{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:55:33Z","timestamp":1787774133983,"version":"build-2784847793"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tech Coloproctol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10151-025-03222-3","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T12:12:02Z","timestamp":1760616722000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Indocyanine green (ICG) fluorescence guided lymph node mapping for determination of resection margins in colon cancer \u2013 ISCAPE trial"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1233-7973","authenticated-orcid":false,"given":"L.","family":"Panaiotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-7229","authenticated-orcid":false,"given":"A.","family":"Karachun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4221-4248","authenticated-orcid":false,"given":"A.","family":"Muravtseva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8655-0377","authenticated-orcid":false,"given":"T.","family":"Golovanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1451-1396","authenticated-orcid":false,"given":"M.","family":"Khaetskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6687-7549","authenticated-orcid":false,"given":"M.","family":"Shkatov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9630-9464","authenticated-orcid":false,"given":"A.","family":"Petrov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"issue":"12","key":"3222_CR1","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1007\/s10151-019-02107-6","volume":"23","author":"M Ankersmit","year":"2019","unstructured":"Ankersmit M, Bonjer HJ, Hannink G, Schoonmade LJ, Van Der Pas MHGM, Meijerink WJHJ (2019) Near-infrared fluorescence imaging for sentinel lymph node identification in colon cancer: a prospective single-center study and systematic review with meta-analysis. Tech Coloproctol 23(12):1113\u20131126","journal-title":"Tech Coloproctol"},{"issue":"3","key":"3222_CR2","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s00464-019-07274-z","volume":"34","author":"E Villegas-Tovar","year":"2020","unstructured":"Villegas-Tovar E, Jimenez-Lillo J, Jimenez-Valerio V, Diaz-Giron-Gidi A, Faes-Petersen R, Otero-Pi\u00f1eiro A, De Lacy FB, Martinez-Portilla RJ, Lacy AM (2020) Performance of indocyanine green for sentinel lymph node mapping and lymph node metastasis in colorectal cancer: a diagnostic test accuracy meta-analysis. Surg Endosc 34(3):1035\u20131047","journal-title":"Surg Endosc"},{"issue":"11","key":"3222_CR3","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1016\/j.ejso.2017.05.026","volume":"43","author":"AC Currie","year":"2017","unstructured":"Currie AC, Brigic A, Thomas-Gibson S, Suzuki N, Moorghen M, Jenkins JT, Faiz OD, Kennedy RH (2017) A pilot study to assess near infrared laparoscopy with indocyanine green (ICG) for intraoperative sentinel lymph node mapping in early colon cancer. Eur J Surg Oncol 43(11):2044\u20132051","journal-title":"Eur J Surg Oncol"},{"issue":"4","key":"3222_CR4","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s10151-018-1773-6","volume":"22","author":"M Chand","year":"2018","unstructured":"Chand M, Keller DS, Joshi HM, Devoto L, Rodriguez-Justo M, Cohen R (2018) Feasibility of fluorescence lymph node imaging in colon cancer: FLICC. Tech Coloproctol 22(4):271\u2013277","journal-title":"Tech Coloproctol"},{"issue":"6","key":"3222_CR5","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/jso.24701","volume":"116","author":"SH Emile","year":"2017","unstructured":"Emile SH, Elfeki H, Shalaby M, Sakr A, Sileri P, Laurberg S, Wexner SD (2017) Sensitivity and specificity of indocyanine green near-infrared fluorescence imaging in detection of metastatic lymph nodes in colorectal cancer: systematic review and meta-analysis. J Surg Oncol 116(6):730\u2013740","journal-title":"J Surg Oncol"},{"issue":"1","key":"3222_CR6","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s00464-011-1854-3","volume":"26","author":"RA