{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:06:36Z","timestamp":1790355996278,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Oncol"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10147-026-03163-3","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T12:15:47Z","timestamp":1786104947000},"page":"2150-2157","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pain response after palliative-intent radiotherapy for pancreatic cancer: a systematic review"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-6708","authenticated-orcid":false,"given":"Kenji","family":"Makita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Hiroshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Takehana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Shioyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"3163_CR1","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41575-021-00457-x","volume":"18","author":"AP Klein","year":"2021","unstructured":"Klein AP (2021) Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors. Nat Rev Gastroenterol Hepatol 18:493\u2013502","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"3163_CR2","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.21873\/anticanres.14133","volume":"40","author":"I Lohse","year":"2020","unstructured":"Lohse I, Brothers SP (2020) Pathogenesis and treatment of pancreatic cancer related pain. Anticancer Res 40:1789\u20131796","journal-title":"Anticancer Res"},{"key":"3163_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-020-00801-4","volume":"22","author":"KG Lee","year":"2021","unstructured":"Lee KG, Roy V, Laszlo M et al (2021) Symptom management in pancreatic cancer. Curr Treat Options Oncol 22:8","journal-title":"Curr Treat Options Oncol"},{"key":"3163_CR4","doi-asserted-by":"publisher","first-page":"e971","DOI":"10.1002\/onco.13796","volume":"26","author":"AL Coveler","year":"2021","unstructured":"Coveler AL, Mizrahi J, Eastman B et al (2021) Pancreas cancer-associated pain management. Oncologist 26:e971\u2013e982","journal-title":"Oncologist"},{"key":"3163_CR5","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1111\/ans.13609","volume":"86","author":"L Dobosz","year":"2016","unstructured":"Dobosz L, Kaczor M, Stefaniak TJ (2016) Pain in pancreatic cancer: review of medical and surgical remedies. ANZ J Surg 86:756\u2013761","journal-title":"ANZ J Surg"},{"issue":"Suppl 7","key":"3163_CR6","doi-asserted-by":"publisher","first-page":"vii33","DOI":"10.1093\/annonc\/mds224","volume":"23","author":"T Seufferlein","year":"2012","unstructured":"Seufferlein T, Bachet JB, Van Cutsem E et al (2012) Pancreatic adenocarcinoma: ESMO-ESDO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 23(Suppl 7):vii33-40","journal-title":"Ann Oncol"},{"key":"3163_CR7","doi-asserted-by":"publisher","first-page":"439","DOI":"10.6004\/jnccn.2021.0017","volume":"19","author":"MA Tempero","year":"2021","unstructured":"Tempero MA, Malafa MP, Al-Hawary M et al (2021) Pancreatic adenocarcinoma, version 2.2021, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 19:439\u2013457","journal-title":"J Natl Compr Canc Netw"},{"key":"3163_CR8","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.pain.2004.09.019","volume":"112","author":"E Kalso","year":"2004","unstructured":"Kalso E, Edwards JE, Moore AR et al (2004) Opioids in chronic non-cancer pain: systematic review of efficacy and safety. Pain 112:372\u2013380","journal-title":"Pain"},{"key":"3163_CR9","doi-asserted-by":"publisher","first-page":"R1046","DOI":"10.1186\/ar1782","volume":"7","author":"RA Moore","year":"2005","unstructured":"Moore RA, McQuay HJ (2005) Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids. Arthritis Res Ther 7:R1046-1051","journal-title":"Arthritis Res Ther"},{"key":"3163_CR10","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13014-022-02076-5","volume":"17","author":"M Vornhulz","year":"2022","unstructured":"Vornhulz M, Anton S, Eross B et al (2022) Role of stereotactic body radiation in the enhancement of the quality of life in locally advanced pancreatic adenocarcinoma: a systematic review. Radiat Oncol 17:108","journal-title":"Radiat Oncol"},{"key":"3163_CR11","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.3390\/curroncol29040214","volume":"29","author":"M Buwenge","year":"2022","unstructured":"Buwenge M, Arcelli A, Cellini F et al (2022) Pain relief after stereotactic radiotherapy of pancreatic adenocarcinoma: an updated systematic review. Curr Oncol 29:2616\u20132629","journal-title":"Curr Oncol"},{"key":"3163_CR12","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1016\/j.ijrobp.2004.01.035","volume":"59","author":"AG Morganti","year":"2004","unstructured":"Morganti AG, Valentini V, Macchia G et al (2004) 5-fluorouracil-based chemoradiation in unresectable pancreatic carcinoma: phase I-II dose-escalation study. Int J Radiat Oncol Biol Phys 59:1454\u20131460","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"3163_CR13","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/j.ijrobp.2004.12.041","volume":"62","author":"H Kawakami","year":"2005","unstructured":"Kawakami H, Uno T, Isobe K et al (2005) Toxicities and effects of involved-field irradiation with concurrent