{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:26:35Z","timestamp":1761182795360,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2006]]},"DOI":"10.1007\/s10156-006-0433-3","type":"journal-article","created":{"date-parts":[[2006,4,28]],"date-time":"2006-04-28T18:29:11Z","timestamp":1146248951000},"page":"83-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Study of upper respiratory tract bacterial flora: first report. Variations in upper respiratory tract bacterial flora in patients with acute upper respiratory tract infection and healthy subjects and variations by subject age"],"prefix":"10.1016","volume":"12","author":[{"given":"Masatoshi","family":"Konno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunkichi","family":"Baba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruki","family":"Mikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimitaka","family":"Kaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadao","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimitsu","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Furuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Moriyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mituru","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Matsushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Yoshizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Sunakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matsuhisa","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimiko","family":"Ubukata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"suppl","key":"10.1007\/s10156-006-0433-3_bib0425","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1542\/peds.101.S1.163","article-title":"Principle of judicious use of antimicrobial agents for pediatrics upper respiratory tract infections","volume":"101","author":"Dowell","year":"1998","journal-title":"Pediatrics"},{"issue":"suppl","key":"10.1007\/s10156-006-0433-3_bib0430","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1542\/peds.101.S1.165","article-title":"Otitis media: principles of judicious use of antimicrobial agents","volume":"101","author":"Dowell","year":"1998","journal-title":"Pediatrics"},{"issue":"suppl","key":"10.1007\/s10156-006-0433-3_bib0435","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1542\/peds.101.S1.171","article-title":"principles of judicious use of antimicrobial agents","volume":"101","author":"Schwartz","year":"1998","journal-title":"Pediatrics"},{"issue":"suppl","key":"10.1007\/s10156-006-0433-3_bib0440","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1542\/peds.101.S1.174","article-title":"Acute sinusitis: principles of judicious use of antimicrobial agents","volume":"101","author":"O'Brien","year":"1998","journal-title":"Pediatrics"},{"issue":"suppl","key":"10.1007\/s10156-006-0433-3_bib0445","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1542\/peds.101.S1.178","article-title":"Cough illness\/bronchitis: principles of judicious use of antimicrobial agents","volume":"101","author":"O'Brien","year":"1998","journal-title":"Pediatrics"},{"issue":"suppl","key":"10.1007\/s10156-006-0433-3_bib0450","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1542\/peds.101.S1.181","article-title":"The common cold: principles of judicious use of antimicrobial agents","volume":"101","author":"Rosenstein","year":"1998","journal-title":"Pediatrics"},{"key":"10.1007\/s10156-006-0433-3_bib0455","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1542\/peds.108.3.798","article-title":"Clinical practice guideline: management of sinusitis","volume":"108","year":"2001","journal-title":"Pediatrics"},{"key":"10.1007\/s10156-006-0433-3_bib0460","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1542\/peds.113.5.1451","article-title":"Diagnosis and management of acute otitis media","volume":"113","year":"2004","journal-title":"Pediatrics"},{"key":"10.1007\/s10156-006-0433-3_bib0465","series-title":"Revised edition: penicillin-resistant Streptococcus pneumoniae.","first-page":"1","article-title":"Penicillin-resistant Streptococcus pneumoniae","author":"Konno","year":"1999"},{"issue":"suppl B","key":"10.1007\/s10156-006-0433-3_bib0470","first-page":"2","volume":"52","year":"1999","journal-title":"Jpn J Antibiot"},{"issue":"suppl B","key":"10.1007\/s10156-006-0433-3_bib0475","first-page":"4","volume":"54","year":"2001","journal-title":"Jpn J Antibiot"},{"issue":"suppl A","key":"10.1007\/s10156-006-0433-3_bib0480","first-page":"77","volume":"58","year":"2005","journal-title":"Jpn J Antibiot"},{"key":"10.1007\/s10156-006-0433-3_bib0485","first-page":"369","article-title":"Postmarketing special investigation and verification of precision for cefditoren pivoxil","volume":"49","author":"Konno","year":"2001","journal-title":"Jpn