{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:24:04Z","timestamp":1787664244330,"version":"build-2736575974"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["No.2022JJ30863 and No.2023JJ30799"],"award-info":[{"award-number":["No.2022JJ30863 and No.2023JJ30799"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"China Primary Health Care Foundation(CPHCF) Emerging Oncology Supportive Care Research Grant Program","award":["No.cphcf-2023-042"],"award-info":[{"award-number":["No.cphcf-2023-042"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s10147-026-03133-9","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T08:06:40Z","timestamp":1784707600000},"page":"1820-1841","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification and functional validation of lipid droplet-associated prognostic biomarkers in breast cancer via integrative multi-omics and machine learning approaches"],"prefix":"10.1007","volume":"31","author":[{"given":"Jia","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongzhi","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"issue":"4","key":"3133_CR1","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1038\/s41591-025-03502-3","volume":"31","author":"J Kim","year":"2025","unstructured":"Kim J, Harper A, McCormack V, Sung H, Houssami N, Morgan E et al (2025) Global patterns and trends in breast cancer incidence and mortality across 185 countries. Nat Med 31(4):1154\u20131162","journal-title":"Nat Med"},{"issue":"1","key":"3133_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40164-022-00363-1","volume":"12","author":"L Guo","year":"2023","unstructured":"Guo L, Kong D, Liu J, Zhan L, Luo L, Zheng W et al (2023) Breast cancer heterogeneity and its implication in personalized precision therapy. Exp Hematol Oncol 12(1):3","journal-title":"Exp Hematol Oncol"},{"issue":"Suppl 7","key":"3133_CR3","doi-asserted-by":"publisher","first-page":"vii41","DOI":"10.1093\/annonc\/mdn439","volume":"19","author":"T Cufer","year":"2008","unstructured":"Cufer T (2008) Which tools can I use in daily clinical practice to improve tailoring of treatment for breast cancer? The 2007 St Gallen guidelines and\/or Adjuvant! Online. Ann Oncol 19(Suppl 7):vii41\u2013vii45","journal-title":"Ann Oncol"},{"issue":"2","key":"3133_CR4","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/s41419-020-2297-3","volume":"11","author":"ALS Cruz","year":"2020","unstructured":"Cruz ALS, Barreto EA, Fazolini NPB, Viola JPB, Bozza PT (2020) Lipid droplets: platforms with multiple functions in cancer hallmarks. Cell Death Dis 11(2):105","journal-title":"Cell Death Dis"},{"key":"3133_CR5","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ceb.2019.03.018","volume":"59","author":"CL Jackson","year":"2019","unstructured":"Jackson CL (2019) Lipid droplet biogenesis. Curr Opin Cell Biol 59:88\u201396","journal-title":"Curr Opin Cell Biol"},{"issue":"1","key":"3133_CR6","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3390\/lipidology1010005","volume":"1","author":"S Dogan","year":"2024","unstructured":"Dogan S, Leopold J, Hoffmann DT, Kubitschke H, Blauth E, Ficorella C et al (2024) Identification of Lipid Droplet-Associated Genes in Breast Cancer Patients. Lipidology 1(1):52\u201374","journal-title":"Lipidology"},{"issue":"10","key":"3133_CR7","doi-asserted-by":"publisher","first-page":"e46456","DOI":"10.1371\/journal.pone.0046456","volume":"7","author":"C Nieva","year":"2012","unstructured":"Nieva C, Marro M, Santana-Codina N, Rao S, Petrov D, Sierra A (2012) The lipid phenotype of breast cancer cells characterized by Raman microspectroscopy: towards a stratification of malignancy. PLoS ONE 7(10):e46456","journal-title":"PLoS ONE"},{"key":"3133_CR8","doi-asserted-by":"crossref","unstructured":"Shyu P Jr., Wong XFA, Crasta K, Thibault G (2018) Dropping in on lipid droplets: insights into cellular stress and cancer. Biosci Rep. ;38(5)","DOI":"10.1042\/BSR20180764"},{"key":"3133_CR9","doi-asserted-by":"publisher","first-page":"576326","DOI":"10.3389\/fonc.2021.576326","volume":"11","author":"AS Zembroski","year":"2021","unstructured":"Zembroski