{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:33:48Z","timestamp":1789655628654,"version":"4.0.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tech Coloproctol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s10151-024-02951-1","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T19:16:03Z","timestamp":1719342963000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of factors that indicated surgery in 400 patients submitted to a complete diagnostic workup for obstructed defecation syndrome and rectal prolapse using a supervised machine learning algorithm"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8384-5081","authenticated-orcid":false,"given":"A. A.","family":"Marra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Simonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Parello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Litta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"De Simone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Campenn\u00ec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-0037","authenticated-orcid":false,"given":"C.","family":"Ratto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"2951_CR1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41575-021-00487-5","volume":"18","author":"PT Heitmann","year":"2021","unstructured":"Heitmann PT, Vollebregt PF, Knowles CH, Lunniss PJ, Dinning PG, Scott SM (2021) Understanding the physiology of human defaecation and disorders of continence and evacuation. Nat Rev Gastroenterol Hepatol 18:751\u2013769","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2951_CR2","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.surg.2022.05.030","volume":"172","author":"M Pescatori","year":"2022","unstructured":"Pescatori M, Zbar AP, Ayabaca SM (2022) Tailoring surgery for obstructed defecation syndrome to the \u201ciceberg diagram\u201d: long-term results. Surgery 172:1636\u20131641","journal-title":"Surgery"},{"key":"2951_CR3","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S2468-1253(21)00111-4","volume":"6","author":"B Barberio","year":"2021","unstructured":"Barberio B, Judge C, Savarino EV, Ford AC (2021) Global prevalence of functional constipation according to the Rome criteria: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 6:638\u2013648","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2951_CR4","doi-asserted-by":"publisher","unstructured":"Mearin F, Lacy BE, Chang L et al (2016) Bowel disorders. Gastroenterology. https:\/\/doi.org\/10.1053\/j.gastro.2016.02.031","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"2951_CR5","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.14050","volume":"33","author":"SM Scott","year":"2021","unstructured":"Scott SM, Simr\u00e9n M, Farmer AD et al (2021) Chronic constipation in adults: contemporary perspectives and clinical challenges. 1: epidemiology, diagnosis, clinical associations, pathophysiology and investigation. Neurogastroenterol Motil 33:e14050","journal-title":"Neurogastroenterol Motil"},{"key":"2951_CR6","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/DCR.0000000000000889","volume":"60","author":"L Bordeianou","year":"2017","unstructured":"Bordeianou L, Paquette I, Johnson E et al (2017) Clinical practice guidelines for the treatment of rectal prolapse. Dis Colon Rectum 60:1121\u20131131","journal-title":"Dis Colon Rectum"},{"key":"2951_CR7","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1097\/DCR.0000000000002495","volume":"65","author":"L Bordeianou","year":"2022","unstructured":"Bordeianou L, Ogilvie J, Murphy M et al (2022) Does concomitant pelvic organ prolapse repair at the time of rectopexy impact rectal prolapse recurrence rates? A retrospective review of the prospectively collected pelvic floor disorders consortium quality improvement database pilot. Dis Colon Rectum 65:1522\u20131530","journal-title":"Dis Colon Rectum"},{"key":"2951_CR8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/DCR.0000000000001829","volume":"64","author":"I Paquette","year":"2021","unstructured":"Paquette I, Rosman D, El Sayed R et al (2021) Consensus definitions and interpretation templates for fluoroscopic imaging of defecatory pelvic floor disordersconsensus definitions and interpretation templates for fluoroscopic imaging of defecatory pelvic floor disorders: proceedings of the consensus meeting of the pelvic floor consortium of the American Society of Colon and Rectal Surgeons, the Society of Abdominal Radiology, the International Continence Society, the American Urogynecologic Society, the International Urogynecological Association, and the Society of Gynecologic Surgeons. Dis Colon Rectum 64:31\u201344","journal-title":"Dis Colon Rectum"},{"key":"2951_CR9","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1097\/DCR.0000000000002155","volume":"64","author":"BH Gurland","year":"2021","unstructured":"Gurland BH, Khatri G, Ram