Cahill","year":"2012","unstructured":"Cahill RA, Anderson M, Wang LM, Lindsey I, Cunningham C, Mortensen NJ (2012) Near-infrared (NIR) laparoscopy for intraoperative lymphatic road-mapping and sentinel node identification during definitive surgical resection of early-stage colorectal neoplasia. Surg Endosc 26(1):197\u2013204","journal-title":"Surg Endosc"},{"issue":"Suppl 2","key":"3222_CR7","doi-asserted-by":"publisher","first-page":"S266","DOI":"10.1245\/s10434-015-4509-0","volume":"23","author":"N Nishigori","year":"2016","unstructured":"Nishigori N, Koyama F, Nakagawa T, Nakamura S, Ueda T, Inoue T, Kawasaki K, Obara S, Nakamoto T, Fujii H et al (2016) Visualization of lymph\/blood flow in laparoscopic colorectal cancer surgery by ICG fluorescence imaging (Lap-IGFI). Ann Surg Oncol 23(Suppl 2):S266-274","journal-title":"Ann Surg Oncol"},{"key":"3222_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71215-3","author":"H Ushijima","year":"2020","unstructured":"Ushijima H, Kawamura J, Ueda K, Yane Y, Yoshioka Y, Daito K, Tokoro T, Hida J-I, Okuno K (2020) Visualization of lymphatic flow in laparoscopic colon cancer surgery using indocyanine green fluorescence imaging. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-020-71215-3","journal-title":"Sci Rep"},{"issue":"4","key":"3222_CR9","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s00384-020-03798-2","volume":"36","author":"M Kakizoe","year":"2021","unstructured":"Kakizoe M, Watanabe J, Suwa Y, Nakagawa K, Suwa H, Ozawa M, Ishibe A, Masui H, Nagahori K (2021) The histopathological evaluation based on the indocyanine green fluorescence imaging of regional lymph node metastasis of splenic flexural colon cancer by near-infrared observation. Int J Colorectal Dis 36(4):717\u2013723","journal-title":"Int J Colorectal Dis"},{"issue":"1","key":"3222_CR10","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s00423-023-02808-5","volume":"408","author":"H Kinoshita","year":"2023","unstructured":"Kinoshita H, Kawada K, Itatani Y, Okamura R, Oshima N, Okada T, Hida K, Obama K (2023) Timing of real-time indocyanine green fluorescence visualization for lymph node dissection during laparoscopic colon cancer surgery. Langenbecks Arch Surg 408(1):38","journal-title":"Langenbecks Arch Surg"},{"issue":"7","key":"3222_CR11","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1097\/DCR.0000000000000608","volume":"59","author":"J Watanabe","year":"2016","unstructured":"Watanabe J, Ota M, Suwa Y, Ishibe A, Masui H, Nagahori K (2016) Real-time indocyanine green fluorescence imaging-guided complete mesocolic excision in laparoscopic flexural colon cancer surgery. Dis Colon Rectum 59(7):701\u2013705","journal-title":"Dis Colon Rectum"},{"issue":"2","key":"3222_CR12","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00384-016-2669-4","volume":"32","author":"J Watanabe","year":"2017","unstructured":"Watanabe J, Ota M, Suwa Y, Ishibe A, Masui H, Nagahori K (2017) Evaluation of lymph flow patterns in splenic flexural colon cancers using laparoscopic real-time indocyanine green fluorescence imaging. Int J Colorectal Dis 32(2):201\u2013207","journal-title":"Int J Colorectal Dis"},{"issue":"1","key":"3222_CR13","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1097\/DCR.0000000000002886","volume":"67","author":"S Daibo","year":"2024","unstructured":"Daibo S, Watanabe J, Suwa H, Sato S, Suwa Y, Ozawa M, Ishibe A, Endo I (2024) Short-term and mid-term outcomes of indocyanine green fluorescence imaging-guided laparoscopic right-sided colectomy: a propensity score-matched cohort study. Dis Colon Rectum 67(1):82\u201389","journal-title":"Dis Colon Rectum"},{"key":"3222_CR14","doi-asserted-by":"publisher","unstructured":"Panaiotti L, Karachun A, Muravtseva A, Petrov A: Protocol for a phase II interventional trial investigating indocyanine green (ICG) fluorescence guided lymph node mapping for determination of bowel resection margins in colon cancer (ISCAPE). International Journal of Surgery Protocols