{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:28:02Z","timestamp":1791520082402,"version":"4.3.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tech Coloproctol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s10151-024-02990-8","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T07:02:17Z","timestamp":1725260537000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Closing the internal opening with a rectal advancement flap increases the efficacy of mesenchymal stem cell injection for complex Crohn's disease anal fistulas"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5219-827X","authenticated-orcid":false,"given":"N.","family":"Fathallah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Haouari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Barr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Roland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Spindler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Safa","family":"Far","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"de Parades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"2990_CR1","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1093\/ecco-jcc\/jjw039","volume":"10","author":"KB Gecse","year":"2016","unstructured":"Gecse KB, Sebastian S, Hertogh Gd, Yassin NA, Kotze PG, Reinisch W, Spinelli A, Koutroubakis IE, Katsanos KH, Hart A, van den Brink GR, Rogler G, Bemelman WA, Results of the Fifth Scientific Workshop of the ECCO [II] (2016) Clinical aspects of perianal fistulising Crohn\u2019s disease-the unmet needs. J Crohns Colitis 10:758\u2013765","journal-title":"J Crohns Colitis"},{"key":"2990_CR2","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/DCR.0b013e3182099d9e","volume":"54","author":"S Mahadev","year":"2011","unstructured":"Mahadev S, Young JM, Selby W, Solomon MJ (2011) Quality of life in perianal Crohn\u2019s disease: what do patients consider important? Dis Colon Rectum 54:579\u2013585","journal-title":"Dis Colon Rectum"},{"key":"2990_CR3","doi-asserted-by":"publisher","first-page":"otad036","DOI":"10.1093\/crocol\/otad036","volume":"5","author":"A Spinelli","year":"2023","unstructured":"Spinelli A, Yanai H, Girardi P, Milicevic S, Carvello M, Maroli A, Avedano L (2023) The impact of Crohn\u2019s perianal fistula on quality of life: results of an international patient survey. Crohns Colitis 5:otad036","journal-title":"Crohns Colitis"},{"key":"2990_CR4","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1053\/j.gastro.2005.01.048","volume":"128","author":"GR Lichtenstein","year":"2005","unstructured":"Lichtenstein GR, Yan S, Bala M, Blank M, Sands BE (2005) Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn\u2019s disease. Gastroenterology 128:862\u2013869","journal-title":"Gastroenterology"},{"key":"2990_CR5","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1056\/NEJMoa030815","volume":"350","author":"BE Sands","year":"2004","unstructured":"Sands BE, Anderson FH, Bernstein CN, Chey WY, Feagan BG, Fedorak RN, Kamm MA, Korzenik JR, Lashner BA, Onken JE, Rachmilewitz D, Rutgeerts P, Wild G, Wolf DC, Marsters PA, Travers SB, Blank MA, van Deventer SJ (2004) Infliximab maintenance therapy for fistulizing Crohn\u2019s disease. N Engl J Med 350:876\u2013885","journal-title":"N Engl J Med"},{"key":"2990_CR6","first-page":"jjad185","volume":"2","author":"SK Vuyyuru","year":"2023","unstructured":"Vuyyuru SK, Solitano V, Narula N, Lee MJ, MacDonald JK, McCurdy JD, Singh S, Ma C, Jairath V (2023) Pharmacological therapies for the management of fistulising Crohn\u2019s disease: A systematic review and meta-analysis. J Crohns Colitis 2:jjad185","journal-title":"J Crohns Colitis"},{"key":"2990_CR7","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/ecco-jcc\/jjz187","volume":"14","author":"M