R et al (2021) Consensus definitions and interpretation templates for magnetic resonance imaging of defecatory pelvic floor disorders: proceedings of the consensus meeting of the pelvic floor disorders consortium of the American Society of Colon and Rectal Surgeons, the Society of Abdominal Rradiology, the International Continence Society, the American Urogynecologic Society, the International Urogynecological Association, and the Society of Gynecologic Surgeons. Dis Colon Rectum 64:1184\u20131197","journal-title":"Dis Colon Rectum"},{"key":"2951_CR10","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s10151-018-1908-9","volume":"22","author":"G Gallo","year":"2018","unstructured":"Gallo G, Martellucci J, Pellino G et al (2018) Consensus statement of the Italian Society of Colorectal Surgery (SICCR): management and treatment of complete rectal prolapse. Tech Coloproctol 22:919\u2013931","journal-title":"Tech Coloproctol"},{"key":"2951_CR11","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/j.gastro.2019.12.034","volume":"158","author":"AE Bharucha","year":"2020","unstructured":"Bharucha AE, Lacy BE (2020) Mechanisms, evaluation, and management of chronic constipation. Gastroenterology 158:1232\u20131249.e3","journal-title":"Gastroenterology"},{"issue":"Suppl 3","key":"2951_CR12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/codi.13775","volume":"19","author":"CH Knowles","year":"2017","unstructured":"Knowles CH, Grossi U, Horrocks EJ et al (2017) Surgery for constipation: systematic review and practice recommendations: graded practice and future research recommendations. Colorectal Dis 19(Suppl 3):101\u2013113","journal-title":"Colorectal Dis"},{"key":"2951_CR13","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/bjs\/znab123","volume":"108","author":"A Picciariello","year":"2021","unstructured":"Picciariello A, O\u2019Connell PR, Hahnloser D et al (2021) Obstructed defaecation syndrome: European consensus guidelines on the surgical management. Br J Surg 108:1149\u20131153","journal-title":"Br J Surg"},{"key":"2951_CR14","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s10151-018-1830-1","volume":"22","author":"EM van der Schans","year":"2018","unstructured":"van der Schans EM, Paulides TJC, Wijffels NA, Consten ECJ (2018) Management of patients with rectal prolapse: the 2017 Dutch guidelines. Tech Coloproctol 22:589\u2013596","journal-title":"Tech Coloproctol"},{"key":"2951_CR15","doi-asserted-by":"crossref","first-page":"4994","DOI":"10.3748\/wjg.v18.i36.4994","volume":"18","author":"A Bove","year":"2012","unstructured":"Bove A, Bellini M, Battaglia E et al (2012) Consensus statement AIGO\/SICCR diagnosis and treatment of chronic constipation and obstructed defecation (part II: treatment). World J Gastroenterol 18:4994\u20135013","journal-title":"World J Gastroenterol"},{"key":"2951_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3748\/wjg.v21.i1.1","volume":"21","author":"S Riss","year":"2015","unstructured":"Riss S, Stift A (2015) Surgery for obstructed defecation syndrome - is there an ideal technique. World J Gastroenterol 21:1\u20135","journal-title":"World J Gastroenterol"},{"key":"2951_CR17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1001\/jamasurg.2022.5444","volume":"158","author":"K Colborn","year":"2023","unstructured":"Colborn K, Brat G, Callcut R (2023) Predictive analytics and artificial intelligence in surgery-opportunities and risks. JAMA Surg 158:337\u2013338","journal-title":"JAMA Surg"},{"key":"2951_CR18","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10151-023-02772-8","volume":"27","author":"A Spinelli","year":"2023","unstructured":"Spinelli A, Carrano FM, Laino ME et al (2023) Artificial intelligence in colorectal surgery: an AI-powered systematic review. Tech Coloproctol 27:615\u2013629","journal-title":"Tech Coloproctol"},{"key":"2951_CR19","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.ijsu.2014.07.013","volume":"12","author":"E von Elm","year":"2014","unstructured":"von Elm E, Altman DG, Egger M et al (2014) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Int J Surg 12:1495\u20131499","journal-title":"Int J Surg"},{"key":"2951_CR20","unstructured":"Breiman L, Friedman J, Olshen R, Stone C (1984) Classification and regression trees. Belmont (CA): Wadsworth chapter 37, pp 237\u2013251"},{"key":"2951_CR21","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1007\/s00464-019-06803-0","volume":"33","author":"SH Emile","year":"2019","unstructured":"Emile SH, Elfeki H, Shalaby M, Sakr A, Sileri P, Wexner SD (2019) Outcome of laparoscopic ventral mesh rectopexy for full-thickness external rectal prolapse: a systematic review, meta-analysis, and meta-regression analysis of the predictors for recurrence. Surg Endosc 33:2444\u20132455","journal-title":"Surg Endosc"},{"key":"2951_CR22","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1002\/bjs.4779","volume":"91","author":"A