cisplatin for unresectable carcinoma of the pancreas. Int J Radiat Oncol Biol Phys 62:1357\u20131362","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"3163_CR14","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1002\/1097-0142(20001201)89:11<2222::AID-CNCR10>3.0.CO;2-V","volume":"89","author":"HM Ceha","year":"2000","unstructured":"Ceha HM, van Tienhoven G, Gouma DJ et al (2000) Feasibility and efficacy of high dose conformal radiotherapy for patients with locally advanced pancreatic carcinoma. Cancer 89:2222\u20132229","journal-title":"Cancer"},{"key":"3163_CR15","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/0360-3016(90)90486-4","volume":"19","author":"Y Shibamoto","year":"1990","unstructured":"Shibamoto Y, Manabe T, Baba N et al (1990) High dose, external beam and intraoperative radiotherapy in the treatment of resectable and unresectable pancreatic cancer. Int J Radiat Oncol Biol Phys 19:605\u2013611","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"3163_CR16","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/S0360-3016(01)01708-4","volume":"51","author":"G Boz","year":"2001","unstructured":"Boz G, De Paoli A, Innocente R et al (2001) Radiotherapy and continuous infusion 5-fluorouracil in patients with nonresectable pancreatic carcinoma. Int J Radiat Oncol Biol Phys 51:736\u2013740","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"3163_CR17","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/S0360-3016(01)02806-1","volume":"53","author":"H Shinchi","year":"2002","unstructured":"Shinchi H, Takao S, Noma H et al (2002) Length and quality of survival after external-beam radiotherapy with concurrent continuous 5-fluorouracil infusion for locally unresectable pancreatic cancer. Int J Radiat Oncol Biol Phys 53:146\u2013150","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"3163_CR18","volume-title":"Minds handbook for clinical practice guideline development 2014","author":"TYM Morizane","year":"2014","unstructured":"Morizane TYM, Kojimahara N (2014) Minds handbook for clinical practice guideline development 2014. Japan Council for Quality Health Care"},{"key":"3163_CR19","unstructured":"Kojimahara N NT, Morizane T et al (2017) Minds manual for guideline development 2017. Japan Council for Quality Health Care."},{"key":"3163_CR20","first-page":"246","volume":"52","author":"FB Zimmermann","year":"2005","unstructured":"Zimmermann FB, Jeremic B, Lersch C et al (2005) Dose escalation of concurrent hypofractionated radiotherapy and continuous infusion 5-FU-chemotherapy in advanced adenocarcinoma of the pancreas. Hepatogastroenterology 52:246\u2013250","journal-title":"Hepatogastroenterology"},{"key":"3163_CR21","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1177\/082585970301900407","volume":"19","author":"AG Morganti","year":"2003","unstructured":"Morganti AG, Trodella L, Valentini V et al (2003) Pain relief with short-term irradiation in locally advanced carcinoma of the pancreas. J Palliat Care 19:258\u2013262","journal-title":"J Palliat Care"},{"key":"3163_CR22","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.3892\/mco.2016.851","volume":"4","author":"E Wolny-Rokicka","year":"2016","unstructured":"Wolny-Rokicka E, Sutkowski K, Grzadziel A et al (2016) Tolerance and efficacy of palliative radiotherapy for advanced pancreatic cancer: a retrospective analysis of single-institutional experiences. Mol Clin Oncol 4:1088\u20131092","journal-title":"Mol Clin Oncol"},{"key":"3163_CR23","doi-asserted-by":"publisher","first-page":"891","DOI":"10.21037\/apm-22-1417","volume":"12","author":"AKN Liu","year":"2023","unstructured":"Liu AKN, Lefresne S (2023) Palliative radiotherapy in pancreatic cancer: a retrospective study of 100 cases and regional patterns of practice. Ann Palliat Med 12:891\u2013899","journal-title":"Ann Palliat Med"},{"key":"3163_CR24","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.ijrobp.2023.08.055","volume":"118","author":"CP Tello Valverde","year":"2024","unstructured":"Tello Valverde CP, Ebrahimi G, Sprangers MA et al (2024) Impact of short-course palliative radiation therapy on pancreatic cancer-related pain: prospective phase 2 nonrandomized PAINPANC trial. Int J Radiat Oncol Biol Phys 118:352\u2013361","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"3163_CR25","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.ijrobp.2022.02.038","volume":"113","author":"L Hammer","year":"2022","unstructured":"Hammer L, Hausner D, Ben-Ayun M et al (2022) Single-fraction celiac plexus radiosurgery: a preliminary proof-of-concept phase 2 clinical trial. Int J Radiat Oncol Biol Phys 113:588\u2013593","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"3163_CR26","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/S1470-2045(24)00223-7","volume":"25","author":"YR Lawrence","year":"2024","unstructured":"Lawrence YR, Miszczyk M, Dawson LA et al (2024) Celiac plexus radiosurgery for pain management in advanced cancer: a multicentre, single-arm, phase 2 trial. Lancet Oncol 25:1070\u20131079","journal-title":"Lancet Oncol"},{"key":"3163_CR27","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.canrad.2018.02.004","volume":"22","author":"Q Tian","year":"2018","unstructured":"Tian