Adamina","year":"2020","unstructured":"Adamina M, Bonovas S, Raine T, Spinelli A, Warusavitarne J, Armuzzi A, Bachmann O, Bager P, Biancone L, Bokemeyer B, Bossuyt P, Burisch J, Collins P, Doherty G, El-Hussuna A, Ellul P, Fiorino G, Frei-Lanter C, Furfaro F, Gingert C, Gionchetti P, Gisbert JP, Gomollon F, Gonz\u00e1lez Lorenzo M, Gordon H, Hlavaty T, Juillerat P, Katsanos K, Kopylov U, Krustins E, Kucharzik T, Lytras T, Maaser C, Magro F, Marshall JK, Myrelid P, Pellino G, Rosa I, Sabino J, Savarino E, Stassen L, Torres J, Uzzan M, Vavricka S, Verstockt B, Zmora O (2020) ECCO Guidelines on Therapeutics in Crohn\u2019s Disease: Surgical Treatment. J Crohns Colitis 14:155\u2013168","journal-title":"J Crohns Colitis"},{"key":"2990_CR8","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/S2468-1253(22)00088-7","volume":"7","author":"EM Meima-van Praag","year":"2022","unstructured":"Meima-van Praag EM, van Rijn KL, Wasmann KATGM, Snijder HJ, Stoker J, D\u2019Haens GR, Gecse KB, Gerhards MF, Jansen JM, Dijkgraaf MGW, van der Bilt JDW, Mundt MW, Spinelli A, Danese S, Bemelman WA, Buskens CJ (2022) Short-term anti-TNF therapy with surgical closure versus anti-TNF therapy in the treatment of perianal fistulas in Crohn\u2019s disease (PISA-II): a patient preference randomised trial. Lancet Gastroenterol Hepatol 7:617\u2013626","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2990_CR9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/codi.16314","volume":"25","author":"M Laland","year":"2023","unstructured":"Laland M, Fran\u00e7ois M, D\u2019Amico F, Zallot C, Brochard C, Dewitte M, Siproudhis L, Peyrin-Biroulet L, Bouguen G (2023) Identification of the optimal medical and surgical management for patients with perianal fistulising Crohn\u2019s disease. Colorectal Dis 25:75\u201382","journal-title":"Colorectal Dis"},{"key":"2990_CR10","first-page":"jjae035","volume":"16","author":"M Fung","year":"2024","unstructured":"Fung M, Farbod Y, Kankouni H, Singh S, McCurdy JD (2024) Does combined medical and surgical treatment improve perianal fistula outcomes in patients with Crohn\u2019s disease? A systematic review and meta-analysis. J Crohns Colitis 16:jjae035","journal-title":"J Crohns Colitis"},{"key":"2990_CR11","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1053\/j.gastro.2017.12.020","volume":"154","author":"J Pan\u00e9s","year":"2018","unstructured":"Pan\u00e9s J, Garc\u00eda-Olmo D, Van Assche G, Colombel JF, Reinisch W, Baumgart DC, Dignass A, Nachury M, Ferrante M, Kazemi-Shirazi L, Grimaud JC, de la Portilla F, Goldin E, Richard MP, Diez MC, Tagarro I, Leselbaum A, Danese S, ADMIRE CD Study Group Collaborators (2018) Long-term efficacy and safety of stem cell therapy (Cx601) for complex perianal fistulas in patients with Crohn\u2019s disease. Gastroenterology 154:1334-1342.e4","journal-title":"Gastroenterology"},{"key":"2990_CR12","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1111\/codi.15587","volume":"23","author":"D Cabalzar-Wondberg","year":"2021","unstructured":"Cabalzar-Wondberg D, Turina M, Biedermann L, Rogler G, Schreiner P (2021) Allogeneic expanded adipose-derived mesenchymal stem cell therapy for perianal fistulas in Crohn\u2019s disease: a case series. Colorectal Dis 23:1444\u20131450","journal-title":"Colorectal Dis"},{"key":"2990_CR13","doi-asserted-by":"publisher","first-page":"3643","DOI":"10.3748\/wjg.v27.i24.3643","volume":"27","author":"O Schwandner","year":"2021","unstructured":"Schwandner O (2021) Stem cell injection for complex anal fistula in Crohn\u2019s disease: a single-center experience. World J Gastroenterol 27:3643\u20133653","journal-title":"World J