{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:29:25Z","timestamp":1786980565385,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2007]]},"DOI":"10.1007\/s10156-007-0516-9","type":"journal-article","created":{"date-parts":[[2007,6,25]],"date-time":"2007-06-25T00:12:11Z","timestamp":1182730331000},"page":"125-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Dengue illness: clinical features and pathogenesis"],"prefix":"10.1016","volume":"13","author":[{"given":"Kazunori","family":"Oishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia A.","family":"Mapua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipinas F.","family":"Natividad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s10156-007-0516-9_bib0005","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1128\/CMR.11.3.480","article-title":"Dengue and dengue hemorrhagic fever","volume":"11","author":"Gubler","year":"1998","journal-title":"Clin Microbiol Rev"},{"key":"10.1007\/s10156-007-0516-9_bib0010","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0966-842X(01)02288-0","article-title":"Epidemic dengue\/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century","volume":"10","author":"Gubler","year":"2002","journal-title":"Trends Microbiol"},{"key":"10.1007\/s10156-007-0516-9_bib0015","unstructured":"Division of Vector-Born Infectious Diseases, National Center for Infectious Disease, Centers for Disease Control and Prevention, Dengue fever. (http:\/\/www.cdc.gov\/ncidod\/dvbid\/dengue\/map-distribution-2003.htm)"},{"key":"10.1007\/s10156-007-0516-9_bib0020","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1473-3099(01)00171-2","article-title":"Dengue: an update","volume":"2","author":"Guzman","year":"2002","journal-title":"Lancet Infect Dis"},{"key":"10.1007\/s10156-007-0516-9_bib0025","unstructured":"World Health Organization, Dengue, dengue haemorrhagic fever and dengue shock syndrome in the context of the integrated management of child illness, 2005. (http:\/\/www.who.int\/child-adolescent-health\/)"},{"key":"10.1007\/s10156-007-0516-9_bib0030","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1056\/NEJMra041927","article-title":"Dengue in travelers","volume":"353","author":"Wilder-Smith","year":"2005","journal-title":"N Eng J Med"},{"key":"10.1007\/s10156-007-0516-9_bib0035","series-title":"Dengue and dengue hemorrhagic fever","first-page":"133","article-title":"Dengue hemorrhagic fever: diagnosis and management","author":"Nimmannitya","year":"1997"},{"key":"10.1007\/s10156-007-0516-9_bib0040","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2149\/tmh1973.31.223","article-title":"Association of dengue virus-specific IgG on platelets is specific for the acute phase in an imported Japanese patient with secondary dengue 2 virus infection","volume":"31","author":"Oishi","year":"2003","journal-title":"Jpn J Trop Med Hyg"},{"key":"10.1007\/s10156-007-0516-9_bib0045","series-title":"Dengue haemorrhagic fever: diagnosis, treatment, prevention and control","year":"1997"},{"key":"10.1007\/s10156-007-0516-9_bib0050","first-page":"642","article-title":"Current advances in dengue diagnosis","volume":"11","author":"Shu","year":"2004","journal-title":"Clin Diag Lab Immunol"},{"key":"10.1007\/s10156-007-0516-9_bib0055","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(97)12483-7","article-title":"Dengue and dengue haemorrhagic fever","volume":"352","author":"Rigau-Perez","year":"1998","journal-title":"Lancet"},{"key":"10.1007\/s10156-007-0516-9_bib0060","doi-asserted-by":"crossref","first-page":"893","DOI":"10.4269\/ajtmh.1999.61.893","article-title":"Application of molecular typing techniques in the 1998 dengue epidemic in Nicaragua","volume":"61","author":"Baalmaseda","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"10.1007\/s10156-007-0516-9_bib0065","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0166-0934(02)00104-0","article-title":"Comparisons of four reverse transcription\u2013polymerase chain reaction procedures for the detection of dengue virus in clinical specimens","volume":"105","author":"Raengsakulrach","year":"2002","journal-title":"J Virol Methods"},{"key":"10.1007\/s10156-007-0516-9_bib0070","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1086\/340365","article-title":"Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infection","volume":"185","author":"Libraty","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1007\/s10156-007-0516-9_bib0075","series-title":"Travel Medicine","article-title":"Fever","author":"Wilson","year":"2004"},{"key":"10.1007\/s10156-007-0516-9_bib0080","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4269\/ajtmh.2005.73.435","article-title":"Comparison