AS, Andolino C, Buhman KK, Teegarden D (2021) Proteomic Characterization of Cytoplasmic Lipid Droplets in Human Metastatic Breast Cancer Cells. Front Oncol 11:576326","journal-title":"Front Oncol"},{"key":"3133_CR10","doi-asserted-by":"crossref","unstructured":"Hershey BJ, Vazzana R, Joppi DL, Havas KM (2019) Lipid Droplets Define a Sub-Population of Breast Cancer Stem Cells. J Clin Med. 9(1):87","DOI":"10.3390\/jcm9010087"},{"issue":"8","key":"3133_CR11","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/j.cell.2023.02.015","volume":"186","author":"D Wang","year":"2023","unstructured":"Wang D, Liu B, Zhang Z (2023) Accelerating the understanding of cancer biology through the lens of genomics. Cell 186(8):1755\u20131771","journal-title":"Cell"},{"issue":"5","key":"3133_CR12","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nmeth.1315","volume":"6","author":"F Tang","year":"2009","unstructured":"Tang F, Barbacioru C, Wang Y, Nordman E, Lee C, Xu N et al (2009) mRNA-Seq whole-transcriptome analysis of a single cell. Nat Methods 6(5):377\u2013382","journal-title":"Nat Methods"},{"issue":"4","key":"3133_CR13","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/nprot.2017.149","volume":"13","author":"V Svensson","year":"2018","unstructured":"Svensson V, Vento-Tormo R, Teichmann SA (2018) Exponential scaling of single-cell RNA-seq in the past decade. Nat Protoc 13(4):599\u2013604","journal-title":"Nat Protoc"},{"issue":"1","key":"3133_CR14","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/s41368-021-00146-0","volume":"13","author":"X Li","year":"2021","unstructured":"Li X, Wang CY (2021) From bulk, single-cell to spatial RNA sequencing. Int J Oral Sci 13(1):36","journal-title":"Int J Oral Sci"},{"issue":"1","key":"3133_CR15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41592-020-01033-y","volume":"18","author":"V Marx","year":"2021","unstructured":"Marx V (2021) Method of the Year: spatially resolved transcriptomics. Nat Methods 18(1):9\u201314","journal-title":"Nat Methods"},{"issue":"5","key":"3133_CR16","doi-asserted-by":"publisher","first-page":"e1264","DOI":"10.1002\/ctm2.1264","volume":"13","author":"D Saul","year":"2023","unstructured":"Saul D, Kosinsky RL (2023) Spatial transcriptomics herald a new era of transcriptome research. Clin Transl Med 13(5):e1264","journal-title":"Clin Transl Med"},{"issue":"1","key":"3133_CR17","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s40364-025-00758-2","volume":"13","author":"A Ocana","year":"2025","unstructured":"Ocana A, Pandiella A, Privat C, Bravo I, Luengo-Oroz M, Amir E et al (2025) Integrating artificial intelligence in drug discovery and early drug development: a transformative approach. Biomark Res 13(1):45","journal-title":"Biomark Res"},{"issue":"4","key":"3133_CR18","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41587-021-01091-3","volume":"40","author":"D Sun","year":"2022","unstructured":"Sun D, Guan X, Moran AE, Wu LY, Qian DZ, Schedin P et al (2022) Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data. Nat Biotechnol 40(4):527\u2013538","journal-title":"Nat Biotechnol"},{"issue":"1","key":"3133_CR19","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12943-025-02258-1","volume":"24","author":"M Wan","year":"2025","unstructured":"Wan M, Pan S, Shan B, Diao H, Jin H, Wang Z et al (2025) Lipid metabolic reprograming: the unsung hero in breast cancer progression and tumor microenvironment. Mol Cancer 24(1):61","journal-title":"Mol Cancer"},{"issue":"2","key":"3133_CR20","doi-asserted-by":"publisher","first-page":"C343","DOI":"10.1152\/ajpcell.00109.2021","volume":"321","author":"KM Turner","year":"2021","unstructured":"Turner KM, Yeo SK, Holm TM, Shaughnessy E, Guan JL (2021) Heterogeneity within molecular subtypes of breast cancer. Am J Physiol Cell Physiol 321(2):C343\u2013C54","journal-title":"Am J Physiol Cell Physiol"},{"key":"3133_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2020.02.006","volume":"106","author":"G Bahcecioglu","year":"2020","unstructured":"Bahcecioglu G, Basara G, Ellis BW, Ren X, Zorlutuna P (2020) Breast cancer models: