{"key":"3099_CR25","doi-asserted-by":"publisher","first-page":"004","DOI":"10.1016\/j.jbo.2018.10.004","volume":"15","author":"S D\u2019Oronzo","year":"2019","unstructured":"D\u2019Oronzo S, Coleman R, Brown J, Silvestris F (2019) Metastatic bone disease: pathogenesis and therapeutic options: up-date on bone metastasis management. J Bone Oncol 15:004\u2013004. https:\/\/doi.org\/10.1016\/j.jbo.2018.10.004","journal-title":"J Bone Oncol"},{"issue":"9486","key":"3099_CR26","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S0140-6736(05)66954-1","volume":"366","author":"RA Patchell","year":"2005","unstructured":"Patchell RA, Tibbs PA, Regine WF et al (2005) Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet 366(9486):643\u2013648. https:\/\/doi.org\/10.1016\/S0140-6736(05)66954-1","journal-title":"Lancet"},{"issue":"6","key":"3099_CR27","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1227\/01.NEU.0000359315.20268.73","volume":"65","author":"JP Sheehan","year":"2009","unstructured":"Sheehan JP, Shaffrey CI, Schlesinger D, Williams BJ, Arlet V, Larner J (2009) Radiosurgery in the treatment of spinal metastases: tumor control, survival, and quality of life after helical tomotherapy. Neurosurgery 65(6):1052\u20131061 discussion 1061\u2009\u2013\u20091052. https:\/\/doi.org\/10.1227\/01.NEU.0000359315.20268.73","journal-title":"Neurosurgery"},{"issue":"2","key":"3099_CR28","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.ijrobp.2004.10.018","volume":"61","author":"HP Bijl","year":"2005","unstructured":"Bijl HP, van Luijk P, Coppes RP, Schippers JM, Konings AW, van Der Kogel AJ (2005) Regional differences in radiosensitivity across the rat cervical spinal cord. Int J Radiat Oncol Biol Phys 61(2):543\u2013551. https:\/\/doi.org\/10.1016\/j.ijrobp.2004.10.018","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"3099_CR29","doi-asserted-by":"publisher","first-page":"727","DOI":"10.3892\/etm.2021.10159","volume":"22","author":"S Xu","year":"2021","unstructured":"Xu S, Liu T, Zhang X et al (2021) Efficacy of percutaneous vertebroplasty for the relief of osteoblastic spinal metastasis pain. Exp Ther Med 22(1):727. https:\/\/doi.org\/10.3892\/etm.2021.10159","journal-title":"Exp Ther Med"},{"issue":"7","key":"3099_CR30","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1016\/j.spinee.2024.12.032","volume":"25","author":"AH Al-Mistarehi","year":"2025","unstructured":"Al-Mistarehi AH, Slika H, El Baba B et al (2025) Optimizing surgical strategies: a systematic review of the effectiveness of preoperative arterial embolization for hyper vascular metastatic spinal tumors. Spine J 25(7):1400\u20131417. https:\/\/doi.org\/10.1016\/j.spinee.2024.12.032","journal-title":"Spine J"},{"issue":"10","key":"3099_CR31","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1007\/s00586-020-06647-6","volume":"30","author":"AM Tarawneh","year":"2021","unstructured":"Tarawneh AM, Pasku D, Quraishi NA (2021) Surgical complications and re-operation rates in spinal metastases surgery: a systematic review. Eur Spine J 30(10):2791\u20132799. https:\/\/doi.org\/10.1007\/s00586-020-06647-6","journal-title":"Eur Spine J"},{"issue":"11","key":"3099_CR32","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1097\/00007632-199011010-00005","volume":"15","author":"Y Tokuhashi","year":"1990","unstructured":"Tokuhashi Y, Matsuzaki H, Toriyama S, Kawano H, Ohsaka S (1990) Scoring system for the preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976) 15(11):1110\u20131113. https:\/\/doi.org\/10.1097\/00007632-199011010-00005","journal-title":"Spine (Phila Pa 1976)"},{"issue":"2","key":"3099_CR33","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1080\/10790268.2019.1610602","volume":"44","author":"LS Yaari","year":"2021","unstructured":"Yaari LS, Novack L, Shemesh S et al (2021) Patient outcomes and survival following surgery for spinal metastases. J Spinal Cord Med 44(2):204\u2013211. https:\/\/doi.org\/10.1080\/10790268.2019.1610602","journal-title":"J Spinal Cord Med"},{"issue":"3","key":"3099_CR34","doi-asserted-by":"publisher","first-page":"235","DOI":"10.22603\/ssrr.2021-0169","volume":"7","author":"S Dohzono","year":"2023","unstructured":"Dohzono S, Sasaoka R, Takamatsu K, Nakamura H (2023) Association between opioid requirement and overall survival in patients with spinal metastases. Spine Surg Relat Res 7(3):235\u2013241. https:\/\/doi.org\/10.22603\/ssrr.2021-0169","journal-title":"Spine Surg Relat Res"},{"issue":"12","key":"3099_CR35","doi-asserted-by":"publisher","first-page":"e0190342","DOI":"10.1371\/journal.pone.0190342","volume":"12","author":"WY