of clinical features and hematologic abnormalities between dengue fever and dengue hemorrhagic fever among children in the Philippines","volume":"73","author":"Carlos","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"10.1007\/s10156-007-0516-9_bib0085","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0950-3536(05)80240-9","article-title":"Mechanism of dengue virus-induced bone marrow suppression","volume":"8","author":"La Russa","year":"1995","journal-title":"Bailliere's Clin Hematol"},{"key":"10.1007\/s10156-007-0516-9_bib0090","doi-asserted-by":"crossref","first-page":"975","DOI":"10.4269\/ajtmh.1977.26.975","article-title":"Hemostatic and platelet kinetic studies in dengue hemorrhagic fever","volume":"26","author":"Mitrakul","year":"1977","journal-title":"Am J Trop Med Hyg"},{"key":"10.1007\/s10156-007-0516-9_bib0095","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/1096-9071(20000201)63:2<143::AID-JMV1009>3.0.CO;2-L","article-title":"Generation of IgM anti-platelet autoantibody in dengue patients","volume":"63","author":"Lin","year":"2001","journal-title":"J Med Virol"},{"key":"10.1007\/s10156-007-0516-9_bib0100","doi-asserted-by":"crossref","first-page":"881","DOI":"10.4269\/ajtmh.1979.28.881","article-title":"Demonstration of dengue antibody complexes on the surface of platelets from patients with dengue hemorrhagic fever","volume":"28","author":"Boonpucknavig","year":"1979","journal-title":"Am J Trop Med Hyg"},{"key":"10.1007\/s10156-007-0516-9_bib0105","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1056\/NEJM198105073041904","article-title":"Chronic idiopathic thrombocytopenic purpura","volume":"304","author":"McMillian","year":"1981","journal-title":"N Eng J Med"},{"key":"10.1007\/s10156-007-0516-9_bib0110","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1056\/NEJMra010501","article-title":"Immune thrombocytopenic purpura","volume":"346","author":"Cines","year":"2002","journal-title":"N Eng J Med"},{"key":"10.1007\/s10156-007-0516-9_bib0115","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2141.1980.tb05942.x","article-title":"The clinical significance of platelet-associated IgG: a study on 298 patients with various disorders","volume":"46","author":"Muller-Eckhardt","year":"1980","journal-title":"Br J Haematol"},{"key":"10.1007\/s10156-007-0516-9_bib0120","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0955-3886(98)00039-3","article-title":"Virus-associated idiopathic thrombocytopenic purpura","volume":"19","author":"Rand","year":"1998","journal-title":"Transfus Sci"},{"key":"10.1007\/s10156-007-0516-9_bib0125","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0140-6736(94)92390-6","article-title":"Idiopathic thrombocytopenic purpura after human herpesvirus 6 infection","volume":"344","author":"Kitamura","year":"1994","journal-title":"Lancet"},{"key":"10.1007\/s10156-007-0516-9_bib0130","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0925-5710(98)00008-5","article-title":"Increase of platelet-associated IgG (PA-IgG) and hemophagocytosis of neutrophils and platelets in parvovirus B19 infection","volume":"67","author":"Toyoshige","year":"1998","journal-title":"Int J Hematol"},{"key":"10.1007\/s10156-007-0516-9_bib0135","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/jmv.10478","article-title":"Correlation between increased platelet-associated IgG and thrombocytopenia in secondary dengue virus infections","volume":"71","author":"Oishi","year":"2003","journal-title":"J Med Virol"},{"key":"10.1007\/s10156-007-0516-9_bib0140","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1006\/viro.1995.1567","article-title":"Antibody-enhanced binding of dengue-2 virus to human platelets","volume":"213","author":"Wang","year":"1995","journal-title":"Virology"},{"key":"10.1007\/s10156-007-0516-9_bib0145","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2249.2004.02626.x","article-title":"Association of increased platelet-associated immunoglobulins with thrombocytopenia and the severity of disease in secondary dengue virus infections","volume":"138","author":"Saito","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1007\/s10156-007-0516-9_bib0150","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1056\/NEJM197311082891902","article-title":"The potential pathogenic role of complement in dengue hemorrhagic shock syndrome","volume":"289","author":"Bokisch","year":"1973","journal-title":"N Eng J