Gastroenterol"},{"key":"2990_CR14","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1093\/ecco-jcc\/jjac144","volume":"17","author":"S Furukawa","year":"2023","unstructured":"Furukawa S, Mizushima T, Nakaya R, Shibata M, Yamaguchi T, Watanabe K, Futami K (2023) Darvadstrocel for complex perianal fistulas in Japanese adults with Crohn\u2019s disease: a phase 3 study. J Crohns Colitis 17:369\u2013378","journal-title":"J Crohns Colitis"},{"key":"2990_CR15","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/codi.16830","volume":"26","author":"I White","year":"2024","unstructured":"White I, Yanai H, Avni I, Slavin M, Naftali T, Tovi S, Dotan I, Wasserberg N (2024) Mesenchymal stem cell therapy for Crohn\u2019s perianal fistula-a real-world experience. Colorectal Dis 26:102\u2013109","journal-title":"Colorectal Dis"},{"key":"2990_CR16","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s00508-023-02283-4","volume":"136","author":"C Dawoud","year":"2024","unstructured":"Dawoud C, Widmann KM, Czipin S, Pramhas M, Scharitzer M, Stift A, Harpain F, Riss S (2024) Efficacy of cx601 (darvadstrocel) for the treatment of perianal fistulizing Crohn\u2019s disease\u2014a prospective nationwide multicenter cohort study. Wien Klin Wochenschr Wien Klin Wochenschr 136:289\u2013294","journal-title":"Wien Klin Wochenschr Wien Klin Wochenschr"},{"key":"2990_CR17","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1007\/s10151-023-02765-7","volume":"27","author":"N Fathallah","year":"2023","unstructured":"Fathallah N, Akaffou M, Haouari MA, Spindler L, Alam A, Barr\u00e9 A, Pommaret E, Fels A, de Parades V (2023) Deep remission improves the quality of life of patients with Crohn\u2019s disease and anoperineal fistula treated with darvadstrocel: results of a French pilot study. Tech Coloproctol 27:1201\u20131210","journal-title":"Tech Coloproctol"},{"key":"2990_CR18","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1111\/codi.16782","volume":"25","author":"N Fathallah","year":"2023","unstructured":"Fathallah N, Siproudhis L, Akaffou M, Haouari MA, Landemaine A, Pommaret E, Spindler L, Brochard C, Bouguen G, de Parades V (2023) Allogenic stem cells for Crohn\u2019s anal fistulas: treating early improves the deep remission rate. Colorectal Dis 25:2170\u20132176","journal-title":"Colorectal Dis"},{"key":"2990_CR19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/00004836-199501000-00008","volume":"20","author":"EJ Irvine","year":"1995","unstructured":"Irvine EJ (1995) Usual therapy improves perianal Crohn\u2019s disease as measured by a new disease activity index, McMaster IBD Study Group. J Clin Gastroenterol 20:27\u201332","journal-title":"J Clin Gastroenterol"},{"key":"2990_CR20","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/BF02050307","volume":"36","author":"JM Jorge","year":"1993","unstructured":"Jorge JM, Wexner SD (1993) Etiology and management of fecal incontinence. Dis Colon Rectum 36:77\u201397","journal-title":"Dis Colon Rectum"},{"key":"2990_CR21","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1136\/gutjnl-2019-320553","volume":"70","author":"SO Adegbola","year":"2021","unstructured":"Adegbola SO, Dibley L, Sahnan K, Wade T, Verjee A, Sawyer R, Mannick S, McCluskey D, Bassett P, Yassin N, Warusavitarne J, Faiz O, Phillips R, Tozer PJ, Norton C, Hart AL (2021) Development and initial psychometric validation of a patient-reported outcome measure for Crohn\u2019s perianal fistula: the Crohn\u2019s Anal Fistula Quality of Life (CAF-QoL) scale. Gut 70:1649\u20131656","journal-title":"Gut"},{"key":"2990_CR22","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1053\/j.gastro.2019.07.027","volume":"157","author":"P Hindryckx","year":"2019","unstructured":"Hindryckx