D'Hoore","year":"2004","unstructured":"D\u2019Hoore A, Cadoni R, Penninckx F (2004) Long-term outcome of laparoscopic ventral rectopexy for total rectal prolapse. Br J Surg 91:1500\u20131505","journal-title":"Br J Surg"},{"key":"2951_CR23","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3390\/jcm12010294","volume":"12","author":"P Campenn\u00ec","year":"2022","unstructured":"Campenn\u00ec P, Marra AA, De Simone V, Litta F, Parello A, Ratto C (2022) Tunneling of mesh during ventral rectopexy: technical aspects and long-term functional results. J Clin Med 12:294","journal-title":"J Clin Med"},{"key":"2951_CR24","doi-asserted-by":"crossref","first-page":"O34","DOI":"10.1111\/codi.12751","volume":"17","author":"N Gouvas","year":"2015","unstructured":"Gouvas N, Georgiou PA, Agalianos C et al (2015) Ventral colporectopexy for overt rectal prolapse and obstructed defaecation syndrome: a systematic review. Colorectal Dis 17:O34-46","journal-title":"Colorectal Dis"},{"key":"2951_CR25","first-page":"O13","volume":"19","author":"SH Emile","year":"2017","unstructured":"Emile SH, Elfeki HA, Youssef M, Farid M, Wexner SD (2017) Abdominal rectopexy for the treatment of internal rectal prolapse: a systematic review and meta-analysis. Colorectal Dis 19:O13\u2013O24","journal-title":"Colorectal Dis"},{"key":"2951_CR26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/DCR.0000000000001250","volume":"62","author":"PM Cavallaro","year":"2019","unstructured":"Cavallaro PM, Staller K, Savitt LR et al (2019) The contributions of internal intussusception, irritable bowel syndrome, and pelvic floor dyssynergia to obstructed defecation syndrome. Dis Colon Rectum 62:56\u201362","journal-title":"Dis Colon Rectum"},{"key":"2951_CR27","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.14343","volume":"34","author":"L Ferrari","year":"2022","unstructured":"Ferrari L, Cuinas K, Hainsworth A et al (2022) Transvaginal rectocoele repair for the surgical treatment of a \u201csymptomatic\u201d rectocoele when conservative measures fail: a 12\u00a0year experience of 215 patients. Neurogastroenterol Motil 34:e14343","journal-title":"Neurogastroenterol Motil"},{"key":"2951_CR28","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/codi.14833","volume":"22","author":"A Tsunoda","year":"2020","unstructured":"Tsunoda A, Takahashi T, Kusanagi H (2020) Transanal repair of rectocele: prospective assessment of functional outcome and quality of life. Colorectal Dis 22:178\u2013186","journal-title":"Colorectal Dis"},{"key":"2951_CR29","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.surg.2013.11.013","volume":"155","author":"CW Hicks","year":"2014","unstructured":"Hicks CW, Weinstein M, Wakamatsu M, Savitt L, Pulliam S, Bordeianou L (2014) In patients with rectoceles and obstructed defecation syndrome, surgery should be the option of last resort. Surgery 155:659\u2013667","journal-title":"Surgery"},{"key":"2951_CR30","volume":"34","author":"AE Bharucha","year":"2022","unstructured":"Bharucha AE, Knowles CH (2022) Rectocele: incidental or important? Observe or operate? Contemporary diagnosis and management in the multidisciplinary era. Neurogastroenterol Motil 34:e14453","journal-title":"Neurogastroenterol Motil"},{"key":"2951_CR31","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/codi.12595","volume":"16","author":"S Palit","year":"2014","unstructured":"Palit S, Bhan C, Lunniss PJ et al (2014) Evacuation proctography: a reappraisal of normal variability. Colorectal Dis 16:538\u2013546","journal-title":"Colorectal Dis"},{"key":"2951_CR32","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1007\/BF02050326","volume":"35","author":"KH Ting","year":"1992","unstructured":"Ting KH, Mangel E, Eibl-Eibesfeldt B, M\u00fcller-Lissner SA (1992) Is the volume retained after defecation a valuable parameter at defecography? Dis Colon Rectum 35:762\u2013767","journal-title":"Dis Colon Rectum"},{"key":"2951_CR33","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ijsu.2015.12.004","volume":"25","author":"AL Bloemendaal","year":"2016","unstructured":"Bloemendaal AL, Buchs NC, Prapasrivorakul S et al (2016) High-grade internal rectal prolapse: does it explain so-called \u201cidiopathic\u201d faecal incontinence? Int J Surg 25:118\u2013122","journal-title":"Int J Surg"},{"key":"2951_CR34","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1463-1318.2009.01891.x","volume":"12","author":"NA Wijffels","year":"2010","unstructured":"Wijffels NA, Collinson R, Cunningham C, Lindsey I (2010) What is the natural history of internal rectal prolapse? Colorectal Dis 12:822\u2013830","journal-title":"Colorectal Dis"},{"key":"2951_CR35","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/DCR.0000000000000510","volume":"59","author":"AT Hawkins","year":"2016","unstructured":"Hawkins AT, Olariu AG, Savitt LR et al (2016) Impact of rising grades