{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:06:44Z","timestamp":1793390804686,"version":"4.5.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10147-026-03134-8","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:25:39Z","timestamp":1784197539000},"page":"2312-2321","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex differences in the prognostic value of body mass index after curative nephrectomy for high-risk renal cell carcinoma: a multicenter cohort study"],"prefix":"10.1007","volume":"31","author":[{"given":"Shigeki","family":"Koterazawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Sumiyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Shibasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinari","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Segawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sojun","family":"Kanamaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Okubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Sugino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Hoshiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Maekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Takuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Yamane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7841-1104","authenticated-orcid":false,"given":"Kimihiko","family":"Masui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Daimonji Clinical Application Database Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"1","key":"3134_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.21871","volume":"75","author":"RL Siegel","year":"2025","unstructured":"Siegel RL, Kratzer TB, Giaquinto AN et al (2025) Cancer statistics, 2025. CA Cancer J Clin 75(1):10\u201345. https:\/\/doi.org\/10.3322\/caac.21871","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"3134_CR2","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.eururo.2025.06.005","volume":"88","author":"A Larcher","year":"2025","unstructured":"Larcher A, Campi R, Bex A et al (2025) Epidemiology of renal cancer: incidence, mortality, survival, genetic predisposition, and risk factors. Eur Urol 88(4):341\u2013358. https:\/\/doi.org\/10.1016\/j.eururo.2025.06.005","journal-title":"Eur Urol"},{"issue":"3","key":"3134_CR3","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.cdp.2008.08.004","volume":"32","author":"AP Polednak","year":"2008","unstructured":"Polednak AP (2008) Estimating the number of U.S. incident cancers attributable to obesity and the impact on temporal trends in incidence rates for obesity-related cancers. Cancer Detect Prev 32(3):190\u2013199. https:\/\/doi.org\/10.1016\/j.cdp.2008.08.004","journal-title":"Cancer Detect Prev"},{"issue":"9612","key":"3134_CR4","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/s0140-6736(08)60269-x","volume":"371","author":"AG Renehan","year":"2008","unstructured":"Renehan AG, Tyson M, Egger M et al (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371(9612):569\u2013578. https:\/\/doi.org\/10.1016\/s0140-6736(08)60269-x","journal-title":"Lancet"},{"issue":"1","key":"3134_CR5","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.urology.2007.03.034","volume":"70","author":"Y Awakura","year":"2007","unstructured":"Awakura Y, Nakamura E, Ito N et al (2007) Influence of body mass index on prognosis of Japanese patients with renal cell carcinoma. Urology 70(1):50\u201354. https:\/\/doi.org\/10.1016\/j.urology.2007.03.034","journal-title":"Urology"},{"issue":"1","key":"3134_CR6","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/s0022-5347(05)00054-6","volume":"175","author":"SM Donat","year":"2006","unstructured":"Donat SM, Salzhauer EW, Mitra N et al (2006) Impact of body mass index on survival of patients with surgically treated renal cell carcinoma. J Urol 175(1):46\u201352. https:\/\/doi.org\/10.1016\/s0022-5347(05)00054-6","journal-title":"J Urol"},{"issue":"1","key":"3134_CR7","doi-asserted-by":"publisher","first-page":"e173","DOI":"10.1016\/j.clgc.2017.08.015","volume":"16","author":"SS Byun","year":"2017","unstructured":"Byun SS, Hwang EC, Kang SH et al (2017) Sex-specific prognostic significance of obesity in nonmetastatic clear-cell renal-cell carcinoma in Korea: a large multicenter cohort analysis. Clin Genitourin Cancer 16(1):e173\u2013e179. https:\/\/doi.org\/10.1016\/j.clgc.2017.08.015","journal-title":"Clin Genitourin Cancer"},{"issue":"7","key":"3134_CR8","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1038\/bjc.2013.512","volume":"109","author":"Y Ohno","year":"2013","unstructured":"Ohno Y, Nakashima J, Nakagami Y et al (2013) Sex and the clinical value of body mass index in patients with clear cell renal cell carcinoma. Br J Cancer 109(7):1899\u20131903. https:\/\/doi.org\/10.1038\/bjc.2013.512","journal-title":"Br J