{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:24:39Z","timestamp":1772119479041,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Danish Agency for Science, Technology and Innovation funded part of the study, while the participating departments covered the remaining expenses"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tech Coloproctol"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In sacral neuromodulation (SNM), the stimulation intensity is set at the sensory threshold (ST) level. However, subsensory stimulation as low\u00a0as 50% of ST has proven effective in reducing faecal incontinence episodes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To explore the relationship between functional outcomes and varying subsensory stimulation amplitude in newly implanted patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This randomised, double-blind study was designed to include patients with\u2009\u2265\u20091 faecal incontinence episodes\/week despite maximal conservative therapy. As part of another trial, patients were offered a one-stage procedure. Postoperatively, patients were randomised into two groups. G-1 received stimulation at 0.05\u00a0V, at 50% and 90% of the ST in three\u20094-week periods, followed by 12 weeks of stimulation at the ST. G-2 received stimulation at 90% of the ST in three\u20094-week periods, followed by 12 weeks of stimulation at ST. Patients were evaluated after each period using St. Marks\u2019s Incontinence Score and a visual analogue scale (VAS) for patient satisfaction regarding social function, bowel function and quality-of-life, along with a bowel habit diary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 73 patients with a median age of 60 years [interquartile range (IQR: 50\u201369 years)] completed the trial. Faecal incontinence episodes were significantly reduced at all follow-ups, with no differences between groups. The only statistical difference between groups was deltaVAS for bowel function after 4 weeks. In G-1 with ultra-low stimulation amplitude [0.05\u00a0V \u2013 equivalent to 9.6% (IQR: 6.5\u201313.4) of ST], the improvement compared with baseline was 30 points (IQR: 10\u201350) significantly lower than G-2 with an improvement of 50 points (IQR: 10\u201370) (\n                      <jats:italic>p<\/jats:italic>\n                      -value: 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Subsensory stimulation is feasible in newly implanted patients with faecal incontinence. An amplitude of 0.05\u00a0V is as effective on the functional outcomes as stimulation with higher amplitudes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10151-025-03254-9","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T16:14:43Z","timestamp":1766592883000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sacral neuromodulation with ultra-low stimulation intensity is effective in faecal incontinence \u2013 results from a randomised study with a one-stage implant procedure"],"prefix":"10.1007","volume":"30","author":[{"given":"J.","family":"Duelund-Jakobsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Buntzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lundby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Laurberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rydningen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"issue":"1","key":"3254_CR1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1097\/00152192-200501000-00009","volume":"32","author":"JA Garcia","year":"2005","unstructured":"Garcia JA et\u00a0al (2005) Breaking the cycle of stigmatization: managing the stigma of incontinence in social interactions. 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The study, design, performance, analysis and reporting were conducted without Medtronic\u2019s influence.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"18"}}