{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:58:01Z","timestamp":1780603081017,"version":"3.54.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2007]]},"DOI":"10.1007\/s10156-007-0528-5","type":"journal-article","created":{"date-parts":[[2007,8,24]],"date-time":"2007-08-24T04:09:01Z","timestamp":1187928541000},"page":"219-223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["High prevalence of erythromycin resistance and macrolide-resistance genes, mefA and ermB, in Streptococcus pneumoniae isolates from the upper respiratory tracts of children in the Sapporo district, Japan"],"prefix":"10.1016","volume":"13","author":[{"given":"Atsushi","family":"Harimaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norikazu","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Himi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s10156-007-0528-5_bib0005","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1093\/jac\/dkf801","article-title":"Global antibiotic resistance in Streptococcus pneumoniae","volume":"50","author":"Adam","year":"2002","journal-title":"J Antimicrob Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0010","doi-asserted-by":"crossref","first-page":"Sii3","DOI":"10.1093\/jac\/dki297","article-title":"The Alexander Project: the benefits from a decade of surveillance","volume":"56","author":"Felmingham","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/jac\/dkf808","article-title":"Increasing prevalence of antimicrobial resistance among isolates of Streptococcus pneumoniae from the PROTEKT surveillance study, and comparative in vitro activity of the ketolide, telithromycin","volume":"50","author":"Felmingham","year":"2002","journal-title":"J Antimicrob Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0020","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/jac\/dkg321","article-title":"Project Group. The Alexander Project 1998\u20132000: susceptibility of pathogens isolated from community-acquired respiratory tract infection to commonly used antimicrobial agents","volume":"52","author":"Jacobs","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0025","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1128\/AAC.40.8.1817","article-title":"Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolide but sensitive to clindamycin: a common resistance pattern mediated by an efflux system","volume":"40","author":"Sutcliffe","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0030","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1128\/AAC.39.3.577","article-title":"Erythromycin resistance by ribosome modification","volume":"39","author":"Weisblum","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0035","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1128\/AAC.41.10.2251","article-title":"mefE is necessary for the erythromycin-resistant M phenotype in Streptococcus pneumoniae","volume":"41","author":"Tait-Kamradt","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0040","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1128\/AAC.46.9.2727-2734.2002","article-title":"Resistance to macrolides and related antibiotics in Streptococcus pneumoniae","volume":"46","author":"Leclercq","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0045","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s10156-006-0473-8","article-title":"Alterations of pbp1apbp2b and pbp2x in Streptococcus pneumoniae isolates from children with otolaryngological infectious disease in Sapporo district, Japan","volume":"12","author":"Harimaya","year":"2006","journal-title":"J Infect Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0050","series-title":"Performance standards for antimicrobial susceptibility test","year":"2005"},{"key":"10.1007\/s10156-007-0528-5_bib0055","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/BF02490033","article-title":"Identification of penicillin and other beta-lactam resistance in Streptococcus pneumoniae by polymerase chain reaction","volume":"3","author":"Ubukata","year":"1997","journal-title":"J Infect Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0060","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10156-003-0258-2","article-title":"In vitro activities of a new ketolide, telithromycin, and eight other macrolide antibiotics against Streptococcus pneumoniae having mefA and ermB genes that mediate macrolide resistance","volume":"9","author":"Ubukata","year":"2003","journal-title":"J Infect Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0065","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/jac\/dki302","article-title":"Antibiotic susceptibility according to genotype of penicillin-binding protein and macrolide resistance genes, and serotype of Streotococcus pneumoniae isolates from community-acquired pneumonia in children","volume":"56","author":"Chiba","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0070","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijid.2004.03.008","article-title":"PROTEKT 1999\u20132000: a multicentre study of the antimicrobial susceptibility of respiratory tract pathogens in Japan","volume":"9","author":"Inoue","year":"2005","journal-title":"Int J Infect Dis"},{"key":"10.1007\/s10156-007-0528-5_bib0075","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s10156-004-0340-4","article-title":"Macrolide-resistant Streptococcus pneumoniae clinical