Q, Zhang F, Wang Y (2018) Clinical assessment of palliative radiotherapy for pancreatic cancer. Cancer Radiother 22:778\u2013783","journal-title":"Cancer Radiother"},{"key":"3163_CR28","doi-asserted-by":"publisher","first-page":"8156","DOI":"10.3748\/wjg.v21.i26.8156","volume":"21","author":"TS Su","year":"2015","unstructured":"Su TS, Liang P, Lu HZ et al (2015) Stereotactic body radiotherapy using CyberKnife for locally advanced unresectable and metastatic pancreatic cancer. World J Gastroenterol 21:8156\u20138162","journal-title":"World J Gastroenterol"},{"key":"3163_CR29","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.jmir.2018.04.033","volume":"49","author":"Y Wang","year":"2018","unstructured":"Wang Y, Timotin E, Zia W et al (2018) Pain palliation using hypofractionated radiotherapy for unresectable pancreatic cancer. J Med Imaging Radiat Sci 49:293\u2013300","journal-title":"J Med Imaging Radiat Sci"},{"key":"3163_CR30","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.prro.2020.02.010","volume":"10","author":"AJ Koong","year":"2020","unstructured":"Koong AJ, Toesca DAS, Baclay JRM et al (2020) The utility of stereotactic ablative radiation therapy for palliation of metastatic pancreatic adenocarcinoma. Pract Radiat Oncol 10:274\u2013281","journal-title":"Pract Radiat Oncol"},{"key":"3163_CR31","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.ijrobp.2023.01.050","volume":"116","author":"N Imano","year":"2023","unstructured":"Imano N, Saito T, Hoskin P et al (2023) Pain response rates after conventional radiation therapy for bone metastases assessed using international consensus pain response endpoints: a systematic review and meta-analysis of initial radiation therapy and reirradiation. Int J Radiat Oncol Biol Phys 116:739\u2013746","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"3163_CR32","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.radonc.2018.01.003","volume":"126","author":"SE Rich","year":"2018","unstructured":"Rich SE, Chow R, Raman S et al (2018) Update of the systematic review of palliative radiation therapy fractionation for bone metastases. Radiother Oncol 126:547\u2013557","journal-title":"Radiother Oncol"},{"key":"3163_CR33","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.adro.2019.06.003","volume":"4","author":"T Saito","year":"2019","unstructured":"Saito T, Yamaguchi K, Toya R et al (2019) Single- versus multiple-fraction radiation therapy for painful bone metastases: a systematic review and meta-analysis of nonrandomized studies. Adv Radiat Oncol 4:706\u2013715","journal-title":"Adv Radiat Oncol"},{"key":"3163_CR34","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.clon.2019.03.042","volume":"31","author":"T Saito","year":"2019","unstructured":"Saito T, Tomitaka E, Toya R et al (2019) Possible dose-response relationship in palliative radiotherapy for non-bone painful lesions. Clin Oncol (R Coll Radiol) 31:391\u2013398","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"3163_CR35","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1093\/jrr\/rrae025","volume":"65","author":"N Imano","year":"2024","unstructured":"Imano N, Kosugi T, Konishi K et al (2024) Pain response in single-fraction 8-Gy radiotherapy for painful non-bone-metastasis tumors: a single-center retrospective study. J Radiat Res 65:408\u2013412","journal-title":"J Radiat Res"},{"key":"3163_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2025.110901","volume":"208","author":"Y Koide","year":"2025","unstructured":"Koide Y, Noguchi M, Shindo Y et al (2025) Pain response to palliative radiotherapy in bone metastases vs. non-bone lesions: prospective study. Radiother Oncol 208:110901","journal-title":"Radiother Oncol"},{"key":"3163_CR37","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.bbcan.2017.02.003","volume":"1868","author":"P Seshacharyulu","year":"2017","unstructured":"Seshacharyulu P, Baine MJ, Souchek JJ et al (2017) Biological determinants of radioresistance and their remediation in pancreatic cancer. Biochim Biophys Acta Rev Cancer 1868:69\u201392","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"3163_CR38","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.ijrobp.2016.10.030","volume":"97","author":"F Petrelli","year":"2017","unstructured":"Petrelli F, Comito T, Ghidini A et al (2017) Stereotactic body radiation therapy for locally advanced pancreatic cancer: a systematic review and pooled analysis of 19 trials. Int J Radiat Oncol Biol Phys 97:313\u2013322","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-026-03163-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10147-026-03163-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10147-026-03163-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:50:12Z","timestamp":1790355012000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10147-026-03163-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["3163"],"URL":"https:\/\/doi.org\/10.1007\/s10147-026-03163-3","relation":{},"ISSN":["1341-9625","1437-7772"],"issn-type":[{"value":"1341-9625","type":"print"},{"value":"1437-7772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]},"assertion":[{"value":"21 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}