Engineering the tumor microenvironment. Acta Biomater 106:1\u201321","journal-title":"Acta Biomater"},{"issue":"17","key":"3133_CR22","doi-asserted-by":"publisher","first-page":"29487","DOI":"10.18632\/oncotarget.15494","volume":"8","author":"ME Monaco","year":"2017","unstructured":"Monaco ME (2017) Fatty acid metabolism in breast cancer subtypes. Oncotarget 8(17):29487\u201329500","journal-title":"Oncotarget"},{"key":"3133_CR23","doi-asserted-by":"publisher","first-page":"1579423","DOI":"10.3389\/fonc.2025.1579423","volume":"15","author":"XX Cai","year":"2025","unstructured":"Cai XX, Zhang ZZ, Yang XX, Shen WR, Yuan LW, Ding X et al (2025) Unveiling the impact of lipid metabolism on triple-negative breast cancer growth and treatment options. Front Oncol 15:1579423","journal-title":"Front Oncol"},{"key":"3133_CR24","doi-asserted-by":"crossref","unstructured":"Joshi S, Garlapati C, Pradhan A, Gandhi K, Balogun A, Aneja R (2026) Lipid Droplets in Cancer: New Insights and Therapeutic Potential. Int J Mol Sci. ;27(2)","DOI":"10.3390\/ijms27020918"},{"key":"3133_CR25","doi-asserted-by":"crossref","unstructured":"Fu Y, Zou T, Shen X, Nelson PJ, Li J, Wu C et al (2020) Lipid metabolism in cancer progression and therapeutic strategies. MedComm 2021;2(1):27\u201359","DOI":"10.1002\/mco2.27"},{"key":"3133_CR26","doi-asserted-by":"publisher","first-page":"1114582","DOI":"10.3389\/fimmu.2023.1114582","volume":"14","author":"CK Keerthana","year":"2023","unstructured":"Keerthana CK, Rayginia TP, Shifana SC, Anto NP, Kalimuthu K, Isakov N et al (2023) The role of AMPK in cancer metabolism and its impact on the immunomodulation of the tumor microenvironment. Front Immunol 14:1114582","journal-title":"Front Immunol"},{"issue":"11","key":"3133_CR27","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.trecan.2019.09.007","volume":"5","author":"B Peck","year":"2019","unstructured":"Peck B, Schulze A (2019) Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment. Trends Cancer 5(11):693\u2013703","journal-title":"Trends Cancer"},{"issue":"20","key":"3133_CR28","doi-asserted-by":"publisher","first-page":"3892","DOI":"10.1111\/febs.13402","volume":"282","author":"Y Xing","year":"2015","unstructured":"Xing Y, Zhao S, Zhou BP, Mi J (2015) Metabolic reprogramming of the tumour microenvironment. FEBS J 282(20):3892\u20133898","journal-title":"FEBS J"},{"issue":"2","key":"3133_CR29","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/imm.12777","volume":"152","author":"KE Allison","year":"2017","unstructured":"Allison KE, Coomber BL, Bridle BW (2017) Metabolic reprogramming in the tumour microenvironment: a hallmark shared by cancer cells and T lymphocytes. Immunology 152(2):175\u2013184","journal-title":"Immunology"},{"issue":"10","key":"3133_CR30","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1038\/s41591-018-0136-1","volume":"24","author":"P Jiang","year":"2018","unstructured":"Jiang P, Gu S, Pan D, Fu J, Sahu A, Hu X et al (2018) Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. Nat Med 24(10):1550\u20131558","journal-title":"Nat Med"},{"issue":"5","key":"3133_CR31","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.cmet.2021.02.015","volume":"33","author":"X Ma","year":"2021","unstructured":"Ma X, Xiao L, Liu L, Ye L, Su P, Bi E et al (2021) CD36-mediated ferroptosis dampens intratumoral CD8(+) T cell effector function and impairs their antitumor ability. Cell Metab 33(5):1001\u201312e5","journal-title":"Cell Metab"},{"issue":"7","key":"3133_CR32","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/j.immuni.2021.05.003","volume":"54","author":"S Xu","year":"2021","unstructured":"Xu S, Chaudhary O, Rodriguez-Morales P, Sun X, Chen D, Zappasodi R et al (2021) Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8(+) T cells in tumors. Immunity 54(7):1561\u20131577 e7","journal-title":"Immunity"},{"issue":"8","key":"3133_CR33","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/s41419-023-05987-7","volume":"14","author":"R Xu","year":"2023","unstructured":"Xu R, Song J, Ruze R, Chen Y, Yin X, Wang C et al (2023) SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src\/PI3K\/Akt