{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:24:36Z","timestamp":1754195076322,"version":"3.37.3"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tech Coloproctol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Although there are various surgical causes of and therapeutic approaches to the chronically failing ileoanal pouch (PF), cases are often detailed without distinguishing the exact cause and corresponding treatment. The aim of our study was to classify causes of PF and corresponding surgical treatment options, and to establish efficacy of surgical approach per cause.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This retrospective study included all consecutive adult patients with chronic PF surgically treated at our tertiary hospital between July 2014 and March 2021. Patients were classified according to a proposed sub-classification for surgical related chronic PF. Results were reported accordingly.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>\u00a0A total of 59 procedures were completed in 50 patients (64% male, median age 45\u00a0years [IQR 34.5\u201354.3]) for chronic PF. Most patients had refractory ulcerative colitis as indication for their restorative proctocolectomy (68%). All patients could be categorized according to the sub-classification. Reasons for chronic PF were septic complications (<jats:italic>n<\/jats:italic>\u2009=\u200925), pouch body complications (<jats:italic>n<\/jats:italic>\u2009=\u200912), outlet problems (<jats:italic>n<\/jats:italic>\u2009=\u200911), cuff problems (<jats:italic>n<\/jats:italic>\u2009=\u20098), retained rectum (<jats:italic>n<\/jats:italic>\u2009=\u20092), and inlet problems (<jats:italic>n<\/jats:italic>\u2009=\u20091). For these indications, 17 pouches were excised, 10 pouch reconstructions were performed, and 32 pouch revision procedures were performed. The various procedures had different complication rates. Technical success rates of redo surgery for the different causes varied from 0 to 100%, with a 75% success rate for septic causes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our sub-classification for chronic PF and corresponding treatments is suitable for all included patients. Outcomes varied between causes and subsequent management. Chronic PF was predominantly caused by septic complications with redo surgery achieving a 75% technical success rate.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10151-022-02688-9","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T10:03:03Z","timestamp":1661853783000},"page":"271-279","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Classification of surgical causes of and approaches to the chronically failing ileoanal pouch"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0932-228X","authenticated-orcid":false,"given":"E. M.","family":"Meima-van Praag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-8847","authenticated-orcid":false,"given":"M. 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EMP, MR, CB had none to declare. RH: Educational Grant: Stryker. Consulting fees: Applied Medical. Speaker fees: Applied Medical, Medtronic, Johnson & Johnson. Stock options: SurgEase. MD: Advisory fees: Echo Pharma, Alimentiv (formerly Robarts Clinical Trials). Unrestricted Grant: Pfizer. Speaker fees: Janssen, Merck & Co., Inc., Pfizer, Takeda, Tillotts Pharma, Galapagos, BMS. Nonfinancial support: Dr. Falk Pharma. WB: Speaker fees: Takeda, Johnson & Johnson, Medtronic, Braun. Grant: VIFOR, Braun.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"According to local law and the Medical Ethical Committee at the Amsterdam UMC, ethical approval was waived for this retrospective study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval statement"}},{"value":"All eligible patients received an opt-out letter and could withdraw permission to collect data for this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient informed consent statement"}}]}}