isolates that occur in Hokkaido prefecture, Japan","volume":"10","author":"Yokota","year":"2004","journal-title":"J Infect Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0080","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1001\/jama.286.15.1857","article-title":"Macrolide resistance among invasive Streptococcus pneumoniae isolates","volume":"286","author":"Hyde","year":"2001","journal-title":"JAMA"},{"key":"10.1007\/s10156-007-0528-5_bib0085","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1086\/324527","article-title":"Clinical relevance of macrolide-resistant Streptococcus pneumoniae for community-acquired pneumonia","volume":"34","author":"Lynch","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1007\/s10156-007-0528-5_bib0090","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/01.mlg.0000154740.48314.d5","article-title":"Increase of macrolide-resistant Streptococcus pneumoniae-expressing mefE or ermB gene in the nasopharynx among children with otitis media","volume":"115","author":"Hotomi","year":"2005","journal-title":"Laryngoscope"},{"key":"10.1007\/s10156-007-0528-5_bib0095","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10156-005-0397-8","article-title":"Antimicrobial activities of tosufloxacin against Streptococcus pneumoniaeHaemophilus influenzae, and Moraxella branhamella catarrhalis isolated from otolaryngological infectious diseases","volume":"11","author":"Suzuki","year":"2005","journal-title":"J Infect Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0100","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s10156-002-0209-3","article-title":"Current status of bacterial resistance in the otolaryngology field: results from the Second Nationwide Survey in Japan","volume":"9","author":"Suzuki","year":"2003","journal-title":"J Infect Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0105","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0732-8893(00)00127-9","article-title":"Antimicrobial susceptibilities and serotypes of Streptococcus pneumoniae in southwestern Japan and correlation of penicillin-binding protein 2b and 2x mutations in susceptibilities of penicillin G and cefotaxime","volume":"37","author":"Nagai","year":"2000","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1007\/s10156-007-0528-5_bib0110","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1080\/00016480252775779","article-title":"Nasopharyngeal carriage of drug-resistant Streptococcus pneumoniae in children with acute otitis media evaluated by polymerase chain reaction-based genotyping of penicillin-binding proteins","volume":"122","author":"Hotomi","year":"2002","journal-title":"Acta Otolaryngol"},{"key":"10.1007\/s10156-007-0528-5_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2739\/kurumemedj.48.1","article-title":"Clinical and laboratory evaluation of penicillin resistant Streptococcus pneumoniae in relation to the mutations of pbp1apbp2b and pbp2x","volume":"48","author":"Tanoue","year":"2001","journal-title":"Kurume Med J"},{"key":"10.1007\/s10156-007-0528-5_bib0120","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1128\/AAC.40.8.1950","article-title":"Comparative activities of clarithromycin, erythromycin, and azithromycin against penicillin-susceptible and penicillin-resistant pneumococci","volume":"40","author":"Ednie","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0125","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s101560200002","article-title":"High frequency of erythromycin A resistance and distribution of mefE and ermB genes in clinical isolates of Steptococcus pneumoniae in Japan","volume":"8","author":"Okamoto","year":"2002","journal-title":"J Infect Chemother"},{"key":"10.1007\/s10156-007-0528-5_bib0130","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1128\/JCM.40.1.159-164.2002","article-title":"Importance of local variations in antibiotic consumption and geographical differences of erythromycin and penicillin resistance in Streptococcus pneumoniae","volume":"40","author":"Garcia-Rey","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1007\/s10156-007-0528-5_bib0135","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00228-003-0724-x","article-title":"The geographic relationship between the use of antimicrobial drugs and the pattern of resistance for Streptococcus pneumoniae in Italy","volume":"60","author":"Boccia","year":"2004","journal-title":"Eur J Clin Pharmacol"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X07708450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X07708450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s10156-007-0528-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:44:48Z","timestamp":1761158688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X07708450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007]]}},"alternative-id":["S1341321X07708450"],"URL":"https:\/\/doi.org\/10.1007\/s10156-007-0528-5","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2007]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High prevalence of erythromycin resistance and macrolide-resistance genes, mefA and ermB, in Streptococcus pneumoniae isolates from the upper respiratory tracts of children in the Sapporo district, Japan","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s10156-007-0528-5","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}