{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:08:00Z","timestamp":1790356080558,"version":"4.1.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["23K14642"],"award-info":[{"award-number":["23K14642"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Photoimmunotherapy, which involves combining targeted antibodies with light-activatable dyes such as IRDye700DX (IR700), is an emerging cancer treatment modality. Cetuximab-based photoimmunotherapy is approved for the treatment of unresectable head and neck cancer and has been covered by the national health insurance in Japan since 2021. Use of conventional ceiling surgical lighting during photoimmunotherapy is problematic due to concerns about potential cytotoxic effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To ensure safe surgical application, we developed a custom short-pass filter for the ORBEYE surgical exoscope to block IR700 excitation light. The filter\u2019s impact on the color tone was evaluated using human skin and a color checker, while that on the cytotoxicity was assessed in vitro using cetuximab-IR700 and an HSC-3 cell line. The clinical feasibility of using this filter was tested in six patients who underwent short surgical procedures (e.g., tracheostomy, arterial ligation) during photoimmunotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recalibrating the white balance after filter placement preserved the natural color tones. In vitro, the filter neutralized the significant cytotoxicity observed under the ORBEYE light. Clinically, the filter could be used safely in all cases with no evidence of postoperative skin damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This filter system enhances the safety and feasibility of surgical procedures during photoimmunotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10147-026-03131-x","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:01:14Z","timestamp":1784682074000},"page":"2243-2248","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Excitation-light blocking filter for photoimmunotherapy tailored to the ORBEYE 4K 3D exoscope"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3589-5054","authenticated-orcid":false,"given":"Ryuhei","family":"Okada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kanebako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisei","family":"Nagahisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Asamori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuchika","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Machida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Asakage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"issue":"8","key":"3131_CR1","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1021\/acs.accounts.9b00273","volume":"52","author":"H Kobayashi","year":"2019","unstructured":"Kobayashi H, Choyke PL (2019) Near-infrared photoimmunotherapy of cancer. Acc Chem Res 52(8):2332\u20132339. https:\/\/doi.org\/10.1021\/acs.accounts.9b00273","journal-title":"Acc Chem Res"},{"key":"3131_CR2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyaf069","author":"R Okada","year":"2025","unstructured":"Okada R, Asakage T (2025) Near-infrared photoimmunotherapy: basics and clinical application. Jpn J Clin Oncol. https:\/\/doi.org\/10.1093\/jjco\/hyaf069","journal-title":"Jpn J Clin Oncol"},{"issue":"12","key":"3131_CR3","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1038\/nm.2554","volume":"17","author":"M Mitsunaga","year":"2011","unstructured":"Mitsunaga M, Ogawa M, Kosaka N et al (2011) Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules. Nat Med 17(12):1685\u20131691. https:\/\/doi.org\/10.1038\/nm.2554","journal-title":"Nat Med"},{"issue":"12","key":"3131_CR4","doi-asserted-by":"publisher","first-page":"3875","DOI":"10.1002\/hed.26885","volume":"43","author":"DM Cognetti","year":"2021","unstructured":"Cognetti DM, Johnson JM, Curry JM et al (2021) Phase 1\/2a, open-label, multicenter study of RM-1929 photoimmunotherapy in patients with locoregional, recurrent head and neck squamous cell carcinoma. Head Neck 43(12):3875\u20133887. https:\/\/doi.org\/10.1002\/hed.26885","journal-title":"Head Neck"},{"issue":"10","key":"3131_CR5","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1007\/s10147-021-01960-6","volume":"26","author":"M Tahara","year":"2021","unstructured":"Tahara M, Okano S, Enokida T et al (2021) A phase I, single-center, open-label study of RM-1929 photoimmunotherapy in Japanese patients with recurrent head and neck squamous cell carcinoma. Int J Clin Oncol 26(10):1812\u20131821. https:\/\/doi.org\/10.1007\/s10147-021-01960-6","journal-title":"Int J Clin Oncol"},{"key":"3131_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12072492","author":"M D'Ambra","year":"2023","unstructured":"D\u2019Ambra M, Tedesco A, Iacone B et al (2023) First application of the Orbeye\u2122 4K 3D exoscope in recurrent papillary thyroid cancer surgery. J Clin Med. https:\/\/doi.org\/10.3390\/jcm12072492","journal-title":"J Clin Med"},{"key":"3131_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14010047","author":"M Yagi","year":"2024","unstructured":"Yagi M, Sakagami T, Shimizu M et al (2024) Application of the ORBEYE three-dimensional exoscope for parotidectomies. 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Pharmaceuticals (Basel). https:\/\/doi.org\/10.3390\/ph17091246","journal-title":"Pharmaceuticals (Basel)"},{"issue":"4","key":"3131_CR16","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.anl.2025.05.001","volume":"52","author":"T Ueda","year":"2025","unstructured":"Ueda T, Taruya T, Chikuie N et al (2025) Evaluation of real-time pharmacokinetics using fluorescence imaging system in near-infrared photoimmunotherapy for head and neck cancer. Auris Nasus Larynx 52(4):346\u2013353. https:\/\/doi.org\/10.1016\/j.anl.2025.05.001","journal-title":"Auris Nasus Larynx"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-026-03131-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-026-03131-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-026-03131-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:49:54Z","timestamp":1790354994000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-026-03131-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["3131"],"URL":"https:\/\/doi.org\/10.1007\/s10147-026-03131-x","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"assertion":[{"value":"15 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"R.O. reports having received advisory fees and research funds from Rakuten Medical. H.K. and M.M. are employees of Rakuten Medical KK. None of the other authors has any potential conflicts of interest to disclose. Rakuten Medical KK collaborated in the study by designing and fabricating the filter based on the concept proposed by R.O., and by conducting analyses of the filter\u2019s physical excitation light-blocking performance and color checker evaluations. The company was not involved in the in vitro cell experiments or in the collection and analysis of clinical data. Rakuten Medical KK reviewed the final version of the manuscript before submission to confirm intellectual property-related matters.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}