{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:03:49Z","timestamp":1792299829840,"version":"4.4.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T00:00:00Z","timestamp":1680393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T00:00:00Z","timestamp":1680393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100015101","name":"Ramsay Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tech Coloproctol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>The aim of this study was to evaluate the efficacy and safety of radiofrequency ablation (RFA) in the management of haemorrhoidal disease with 1\u00a0year\u2019s follow-up.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>This prospective multicentre study assessed RFA (Rafaelo<jats:sup>\u00a9<\/jats:sup>) in outpatients with grade\u00a0II\u2013III haemorrhoids. RFA was performed in the operating room under locoregional or general anaesthesia. Primary endpoint was the evolution of a quality-of-life score adapted to the haemorrhoid pathology (HEMO-FISS-QoL) 3\u00a0months after surgery. Secondary endpoints were evolution of symptoms (prolapsus, bleeding, pain, itching, anal discomfort), complications, postoperative pain and medical leave.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 129 patients (69% men, median age 49\u00a0years) were operated on in 16 French centres. Median HEMO-FISS-QoL score dropped significantly from 17.4\/100 to 0\/100 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) at 3\u00a0months. At 3\u00a0months, the rate of patients reporting bleeding (21% vs. 84%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), prolapse (34% vs. 91.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and anal discomfort (0\/10 vs. 5\/10, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) decreased significantly. Median medical leave was 4\u00a0days [1\u201314]. Postoperative pain was 4\/10, 1\/10, 0\/10 and 0\/10 at weeks\u00a01, 2, 3 and 4. Seven patients (5.4%) were reoperated on by haemorrhoidectomy for relapse, and three for complications. Reported complications were haemorrhage (3), dysuria (3), abscess (2), anal fissure (1), external haemorrhoidal thrombosis (10), pain requiring morphine (11). Degree of satisfaction was high (+\u20095 at 3\u00a0months on a \u2212\u00a05\/+\u20095 scale).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>RFA is associated with an improvement in quality of life and symptoms with a good safety profile. As expected for minimally invasive surgery, postoperative pain is minor with short medical leave.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical trial registration and date<\/jats:title>\n                <jats:p>Clinical trial NCT04229784 (18\/01\/2020).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10151-023-02787-1","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T05:45:46Z","timestamp":1680500746000},"page":"873-883","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["French multicentre prospective evaluation of radiofrequency ablation in the management of haemorrhoidal disease"],"prefix":"10.1007","volume":"27","clinical-trial-number":[{"clinical-trial-number":"nct04229784","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9806-7953","authenticated-orcid":false,"given":"A.","family":"Laurain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bouchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-M.","family":"Rouillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Petit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Liddo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Vinson Bonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Venara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-M.","family":"Didelot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bonnaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sen\u00e9joux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Higuero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Delasalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.-L.","family":"Tarrerias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Devulder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Castinel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Pillant Le Moult","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Favreau-Weltzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Abramowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,2]]},"reference":[{"issue":"2","key":"2787_CR1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s00384-011-1316-3","volume":"27","author":"S Riss","year":"2012","unstructured":"Riss S, Weiser FA, Schwameis K et al (2012) The prevalence of hemorrhoids in adults. 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Aurelien Venara is consultant for Intuitive surgery, Sanofi Aventis, Takeda, Thermofisher. Guillaume Bonnaud is consultant for Abbvie, Alfasigma, Bouchara Recordatti, Celltrion, Ferring, Janssen, Gilead, Medtronic, MSD, Norgine, PFIZER, Roche, Takeda, Tillotts. The other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was validated by the Ile de France Ethics Committee. The MR 001 reference methodology was applied for the CNIL assessment. The protocol design, the analysis of results and the drafting of the article were carried out independently from the study sponsors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent forms were collected from the patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent"}}]}}