{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:20:02Z","timestamp":1770337202390,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006389","name":"Universit\u00e9 de Gen\u00e8ve","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006389","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tech Coloproctol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The development of high-resolution anoscopy (HRA) has advanced our ability to detect anal dysplasia. Historically, HRA is performed in a clinical setting and subsequent ablation is performed in the clinical setting or operating room. The aim of this study was to determine the most effective venue for the performance of HRA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Following institutional review board (IRB) approval, the correlation between anal cytology and HRA performed in the clinic versus in the operating room was evaluated. Data were extracted from our IRB-approved prospective HRA database over the time period of 2013\u20132017.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>One hundred twenty-eight HRAs were compared (101 in the clinical setting, 27 in the operating room). There was a statistically significant difference in the correlation between anal cytology and HRA pathology for procedures performed in the clinical setting (55% [56\/101]) versus those performed in the operating room (82% [22\/27]) (<jats:italic>p<\/jats:italic>\u2009=\u20090.014). More biopsies were obtained in the operating room than in the clinic setting (3 vs. 1, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The majority of patients who had HRA in a clinical setting with subsequent HRA in the operating room stated that they preferred to have their HRAs performed in the operating room due to discomfort from the HRA procedure.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Detection rates for anal dysplasia on HRA, are significantly higher when performed in the operating room. To prevent discomfort in the clinical setting, patients with high-grade dysplasia on anal pap testing may benefit from proceeding directly to the operating room for concurrent HRA and ablation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10151-021-02416-9","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T09:20:56Z","timestamp":1613035256000},"page":"461-466","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High-resolution anoscopy, is there a benefit in proceeding directly to the operating room?"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9020-8416","authenticated-orcid":false,"given":"B.","family":"Moeckli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Canner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Najafian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Carbunaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Cowell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Atallah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Paredes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Chudnovets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. H.","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"2416_CR1","unstructured":"SEER Stat Fact Sheets: Anal Cancer (2018) National Cancer Institute."},{"issue":"7","key":"2416_CR2","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1097\/DCR.0b013e318255815e","volume":"55","author":"SR Steele","year":"2012","unstructured":"Steele SR, Varma MG, Melton GB, Ross HM, Rafferty JF, Buie WD, Standards Practice Task Force of the American Society of C, Rectal S (2012) Practice parameters for anal squamous neoplasms. Dis Colon Rectum 55(7):735\u2013749. https:\/\/doi.org\/10.1097\/DCR.0b013e318255815e","journal-title":"Dis Colon Rectum"},{"issue":"1","key":"2416_CR3","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/sj.bjc.6603175","volume":"95","author":"DH Brewster","year":"2006","unstructured":"Brewster DH, Bhatti LA (2006) Increasing incidence of squamous cell carcinoma of the anus in Scotland, 1975\u20132002. Br J Cancer 95(1):87\u201390. https:\/\/doi.org\/10.1038\/sj.bjc.6603175","journal-title":"Br J Cancer"},{"issue":"4","key":"2416_CR4","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1097\/QAI.0b013e31817aebfe","volume":"48","author":"G D'Souza","year":"2008","unstructured":"D\u2019Souza G, Wiley DJ, Li X, Chmiel JS, Margolick JB, Cranston RD, Jacobson LP (2008) Incidence and epidemiology of anal cancer in the multicenter AIDS cohort study. J Acquir Immun Defic Syndr 48(4):491\u2013499. https:\/\/doi.org\/10.1097\/QAI.0b013e31817aebfe","journal-title":"J Acquir Immun Defic Syndr"},{"issue":"1","key":"2416_CR5","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/bjc.2011.196","volume":"105","author":"G Foley","year":"2011","unstructured":"Foley G, Alston R, Geraci M, Brabin L, Kitchener H, Birch J (2011) Increasing rates of cervical cancer in young women in England: an analysis of national data 1982\u20132006. Br J Cancer 105(1):177\u2013184. https:\/\/doi.org\/10.1038\/bjc.2011.196","journal-title":"Br J Cancer"},{"issue":"19","key":"2416_CR6","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1056\/NEJM199711063371904","volume":"337","author":"M