Med"},{"key":"10.1007\/s10156-007-0516-9_bib0155","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1086\/500949","article-title":"Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement","volume":"193","author":"Avirutnan","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1007\/s10156-007-0516-9_bib0160","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.239.4839.476","article-title":"Pathogenesis of dengue: challenges of molecular biology","volume":"239","author":"Halstead","year":"1988","journal-title":"Science"},{"key":"10.1007\/s10156-007-0516-9_bib0165","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/oxfordjournals.aje.a113932","article-title":"Risk factors in dengue shock syndrome: a prospective epidemiological study in Rayong, Thailand","volume":"120","author":"Sangkawawibha","year":"1984","journal-title":"Am J Epidemiol"},{"key":"10.1007\/s10156-007-0516-9_bib0170","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4269\/ajtmh.1988.38.172","article-title":"A prospective study of dengue infections in Bangkok","volume":"38","author":"Burke","year":"1988","journal-title":"Am J Trop Med Hyg"},{"key":"10.1007\/s10156-007-0516-9_bib0175","doi-asserted-by":"crossref","first-page":"642","DOI":"10.4269\/ajtmh.1986.35.642","article-title":"Dengue in Greece in 1927 and 1928 and the pathogenesis of dengue hemorrhagic fever: new data and a different conclusion","volume":"35","author":"Rosen","year":"1986","journal-title":"Am J Trop Med Hyg"},{"key":"10.1007\/s10156-007-0516-9_bib0180","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1086\/383043","article-title":"Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridization","volume":"189","author":"Jassie","year":"2004","journal-title":"J Infect Dis"},{"key":"10.1007\/s10156-007-0516-9_bib0185","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/77553","article-title":"Human skin Langerhans cells are targets of dengue virus infection","volume":"6","author":"Wu","year":"2000","journal-title":"Nat Med"},{"key":"10.1007\/s10156-007-0516-9_bib0190","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1084\/jem.20021840","article-title":"DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells","volume":"197","author":"Tassaneetrithep","year":"2003","journal-title":"J Exp Med"},{"key":"10.1007\/s10156-007-0516-9_bib0195","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/265739a0","article-title":"Antibody-enhanced dengue virus infection in primate leukocytes","volume":"265","author":"Halstead","year":"1977","journal-title":"Nature"},{"key":"10.1007\/s10156-007-0516-9_bib0200","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1084\/jem.146.1.201","article-title":"Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody","volume":"146","author":"Halstead","year":"1977","journal-title":"J Exp Med"},{"key":"10.1007\/s10156-007-0516-9_bib0205","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1128\/iai.36.3.1036-1041.1982","article-title":"Infection enhancement of dengue-2 virus in the U937 human monocyte cell line by antibodies to flavivirus cross-reactive determinants","volume":"36","author":"Brandt","year":"1982","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-007-0516-9_bib0210","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1128\/iai.32.2.469-473.1981","article-title":"Evidence for two mechanisms of dengue virus infection of adherent human monocytes: trypsin-sensitive virus receptors and trypsin-resistant immune complex receptors","volume":"32","author":"Daughaday","year":"1981","journal-title":"Infect Immun"},{"key":"10.1007\/s10156-007-0516-9_bib0215","series-title":"Dengue and dengue hemorrhagic fever","first-page":"273","article-title":"Immunopathogenesis of dengue virus infections","author":"Kurane","year":"1997"},{"key":"10.1007\/s10156-007-0516-9_bib0220","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.4049\/jimmunol.166.3.1499","article-title":"Infection of human dendritic cells by dengue virus causes cell maturation and cytokine production","volume":"166","author":"Ho","year":"2001","journal-title":"J Immunol"},{"key":"10.1007\/s10156-007-0516-9_bib0225","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/(SICI)1096-9071(199803)54:3<210::AID-JMV12>3.0.CO;2-L","article-title":"Tumor necrosis factor alpha levels in plasma and whole-blood culture in dengue-infected patients","volume":"54","author":"Hober","year":"1998","journal-title":"J Med Virol"},{"key":"10.1007\/s10156-007-0516-9_bib0230","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1086\/314680","article-title":"Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity","volume":"179","author":"Green","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1007\/s10156-007-0516-9_bib0235","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.4049\/jimmunol.161.11.6338","article-title":"Dengue