Lo","year":"2017","unstructured":"Lo WY, Yang SH (2017) Metastatic spinal cord compression (MSCC) treated with palliative decompression: surgical timing and survival rate. PLoS ONE 12(12):e0190342. https:\/\/doi.org\/10.1371\/journal.pone.0190342","journal-title":"PLoS ONE"},{"issue":"4","key":"3099_CR36","doi-asserted-by":"publisher","first-page":"432","DOI":"10.3171\/2018.9.SPINE18147","volume":"30","author":"I Hussain","year":"2019","unstructured":"Hussain I, Barzilai O, Reiner AS et al (2019) Spinal instability neoplastic score component validation using patient-reported outcomes. J Neurosurg Spine 30(4):432\u2013438. https:\/\/doi.org\/10.3171\/2018.9.SPINE18147","journal-title":"J Neurosurg Spine"},{"issue":"8","key":"3099_CR37","doi-asserted-by":"publisher","first-page":"rjaa217","DOI":"10.1093\/jscr\/rjaa217","volume":"2020","author":"P Hamilton","year":"2020","unstructured":"Hamilton P, Lawrence P, Eisenring CV (2020) Metastatic epidural spinal cord compression. J Surg Case Rep 2020(8):rjaa217. https:\/\/doi.org\/10.1093\/jscr\/rjaa217","journal-title":"J Surg Case Rep"},{"issue":"3","key":"3099_CR38","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1200\/JCO.2015.61.9338","volume":"34","author":"MG Fehlings","year":"2016","unstructured":"Fehlings MG, Nater A, Tetreault L et al (2016) Survival and clinical outcomes in surgically treated patients with metastatic epidural spinal cord compression: results of the prospective multicenter AO spine study. J Clin Oncol 34(3):268\u2013276. https:\/\/doi.org\/10.1200\/JCO.2015.61.9338","journal-title":"J Clin Oncol"},{"issue":"6","key":"3099_CR39","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s00586-012-2635-y","volume":"22","author":"NA Quraishi","year":"2013","unstructured":"Quraishi NA, Rajagopal TS, Manoharan SR, Elsayed S, Edwards KL, Boszczyk BM (2013) Effect of timing of surgery on neurological outcome and survival in metastatic spinal cord compression. Eur Spine J 22(6):1383\u20131388. https:\/\/doi.org\/10.1007\/s00586-012-2635-y","journal-title":"Eur Spine J"},{"issue":"Suppl 20","key":"3099_CR40","doi-asserted-by":"publisher","first-page":"S224","DOI":"10.1097\/BRS.0000000000001827","volume":"41","author":"I Laufer","year":"2016","unstructured":"Laufer I, Zuckerman SL, Bird JE et al (2016) Predicting neurologic recovery after surgery in patients with deficits secondary to MESCC: systematic review. Spine (Phila Pa 1976) 41(Suppl 20):S224\u2013S230. https:\/\/doi.org\/10.1097\/BRS.0000000000001827","journal-title":"Spine (Phila Pa 1976)"},{"issue":"4","key":"3099_CR41","doi-asserted-by":"publisher","first-page":"564","DOI":"10.14444\/8480","volume":"17","author":"G Santangelo","year":"2023","unstructured":"Santangelo G, Ellens N, Singh A et al (2023) Comparing 30-day outcomes after emergent spine procedures performed during hours vs after hours. Int J Spine Surg 17(4):564\u2013569. https:\/\/doi.org\/10.14444\/8480","journal-title":"Int J Spine Surg"},{"issue":"1","key":"3099_CR42","doi-asserted-by":"publisher","first-page":"314","DOI":"10.14245\/ns.2347012.506","volume":"21","author":"Y Kanda","year":"2024","unstructured":"Kanda Y, Kakutani K, Sakai Y et al (2024) Clinical characteristics, surgical outcomes, and risk factors for emergency surgery in patients with spinal metastases: a prospective cohort study. Neurospine 21(1):314\u2013327. https:\/\/doi.org\/10.14245\/ns.2347012.506","journal-title":"Neurospine"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-026-03099-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-026-03099-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-026-03099-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:08:46Z","timestamp":1787663326000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-026-03099-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["3099"],"URL":"https:\/\/doi.org\/10.1007\/s10147-026-03099-8","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]},"assertion":[{"value":"1 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The research was conducted in the spirit of the Declaration of Helsinki, with the approval of the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (ETT-TUKEB Registration Number: BM\/26599-1\/2023).","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Due to the retrospective nature of the study, the Scientific and Research Ethics Committee of the Hungarian Medical Research Council waived the need to obtaining informed consent.","order":3,"name":"Ethics","label":"Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Clinical Trial Number","group":{"name":"EthicsHeading","label":"Declarations"}}]}}