Frisch","year":"1997","unstructured":"Frisch M, Glimelius B, van den Brule AJ, Wohlfahrt J, Meijer CJ, Walboomers JM, Goldman S, Svensson C, Adami HO, Melbye M (1997) Sexually transmitted infection as a cause of anal cancer. N Engl J Med 337(19):1350\u20131358. https:\/\/doi.org\/10.1056\/NEJM199711063371904","journal-title":"N Engl J Med"},{"issue":"5","key":"2416_CR7","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1681\/ASN.2015040345","volume":"27","author":"PP Reese","year":"2016","unstructured":"Reese PP, Hall IE, Weng FL, Schroppel B, Doshi MD, Hasz RD, Thiessen-Philbrook H, Ficek J, Rao V, Murray P, Lin H, Parikh CR (2016) Associations between deceased-donor urine injury biomarkers and kidney transplant outcomes. J Am Soc Nephrol 27(5):1534\u20131543. https:\/\/doi.org\/10.1681\/ASN.2015040345","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"2416_CR8","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.5858\/arpa.LGT200570","volume":"136","author":"TM Darragh","year":"2012","unstructured":"Darragh TM, Colgan TJ, Cox JT, Heller DS, Henry MR, Luff RD, McCalmont T, Nayar R, Palefsky JM, Stoler MH, Wilkinson EJ, Zaino RJ, Wilbur DC, Members of LPWG (2012) The lower anogenital squamous terminology standardization project for HPV-associated lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology. Arch Pathol Lab Med 136(10):1266\u20131297. https:\/\/doi.org\/10.5858\/arpa.LGT200570","journal-title":"Arch Pathol Lab Med"},{"issue":"6","key":"2416_CR9","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1111\/j.1365-2133.2010.09712.x","volume":"162","author":"A Kreuter","year":"2010","unstructured":"Kreuter A, Potthoff A, Brockmeyer NH, Gambichler T, Swoboda J, Stucker M, Schmitt M, Pfister H, Wieland U, German Competence Network HA (2010) Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany. Br J Dermatol 162(6):1269\u20131277. https:\/\/doi.org\/10.1111\/j.1365-2133.2010.09712.x","journal-title":"Br J Dermatol"},{"issue":"9","key":"2416_CR10","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1002\/bjs.4994","volume":"92","author":"JH Scholefield","year":"2005","unstructured":"Scholefield JH, Castle MT, Watson NF (2005) Malignant transformation of high-grade anal intraepithelial neoplasia. Br J Surg 92(9):1133\u20131136. https:\/\/doi.org\/10.1002\/bjs.4994","journal-title":"Br J Surg"},{"issue":"8","key":"2416_CR11","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1111\/j.1445-2197.2006.03837.x","volume":"76","author":"AJ Watson","year":"2006","unstructured":"Watson AJ, Smith BB, Whitehead MR, Sykes PH, Frizelle FA (2006) Malignant progression of anal intra-epithelial neoplasia. ANZ J Surg 76(8):715\u2013717. https:\/\/doi.org\/10.1111\/j.1445-2197.2006.03837.x","journal-title":"ANZ J Surg"},{"key":"2416_CR12","unstructured":"SEER Cancer Statistics Review, 1975\u20132014, National Cancer Institute. Bethesda, MD, https:\/\/seer.cancer.gov\/csr\/1975_2014\/, based on November 2016 SEER data submission, posted to the SEER web site, April 2017 (2017) https:\/\/seer.cancer.gov\/csr\/1975_2014\/."},{"issue":"9","key":"2416_CR13","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1038\/bjc.2016.290","volume":"115","author":"R Landy","year":"2016","unstructured":"Landy R, Pesola F, Castanon A, Sasieni P (2016) Impact of cervical screening on cervical cancer mortality: estimation using stage-specific results from a nested case-control study. Br J Cancer 115(9):1140\u20131146. https:\/\/doi.org\/10.1038\/bjc.2016.290","journal-title":"Br J Cancer"},{"issue":"8666","key":"2416_CR14","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/s0140-6736(89)90830-1","volume":"334","author":"JH Scholefield","year":"1989","unstructured":"Scholefield JH, Talbot IC, Whatrup C, Sonnex C, Palmer JG, Mindel A, Northover JMA (1989) Anal and cervical intraepithelial neoplasia: possible parallel. The Lancet 334(8666):765\u2013769. https:\/\/doi.org\/10.1016\/s0140-6736(89)90830-1","journal-title":"The Lancet"},{"issue":"6","key":"2416_CR15","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1071\/SH12045","volume":"9","author":"JM Palefsky","year":"2012","unstructured":"Palefsky JM (2012) Practising high-resolution anoscopy. Sex Health 9(6):580\u2013586. https:\/\/doi.org\/10.1071\/SH12045","journal-title":"Sex Health"},{"issue":"6","key":"2416_CR16","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1097\/QAD.0000000000000160","volume":"28","author":"A Dalla Pria","year":"2014","unstructured":"Dalla Pria A, Alfa-Wali M, Fox P, Holmes P, Weir J, Francis N, Bower M (2014) High-resolution anoscopy screening of HIV-positive MSM: longitudinal results from a pilot study. AIDS 28(6):861\u2013867. https:\/\/doi.org\/10.1097\/QAD.0000000000000160","journal-title":"AIDS"},{"issue":"9","key":"2416_CR17","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1097\/QAD.0000000000001045","volume":"30","author":"AM Schofield","year":"2016","unstructured":"Schofield AM, Sadler L, Nelson L, Gittins M, Desai M, Sargent A, McMahon RF, Hill J, Crosbie EJ, Patnick J, Kitchener HC (2016) A prospective study of anal cancer screening in HIV-positive and negative MSM. AIDS 