virus infection in human endothelial cells leads to chemokine production, complement activation and apoptosis","volume":"161","author":"Avirutnan","year":"1998","journal-title":"J Immunol"},{"key":"10.1007\/s10156-007-0516-9_bib0240","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1099\/vir.0.82093-0","article-title":"MCP-1, a highly expressed chemokine in dengue haemorrhagic fever\/dengue shock syndrome patients, may cause pearmeabilty change, possibly through reduced tight junctions of vascular endothelium cells","volume":"87","author":"Lee","year":"2006","journal-title":"J Gen Virol"},{"key":"10.1007\/s10156-007-0516-9_bib0245","doi-asserted-by":"crossref","first-page":"395","DOI":"10.4049\/jimmunol.174.1.395","article-title":"Expression of cytokine, chemokine and adhesion molecules during endothelial cell activation induced by antibodies against dengue virus nonstructural protein 1","volume":"174","author":"Lin","year":"2005","journal-title":"J Immunol"},{"key":"10.1007\/s10156-007-0516-9_bib0250","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1128\/jvi.71.6.4226-4232.1997","article-title":"Activation of endothelial cells via antibody-enhanced dengue virus infection of peripheral monocytes","volume":"71","author":"Anderson","year":"1997","journal-title":"J Virol"},{"key":"10.1007\/s10156-007-0516-9_bib0255","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1128\/JVI.00062-06","article-title":"Murine model for dengue virus-induced lethal disease with increased vascular permeability","volume":"80","author":"Shresta","year":"2006","journal-title":"J Virol"},{"key":"10.1007\/s10156-007-0516-9_bib0260","doi-asserted-by":"crossref","first-page":"395","DOI":"10.4049\/jimmunol.174.1.395","article-title":"Expression of cytokine, chemokine, and adhesion molecules during endothelial activation induced by antibodies against dengue virus nonstructural protein 1","volume":"174","author":"Lin","year":"2005","journal-title":"J Immunol"},{"key":"10.1007\/s10156-007-0516-9_bib0265","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/sj.embor.7400814","article-title":"Dengue-virus-infected dendritic cells trigger vascular leakage through metalloproteinase overproduction","volume":"7","author":"Luplerdlop","year":"2006","journal-title":"EMBO Rep"},{"key":"10.1007\/s10156-007-0516-9_bib0270","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3201\/eid0506.990615","article-title":"Dengue seroconversion among Israeli travelers to tropical countries","volume":"5","author":"Potasman","year":"1999","journal-title":"Emerging Infect Dis"},{"key":"10.1007\/s10156-007-0516-9_bib0275","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2310\/7060.2005.12308","article-title":"Epidemiology of travel-related hospitalization","volume":"12","author":"Steinlauf","year":"2005","journal-title":"T Travel Med"},{"key":"10.1007\/s10156-007-0516-9_bib0280","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1056\/NEJMoa051331","article-title":"Spectrum of diseases and relation to place of exposure among ill returned travelers","volume":"354","author":"Freedman","year":"2006","journal-title":"N Eng J Med"},{"key":"10.1007\/s10156-007-0516-9_bib0285","doi-asserted-by":"crossref","first-page":"470","DOI":"10.4269\/ajtmh.2006.75.470","article-title":"Clinical features of 62 imported cases of dengue fever in Japan","volume":"75","author":"Itoda","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"10.1007\/s10156-007-0516-9_bib0290","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4269\/ajtmh.2006.75.1.0750026","article-title":"Short report. Immune response and occurrence of dengue infection in Thai children three to eight years after vaccination with live attenuated tetravalent dengue vaccine","volume":"75","author":"Chanthavanich","year":"2006","journal-title":"Am J Trop Med Hyg"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X07708565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X07708565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s10156-007-0516-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:45:15Z","timestamp":1761158715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X07708565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007]]}},"alternative-id":["S1341321X07708565"],"URL":"https:\/\/doi.org\/10.1007\/s10156-007-0516-9","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2007]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dengue illness: clinical features and pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s10156-007-0516-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}