{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:59:12Z","timestamp":1785527952160,"version":"3.56.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":61,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tech Coloproctol"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Metastatic Crohn\u2019s disease (MCD) is a rare extra-intestinal manifestation (EIM) of Crohn\u2019s disease (CD), defined by granulomatous inflammation of skin non-contiguous to the gastrointestinal tract. This study describes the clinical features, surgical management and wound healing outcomes of the largest national surgical cohort of patients with severe MCD, a topic that remains poorly represented in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single-centre case series included adults (&gt; 18 years) undergoing surgical management for MCD from 2019 to 2024. Diagnosis was confirmed by expert clinical and histopathological assessment. We describe pre-operative optimisation, individualised surgical approaches and post-operative management delivered by a multi-disciplinary team led by consultant colorectal and plastic surgeons. Wound healing was assessed clinically in a specialist complex wounds clinic at 6 and 12 months and at final long-term follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eleven female patients (median age 37 years) underwent surgical intervention. At 6 and 12 months, 45.5% achieved complete healing, improving to 81.8% by final follow-up (median 36 months). Most underwent a combined medical and surgical approach with proctocolectomy and tailored perineal reconstruction. Persistent lesions and non-healing ulcers required additional adjuncts to treatment which included topical tacrolimus, hyperbaric oxygen therapy and surgical re-excision to improve healing outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MCD is a challenging condition requiring surgical treatment in refractory cases despite medical therapy. Our study highlights the need for multidisciplinary working alongside meticulous pre-operative optimisation and close post-operative follow-up to improve long-term wound healing outcomes for patients with this rare and complex disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10151-026-03313-9","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:04:55Z","timestamp":1780041895000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surgical management of metastatic cutaneous Crohn\u2019s disease: a case series from a tertiary centre in the United Kingdom"],"prefix":"10.1007","volume":"30","author":[{"given":"D.","family":"Selvakumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Leiberman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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This study (IRAS ID: 321786) was reviewed and approved by the Wales Research Ethics Committee (REC reference: 23\/WA\/0164). All identifiable patient information was removed, and all analyses were performed using anonymised data.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors affirm that human research participants provided informed consent for publication of the images used in this manuscript.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"125"}}