J Chemother"},{"issue":"suppl B","key":"10.1007\/s10156-006-0433-3_bib0490","first-page":"4","article-title":"Community acquired infection for which reexamination is pressed","volume":"52","author":"Ubukata","year":"1999","journal-title":"Problem institution for the bacteriological examination. Jpn J Antibiot"},{"issue":"suppl B","key":"10.1007\/s10156-006-0433-3_bib0495","first-page":"84","article-title":"Community acquired infection for which reexamination is pressed. Verification to the accuracy of bacteriological examination:","volume":"52","author":"Ubukata","year":"1999","journal-title":"Jpn J Antibiot"},{"key":"10.1007\/s10156-006-0433-3_bib0500","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1128\/AAC.48.5.1509-1514.2004","article-title":"Rapidly increasing prevalence of \u03b2-lactamasenonproducing, ampicillin-resistant Haemophilus influenzae type b in patients with meningitis","volume":"48","author":"Hasegawa","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-006-0433-3_bib0505","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1128\/AAC.49.3.889-894.2005","article-title":"In vivo activity of Tebipenem, a new oral carbapenem antibiotic, against penicillin-nonsusceptible Streptococcus pneumoniae","volume":"49","author":"Kobayashi","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-006-0433-3_bib0510","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/jac\/48.6.915","article-title":"Evolution of PCR primers to screen for Streptococcus pneumoniae isolates and \u03b2-lactam resistance, and to detect common macrolide resistance determinants","volume":"48","author":"Nagai","year":"2001","journal-title":"J Antimicrob Chemother"},{"key":"10.1007\/s10156-006-0433-3_bib0515","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1128\/AAC.45.6.1693-1699.2001","article-title":"Association of amino acid substitutions in penicillin-binding protein 3 with \u03b2-lactam resistance in \u03b2- lactamase-negative ampicillin-resistant Haemophilus influenzae","volume":"45","author":"Ubukata","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-006-0433-3_bib0520","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/028134398750003340","article-title":"The prevalence of potential pathogenic bacteria in nasopharyngeal samples from healthy children and adults","volume":"16","author":"Gunnarsson","year":"1998","journal-title":"Scand J Prim Health Care"},{"key":"10.1007\/s10156-006-0433-3_bib0525","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/fampra\/18.3.266","article-title":"The prevalence of potential pathogenic bacteria in nasopharyngeal samples from individuals with a respiratory tract infection and a sore throat: implications for the diagnosis of pharyngotonsillitis","volume":"18","author":"Gunnarsson","year":"2001","journal-title":"Fam Pract"},{"key":"10.1007\/s10156-006-0433-3_bib0530","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1128\/jcm.26.3.592-594.1988","article-title":"Aerobic and anaerobic bacteriology of purulent nasopharingitis in children","volume":"26","author":"Brook","year":"1988","journal-title":"J Clin Microbiol"},{"key":"10.1007\/s10156-006-0433-3_bib0535","first-page":"623","article-title":"Changes in nasopharyngeal flora during otitis media of childhood","volume":"9","author":"Faden","year":"1990","journal-title":"Pediatr Infect Dis J"},{"key":"10.1007\/s10156-006-0433-3_bib0540","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1128\/jcm.27.12.2736-2743.1989","article-title":"Comparison of the nasal bacterial flora in two groups of healthy subjects and in patients with acute maxillary sinusitis","volume":"27","author":"Jousimies-Somer","year":"1989","journal-title":"J Clin Microbiol"},{"key":"10.1007\/s10156-006-0433-3_bib0545","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1128\/jb.51.6.671-684.1946","article-title":"The inhibitory action of saliva on the diphtheria bacillus: the antibiotic effect of salivary streptococci","volume":"51","author":"Tompson","year":"1946","journal-title":"J Bacteriol"},{"key":"10.1007\/s10156-006-0433-3_bib0550","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1093\/infdis\/120.6.698","article-title":"Bacterial interference I. Its occurrence among the respiratory tract flora and characterization of inhibition of group A streptococci by viridans streptococci","volume":"120","author":"Sanders","year":"1969","journal-title":"J Infect Dis"},{"key":"10.1007\/s10156-006-0433-3_bib0555","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/infdis\/128.4.527","article-title":"Bacterial interference II. Role of the normal flora in prevention of colonization by group A Streptococcus","volume":"128","author":"Crowe","year":"1973","journal-title":"J Infect