of internal rectal intussusception on fecal continence and symptoms of constipation. Dis Colon Rectum 59:54\u201361","journal-title":"Dis Colon Rectum"},{"key":"2951_CR36","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/j.1463-1318.2009.02050.x","volume":"12","author":"C Morandi","year":"2010","unstructured":"Morandi C, Martellucci J, Talento P, Carriero A (2010) Role of enterocele in the obstructed defecation syndrome (ODS): a new radiological point of view. Colorectal Dis 12:810\u2013816","journal-title":"Colorectal Dis"},{"key":"2951_CR37","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s00384-017-2887-4","volume":"32","author":"D Mege","year":"2017","unstructured":"Mege D, Sans A, Maignan A et al (2017) Temporary successful results of ventral rectopexy for enterocele surgical correction, about 138 patients. Int J Colorectal Dis 32:1569\u20131575","journal-title":"Int J Colorectal Dis"},{"key":"2951_CR38","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s10151-020-02199-5","volume":"24","author":"G Campagna","year":"2020","unstructured":"Campagna G, Panico G, Caramazza D et al (2020) Laparoscopic sacrocolpopexy plus ventral rectopexy as combined treatment for multicompartment pelvic organ prolapse. Tech Coloproctol 24:573\u2013584","journal-title":"Tech Coloproctol"},{"key":"2951_CR39","doi-asserted-by":"crossref","DOI":"10.1148\/rg.220119","volume":"43","author":"JW Revels","year":"2023","unstructured":"Revels JW, Mansoori B, Fadl S et al (2023) MR defecating proctography with emphasis on posterior compartment disorders. Radiographics 43:e220119","journal-title":"Radiographics"},{"key":"2951_CR40","volume":"9","author":"IM van Gruting","year":"2021","unstructured":"van Gruting IM, Stankiewicz A, Thakar R, Santoro GA, IntHout J, Sultan AH (2021) Imaging modalities for the detection of posterior pelvic floor disorders in women with obstructed defaecation syndrome. Cochrane Database Syst Rev 9:CD011482","journal-title":"Cochrane Database Syst Rev"},{"key":"2951_CR41","doi-asserted-by":"crossref","first-page":"e749","DOI":"10.1111\/codi.12443","volume":"15","author":"MP Gosselink","year":"2013","unstructured":"Gosselink MP, Adusumilli S, Harmston C et al (2013) Impact of slow transit constipation on the outcome of laparoscopic ventral rectopexy for obstructed defaecation associated with high grade internal rectal prolapse. Colorectal Dis 15:e749\u2013756","journal-title":"Colorectal Dis"},{"key":"2951_CR42","doi-asserted-by":"crossref","first-page":"e680","DOI":"10.1111\/codi.12367","volume":"15","author":"S Adusumilli","year":"2013","unstructured":"Adusumilli S, Gosselink MP, Fourie S et al (2013) Does the presence of a high grade internal rectal prolapse affect the outcome of pelvic floor retraining in patients with faecal incontinence or obstructed defaecation? Colorectal Dis 15:e680\u2013685","journal-title":"Colorectal Dis"},{"key":"2951_CR43","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1007\/BF02047867","volume":"35","author":"JG Williams","year":"1992","unstructured":"Williams JG, Rothenberger DA, Madoff RD, Goldberg SM (1992) Treatment of rectal prolapse in the elderly by perineal rectosigmoidectomy. Dis Colon Rectum 35:830\u2013834","journal-title":"Dis Colon Rectum"},{"key":"2951_CR44","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.19686","volume":"3","author":"CK Ettman","year":"2020","unstructured":"Ettman CK, Abdalla SM, Cohen GH, Sampson L, Vivier PM, Galea S (2020) Prevalence of depression symptoms in US adults before and during the COVID-19 pandemic. JAMA Netw Open 3:e2019686","journal-title":"JAMA Netw Open"},{"key":"2951_CR45","doi-asserted-by":"crossref","unstructured":"Marra AA, Porfiri F, Biffoni B et al (2023) Anxiety and depression should be considered more in rectal prolapse surgery: an analysis of long-term results after ventral mesh rectopexy. Surgery 174:1486\u20131487","DOI":"10.1016\/j.surg.2023.05.043"}],"container-title":["Techniques in Coloproctology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10151-024-02951-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10151-024-02951-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10151-024-02951-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T22:02:37Z","timestamp":1733954557000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10151-024-02951-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["2951"],"URL":"https:\/\/doi.org\/10.1007\/s10151-024-02951-1","relation":{},"ISSN":["1123-6337","1128-045X"],"issn-type":[{"value":"1123-6337","type":"print"},{"value":"1128-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,25]]},"assertion":[{"value":"13 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the local Ethics Committee (ID approval 2574) and an informed written consent was signed by patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and informed consent"}}],"article-number":"73"}}