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Histological assessment is informative, but no single scoring system is widely adopted. We previously proposed an eight-item histological scheme for the easy, fast reporting of disease activity in the intestine. The aim of the present study was to evaluate the performance of our Simplified Histologic Mucosal Healing Scheme (SHMHS).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Between April and May 2021 pathologists and gastroenterologists in Italy were invited to contribute to this multicenter study by providing data on single endoscopic\u2013histological examinations for their IBD patients undergoing treatment. Disease activity was expressed using SHMHS (maximum score, 8) and either Simple Endoscopic Score for Crohn\u2019s Disease (categorized into grades 0\u20133) or Mayo Endoscopic Subscore (range 0\u20133).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Thirty hospitals provided data on 597 patients (291 Crohn\u2019s disease; 306 ulcerative colitis). The mean SHMHS score was 2.96 (SD\u2009=\u20092.42) and 66.8% of cases had active disease (score\u2009\u2265\u20092). The mean endoscopic score was 1.23 (SD\u2009=\u20091.05), with 67.8% having active disease (score\u2009\u2265\u20091). Histologic and endoscopic scores correlated (Spearman\u2019s \u03c1\u2009=\u20090.76), and scores for individual SHMHS items associated directly with endoscopic scores (chi-square <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, all comparisons). Between IBD types, scores for SHMHS items reflected differences in presentation, with cryptitis more common and erosions\/ulcerations less common in Crohn\u2019s disease, and the distal colon more affected in ulcerative colitis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>SHMHS captures the main histological features of IBD. Routine adoption may simplify pathologist workload while ensuring accurate reporting for clinical decision making.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10151-022-02628-7","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T10:03:21Z","timestamp":1654077801000},"page":"713-723","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Simplified Histologic Mucosal Healing Scheme (SHMHS) for inflammatory bowel disease: a nationwide multicenter study of performance and applicability"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-3869","authenticated-orcid":false,"given":"A.","family":"Caputo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Parente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cadei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rispo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Leoncini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Bassotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Del Sordo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Metelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Daperno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Armuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Villanacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The SHMHS Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"2628_CR1","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1016\/j.crohns.2014.08.011","volume":"8","author":"RV Bryant","year":"2014","unstructured":"Bryant RV, Winer S, Travis SP, Riddell RH (2014) Systematic review: histological remission in inflammatory bowel disease. 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All other authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval for the study was granted by the institutional review board of Spedali Civili and\u00a0University of Brescia (approval number NP4700, 22 April 2021). All patients (or the guardians of patients aged < 18\u00a0years) provided informed consent for the collection of their clinical data for medical purposes, and the institutional review board waived the need for further informed consent. The data were anonymized by each contributor before\u00a0transmission.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}