signaling pathway. Cell Death Dis 14(8):497","journal-title":"Cell Death Dis"},{"issue":"1","key":"3133_CR34","doi-asserted-by":"publisher","first-page":"113805","DOI":"10.1016\/j.yexcr.2023.113805","volume":"433","author":"D Tuluhong","year":"2023","unstructured":"Tuluhong D, Gao H, Li X, Wang L, Zhu Y, Xu C et al (2023) Squalene epoxidase promotes breast cancer progression by regulating CCNB1 protein stability. Exp Cell Res 433(1):113805","journal-title":"Exp Cell Res"},{"issue":"6","key":"3133_CR35","doi-asserted-by":"publisher","first-page":"e37030","DOI":"10.1097\/MD.0000000000037030","volume":"103","author":"M Shao","year":"2024","unstructured":"Shao M, Wang M, Wang X, Feng X, Zhang L, Lv H (2024) SQLE is a promising prognostic and immunological biomarker and correlated with immune Infiltration in Sarcoma. Med (Baltim) 103(6):e37030","journal-title":"Med (Baltim)"},{"issue":"17","key":"3133_CR36","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.1007\/s00018-016-2234-x","volume":"73","author":"R Mahony","year":"2016","unstructured":"Mahony R, Ahmed S, Diskin C, Stevenson NJ (2016) SOCS3 revisited: a broad regulator of disease, now ready for therapeutic use? Cell Mol Life Sci 73(17):3323\u20133336","journal-title":"Cell Mol Life Sci"},{"key":"3133_CR37","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fimmu.2014.00058","volume":"5","author":"B Carow","year":"2014","unstructured":"Carow B, Rottenberg ME (2014) SOCS3, a Major Regulator of Infection and Inflammation. Front Immunol 5:58","journal-title":"Front Immunol"},{"issue":"7","key":"3133_CR38","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1158\/2326-6066.CIR-15-0004","volume":"3","author":"H Yu","year":"2015","unstructured":"Yu H, Liu Y, McFarland BC, Deshane JS, Hurst DR, Ponnazhagan S et al (2015) SOCS3 Deficiency in Myeloid Cells Promotes Tumor Development: Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells. Cancer Immunol Res 3(7):727\u2013740","journal-title":"Cancer Immunol Res"},{"issue":"4","key":"3133_CR39","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3892\/ol.2021.12520","volume":"21","author":"NI Kim","year":"2021","unstructured":"Kim NI, Park MH, Kweon SS, Cho N, Lee JS (2021) Squalene epoxidase expression is associated with breast tumor progression and with a poor prognosis in breast cancer. Oncol Lett 21(4):259","journal-title":"Oncol Lett"},{"issue":"16suppl","key":"3133_CR40","doi-asserted-by":"publisher","first-page":"e13101","DOI":"10.1200\/JCO.2023.41.16_suppl.e13101","volume":"41","author":"S-P Wang","year":"2023","unstructured":"Wang S-P, Yeh J-Y, Lee PY-L, Lin K-Y, Chang CD, Yang C-C et al (2023) Identification of a novel squalene epoxidase function in breast cancer brain metastasis. J Clin Oncol 41(16suppl):e13101\u2013e","journal-title":"J Clin Oncol"},{"issue":"8","key":"3133_CR41","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1002\/ijc.24172","volume":"124","author":"JL Barclay","year":"2009","unstructured":"Barclay JL, Anderson ST, Waters MJ, Curlewis JD (2009) SOCS3 as a tumor suppressor in breast cancer cells, and its regulation by PRL. Int J Cancer 124(8):1756\u20131766","journal-title":"Int J Cancer"},{"issue":"12","key":"3133_CR42","doi-asserted-by":"publisher","first-page":"992","DOI":"10.2174\/0109298665245603231106050224","volume":"30","author":"X Li","year":"2023","unstructured":"Li X, Peng B, Li J, Tian M, He L (2023) Unleashing Breast Cancer Progression: miR-455-5p\u2019s Targeting of SOCS3 Drives Proliferation, Migration, and Invasion. Protein Pept Lett 30(12):992\u20131000","journal-title":"Protein Pept Lett"},{"issue":"3","key":"3133_CR43","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41419-019-1382-y","volume":"10","author":"JZ Xu","year":"2019","unstructured":"Xu JZ, Shao CC, Wang XJ, Zhao X, Chen JQ, Ouyang YX et al (2019) circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p\/SOCS3 axis. Cell Death Dis 10(3):175","journal-title":"Cell Death Dis"},{"issue":"1","key":"3133_CR44","doi-asserted-by":"publisher","first-page":"e23388","DOI":"10.1096\/fj.202301764RR","volume":"38","author":"X