Cancer"},{"issue":"1","key":"3134_CR9","doi-asserted-by":"publisher","first-page":"50.e19","DOI":"10.1016\/j.urolonc.2022.09.020","volume":"41","author":"E Midenberg","year":"2023","unstructured":"Midenberg E, Higgins MI, Schmeusser BN et al (2023) Prognostic value of sarcopenia and albumin in the surgical management of localized renal cell carcinoma. Urol Oncol 41(1):50.e19-50.e26. https:\/\/doi.org\/10.1016\/j.urolonc.2022.09.020","journal-title":"Urol Oncol"},{"issue":"5","key":"3134_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2025.102400","volume":"23","author":"S Koterazawa","year":"2025","unstructured":"Koterazawa S, Sumiyoshi T, Ito K et al (2025) Risk stratification for the prognosis of patients with pT3aN0M0 clear cell renal cell carcinoma. Clin Genitourin Cancer 23(5):102400. https:\/\/doi.org\/10.1016\/j.clgc.2025.102400","journal-title":"Clin Genitourin Cancer"},{"issue":"8","key":"3134_CR11","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1056\/NEJMoa2106391","volume":"385","author":"TK Choueiri","year":"2021","unstructured":"Choueiri TK, Tomczak P, Park SH et al (2021) Adjuvant pembrolizumab after nephrectomy in renal-cell carcinoma. N Engl J Med 385(8):683\u2013694. https:\/\/doi.org\/10.1056\/NEJMoa2106391","journal-title":"N Engl J Med"},{"issue":"1","key":"3134_CR12","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.eururo.2016.02.029","volume":"70","author":"H Moch","year":"2016","unstructured":"Moch H, Cubilla AL, Humphrey PA et al (2016) The 2016 WHO classification of tumours of the urinary system and male genital organs-Part A: renal, penile, and testicular tumours. Eur Urol 70(1):93\u2013105. https:\/\/doi.org\/10.1016\/j.eururo.2016.02.029","journal-title":"Eur Urol"},{"issue":"4","key":"3134_CR13","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.eururo.2017.12.018","volume":"73","author":"GP Paner","year":"2018","unstructured":"Paner GP, Stadler WM, Hansel DE et al (2018) Updates in the eighth edition of the tumor-node-metastasis staging classification for urologic cancers. Eur Urol 73(4):560\u2013569. https:\/\/doi.org\/10.1016\/j.eururo.2017.12.018","journal-title":"Eur Urol"},{"issue":"3","key":"3134_CR14","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y (2013) Investigation of the freely available easy-to-use software \u201cEZR\u201d for medical statistics. Bone Marrow Transplant 48(3):452\u2013458. https:\/\/doi.org\/10.1038\/bmt.2012.244","journal-title":"Bone Marrow Transplant"},{"issue":"12","key":"3134_CR15","doi-asserted-by":"publisher","first-page":"457","DOI":"10.2188\/jea.JE20180124","volume":"29","author":"A Hozawa","year":"2019","unstructured":"Hozawa A, Hirata T, Yatsuya H et al (2019) Association between body mass index and all-cause death in Japanese population: pooled individual participant data analysis of 13 cohort studies. J Epidemiol 29(12):457\u2013463. https:\/\/doi.org\/10.2188\/jea.JE20180124","journal-title":"J Epidemiol"},{"issue":"5","key":"3134_CR16","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1136\/bjsm.37.5.436","volume":"37","author":"T Abe","year":"2003","unstructured":"Abe T, Kearns CF, Fukunaga T (2003) Sex differences in whole body skeletal muscle mass measured by magnetic resonance imaging and its distribution in young Japanese adults. Br J Sports Med 37(5):436\u2013440. https:\/\/doi.org\/10.1136\/bjsm.37.5.436","journal-title":"Br J Sports Med"},{"issue":"4","key":"3134_CR17","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1245\/s10434-021-10881-7","volume":"29","author":"J Lee","year":"2022","unstructured":"Lee J, Suh J, Song C et al (2022) Association between sarcopenia and survival of patients with organ-confined renal cell carcinoma after radical nephrectomy. Ann Surg Oncol 29(4):2473\u20132479. https:\/\/doi.org\/10.1245\/s10434-021-10881-7","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"3134_CR18","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000024400","volume":"100","author":"Y Soh","year":"2021","unstructured":"Soh Y, Won CW (2021) Sex differences in association between body composition and frailty or physical performance in community-dwelling older adults. Medicine (Baltimore) 100(4):e24400. https:\/\/doi.org\/10.1097\/md.0000000000024400","journal-title":"Medicine (Baltimore)"},{"key":"3134_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2016.12.036","volume":"394","author":"K Wang","year":"2017","unstructured":"Wang K, Sun Y, Tao W et al (2017) Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1\/miR-195-5p\/29a-3p\/29c-3p\/CDC42 signals. Cancer Lett 394:1\u201312. https:\/\/doi.org\/10.1016\/j.canlet.2016.12.036","journal-title":"Cancer Lett"},{"issue":"6","key":"3134_CR20","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1530\/eje-12-0955","volume":"168","author":"G Corona","year":"2013","unstructured":"Corona