https:\/\/doi.org\/10.1097\/SP1099.0000000000000041.","DOI":"10.1097\/SP1099.0000000000000041"},{"issue":"2","key":"3222_CR15","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","volume":"250","author":"PA Clavien","year":"2009","unstructured":"Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, de Santiba\u00f1es E, Pekolj J, Slankamenac K, Bassi C et al (2009) The clavien-dindo classification of surgical complications: five-year experience. Ann Surg 250(2):187\u2013196","journal-title":"Ann Surg"},{"issue":"9","key":"3222_CR16","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1111\/j.1553-2712.1996.tb03538.x","volume":"3","author":"NM Buderer","year":"1996","unstructured":"Buderer NM (1996) Statistical methodology: I. Incorporating the prevalence of disease into the sample size calculation for sensitivity and specificity. Acad Emerg Med 3(9):895\u2013900","journal-title":"Acad Emerg Med"},{"key":"3222_CR17","doi-asserted-by":"crossref","unstructured":"Brierley JD GM, Wittekind C et al. (2017) TNM Classification of Malignant Tumours, 8th edition.;","DOI":"10.1002\/9780471420194.tnmc26.pub3"},{"issue":"3","key":"3222_CR18","doi-asserted-by":"publisher","first-page":"190","DOI":"10.47717\/turkjsurg.2023.6106","volume":"39","author":"Z Ahmed","year":"2023","unstructured":"Ahmed Z, Patil SM, Sekaran A, Rebala P, Rao GV (2023) Indocyanine green guided sentinel lymph node biopsy may have a high sensitivity for early (T1\/T2) colon cancer: a prospective study in Indian patients. Turk J Surg 39(3):190\u2013196","journal-title":"Turk J Surg"},{"key":"3222_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2020.103149","volume":"158","author":"TA Burghgraef","year":"2021","unstructured":"Burghgraef TA, Zweep AL, Sikkenk DJ, van der Pas M, Verheijen PM, Consten ECJ (2021) In vivo sentinel lymph node identification using fluorescent tracer imaging in colon cancer: a systematic review and meta-analysis. Crit Rev Oncol Hematol 158:103149","journal-title":"Crit Rev Oncol Hematol"},{"key":"3222_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13144003","author":"S Khalafi","year":"2024","unstructured":"Khalafi S, Botero Fonnegra C, Reyes A, Hui VW (2024) Developments in the use of indocyanine green (ICG) fluorescence in colorectal surgery. J Clin Med. https:\/\/doi.org\/10.3390\/jcm13144003","journal-title":"J Clin Med"},{"key":"3222_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15123196","author":"K Lucas","year":"2023","unstructured":"Lucas K, Melling N, Giannou AD, Reeh M, Mann O, Hackert T, Izbicki JR, Perez D, Grass JK (2023) Lymphatic mapping in colon cancer depending on injection time and tracing agent: a systematic review and meta-analysis of prospective designed studies. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers15123196","journal-title":"Cancers (Basel)"},{"key":"3222_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/jpm15020054","author":"RL Negrut","year":"2025","unstructured":"Negrut RL, Cote A, Feder B, Bodog FD, Maghiar AM (2025) Enhanced lymph node detection in colon cancer using indocyanine green fluorescence: a systematic review of studies from 2020 onwards. J Pers Med. https:\/\/doi.org\/10.3390\/jpm15020054","journal-title":"J Pers Med"},{"issue":"2","key":"3222_CR23","volume":"16","author":"I Shevchenko","year":"2024","unstructured":"Shevchenko I, Serban D, Dascalu AM, Tribus L, Alius C, Cristea BM, Suceveanu AI, Voiculescu D, Dumitrescu D, Bobirca F et al (2024) Factors affecting the efficiency of near-infrared indocyanine green (NIR\/ICG) in lymphatic mapping for colorectal cancer: a systematic review. Cureus 16(2):e55290","journal-title":"Cureus"},{"key":"3222_CR24","doi-asserted-by":"publisher","first-page":"117955491769076","DOI":"10.1177\/1179554917690766","volume":"11","author":"KM Augestad","year":"2017","unstructured":"Augestad KM, Merok MA, Ignatovic D (2017) Tailored treatment of colorectal cancer: surgical, molecular, and genetic considerations. Clin Med Insights Oncol 11:1179554917690766","journal-title":"Clin