Dis"},{"key":"10.1007\/s10156-006-0433-3_bib0560","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1128\/iai.13.3.808-812.1976","article-title":"Bacterial interference Effects of oral antibiotics on the normal throat flora and its ability to interfere with group A streptococci","volume":"13","author":"Sanders","year":"1976","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-006-0433-3_bib0565","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1128\/iai.16.2.599-603.1977","article-title":"Bacterial interference IV. Epidemiological determinants of the antagonistic activity of the normal throat flora against group A streptococci","volume":"16","author":"Sanders","year":"1977","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-006-0433-3_bib0570","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1128\/AAC.9.1.81","article-title":"Viridins, bacteriocins of alphahemolytic streptococci; isolation, characterization, and partial purification","volume":"9","author":"Dajani","year":"1976","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-006-0433-3_bib0575","doi-asserted-by":"crossref","first-page":"559","DOI":"10.11150\/kansenshogakuzasshi1970.59.559","article-title":"The inhibitory action of streptococci isolated from pharynx on the growth of pathogenic organisms: study in the pharynx of children with acute respiratory infection","volume":"59","author":"Masuda","year":"1985","journal-title":"Kanssensyogaku Zasshi"},{"key":"10.1007\/s10156-006-0433-3_bib0580","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1128\/mr.59.2.171-200.1995","article-title":"Bacteriocin of gram-positive bacteria","volume":"59","author":"Jack","year":"1995","journal-title":"Microbiol Rev"},{"key":"10.1007\/s10156-006-0433-3_bib0585","first-page":"1","article-title":"Bacterial interference in nasopharyngeal flora of otitis prone and non-otitis-prone children","volume":"48","author":"Bernstein","year":"1994","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"10.1007\/s10156-006-0433-3_bib0590","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1001\/archotol.1995.01890120061012","article-title":"Role of bacterial interference and betalactamase- producing bacteria in the failure of penicillin to eradicate group A streptococcal pharyngotonsillitis","volume":"121","author":"Brook","year":"1995","journal-title":"Arch Otolaryngol Head Neck Surg"},{"doi-asserted-by":"crossref","unstructured":"Tano K, Grahn-Hakansson E, Holm SE, Hellstrom S. Inhibition of OM pathogens by alpha-hemolytic streptococci from healthy children, children with SOM and children with rAOM. Int J Pediatr Otorhinolaryngol 200;56:185-90.","key":"10.1007\/s10156-006-0433-3_bib0595","DOI":"10.1016\/S0165-5876(00)00428-6"},{"key":"10.1007\/s10156-006-0433-3_bib0600","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1128\/jcm.26.10.1926-1933.1988","article-title":"Macroscopic purulence, leukocyte counts, and bacterial morphotype in relation to culture findings for sinus secretions in acute maxillary sinusitis","volume":"26","author":"Jousimies-Somer","year":"1988","journal-title":"J Clin Microbiol"},{"key":"10.1007\/s10156-006-0433-3_bib0605","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/BF02598283","article-title":"Adult bacterial nasopharyngitis: a clinical entry?","volume":"8","author":"Heald","year":"1993","journal-title":"J Gen Intern Med"},{"key":"10.1007\/s10156-006-0433-3_bib0610","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1128\/AAC.48.5.1488-1494.2004","article-title":"Antibiotic susceptibility in relation to penicillinbinding protein genes and serotype distribution of Streptococcus pneumoniae strains responsible for meningitis in Japan, 1999 to 2002","volume":"48","author":"Ubukata","year":"2004","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X06709497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X06709497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s10156-006-0433-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:45:32Z","timestamp":1761158732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X06709497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006]]}},"alternative-id":["S1341321X06709497"],"URL":"https:\/\/doi.org\/10.1007\/s10156-006-0433-3","relation":{},"ISSN":["1341-321X"],"issn-type":[{"type":"print","value":"1341-321X"}],"subject":[],"published":{"date-parts":[[2006]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study of upper respiratory tract bacterial flora: first report. Variations in upper respiratory tract bacterial flora in patients with acute upper respiratory tract infection and healthy subjects and variations by subject age","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s10156-006-0433-3","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}