30(9):1375\u20131383. https:\/\/doi.org\/10.1097\/QAD.0000000000001045","journal-title":"AIDS"},{"issue":"5","key":"2416_CR18","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1097\/QAD.0b013e3283434594","volume":"25","author":"JM Lam","year":"2011","unstructured":"Lam JM, Hoch JS, Tinmouth J, Sano M, Raboud J, Salit IE (2011) Cost-effectiveness of screening for anal precancers in HIV-positive men. AIDS 25(5):635\u2013642. https:\/\/doi.org\/10.1097\/QAD.0b013e3283434594","journal-title":"AIDS"},{"issue":"1","key":"2416_CR19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1071\/SH11135","volume":"10","author":"LP Botes","year":"2013","unstructured":"Botes LP, Pett S, Carr A, Marriott D, Cooper DA, Matthews G, Carbone S, Kumaradevan N, McHugh L, Hillman RJ (2013) Anal cytological abnormalities are poor predictors of high-grade intraepithelial neoplasia amongst HIV-positive men who have sex with men. Sex Health 10(1):9\u201317. https:\/\/doi.org\/10.1071\/SH11135","journal-title":"Sex Health"},{"issue":"2","key":"2416_CR20","doi-asserted-by":"publisher","first-page":"199","DOI":"10.5858\/arpa.2012-0250-OA","volume":"137","author":"BA Crothers","year":"2013","unstructured":"Crothers BA, Jones BA, Cahill LA, Moriarty AT, Mody DR, Tench WD, Souers RJ (2013) Quality improvement opportunities in gynecologic cytologic-histologic correlations: findings from the College of American Pathologists Gynecologic Cytopathology Quality Consensus Conference working group 4. Arch Pathol Lab Med 137(2):199\u2013213. https:\/\/doi.org\/10.5858\/arpa.2012-0250-OA","journal-title":"Arch Pathol Lab Med"},{"issue":"5","key":"2416_CR21","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1093\/ajcp\/103.5.594","volume":"103","author":"DM Tritz","year":"1995","unstructured":"Tritz DM, Weeks JA, Spires SE, Sattich M, Banks H, Cibull ML, Davey DD (1995) Etiologies for non-correlating cervical cytologies and biopsies. Am J Clin Pathol 103(5):594\u2013597","journal-title":"Am J Clin Pathol"},{"key":"2416_CR22","unstructured":"Joste NE, Crum CP, Cibas ES (1995) Cytologic\/histologic correlation for quality control in cervicovaginal cytology. Experience with 1,582 paired cases. Am J Clin Pathol 103(1):32\u201334"},{"issue":"1","key":"2416_CR23","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1097\/QAI.0b013e3182a9b3d3","volume":"65","author":"R Silvera","year":"2014","unstructured":"Silvera R, Gaisa MM, Goldstone SE (2014) Random biopsy during high-resolution anoscopy increases diagnosis of anal high-grade squamous intraepithelial lesions. J Acquir Immune Defic Syndr 65(1):65\u201371. https:\/\/doi.org\/10.1097\/QAI.0b013e3182a9b3d3","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2416_CR24","doi-asserted-by":"publisher","unstructured":"Pineda CE, Berry JM, Jay N, Palefsky JM, Welton ML (2008) High-resolution anoscopy targeted surgical destruction of anal high-grade squamous intraepithelial lesions: a ten-year experience. Dis Colon Rectum 51 (6):829\u2013835 (discussion 835\u2013827). https:\/\/doi.org\/10.1007\/s10350-008-9233-4","DOI":"10.1007\/s10350-008-9233-4"},{"issue":"3","key":"2416_CR25","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1097\/QAI.0b013e3182437469","volume":"59","author":"DK Marks","year":"2012","unstructured":"Marks DK, Goldstone SE (2012) Electrocautery ablation of high-grade anal squamous intraepithelial lesions in HIV-negative and HIV-positive men who have sex with men. J Acquir Immune Defic Syndr 59(3):259\u2013265. https:\/\/doi.org\/10.1097\/QAI.0b013e3182437469","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"23","key":"2416_CR26","doi-asserted-by":"publisher","first-page":"4709","DOI":"10.1002\/cncr.31035","volume":"123","author":"AA Deshmukh","year":"2017","unstructured":"Deshmukh AA, Chiao EY, Cantor SB, Stier EA, Goldstone SE, Nyitray AG, Wilkin T, Wang X, Chhatwal J (2017) Management of precancerous anal intraepithelial lesions in human immunodeficiency virus-positive men who have sex with men: Clinical effectiveness and cost-effectiveness. Cancer 123(23):4709\u20134719. https:\/\/doi.org\/10.1002\/cncr.31035","journal-title":"Cancer"}],"container-title":["Techniques in Coloproctology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10151-021-02416-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10151-021-02416-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10151-021-02416-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T20:05:30Z","timestamp":1617307530000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10151-021-02416-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,10]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["2416"],"URL":"https:\/\/doi.org\/10.1007\/s10151-021-02416-9","relation":{},"ISSN":["1123-6337","1128-045X"],"issn-type":[{"value":"1123-6337","type":"print"},{"value":"1128-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,10]]},"assertion":[{"value":"21 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This prospectively maintained database was approved by our institutional review board. All procedures performed (high resolution anoscopy and biopsies) were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}