P, Jairath V, Zou G, Feagan BG, Sandborn WJ, Stoker J, Khanna R, Stitt L, van Viegen T, Shackelton LM, Taylor SA, Santillan C, Mearadji B, D\u2019Haens G, Richard MP, Panes J, Rimola J (2019) Development and validation of a magnetic resonance index for assessing fistulas in patients with Crohn\u2019s disease. Gastroenterology 157:1233-1244.e5","journal-title":"Gastroenterology"},{"key":"2990_CR23","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1007\/DCR.0b013e3181ce8b01","volume":"53","author":"A Soltani","year":"2010","unstructured":"Soltani A, Kaiser AM (2010) Endorectal advancement flap for cryptoglandular or Crohn\u2019s fistula-in-ano. Dis Colon Rectum 53:486\u2013495","journal-title":"Dis Colon Rectum"},{"key":"2990_CR24","doi-asserted-by":"crossref","unstructured":"Serclova Z. Efficacy and safety of darvadstrocel treatment in patients with complex perianal fistulas and Crohn\u2019s Disease: results from the global ADMIRE-CD II phase 3 study. In: OP18, ECCO 2023.","DOI":"10.1093\/ecco-jcc\/jjad212.0018"},{"key":"2990_CR25","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.dld.2018.12.010","volume":"51","author":"M Chambaz","year":"2019","unstructured":"Chambaz M, Verdalle-Cazes M, Desprez C, Thomassin L, Charpentier C, Grigioni S, Armengol-Debeir L, Bridoux V, Savoye G, Savoye-Collet C (2019) Deep remission on magnetic resonance imaging impacts outcomes of perianal fistulizing Crohn\u2019s disease. Dig Liver Dis 51:358\u2013363","journal-title":"Dig Liver Dis"},{"key":"2990_CR26","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1093\/ecco-jcc\/jjab168","volume":"16","author":"KL van Rijn","year":"2022","unstructured":"van Rijn KL, Meima-van Praag EM, Bossuyt PM, D\u2019Haens GR, Gecse KB, Horsthuis K, Snijder HJ, Tielbeek JAW, Buskens CJ, Stoker J (2022) Fibrosis and MAGNIFI-CD activity index at magnetic resonance imaging to predict treatment outcome in perianal fistulizing Crohn\u2019s disease patients. J Crohns Colitis 16:708\u2013716","journal-title":"J Crohns Colitis"},{"key":"2990_CR27","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1097\/DCR.0000000000002325","volume":"65","author":"D Garcia-Olmo","year":"2022","unstructured":"Garcia-Olmo D, Gilaberte I, Binek M, Hoore D, AJL, Lindner D, Selvaggi F, Spinelli A, Pan\u00e9s J, (2022) Follow-up study to evaluate the long-term safety and efficacy of darvadstrocel (Mesenchymal Stem Cell Treatment) in patients with perianal fistulizing Crohn\u2019s disease: ADMIRE-CD phase 3 randomized controlled trial. Dis Colon Rectum 65:713\u2013720","journal-title":"Dis Colon Rectum"}],"container-title":["Techniques in Coloproctology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10151-024-02990-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10151-024-02990-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10151-024-02990-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T17:04:36Z","timestamp":1733936676000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10151-024-02990-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,2]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["2990"],"URL":"https:\/\/doi.org\/10.1007\/s10151-024-02990-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4481309\/v1","asserted-by":"object"}]},"ISSN":["1123-6337","1128-045X"],"issn-type":[{"value":"1123-6337","type":"print"},{"value":"1128-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,2]]},"assertion":[{"value":"26 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Nadia Fathallah and Vincent de Parades: Takeda Company: grants and research support, consultant. The other authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical and Informed Consent"}}],"article-number":"118"}}