Gu","year":"2024","unstructured":"Gu X, Wei F, Tong J, Liu Y, Chen S, Zheng L et al (2024) MiR-9 promotes G-MDSC recruitment and tumor proliferation by targeting SOCS3 in breast cancer. FASEB J 38(1):e23388","journal-title":"FASEB J"},{"key":"3133_CR45","doi-asserted-by":"publisher","first-page":"848394","DOI":"10.3389\/fonc.2022.848394","volume":"12","author":"BZC Weber","year":"2022","unstructured":"Weber BZC, Arabaci DH, Kir S (2022) Metabolic Reprogramming in Adipose Tissue During Cancer Cachexia. Front Oncol 12:848394","journal-title":"Front Oncol"},{"key":"3133_CR46","doi-asserted-by":"crossref","unstructured":"Rybinska I, Agresti R, Trapani A, Tagliabue E, Triulzi T (2020) Adipocytes in Breast Cancer, the Thick and the Thin. Cells 9(3):560","DOI":"10.3390\/cells9030560"},{"issue":"10","key":"3133_CR47","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1016\/j.bbalip.2013.02.010","volume":"1831","author":"KM Nieman","year":"2013","unstructured":"Nieman KM, Romero IL, Van Houten B, Lengyel E (2013) Adipose tissue and adipocytes support tumorigenesis and metastasis. Biochim Biophys Acta 1831(10):1533\u20131541","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"3133_CR48","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1128\/MCB.01344-13","volume":"34","author":"MS Madsen","year":"2014","unstructured":"Madsen MS, Siersbaek R, Boergesen M, Nielsen R, Mandrup S (2014) Peroxisome proliferator-activated receptor gamma and C\/EBPalpha synergistically activate key metabolic adipocyte genes by assisted loading. Mol Cell Biol 34(6):939\u2013954","journal-title":"Mol Cell Biol"},{"issue":"3","key":"3133_CR49","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.tjnut.2023.01.018","volume":"153","author":"CY Park","year":"2023","unstructured":"Park CY, Kim D, Seo MK, Kim J, Choe H, Kim JH et al (2023) Dysregulation of Lipid Droplet Protein Expression in Adipose Tissues and Association with Metabolic Risk Factors in Adult Females with Obesity and Type 2 Diabetes. J Nutr 153(3):691\u2013702","journal-title":"J Nutr"},{"issue":"1","key":"3133_CR50","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/s41467-023-44559-3","volume":"15","author":"Y Wang","year":"2024","unstructured":"Wang Y, Nguyen HP, Xue P, Xie Y, Yi D, Lin F et al (2024) ApoL6 associates with lipid droplets and disrupts Perilipin1-HSL interaction to inhibit lipolysis. Nat Commun 15(1):186","journal-title":"Nat Commun"},{"issue":"1","key":"3133_CR51","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10555-020-09934-2","volume":"40","author":"JF Dumas","year":"2021","unstructured":"Dumas JF, Brisson L (2021) Interaction between adipose tissue and cancer cells: role for cancer progression. Cancer Metastasis Rev 40(1):31\u201346","journal-title":"Cancer Metastasis Rev"},{"issue":"5","key":"3133_CR52","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.molmed.2017.02.009","volume":"23","author":"AJ Hoy","year":"2017","unstructured":"Hoy AJ, Balaban S, Saunders DN (2017) Adipocyte-Tumor Cell Metabolic Crosstalk in Breast Cancer. Trends Mol Med 23(5):381\u2013392","journal-title":"Trends Mol Med"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-026-03133-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-026-03133-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-026-03133-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:08:51Z","timestamp":1787663331000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-026-03133-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["3133"],"URL":"https:\/\/doi.org\/10.1007\/s10147-026-03133-9","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"assertion":[{"value":"13 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the patients signed the informed consent, and all procedures were conducted with the approval of the Medical Ethics Committee of the Second Xiangya Hospital (No.2023Yan0316). All animal experiments were approved by the Institutional Animal Care and Use Committee of the Second Xiangya Hospital of Central South University (No. 2021071).","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}