{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:27:47Z","timestamp":1761182867161,"version":"build-2065373602"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2005]]},"DOI":"10.1007\/s10156-005-0381-3","type":"journal-article","created":{"date-parts":[[2005,6,30]],"date-time":"2005-06-30T07:31:56Z","timestamp":1120116716000},"page":"164-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of pazufloxacin mesilate in Legionnaires\u2019 disease: a case report and in vitro study of the isolate"],"prefix":"10.1016","volume":"11","author":[{"given":"Futoshi","family":"Higa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Shinzato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusaku","family":"Haranaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Furugen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Tateyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s10156-005-0381-3_bib0005","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/clinids\/11.4.586","article-title":"Community-acquired pneumonia requiring hospitalization: 5-year prospective study","volume":"11","author":"Marrie","year":"1989","journal-title":"Rev Infect Dis"},{"key":"10.1007\/s10156-005-0381-3_bib0010","doi-asserted-by":"crossref","first-page":"240","DOI":"10.7326\/0003-4819-93-2-240","article-title":"Legionnaires\u2019 disease: unusual clinical and laboratory features","volume":"93","author":"Meyer","year":"1980","journal-title":"Ann Intern Med"},{"key":"10.1007\/s10156-005-0381-3_bib0015","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1172\/JCI111493","article-title":"Interaction between the Legionnaires\u2019 disease bacterium (Legionella pneumophila) and human alveolar macrophages: influence of antibody, lymphokines, and hydrocortisone","volume":"74","author":"Nash","year":"1984","journal-title":"J Clin Invest"},{"key":"10.1007\/s10156-005-0381-3_bib0020","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1093\/infdis\/167.5.1138","article-title":"Legionella pneumophila replicates within rat alveolar epithelial cells","volume":"167","author":"Mody","year":"1993","journal-title":"J Infect Dis"},{"key":"10.1007\/s10156-005-0381-3_bib0025","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJM197712012972201","article-title":"Legionnaires\u2019 disease: description of an epidemic of pneumonia","volume":"297","author":"Fraser","year":"1977","journal-title":"N Engl J Med"},{"key":"10.1007\/s10156-005-0381-3_bib0030","doi-asserted-by":"crossref","first-page":"328","DOI":"10.7326\/0003-4819-129-4-199808150-00012","article-title":"Antimicrobial chemotherapy for Legionnaires\u2019 disease: time for a change","volume":"129","author":"Edelstein","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1007\/s10156-005-0381-3_bib0035","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1128\/AAC.36.10.2293","article-title":"In vitro activity of T-3761, a new fluoroquinolone","volume":"36","author":"Muratani","year":"1992","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-005-0381-3_bib0040","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1128\/AAC.37.3.384","article-title":"In vitro and in vivo antibacterial activities of T-3761, a new quinolone derivative","volume":"37","author":"Fukuoka","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-005-0381-3_bib0045","first-page":"611","article-title":"Successfully treatment of Legionella pneumonia with pazufloxacin mesilate. Kagaku","volume":"20","author":"Niki","year":"2004","journal-title":"ryoho no Ryouiki"},{"key":"10.1007\/s10156-005-0381-3_bib0050","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/jac\/dkh001","article-title":"In vitro and in vivo activity of olamufloxacin (HSR-903) against Legionella spp","volume":"52","author":"Higa","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"10.1007\/s10156-005-0381-3_bib0055","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1128\/JCM.36.5.1392-1398.1998","article-title":"Simplified quantitative assay system for measuring activities of drugs against intracellular Legionella pneumophila","volume":"36","author":"Higa","year":"1998","journal-title":"J Clin Microbiol"},{"key":"10.1007\/s10156-005-0381-3_bib0060","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/BF01695659","article-title":"Delay in appropriate therapy of Legionella pneumonia associated with increased mortality","volume":"15","author":"Heath","year":"1996","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1007\/s10156-005-0381-3_bib0065","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1128\/CMR.15.3.506-526.2002","article-title":"Legionella and Legionnaires\u2019 disease: 25 years of investigation","volume":"15","author":"Fields","year":"2002","journal-title":"Clin Microbiol Rev"},{"key":"10.1007\/s10156-005-0381-3_bib0070","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1128\/JCM.41.2.838-840.2003","article-title":"Clinical utility of urinary antigen detection for diagnosis of community-acquired, travel-associated, and nosocomial Legionnaires\u2019 disease","volume":"41","author":"Helbig","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1007\/s10156-005-0381-3_bib0075","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1099\/jmm.0.45528-0","article-title":"Comparison between real-time PCR, conventional PCR and different staining techniques for diagnosing Pneumocystis jiroveci pneumonia from bronchoalveolar lavage specimens","volume":"53","author":"Flori","year":"2004","journal-title":"J Med Microbiol"},{"key":"10.1007\/s10156-005-0381-3_bib0080","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1378\/chest.115.4.1076","article-title":"The clinical utility of invasive diagnostic techniques in the setting of ventilator-associated pneumonia; Canadian Critical Care Trials Group","volume":"115","author":"Heyland","year":"1999","journal-title":"Chest"},{"key":"10.1007\/s10156-005-0381-3_bib0085","first-page":"186","article-title":"Rapid diagnosis of Legionnaires\u2019 disease by bronchoalveolar lavage","volume":"84","author":"Kohorst","year":"1983","journal-title":"Chest"},{"key":"10.1007\/s10156-005-0381-3_bib0090","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1128\/JCM.41.5.2265.2003","article-title":"Detection of Legionella pneumophila serogroup 1 antigen in bronchoalveolar lavage fluid by an immunochromatographic assay","volume":"41","author":"Wever","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1007\/s10156-005-0381-3_bib0095","first-page":"141","article-title":"Phase I clinical study of pazufloxacin mesilate","volume":"47","author":"Nakashima","year":"1999","journal-title":"Jpn J Chemother"},{"key":"10.1007\/s10156-005-0381-3_bib0100","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/jac\/46.5.669","article-title":"Application of fluoroquinolone pharmacodynamics","volume":"46","author":"Wright","year":"2000","journal-title":"J Antimicrob Chemother"},{"key":"10.1007\/s10156-005-0381-3_bib0105","first-page":"2701","article-title":"Phase I clinical study of ciprofloxacin","volume":"31","author":"Azuma","year":"1997","journal-title":"Kiso to Rinsyo"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X05710011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X05710011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s10156-005-0381-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:44:12Z","timestamp":1761158652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X05710011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005]]}},"alternative-id":["S1341321X05710011"],"URL":"https:\/\/doi.org\/10.1007\/s10156-005-0381-3","relation":{},"ISSN":["1341-321X"],"issn-type":[{"type":"print","value":"1341-321X"}],"subject":[],"published":{"date-parts":[[2005]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of pazufloxacin mesilate in Legionnaires\u2019 disease: a case report and in vitro study of the isolate","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s10156-005-0381-3","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}