G, Rastrelli G, Monami M et al (2013) Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis. Eur J Endocrinol 168(6):829\u2013843. https:\/\/doi.org\/10.1530\/eje-12-0955","journal-title":"Eur J Endocrinol"},{"issue":"11","key":"3134_CR21","doi-asserted-by":"publisher","first-page":"4589","DOI":"10.1210\/endo.142.11.8547","volume":"142","author":"ER Simpson","year":"2001","unstructured":"Simpson ER, Davis SR (2001) Minireview: aromatase and the regulation of estrogen biosynthesis\u2013some new perspectives. Endocrinology 142(11):4589\u20134594. https:\/\/doi.org\/10.1210\/endo.142.11.8547","journal-title":"Endocrinology"},{"issue":"5","key":"3134_CR22","doi-asserted-by":"publisher","first-page":"E528","DOI":"10.1152\/ajpendo.00075.2017","volume":"313","author":"KB Rubinow","year":"2017","unstructured":"Rubinow KB, Chao JH, Hagman D et al (2017) Circulating sex steroids coregulate adipose tissue immune cell populations in healthy men. Am J Physiol Endocrinol Metab 313(5):E528-e539. https:\/\/doi.org\/10.1152\/ajpendo.00075.2017","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"3134_CR23","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s13293-024-00677-1","volume":"15","author":"LT Schuetz","year":"2024","unstructured":"Schuetz LT, Duran G, Baeten P et al (2024) Sex differentially affects pro-inflammatory cell subsets in adipose tissue depots in a diet induced obesity model. Biol Sex Differ 15(1):105. https:\/\/doi.org\/10.1186\/s13293-024-00677-1","journal-title":"Biol Sex Differ"},{"key":"3134_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1323192","volume":"14","author":"Q Tang","year":"2024","unstructured":"Tang Q, Li X, Sun CR (2024) Predictive value of serum albumin levels on cancer survival: a prospective cohort study. Front Oncol 14:1323192. https:\/\/doi.org\/10.3389\/fonc.2024.1323192","journal-title":"Front Oncol"},{"issue":"12","key":"3134_CR25","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1007\/s00277-014-2155-4","volume":"93","author":"T Ju\u00e1rez-Cedillo","year":"2014","unstructured":"Ju\u00e1rez-Cedillo T, Basurto-Acevedo L, Vega-Garc\u00eda S et al (2014) Prevalence of anemia and its impact on the state of frailty in elderly people living in the community: SADEM study. Ann Hematol 93(12):2057\u20132062. https:\/\/doi.org\/10.1007\/s00277-014-2155-4","journal-title":"Ann Hematol"},{"issue":"8","key":"3134_CR26","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s12603-018-1049-x","volume":"22","author":"K Palmer","year":"2018","unstructured":"Palmer K, Vetrano DL, Marengoni A et al (2018) The relationship between anaemia and frailty: a systematic review and meta-analysis of observational studies. J Nutr Health Aging 22(8):965\u2013974. https:\/\/doi.org\/10.1007\/s12603-018-1049-x","journal-title":"J Nutr Health Aging"},{"issue":"10","key":"3134_CR27","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1007\/s10147-025-02823-0","volume":"30","author":"T Anami","year":"2025","unstructured":"Anami T, Motoshima T, Matsushita Y et al (2025) Impact of body mass index on the efficacy of immune combination therapy in metastatic renal cell carcinoma: a multicenter study in Japan. Int J Clin Oncol 30(10):2079\u20132086. https:\/\/doi.org\/10.1007\/s10147-025-02823-0","journal-title":"Int J Clin Oncol"},{"key":"3134_CR28","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.euros.2022.03.002","volume":"39","author":"K Takemura","year":"2022","unstructured":"Takemura K, Yonekura S, Downey LE et al (2022) Impact of body mass index on survival outcomes of patients with metastatic renal cell carcinoma in the immuno-oncology era: a systematic review and meta-analysis. Eur Urol Open Sci 39:62\u201371. https:\/\/doi.org\/10.1016\/j.euros.2022.03.002","journal-title":"Eur Urol Open Sci"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-026-03134-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-026-03134-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-026-03134-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:50:30Z","timestamp":1790355030000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-026-03134-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["3134"],"URL":"https:\/\/doi.org\/10.1007\/s10147-026-03134-8","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]},"assertion":[{"value":"29 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present study was conducted according to the ethical standards established by the Declaration of Helsinki. The Institutional Review Board of Kyoto University Hospital approved this study and the Common Study Database (R1581).","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The need for informed consent was waived because of the retrospective design of the study.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}