Med Insights Oncol"},{"issue":"8","key":"3222_CR25","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1002\/bjs.7518","volume":"98","author":"Y Hashiguchi","year":"2011","unstructured":"Hashiguchi Y, Hase K, Ueno H, Mochizuki H, Shinto E, Yamamoto J (2011) Optimal margins and lymphadenectomy in colonic cancer surgery. Br J Surg 98(8):1171\u20131178","journal-title":"Br J Surg"},{"issue":"4","key":"3222_CR26","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1111\/j.1463-1318.2008.01735.x","volume":"11","author":"W Hohenberger","year":"2009","unstructured":"Hohenberger W, Weber K, Matzel K, Papadopoulos T, Merkel S (2009) Standardized surgery for colonic cancer: complete mesocolic excision and central ligation\u2013technical notes and outcome. Colorectal Dis 11(4):354\u2013364","journal-title":"Colorectal Dis"},{"issue":"15","key":"3222_CR27","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1200\/JCO.2011.38.3992","volume":"30","author":"NP West","year":"2012","unstructured":"West NP, Kobayashi H, Takahashi K, Perrakis A, Weber K, Hohenberger W, Sugihara K, Quirke P (2012) Understanding optimal colonic cancer surgery: comparison of Japanese D3 resection and European complete mesocolic excision with central vascular ligation. J Clin Oncol 30(15):1763\u20131769","journal-title":"J Clin Oncol"},{"key":"3222_CR28","doi-asserted-by":"publisher","DOI":"10.1093\/bjsopen\/zrac151","author":"J Wan","year":"2022","unstructured":"Wan J, Wang S, Yan B, Tang Y, Zheng J, Ji H, Hu Y, Zhuang B, Deng H, Yan J (2022) Indocyanine green for radical lymph node dissection in patients with sigmoid and rectal cancer: randomized clinical trial. BJS Open. https:\/\/doi.org\/10.1093\/bjsopen\/zrac151","journal-title":"BJS Open"},{"key":"3222_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10030541","author":"D Ribero","year":"2022","unstructured":"Ribero D, Mento F, Sega V, Lo Conte D, Mellano A, Spinoglio G (2022) ICG-guided lymphadenectomy during surgery for colon and rectal cancer-interim analysis of the GREENLIGHT trial. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines10030541","journal-title":"Biomedicines"},{"issue":"2","key":"3222_CR30","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1200\/JCO.2009.24.1448","volume":"28","author":"NP West","year":"2010","unstructured":"West NP, Hohenberger W, Weber K, Perrakis A, Finan PJ, Quirke P (2010) Complete mesocolic excision with central vascular ligation produces an oncologically superior specimen compared with standard surgery for carcinoma of the colon. J Clin Oncol 28(2):272\u2013278","journal-title":"J Clin Oncol"},{"key":"3222_CR31","doi-asserted-by":"crossref","unstructured":"Japanese Classification of Colorectal (2019) Appendiceal, and Anal Carcinoma: the 3d English Edition [Secondary Publication]. J Anus Rectum Colon, 3(4):175\u2013195.","DOI":"10.23922\/jarc.2019-018"}],"container-title":["Techniques in Coloproctology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10151-025-03222-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10151-025-03222-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10151-025-03222-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:58:53Z","timestamp":1766051933000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10151-025-03222-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,16]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["3222"],"URL":"https:\/\/doi.org\/10.1007\/s10151-025-03222-3","relation":{},"ISSN":["1123-6337","1128-045X"],"issn-type":[{"value":"1123-6337","type":"print"},{"value":"1128-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,16]]},"assertion":[{"value":"7 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Trial protocol and informed consent form were approved by the Ethics Committee of NMRC of Oncology named after N.N. Petrov on 23 December 2023, protocol no. 8\/328. No significant amendments were made to trial protocol after its launch.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"179"}}